Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	54429
Gene name	Taste 2 receptor member 5
Gene symbol	TAS2R5
Synonyms (NCBI Gene)	T2R5
Chromosome	7
Chromosome location	7q34
Summary	This gene encodes a bitter taste receptor; bitter taste receptors are members of the G protein-coupled receptor superfamily and are specifically expressed by taste receptor cells of the tongue and palate epithelia. Each of these apparently intronless tast

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Show/Hide all (139)

miRTarBase ID	miRNA	Experiments	Reference
MIRT680465	hsa-miR-4438	HITS-CLIP	23824327
MIRT665002	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT650281	hsa-miR-1247-3p	HITS-CLIP	23824327
MIRT650280	hsa-miR-4532	HITS-CLIP	23824327
MIRT680464	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT680463	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT680462	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT680461	hsa-miR-1292-3p	HITS-CLIP	23824327
MIRT680460	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT680459	hsa-miR-1976	HITS-CLIP	23824327
MIRT680458	hsa-miR-6789-3p	HITS-CLIP	23824327
MIRT680457	hsa-miR-5095	HITS-CLIP	23824327
MIRT680456	hsa-miR-7151-3p	HITS-CLIP	23824327
MIRT680455	hsa-miR-4279	HITS-CLIP	23824327
MIRT665002	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT650281	hsa-miR-1247-3p	HITS-CLIP	23824327
MIRT650280	hsa-miR-4532	HITS-CLIP	23824327
MIRT627448	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT650279	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT650281	hsa-miR-1247-3p	HITS-CLIP	23824327
MIRT650280	hsa-miR-4532	HITS-CLIP	23824327
MIRT627448	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT650279	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT627450	hsa-miR-5693	HITS-CLIP	23824327
MIRT627446	hsa-miR-1267	HITS-CLIP	23824327
MIRT627445	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT627444	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT627443	hsa-miR-3135b	HITS-CLIP	23824327
MIRT627442	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT627441	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT627440	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT627439	hsa-miR-3652	HITS-CLIP	23824327
MIRT627438	hsa-miR-4430	HITS-CLIP	23824327
MIRT627437	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT627436	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT627435	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT627434	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT627433	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT627432	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT627431	hsa-miR-5698	HITS-CLIP	23824327
MIRT627450	hsa-miR-5693	HITS-CLIP	23824327
MIRT627449	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT627448	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT627447	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT627446	hsa-miR-1267	HITS-CLIP	23824327
MIRT627445	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT627444	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT627443	hsa-miR-3135b	HITS-CLIP	23824327
MIRT627442	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT627441	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT627440	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT627439	hsa-miR-3652	HITS-CLIP	23824327
MIRT627438	hsa-miR-4430	HITS-CLIP	23824327
MIRT627437	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT627436	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT627435	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT627434	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT627433	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT627432	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT627431	hsa-miR-5698	HITS-CLIP	23824327
MIRT627441	hsa-miR-122-5p	PAR-CLIP	27292025
MIRT627446	hsa-miR-1267	PAR-CLIP	27292025
MIRT627448	hsa-miR-1307-3p	PAR-CLIP	27292025
MIRT627437	hsa-miR-143-5p	PAR-CLIP	27292025
MIRT627443	hsa-miR-3135b	PAR-CLIP	27292025
MIRT627440	hsa-miR-3622b-5p	PAR-CLIP	27292025
MIRT627439	hsa-miR-3652	PAR-CLIP	27292025
MIRT627445	hsa-miR-367-5p	PAR-CLIP	27292025
MIRT627435	hsa-miR-4423-5p	PAR-CLIP	27292025
MIRT627438	hsa-miR-4430	PAR-CLIP	27292025
MIRT627447	hsa-miR-4638-5p	PAR-CLIP	27292025
MIRT627442	hsa-miR-504-3p	PAR-CLIP	27292025
MIRT627450	hsa-miR-5693	PAR-CLIP	27292025
MIRT627431	hsa-miR-5698	PAR-CLIP	27292025
MIRT627444	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT627436	hsa-miR-6501-5p	PAR-CLIP	27292025
MIRT627434	hsa-miR-6843-3p	PAR-CLIP	27292025
MIRT627433	hsa-miR-6848-3p	PAR-CLIP	27292025
MIRT627432	hsa-miR-744-3p	PAR-CLIP	27292025
MIRT680465	hsa-miR-4438	HITS-CLIP	23824327
MIRT665002	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT650281	hsa-miR-1247-3p	HITS-CLIP	23824327
MIRT650280	hsa-miR-4532	HITS-CLIP	23824327
MIRT680464	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT680463	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT680462	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT680461	hsa-miR-1292-3p	HITS-CLIP	23824327
MIRT680460	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT680459	hsa-miR-1976	HITS-CLIP	23824327
MIRT680458	hsa-miR-6789-3p	HITS-CLIP	23824327
MIRT680457	hsa-miR-5095	HITS-CLIP	23824327
MIRT680456	hsa-miR-7151-3p	HITS-CLIP	23824327
MIRT680455	hsa-miR-4279	HITS-CLIP	23824327
MIRT665002	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT650281	hsa-miR-1247-3p	HITS-CLIP	23824327
MIRT650280	hsa-miR-4532	HITS-CLIP	23824327
MIRT627448	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT650279	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT650281	hsa-miR-1247-3p	HITS-CLIP	23824327
MIRT650280	hsa-miR-4532	HITS-CLIP	23824327
MIRT627448	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT650279	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT627450	hsa-miR-5693	HITS-CLIP	23824327
MIRT627446	hsa-miR-1267	HITS-CLIP	23824327
MIRT627445	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT627444	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT627443	hsa-miR-3135b	HITS-CLIP	23824327
MIRT627442	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT627441	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT627440	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT627439	hsa-miR-3652	HITS-CLIP	23824327
MIRT627438	hsa-miR-4430	HITS-CLIP	23824327
MIRT627437	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT627436	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT627435	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT627434	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT627433	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT627432	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT627431	hsa-miR-5698	HITS-CLIP	23824327
MIRT627450	hsa-miR-5693	HITS-CLIP	23824327
MIRT627449	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT627448	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT627447	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT627446	hsa-miR-1267	HITS-CLIP	23824327
MIRT627445	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT627444	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT627443	hsa-miR-3135b	HITS-CLIP	23824327
MIRT627442	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT627441	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT627440	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT627439	hsa-miR-3652	HITS-CLIP	23824327
MIRT627438	hsa-miR-4430	HITS-CLIP	23824327
MIRT627437	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT627436	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT627435	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT627434	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT627433	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT627432	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT627431	hsa-miR-5698	HITS-CLIP	23824327

Show/Hide all (17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001580	Process	Detection of chemical stimulus involved in sensory perception of bitter taste	IBA
GO:0001580	Process	Detection of chemical stimulus involved in sensory perception of bitter taste	IDA	20022913
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007635	Process	Chemosensory behavior	TAS	10761935
GO:0008527	Function	Taste receptor activity	TAS	10761934
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IC	20022913
GO:0016020	Component	Membrane	IEA
GO:0033038	Function	Bitter taste receptor activity	IBA
GO:0033038	Function	Bitter taste receptor activity	IDA	20022913
GO:0033038	Function	Bitter taste receptor activity	IEA
GO:0050909	Process	Sensory perception of taste	IEA

MIM	HGNC	e!Ensembl
605062	14912	ENSG00000127366

Q9NYW4

Protein name

Taste receptor type 2 member 5 (T2R5)

Protein function

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05296	TAS2R	1 → 291	Taste receptor protein (TAS2R)	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.

Sequence

MLSAGLGLLMLVAVVEFLIGLIGNGSLVVWSFREWIRKFNWSSYNLIILGLAGCRFLLQW
LIILDLSLFPLFQSSRWLRYLSIFWVLVSQASLWFATFLSVFYCKKITTFDRPAYLWLKQ
RAYNLSLWCLLGYFIINLLLTVQIGLTFYHPPQGNSSIRYPFESWQYLYAFQLNSGSYLP
LVVFLVSSGMLIVSLYTHHKKMKVHSAGRRDVRAKAHITALKSLGCFLLLHLVYIMASPF
SITSKTYPPDLTSVFIWETLMAAYPSLHSLILIMGIPRVKQTCQKILWKTVCARRCWGP

Sequence length

299

Interactions

View interactions

	KEGG		Reactome
	Taste transduction		G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
LATE-ONSET ALZHEIMER'S DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (3)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Head and Neck Carcinoma	Head And Neck Carcinoma	BEFREE	26422579		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Head and Neck Neoplasm	Head and neck cancer	BEFREE	26422579		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	33572225	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

TAS2R5 (taste 2 receptor member 5)