POLR2F (RNA polymerase II, I and III subunit F)

Gene

• Entrez ID: 5435
• Gene name: RNA polymerase II, I and III subunit F
• Gene symbol: POLR2F
• Synonyms (NCBI Gene): HRBP14.4, POLRF, RPABC14.4, RPABC2, RPB14.4, RPB6, RPC15
• Chromosome: 22
• Chromosome location: 22q13.1
• Summary: This gene encodes the sixth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, this polymerase subunit, in combination with at least two other subunits, forms a structure that stabilize

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs533778281	G>C	Likely-pathogenic, uncertain-significance	Genic downstream transcript variant, intron variant
rs606231342	G>A	Likely-pathogenic	Intron variant, genic downstream transcript variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT029533	hsa-miR-26b-5p	Microarray	19088304
MIRT044569	hsa-miR-320a	CLASH	23622248
MIRT044006	hsa-miR-378a-5p	CLASH	23622248
MIRT036080	hsa-miR-1296-5p	CLASH	23622248
MIRT503651	hsa-miR-4676-5p	PAR-CLIP	22012620
MIRT503650	hsa-miR-575	PAR-CLIP	22012620
MIRT503649	hsa-miR-4695-5p	PAR-CLIP	22012620
MIRT503648	hsa-miR-4779	PAR-CLIP	22012620
MIRT503647	hsa-miR-1321	PAR-CLIP	22012620
MIRT503646	hsa-miR-4739	PAR-CLIP	22012620
MIRT503645	hsa-miR-4756-5p	PAR-CLIP	22012620
MIRT503644	hsa-miR-4302	PAR-CLIP	22012620
MIRT503643	hsa-miR-199a-5p	PAR-CLIP	22012620
MIRT503642	hsa-miR-199b-5p	PAR-CLIP	22012620
MIRT503641	hsa-miR-3663-5p	PAR-CLIP	22012620
MIRT503640	hsa-miR-4419a	PAR-CLIP	22012620
MIRT503639	hsa-miR-4510	PAR-CLIP	22012620
MIRT503638	hsa-miR-6127	PAR-CLIP	22012620
MIRT503637	hsa-miR-6129	PAR-CLIP	22012620
MIRT503636	hsa-miR-6130	PAR-CLIP	22012620
MIRT503635	hsa-miR-6133	PAR-CLIP	22012620
MIRT503634	hsa-miR-505-5p	PAR-CLIP	22012620
MIRT503633	hsa-miR-765	PAR-CLIP	22012620
MIRT503632	hsa-miR-1249-5p	PAR-CLIP	22012620
MIRT503631	hsa-miR-6797-5p	PAR-CLIP	22012620
MIRT503630	hsa-miR-7106-5p	PAR-CLIP	22012620
MIRT503629	hsa-miR-200c-5p	PAR-CLIP	22012620
MIRT503628	hsa-miR-550a-3p	PAR-CLIP	22012620
MIRT503627	hsa-miR-134-5p	PAR-CLIP	22012620
MIRT503626	hsa-miR-3118	PAR-CLIP	22012620
MIRT503624	hsa-miR-3164	PAR-CLIP	22012620
MIRT503625	hsa-miR-6820-3p	PAR-CLIP	22012620
MIRT503623	hsa-miR-4777-3p	PAR-CLIP	22012620
MIRT503622	hsa-miR-4266	PAR-CLIP	22012620
MIRT503651	hsa-miR-4676-5p	PAR-CLIP	23446348
MIRT503650	hsa-miR-575	PAR-CLIP	23446348
MIRT503649	hsa-miR-4695-5p	PAR-CLIP	23446348
MIRT503648	hsa-miR-4779	PAR-CLIP	23446348
MIRT503647	hsa-miR-1321	PAR-CLIP	23446348
MIRT503646	hsa-miR-4739	PAR-CLIP	23446348
MIRT503645	hsa-miR-4756-5p	PAR-CLIP	23446348
MIRT503644	hsa-miR-4302	PAR-CLIP	23446348
MIRT503643	hsa-miR-199a-5p	PAR-CLIP	23446348
MIRT503642	hsa-miR-199b-5p	PAR-CLIP	23446348
MIRT503641	hsa-miR-3663-5p	PAR-CLIP	23446348
MIRT503640	hsa-miR-4419a	PAR-CLIP	23446348
MIRT503639	hsa-miR-4510	PAR-CLIP	23446348
MIRT503638	hsa-miR-6127	PAR-CLIP	23446348
MIRT503637	hsa-miR-6129	PAR-CLIP	23446348
MIRT503636	hsa-miR-6130	PAR-CLIP	23446348
MIRT503635	hsa-miR-6133	PAR-CLIP	23446348
MIRT503634	hsa-miR-505-5p	PAR-CLIP	23446348
MIRT503633	hsa-miR-765	PAR-CLIP	23446348
MIRT503632	hsa-miR-1249-5p	PAR-CLIP	23446348
MIRT503631	hsa-miR-6797-5p	PAR-CLIP	23446348
MIRT503630	hsa-miR-7106-5p	PAR-CLIP	23446348
MIRT503629	hsa-miR-200c-5p	PAR-CLIP	23446348
MIRT503628	hsa-miR-550a-3p	PAR-CLIP	23446348
MIRT503627	hsa-miR-134-5p	PAR-CLIP	23446348
MIRT503626	hsa-miR-3118	PAR-CLIP	23446348
MIRT503624	hsa-miR-3164	PAR-CLIP	23446348
MIRT503625	hsa-miR-6820-3p	PAR-CLIP	23446348
MIRT503623	hsa-miR-4777-3p	PAR-CLIP	23446348
MIRT503622	hsa-miR-4266	PAR-CLIP	23446348
MIRT503651	hsa-miR-4676-5p	PAR-CLIP	23446348
MIRT503650	hsa-miR-575	PAR-CLIP	23446348
MIRT503649	hsa-miR-4695-5p	PAR-CLIP	23446348
MIRT503648	hsa-miR-4779	PAR-CLIP	23446348
MIRT503647	hsa-miR-1321	PAR-CLIP	23446348
MIRT503646	hsa-miR-4739	PAR-CLIP	23446348
MIRT503645	hsa-miR-4756-5p	PAR-CLIP	23446348
MIRT503644	hsa-miR-4302	PAR-CLIP	23446348
MIRT503643	hsa-miR-199a-5p	PAR-CLIP	23446348
MIRT503642	hsa-miR-199b-5p	PAR-CLIP	23446348
MIRT503641	hsa-miR-3663-5p	PAR-CLIP	23446348
MIRT503640	hsa-miR-4419a	PAR-CLIP	23446348
MIRT503639	hsa-miR-4510	PAR-CLIP	23446348
MIRT503638	hsa-miR-6127	PAR-CLIP	23446348
MIRT503637	hsa-miR-6129	PAR-CLIP	23446348
MIRT503636	hsa-miR-6130	PAR-CLIP	23446348
MIRT503635	hsa-miR-6133	PAR-CLIP	23446348
MIRT503634	hsa-miR-505-5p	PAR-CLIP	23446348
MIRT503633	hsa-miR-765	PAR-CLIP	23446348
MIRT503632	hsa-miR-1249-5p	PAR-CLIP	23446348
MIRT503631	hsa-miR-6797-5p	PAR-CLIP	23446348
MIRT503630	hsa-miR-7106-5p	PAR-CLIP	23446348
MIRT503629	hsa-miR-200c-5p	PAR-CLIP	23446348
MIRT503628	hsa-miR-550a-3p	PAR-CLIP	23446348
MIRT503627	hsa-miR-134-5p	PAR-CLIP	23446348
MIRT503626	hsa-miR-3118	PAR-CLIP	23446348
MIRT503624	hsa-miR-3164	PAR-CLIP	23446348
MIRT503625	hsa-miR-6820-3p	PAR-CLIP	23446348
MIRT503623	hsa-miR-4777-3p	PAR-CLIP	23446348
MIRT503622	hsa-miR-4266	PAR-CLIP	23446348
MIRT503632	hsa-miR-1249-5p	PAR-CLIP	26701625
MIRT503632	hsa-miR-1249-5p	PAR-CLIP	26701625
MIRT503632	hsa-miR-1249-5p	PAR-CLIP	26701625
MIRT503647	hsa-miR-1321	PAR-CLIP	26701625
MIRT503647	hsa-miR-1321	PAR-CLIP	26701625
MIRT503647	hsa-miR-1321	PAR-CLIP	26701625
MIRT503627	hsa-miR-134-5p	PAR-CLIP	26701625
MIRT503627	hsa-miR-134-5p	PAR-CLIP	26701625
MIRT503627	hsa-miR-134-5p	PAR-CLIP	26701625
MIRT503627	hsa-miR-134-5p	PAR-CLIP	26701625
MIRT503627	hsa-miR-134-5p	PAR-CLIP	26701625
MIRT503643	hsa-miR-199a-5p	PAR-CLIP	26701625
MIRT503643	hsa-miR-199a-5p	PAR-CLIP	26701625
MIRT503643	hsa-miR-199a-5p	PAR-CLIP	26701625
MIRT503643	hsa-miR-199a-5p	PAR-CLIP	26701625
MIRT503643	hsa-miR-199a-5p	PAR-CLIP	26701625
MIRT503642	hsa-miR-199b-5p	PAR-CLIP	26701625
MIRT503642	hsa-miR-199b-5p	PAR-CLIP	26701625
MIRT503642	hsa-miR-199b-5p	PAR-CLIP	26701625
MIRT503642	hsa-miR-199b-5p	PAR-CLIP	26701625
MIRT503642	hsa-miR-199b-5p	PAR-CLIP	26701625
MIRT503629	hsa-miR-200c-5p	PAR-CLIP	26701625
MIRT503629	hsa-miR-200c-5p	PAR-CLIP	26701625
MIRT503629	hsa-miR-200c-5p	PAR-CLIP	26701625
MIRT503629	hsa-miR-200c-5p	PAR-CLIP	26701625
MIRT503629	hsa-miR-200c-5p	PAR-CLIP	26701625
MIRT503626	hsa-miR-3118	PAR-CLIP	26701625
MIRT503626	hsa-miR-3118	PAR-CLIP	26701625
MIRT503626	hsa-miR-3118	PAR-CLIP	26701625
MIRT503626	hsa-miR-3118	PAR-CLIP	26701625
MIRT503626	hsa-miR-3118	PAR-CLIP	26701625
MIRT503624	hsa-miR-3164	PAR-CLIP	26701625
MIRT503624	hsa-miR-3164	PAR-CLIP	26701625
MIRT503624	hsa-miR-3164	PAR-CLIP	26701625
MIRT503624	hsa-miR-3164	PAR-CLIP	26701625
MIRT503624	hsa-miR-3164	PAR-CLIP	26701625
MIRT503641	hsa-miR-3663-5p	PAR-CLIP	26701625
MIRT503641	hsa-miR-3663-5p	PAR-CLIP	26701625
MIRT503641	hsa-miR-3663-5p	PAR-CLIP	26701625
MIRT503641	hsa-miR-3663-5p	PAR-CLIP	26701625
MIRT503641	hsa-miR-3663-5p	PAR-CLIP	26701625
MIRT503622	hsa-miR-4266	PAR-CLIP	26701625
MIRT503622	hsa-miR-4266	PAR-CLIP	26701625
MIRT503622	hsa-miR-4266	PAR-CLIP	26701625
MIRT503644	hsa-miR-4302	PAR-CLIP	26701625
MIRT503644	hsa-miR-4302	PAR-CLIP	26701625
MIRT503644	hsa-miR-4302	PAR-CLIP	26701625
MIRT503644	hsa-miR-4302	PAR-CLIP	26701625
MIRT503644	hsa-miR-4302	PAR-CLIP	26701625
MIRT503640	hsa-miR-4419a	PAR-CLIP	26701625
MIRT503640	hsa-miR-4419a	PAR-CLIP	26701625
MIRT503640	hsa-miR-4419a	PAR-CLIP	26701625
MIRT503639	hsa-miR-4510	PAR-CLIP	26701625
MIRT503639	hsa-miR-4510	PAR-CLIP	26701625
MIRT503639	hsa-miR-4510	PAR-CLIP	26701625
MIRT503651	hsa-miR-4676-5p	PAR-CLIP	26701625
MIRT503651	hsa-miR-4676-5p	PAR-CLIP	26701625
MIRT503651	hsa-miR-4676-5p	PAR-CLIP	26701625
MIRT503651	hsa-miR-4676-5p	PAR-CLIP	26701625
MIRT503651	hsa-miR-4676-5p	PAR-CLIP	26701625
MIRT503649	hsa-miR-4695-5p	PAR-CLIP	26701625
MIRT503649	hsa-miR-4695-5p	PAR-CLIP	26701625
MIRT503649	hsa-miR-4695-5p	PAR-CLIP	26701625
MIRT503646	hsa-miR-4739	PAR-CLIP	26701625
MIRT503646	hsa-miR-4739	PAR-CLIP	26701625
MIRT503646	hsa-miR-4739	PAR-CLIP	26701625
MIRT503645	hsa-miR-4756-5p	PAR-CLIP	26701625
MIRT503645	hsa-miR-4756-5p	PAR-CLIP	26701625
MIRT503645	hsa-miR-4756-5p	PAR-CLIP	26701625
MIRT503623	hsa-miR-4777-3p	PAR-CLIP	26701625
MIRT503623	hsa-miR-4777-3p	PAR-CLIP	26701625
MIRT503623	hsa-miR-4777-3p	PAR-CLIP	26701625
MIRT503623	hsa-miR-4777-3p	PAR-CLIP	26701625
MIRT503623	hsa-miR-4777-3p	PAR-CLIP	26701625
MIRT503648	hsa-miR-4779	PAR-CLIP	26701625
MIRT503648	hsa-miR-4779	PAR-CLIP	26701625
MIRT503648	hsa-miR-4779	PAR-CLIP	26701625
MIRT503634	hsa-miR-505-5p	PAR-CLIP	26701625
MIRT503634	hsa-miR-505-5p	PAR-CLIP	26701625
MIRT503634	hsa-miR-505-5p	PAR-CLIP	26701625
MIRT503634	hsa-miR-505-5p	PAR-CLIP	26701625
MIRT503634	hsa-miR-505-5p	PAR-CLIP	26701625
MIRT503628	hsa-miR-550a-3p	PAR-CLIP	26701625
MIRT503628	hsa-miR-550a-3p	PAR-CLIP	26701625
MIRT503628	hsa-miR-550a-3p	PAR-CLIP	26701625
MIRT503628	hsa-miR-550a-3p	PAR-CLIP	26701625
MIRT503628	hsa-miR-550a-3p	PAR-CLIP	26701625
MIRT503650	hsa-miR-575	PAR-CLIP	26701625
MIRT503650	hsa-miR-575	PAR-CLIP	26701625
MIRT503650	hsa-miR-575	PAR-CLIP	26701625
MIRT503650	hsa-miR-575	PAR-CLIP	26701625
MIRT503650	hsa-miR-575	PAR-CLIP	26701625
MIRT503638	hsa-miR-6127	PAR-CLIP	26701625
MIRT503638	hsa-miR-6127	PAR-CLIP	26701625
MIRT503638	hsa-miR-6127	PAR-CLIP	26701625
MIRT503637	hsa-miR-6129	PAR-CLIP	26701625
MIRT503637	hsa-miR-6129	PAR-CLIP	26701625
MIRT503637	hsa-miR-6129	PAR-CLIP	26701625
MIRT503636	hsa-miR-6130	PAR-CLIP	26701625
MIRT503636	hsa-miR-6130	PAR-CLIP	26701625
MIRT503636	hsa-miR-6130	PAR-CLIP	26701625
MIRT503635	hsa-miR-6133	PAR-CLIP	26701625
MIRT503635	hsa-miR-6133	PAR-CLIP	26701625
MIRT503635	hsa-miR-6133	PAR-CLIP	26701625
MIRT503631	hsa-miR-6797-5p	PAR-CLIP	26701625
MIRT503631	hsa-miR-6797-5p	PAR-CLIP	26701625
MIRT503631	hsa-miR-6797-5p	PAR-CLIP	26701625
MIRT503625	hsa-miR-6820-3p	PAR-CLIP	26701625
MIRT503625	hsa-miR-6820-3p	PAR-CLIP	26701625
MIRT503625	hsa-miR-6820-3p	PAR-CLIP	26701625
MIRT503625	hsa-miR-6820-3p	PAR-CLIP	26701625
MIRT503625	hsa-miR-6820-3p	PAR-CLIP	26701625
MIRT503630	hsa-miR-7106-5p	PAR-CLIP	26701625
MIRT503630	hsa-miR-7106-5p	PAR-CLIP	26701625
MIRT503630	hsa-miR-7106-5p	PAR-CLIP	26701625
MIRT503633	hsa-miR-765	PAR-CLIP	26701625
MIRT503633	hsa-miR-765	PAR-CLIP	26701625
MIRT503633	hsa-miR-765	PAR-CLIP	26701625
MIRT503651	hsa-miR-4676-5p	PAR-CLIP	22012620
MIRT503650	hsa-miR-575	PAR-CLIP	22012620
MIRT503649	hsa-miR-4695-5p	PAR-CLIP	22012620
MIRT503648	hsa-miR-4779	PAR-CLIP	22012620
MIRT503647	hsa-miR-1321	PAR-CLIP	22012620
MIRT503646	hsa-miR-4739	PAR-CLIP	22012620
MIRT503645	hsa-miR-4756-5p	PAR-CLIP	22012620
MIRT503644	hsa-miR-4302	PAR-CLIP	22012620
MIRT503643	hsa-miR-199a-5p	PAR-CLIP	22012620
MIRT503642	hsa-miR-199b-5p	PAR-CLIP	22012620
MIRT503641	hsa-miR-3663-5p	PAR-CLIP	22012620
MIRT503640	hsa-miR-4419a	PAR-CLIP	22012620
MIRT503639	hsa-miR-4510	PAR-CLIP	22012620
MIRT503638	hsa-miR-6127	PAR-CLIP	22012620
MIRT503637	hsa-miR-6129	PAR-CLIP	22012620
MIRT503636	hsa-miR-6130	PAR-CLIP	22012620
MIRT503635	hsa-miR-6133	PAR-CLIP	22012620
MIRT503634	hsa-miR-505-5p	PAR-CLIP	22012620
MIRT503633	hsa-miR-765	PAR-CLIP	22012620
MIRT503632	hsa-miR-1249-5p	PAR-CLIP	22012620
MIRT503631	hsa-miR-6797-5p	PAR-CLIP	22012620
MIRT503630	hsa-miR-7106-5p	PAR-CLIP	22012620
MIRT503629	hsa-miR-200c-5p	PAR-CLIP	22012620
MIRT503628	hsa-miR-550a-3p	PAR-CLIP	22012620
MIRT503627	hsa-miR-134-5p	PAR-CLIP	22012620
MIRT503626	hsa-miR-3118	PAR-CLIP	22012620
MIRT503624	hsa-miR-3164	PAR-CLIP	22012620
MIRT503625	hsa-miR-6820-3p	PAR-CLIP	22012620
MIRT503623	hsa-miR-4777-3p	PAR-CLIP	22012620
MIRT503622	hsa-miR-4266	PAR-CLIP	22012620
MIRT503651	hsa-miR-4676-5p	PAR-CLIP	23446348
MIRT503650	hsa-miR-575	PAR-CLIP	23446348
MIRT503649	hsa-miR-4695-5p	PAR-CLIP	23446348
MIRT503648	hsa-miR-4779	PAR-CLIP	23446348
MIRT503647	hsa-miR-1321	PAR-CLIP	23446348
MIRT503646	hsa-miR-4739	PAR-CLIP	23446348
MIRT503645	hsa-miR-4756-5p	PAR-CLIP	23446348
MIRT503644	hsa-miR-4302	PAR-CLIP	23446348
MIRT503643	hsa-miR-199a-5p	PAR-CLIP	23446348
MIRT503642	hsa-miR-199b-5p	PAR-CLIP	23446348
MIRT503641	hsa-miR-3663-5p	PAR-CLIP	23446348
MIRT503640	hsa-miR-4419a	PAR-CLIP	23446348
MIRT503639	hsa-miR-4510	PAR-CLIP	23446348
MIRT503638	hsa-miR-6127	PAR-CLIP	23446348
MIRT503637	hsa-miR-6129	PAR-CLIP	23446348
MIRT503636	hsa-miR-6130	PAR-CLIP	23446348
MIRT503635	hsa-miR-6133	PAR-CLIP	23446348
MIRT503634	hsa-miR-505-5p	PAR-CLIP	23446348
MIRT503633	hsa-miR-765	PAR-CLIP	23446348
MIRT503632	hsa-miR-1249-5p	PAR-CLIP	23446348
MIRT503631	hsa-miR-6797-5p	PAR-CLIP	23446348
MIRT503630	hsa-miR-7106-5p	PAR-CLIP	23446348
MIRT503629	hsa-miR-200c-5p	PAR-CLIP	23446348
MIRT503628	hsa-miR-550a-3p	PAR-CLIP	23446348
MIRT503627	hsa-miR-134-5p	PAR-CLIP	23446348
MIRT503626	hsa-miR-3118	PAR-CLIP	23446348
MIRT503624	hsa-miR-3164	PAR-CLIP	23446348
MIRT503625	hsa-miR-6820-3p	PAR-CLIP	23446348
MIRT503623	hsa-miR-4777-3p	PAR-CLIP	23446348
MIRT503622	hsa-miR-4266	PAR-CLIP	23446348
MIRT503651	hsa-miR-4676-5p	PAR-CLIP	23446348
MIRT503650	hsa-miR-575	PAR-CLIP	23446348
MIRT503649	hsa-miR-4695-5p	PAR-CLIP	23446348
MIRT503648	hsa-miR-4779	PAR-CLIP	23446348
MIRT503647	hsa-miR-1321	PAR-CLIP	23446348
MIRT503646	hsa-miR-4739	PAR-CLIP	23446348
MIRT503645	hsa-miR-4756-5p	PAR-CLIP	23446348
MIRT503644	hsa-miR-4302	PAR-CLIP	23446348
MIRT503643	hsa-miR-199a-5p	PAR-CLIP	23446348
MIRT503642	hsa-miR-199b-5p	PAR-CLIP	23446348
MIRT503641	hsa-miR-3663-5p	PAR-CLIP	23446348
MIRT503640	hsa-miR-4419a	PAR-CLIP	23446348
MIRT503639	hsa-miR-4510	PAR-CLIP	23446348
MIRT503638	hsa-miR-6127	PAR-CLIP	23446348
MIRT503637	hsa-miR-6129	PAR-CLIP	23446348
MIRT503636	hsa-miR-6130	PAR-CLIP	23446348
MIRT503635	hsa-miR-6133	PAR-CLIP	23446348
MIRT503634	hsa-miR-505-5p	PAR-CLIP	23446348
MIRT503633	hsa-miR-765	PAR-CLIP	23446348
MIRT503632	hsa-miR-1249-5p	PAR-CLIP	23446348
MIRT503631	hsa-miR-6797-5p	PAR-CLIP	23446348
MIRT503630	hsa-miR-7106-5p	PAR-CLIP	23446348
MIRT503629	hsa-miR-200c-5p	PAR-CLIP	23446348
MIRT503628	hsa-miR-550a-3p	PAR-CLIP	23446348
MIRT503627	hsa-miR-134-5p	PAR-CLIP	23446348
MIRT503626	hsa-miR-3118	PAR-CLIP	23446348
MIRT503624	hsa-miR-3164	PAR-CLIP	23446348
MIRT503625	hsa-miR-6820-3p	PAR-CLIP	23446348
MIRT503623	hsa-miR-4777-3p	PAR-CLIP	23446348
MIRT503622	hsa-miR-4266	PAR-CLIP	23446348
MIRT1248712	hsa-miR-1193	CLIP-seq
MIRT1248713	hsa-miR-1202	CLIP-seq
MIRT1248714	hsa-miR-122	CLIP-seq
MIRT1248715	hsa-miR-1254	CLIP-seq
MIRT1248716	hsa-miR-134	CLIP-seq
MIRT1248717	hsa-miR-214	CLIP-seq
MIRT1248718	hsa-miR-2467-3p	CLIP-seq
MIRT1248719	hsa-miR-29a	CLIP-seq
MIRT1248720	hsa-miR-29b	CLIP-seq
MIRT1248721	hsa-miR-29c	CLIP-seq
MIRT1248722	hsa-miR-3074-5p	CLIP-seq
MIRT1248723	hsa-miR-3116	CLIP-seq
MIRT1248724	hsa-miR-3120-5p	CLIP-seq
MIRT1248725	hsa-miR-3165	CLIP-seq
MIRT1248726	hsa-miR-3179	CLIP-seq
MIRT1248727	hsa-miR-3194-3p	CLIP-seq
MIRT1248728	hsa-miR-3194-5p	CLIP-seq
MIRT1248729	hsa-miR-3202	CLIP-seq
MIRT1248730	hsa-miR-346	CLIP-seq
MIRT1248731	hsa-miR-3591-3p	CLIP-seq
MIRT1248732	hsa-miR-3611	CLIP-seq
MIRT1248733	hsa-miR-3619-5p	CLIP-seq
MIRT1248734	hsa-miR-3622b-5p	CLIP-seq
MIRT1248735	hsa-miR-3647-3p	CLIP-seq
MIRT1248736	hsa-miR-3663-3p	CLIP-seq
MIRT1248737	hsa-miR-3675-5p	CLIP-seq
MIRT1248738	hsa-miR-3691-5p	CLIP-seq
MIRT1248739	hsa-miR-370	CLIP-seq
MIRT1248740	hsa-miR-3714	CLIP-seq
MIRT1248741	hsa-miR-3945	CLIP-seq
MIRT1248742	hsa-miR-3972	CLIP-seq
MIRT1248743	hsa-miR-3978	CLIP-seq
MIRT1248744	hsa-miR-4253	CLIP-seq
MIRT1248745	hsa-miR-4271	CLIP-seq
MIRT1248746	hsa-miR-4288	CLIP-seq
MIRT1248747	hsa-miR-432	CLIP-seq
MIRT1248748	hsa-miR-4438	CLIP-seq
MIRT1248749	hsa-miR-4443	CLIP-seq
MIRT1248750	hsa-miR-4484	CLIP-seq
MIRT1248751	hsa-miR-4530	CLIP-seq
MIRT1248752	hsa-miR-4533	CLIP-seq
MIRT1248753	hsa-miR-4725-3p	CLIP-seq
MIRT1248754	hsa-miR-4731-5p	CLIP-seq
MIRT1248755	hsa-miR-4747-5p	CLIP-seq
MIRT1248756	hsa-miR-516a-3p	CLIP-seq
MIRT1248757	hsa-miR-552	CLIP-seq
MIRT1248758	hsa-miR-574-5p	CLIP-seq
MIRT1248759	hsa-miR-580	CLIP-seq
MIRT1248760	hsa-miR-619	CLIP-seq
MIRT1248761	hsa-miR-632	CLIP-seq
MIRT1248762	hsa-miR-661	CLIP-seq
MIRT1248763	hsa-miR-665	CLIP-seq
MIRT1248764	hsa-miR-760	CLIP-seq
MIRT1248765	hsa-miR-761	CLIP-seq
MIRT1248724	hsa-miR-3120-5p	CLIP-seq
MIRT1248729	hsa-miR-3202	CLIP-seq
MIRT1248730	hsa-miR-346	CLIP-seq
MIRT1248740	hsa-miR-3714	CLIP-seq
MIRT1248746	hsa-miR-4288	CLIP-seq
MIRT1248752	hsa-miR-4533	CLIP-seq
MIRT1248761	hsa-miR-632	CLIP-seq
MIRT1248717	hsa-miR-214	CLIP-seq
MIRT1248729	hsa-miR-3202	CLIP-seq
MIRT1248733	hsa-miR-3619-5p	CLIP-seq
MIRT2073447	hsa-miR-3918	CLIP-seq
MIRT2073448	hsa-miR-4267	CLIP-seq
MIRT2073449	hsa-miR-4436b-3p	CLIP-seq
MIRT1248751	hsa-miR-4530	CLIP-seq
MIRT1248752	hsa-miR-4533	CLIP-seq
MIRT2073450	hsa-miR-4685-5p	CLIP-seq
MIRT1248755	hsa-miR-4747-5p	CLIP-seq
MIRT1248765	hsa-miR-761	CLIP-seq
MIRT1248712	hsa-miR-1193	CLIP-seq
MIRT1248714	hsa-miR-122	CLIP-seq
MIRT2300494	hsa-miR-1285	CLIP-seq
MIRT1248725	hsa-miR-3165	CLIP-seq
MIRT2300495	hsa-miR-3187-5p	CLIP-seq
MIRT2300496	hsa-miR-326	CLIP-seq
MIRT2300497	hsa-miR-330-5p	CLIP-seq
MIRT2300498	hsa-miR-3678-3p	CLIP-seq
MIRT1248738	hsa-miR-3691-5p	CLIP-seq
MIRT2073448	hsa-miR-4267	CLIP-seq
MIRT1248745	hsa-miR-4271	CLIP-seq
MIRT1248746	hsa-miR-4288	CLIP-seq
MIRT1248747	hsa-miR-432	CLIP-seq
MIRT1248749	hsa-miR-4443	CLIP-seq
MIRT2300499	hsa-miR-4667-5p	CLIP-seq
MIRT2300500	hsa-miR-4700-5p	CLIP-seq
MIRT1248753	hsa-miR-4725-3p	CLIP-seq
MIRT1248757	hsa-miR-552	CLIP-seq
MIRT1248758	hsa-miR-574-5p	CLIP-seq
MIRT2300501	hsa-miR-612	CLIP-seq
MIRT1248761	hsa-miR-632	CLIP-seq
MIRT2300502	hsa-miR-637	CLIP-seq
MIRT1248727	hsa-miR-3194-3p	CLIP-seq
MIRT1248729	hsa-miR-3202	CLIP-seq
MIRT1248740	hsa-miR-3714	CLIP-seq
MIRT1248752	hsa-miR-4533	CLIP-seq
MIRT1248719	hsa-miR-29a	CLIP-seq
MIRT1248720	hsa-miR-29b	CLIP-seq
MIRT1248721	hsa-miR-29c	CLIP-seq
MIRT2688358	hsa-miR-3065-3p	CLIP-seq
MIRT1248736	hsa-miR-3663-3p	CLIP-seq
MIRT2688359	hsa-miR-767-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000428	Component	DNA-directed RNA polymerase complex	IEA
GO:0001650	Component	Fibrillar center	IDA
GO:0003677	Function	DNA binding	IEA
GO:0003899	Function	DNA-directed RNA polymerase activity	IBA
GO:0003899	Function	DNA-directed RNA polymerase activity	IEA
GO:0005634	Component	Nucleus	IDA	9852112
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005665	Component	RNA polymerase II, core complex	IBA
GO:0005665	Component	RNA polymerase II, core complex	IDA	9852112
GO:0005665	Component	RNA polymerase II, core complex	IEA
GO:0005666	Component	RNA polymerase III complex	IBA
GO:0005666	Component	RNA polymerase III complex	IDA	33335104, 34675218
GO:0005730	Component	Nucleolus	IEA
GO:0005736	Component	RNA polymerase I complex	IBA
GO:0005736	Component	RNA polymerase I complex	IDA	34671025, 36271492
GO:0005829	Component	Cytosol	TAS
GO:0006351	Process	DNA-templated transcription	IEA
GO:0006360	Process	Transcription by RNA polymerase I	IBA
GO:0006366	Process	Transcription by RNA polymerase II	IBA
GO:0006366	Process	Transcription by RNA polymerase II	IDA	9852112
GO:0042797	Process	TRNA transcription by RNA polymerase III	IBA

Other IDs

• MIM: 604414
• HGNC: 9193
• e!Ensembl: ENSG00000100142

Protein

• UniProt ID: P61218
• Protein name: DNA-directed RNA polymerases I, II, and III subunit RPABC2 (RNA polymerases I, II, and III subunit ABC2) (DNA-directed RNA polymerase II subunit F) (DNA-directed RNA polymerases I, II, and III 14.4 kDa polypeptide) (RPABC14.4) (RPB14.4) (RPB6 homolog) (RP
• Protein function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II, and III which synthesize ribosomal RNA precursors, mRNA precursors and
• PDB: 1QKL, 5IY6, 5IY7, 5IY8, 5IY9, 5IYA, 5IYB, 5IYC, 5IYD, 6DRD, 6O9L, 6XRE, 7A6H, 7AE1, 7AE3, 7AEA, 7AST, 7D58, 7D59, 7DN3, 7DTH, 7DTI, 7DU2, 7FJI, 7FJJ, 7LBM, 7OB9, 7OBA, 7OBB, 7VBA, 7VBB, 7VBC, 8A43, 8ITY, 8IUE, 8IUH, 9EHZ, 9EI1, 9EI3, 9EI4, 9FSO, 9FSP, 9FSQ, 9FSR, 9FSS
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01192	RNA_pol_Rpb6	51 → 104	RNA polymerase Rpb6	Family

• Sequence:

  MSDNEDNFDGDDFDDVEEDEGLDDLENAEEEGQENVEILPSGERPQANQKRITTPYMTKY
  ERARVLGTRALQIAMCAPVMVELEGETDPLLIAMKELKARKIPIIIRRYLPDGSYEDWGV
  DELIITD

• Sequence length: 127

Pathways

KEGG:

RNA polymerase
Nucleotide excision repair
Cytosolic DNA-sensing pathway
Huntington disease

Reactome:

Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV-1 elongation complex containing HIV-1 Tat
Viral Messenger RNA Synthesis
Cytosolic sensors of pathogen-associated DNA
MicroRNA (miRNA) biogenesis
B-WICH complex positively regulates rRNA expression
Transcriptional regulation by small RNAs
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
FGFR2 alternative splicing
RNA polymerase II transcribes snRNA genes
mRNA Capping
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase I Transcription Termination
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Polymerase III Transcription Initiation From Type 1 Promoter
RNA Polymerase III Transcription Initiation From Type 2 Promoter
RNA Polymerase III Transcription Initiation From Type 3 Promoter
RNA Pol II CTD phosphorylation and interaction with CE
Estrogen-dependent gene expression

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CHARCOT-MARIE-TOOTH DISEASE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEARING IMPAIRMENT	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HIRSCHSPRUNG DISEASE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Intellectual disability	Uncertain significance	ClinVar Disgenet	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
KALLMANN SYNDROME	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
WAARDENBURG SYNDROME	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
WAARDENBURG SYNDROME TYPE 1	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
WAARDENBURG SYNDROME, TYPE 4A	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
WAARDENBURG SYNDROME, TYPE 4C	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
WAARDENBURG SYNDROME, TYPE IIA	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
WAARDENBURG SYNDROME, TYPE IIE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Carcinogenesis	Carcinogenesis	Pubtator	18505059	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	18505059		★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	18505059		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal Neoplasms	LHGDN	18505059		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	18505059	Stimulate	★☆☆☆☆ Found in Text Mining only
Demyelinating sensory neuropathy	Demyelinating Sensory Neuropathy	CLINVAR_DG			★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	31633244		★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	31633244		★☆☆☆☆ Found in Text Mining only
Graves Ophthalmopathy	Graves ophthalmopathy	Pubtator	37884559	Associate	★☆☆☆☆ Found in Text Mining only
Hirschsprung Disease	Hirschsprung Disease	CLINVAR_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hypoplasia of the olfactory bulb	Hypoplasia of the olfactory bulb	CLINVAR_DG			★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	UNIPROT_DG			★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	18505059		★☆☆☆☆ Found in Text Mining only
Peripheral demyelinating neuropathy	Demyelinating neuropathy	CLINVAR_DG			★☆☆☆☆ Found in Text Mining only
Peripheral Demyelinating Neuropathy, Central Dysmyelination, Waardenburg Syndrome, and Hirschsprung Disease	Peripheral Demyelinating Neuropathy, Central Dysmyelination, Waardenburg Syndrome, And Hirschsprung Disease	CLINVAR_DG			★☆☆☆☆ Found in Text Mining only
Sensorineural Hearing Loss (disorder)	Hearing Loss	CLINVAR_DG			★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	32064753	Associate	★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	32066835	Associate	★☆☆☆☆ Found in Text Mining only
WAARDENBURG SYNDROME, TYPE 4A	Waardenburg syndrome	CLINVAR_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Waardenburg Syndrome, Type 4c	Waardenburg syndrome	CLINVAR_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
WAARDENBURG SYNDROME, TYPE IIA	Waardenburg syndrome	CLINVAR_DG	29407415		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
WAARDENBURG SYNDROME, TYPE IIE	Waardenburg syndrome	CLINVAR_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations