POLR2E (RNA polymerase II, I and III subunit E)

Gene

• Entrez ID: 5434
• Gene name: RNA polymerase II, I and III subunit E
• Gene symbol: POLR2E
• Synonyms (NCBI Gene): RPABC1, RPB5, XAP4, hRPB25, hsRPB5
• Chromosome: 19
• Chromosome location: 19p13.3
• Summary: This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is present in two-fold molar excess over th

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs1297383239	T>C	Pathogenic	Splice acceptor variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT025749	hsa-miR-7-5p	Microarray	19073608
MIRT045424	hsa-miR-149-5p	CLASH	23622248
MIRT042771	hsa-miR-339-5p	CLASH	23622248
MIRT038716	hsa-miR-99a-3p	CLASH	23622248
MIRT715322	hsa-miR-8062	HITS-CLIP	19536157
MIRT715321	hsa-miR-6513-3p	HITS-CLIP	19536157
MIRT715320	hsa-miR-4722-3p	HITS-CLIP	19536157
MIRT715319	hsa-miR-6727-3p	HITS-CLIP	19536157
MIRT715318	hsa-miR-6747-3p	HITS-CLIP	19536157
MIRT715317	hsa-miR-939-3p	HITS-CLIP	19536157
MIRT715316	hsa-miR-6852-5p	HITS-CLIP	19536157
MIRT715315	hsa-miR-6742-3p	HITS-CLIP	19536157
MIRT715314	hsa-miR-3653-5p	HITS-CLIP	19536157
MIRT715313	hsa-miR-1976	HITS-CLIP	19536157
MIRT715312	hsa-miR-23a-5p	HITS-CLIP	19536157
MIRT715311	hsa-miR-23b-5p	HITS-CLIP	19536157
MIRT715310	hsa-miR-1297	HITS-CLIP	19536157
MIRT715309	hsa-miR-26a-5p	HITS-CLIP	19536157
MIRT715308	hsa-miR-26b-5p	HITS-CLIP	19536157
MIRT715307	hsa-miR-4465	HITS-CLIP	19536157
MIRT715306	hsa-miR-1343-3p	HITS-CLIP	19536157
MIRT715305	hsa-miR-6783-3p	HITS-CLIP	19536157
MIRT715304	hsa-miR-4279	HITS-CLIP	19536157
MIRT532734	hsa-miR-6750-5p	PAR-CLIP	22012620
MIRT532733	hsa-miR-6822-5p	PAR-CLIP	22012620
MIRT532732	hsa-miR-4258	PAR-CLIP	22012620
MIRT532731	hsa-miR-6134	PAR-CLIP	22012620
MIRT532730	hsa-miR-381-5p	PAR-CLIP	22012620
MIRT532729	hsa-miR-296-5p	PAR-CLIP	22012620
MIRT715322	hsa-miR-8062	HITS-CLIP	19536157
MIRT715321	hsa-miR-6513-3p	HITS-CLIP	19536157
MIRT715320	hsa-miR-4722-3p	HITS-CLIP	19536157
MIRT715319	hsa-miR-6727-3p	HITS-CLIP	19536157
MIRT715318	hsa-miR-6747-3p	HITS-CLIP	19536157
MIRT715317	hsa-miR-939-3p	HITS-CLIP	19536157
MIRT715316	hsa-miR-6852-5p	HITS-CLIP	19536157
MIRT715315	hsa-miR-6742-3p	HITS-CLIP	19536157
MIRT715314	hsa-miR-3653-5p	HITS-CLIP	19536157
MIRT715313	hsa-miR-1976	HITS-CLIP	19536157
MIRT715312	hsa-miR-23a-5p	HITS-CLIP	19536157
MIRT715311	hsa-miR-23b-5p	HITS-CLIP	19536157
MIRT715310	hsa-miR-1297	HITS-CLIP	19536157
MIRT715309	hsa-miR-26a-5p	HITS-CLIP	19536157
MIRT715308	hsa-miR-26b-5p	HITS-CLIP	19536157
MIRT715307	hsa-miR-4465	HITS-CLIP	19536157
MIRT715306	hsa-miR-1343-3p	HITS-CLIP	19536157
MIRT715305	hsa-miR-6783-3p	HITS-CLIP	19536157
MIRT715304	hsa-miR-4279	HITS-CLIP	19536157
MIRT532734	hsa-miR-6750-5p	PAR-CLIP	22012620
MIRT532733	hsa-miR-6822-5p	PAR-CLIP	22012620
MIRT532732	hsa-miR-4258	PAR-CLIP	22012620
MIRT532731	hsa-miR-6134	PAR-CLIP	22012620
MIRT532730	hsa-miR-381-5p	PAR-CLIP	22012620
MIRT532729	hsa-miR-296-5p	PAR-CLIP	22012620
MIRT1248609	hsa-miR-105	CLIP-seq
MIRT1248610	hsa-miR-106a	CLIP-seq
MIRT1248611	hsa-miR-106b	CLIP-seq
MIRT1248612	hsa-miR-10a	CLIP-seq
MIRT1248613	hsa-miR-10b	CLIP-seq
MIRT1248614	hsa-miR-1184	CLIP-seq
MIRT1248615	hsa-miR-1200	CLIP-seq
MIRT1248616	hsa-miR-1207-5p	CLIP-seq
MIRT1248617	hsa-miR-1224-3p	CLIP-seq
MIRT1248618	hsa-miR-1234	CLIP-seq
MIRT1248619	hsa-miR-125a-3p	CLIP-seq
MIRT1248620	hsa-miR-129-5p	CLIP-seq
MIRT1248621	hsa-miR-1343	CLIP-seq
MIRT1248622	hsa-miR-150	CLIP-seq
MIRT1248623	hsa-miR-17	CLIP-seq
MIRT1248624	hsa-miR-1909	CLIP-seq
MIRT1248625	hsa-miR-20a	CLIP-seq
MIRT1248626	hsa-miR-20b	CLIP-seq
MIRT1248627	hsa-miR-2861	CLIP-seq
MIRT1248628	hsa-miR-302a	CLIP-seq
MIRT1248629	hsa-miR-302b	CLIP-seq
MIRT1248630	hsa-miR-302c	CLIP-seq
MIRT1248631	hsa-miR-302d	CLIP-seq
MIRT1248632	hsa-miR-302e	CLIP-seq
MIRT1248633	hsa-miR-3128	CLIP-seq
MIRT1248634	hsa-miR-3135b	CLIP-seq
MIRT1248635	hsa-miR-3136-3p	CLIP-seq
MIRT1248636	hsa-miR-3147	CLIP-seq
MIRT1248637	hsa-miR-3150a-3p	CLIP-seq
MIRT1248638	hsa-miR-3151	CLIP-seq
MIRT1248639	hsa-miR-3155	CLIP-seq
MIRT1248640	hsa-miR-3155b	CLIP-seq
MIRT1248641	hsa-miR-3175	CLIP-seq
MIRT1248642	hsa-miR-3202	CLIP-seq
MIRT1248643	hsa-miR-3663-5p	CLIP-seq
MIRT1248644	hsa-miR-3670	CLIP-seq
MIRT1248645	hsa-miR-372	CLIP-seq
MIRT1248646	hsa-miR-373	CLIP-seq
MIRT1248647	hsa-miR-3934	CLIP-seq
MIRT1248648	hsa-miR-4320	CLIP-seq
MIRT1248649	hsa-miR-4323	CLIP-seq
MIRT1248650	hsa-miR-4324	CLIP-seq
MIRT1248651	hsa-miR-4418	CLIP-seq
MIRT1248652	hsa-miR-4425	CLIP-seq
MIRT1248653	hsa-miR-4436b-3p	CLIP-seq
MIRT1248654	hsa-miR-4436b-5p	CLIP-seq
MIRT1248655	hsa-miR-4438	CLIP-seq
MIRT1248656	hsa-miR-4447	CLIP-seq
MIRT1248657	hsa-miR-4454	CLIP-seq
MIRT1248658	hsa-miR-4472	CLIP-seq
MIRT1248659	hsa-miR-4488	CLIP-seq
MIRT1248660	hsa-miR-450b-3p	CLIP-seq
MIRT1248661	hsa-miR-4512	CLIP-seq
MIRT1248662	hsa-miR-4521	CLIP-seq
MIRT1248663	hsa-miR-4649-5p	CLIP-seq
MIRT1248664	hsa-miR-4659a-5p	CLIP-seq
MIRT1248665	hsa-miR-4659b-5p	CLIP-seq
MIRT1248666	hsa-miR-4667-5p	CLIP-seq
MIRT1248667	hsa-miR-4690-3p	CLIP-seq
MIRT1248668	hsa-miR-4691-5p	CLIP-seq
MIRT1248669	hsa-miR-4697-5p	CLIP-seq
MIRT1248670	hsa-miR-4700-3p	CLIP-seq
MIRT1248671	hsa-miR-4700-5p	CLIP-seq
MIRT1248672	hsa-miR-4716-5p	CLIP-seq
MIRT1248673	hsa-miR-4720-5p	CLIP-seq
MIRT1248674	hsa-miR-4725-5p	CLIP-seq
MIRT1248675	hsa-miR-4726-3p	CLIP-seq
MIRT1248676	hsa-miR-4731-5p	CLIP-seq
MIRT1248677	hsa-miR-4736	CLIP-seq
MIRT1248678	hsa-miR-4743	CLIP-seq
MIRT1248679	hsa-miR-4747-5p	CLIP-seq
MIRT1248680	hsa-miR-4758-3p	CLIP-seq
MIRT1248681	hsa-miR-4763-3p	CLIP-seq
MIRT1248682	hsa-miR-4764-3p	CLIP-seq
MIRT1248683	hsa-miR-4776-3p	CLIP-seq
MIRT1248684	hsa-miR-4781-3p	CLIP-seq
MIRT1248685	hsa-miR-4799-3p	CLIP-seq
MIRT1248686	hsa-miR-484	CLIP-seq
MIRT1248687	hsa-miR-491-5p	CLIP-seq
MIRT1248688	hsa-miR-504	CLIP-seq
MIRT1248689	hsa-miR-509-3-5p	CLIP-seq
MIRT1248690	hsa-miR-5095	CLIP-seq
MIRT1248691	hsa-miR-509-5p	CLIP-seq
MIRT1248692	hsa-miR-512-3p	CLIP-seq
MIRT1248693	hsa-miR-519d	CLIP-seq
MIRT1248694	hsa-miR-520a-3p	CLIP-seq
MIRT1248695	hsa-miR-520b	CLIP-seq
MIRT1248696	hsa-miR-520c-3p	CLIP-seq
MIRT1248697	hsa-miR-520d-3p	CLIP-seq
MIRT1248698	hsa-miR-520e	CLIP-seq
MIRT1248699	hsa-miR-520g	CLIP-seq
MIRT1248700	hsa-miR-520h	CLIP-seq
MIRT1248701	hsa-miR-544b	CLIP-seq
MIRT1248702	hsa-miR-552	CLIP-seq
MIRT1248703	hsa-miR-561	CLIP-seq
MIRT1248704	hsa-miR-574-3p	CLIP-seq
MIRT1248705	hsa-miR-661	CLIP-seq
MIRT1248706	hsa-miR-663b	CLIP-seq
MIRT1248707	hsa-miR-676	CLIP-seq
MIRT1248708	hsa-miR-764	CLIP-seq
MIRT1248709	hsa-miR-769-3p	CLIP-seq
MIRT1248710	hsa-miR-93	CLIP-seq
MIRT1248711	hsa-miR-939	CLIP-seq
MIRT1248642	hsa-miR-3202	CLIP-seq
MIRT1248675	hsa-miR-4726-3p	CLIP-seq
MIRT1248679	hsa-miR-4747-5p	CLIP-seq
MIRT1552436	hsa-miR-4775	CLIP-seq
MIRT1248704	hsa-miR-574-3p	CLIP-seq
MIRT1552437	hsa-miR-590-3p	CLIP-seq
MIRT1248642	hsa-miR-3202	CLIP-seq
MIRT1248679	hsa-miR-4747-5p	CLIP-seq
MIRT1248704	hsa-miR-574-3p	CLIP-seq
MIRT1248619	hsa-miR-125a-3p	CLIP-seq
MIRT1922318	hsa-miR-1290	CLIP-seq
MIRT1248620	hsa-miR-129-5p	CLIP-seq
MIRT1248639	hsa-miR-3155	CLIP-seq
MIRT1248640	hsa-miR-3155b	CLIP-seq
MIRT1248643	hsa-miR-3663-5p	CLIP-seq
MIRT1248647	hsa-miR-3934	CLIP-seq
MIRT1248657	hsa-miR-4454	CLIP-seq
MIRT1922319	hsa-miR-450b-5p	CLIP-seq
MIRT1248664	hsa-miR-4659a-5p	CLIP-seq
MIRT1248665	hsa-miR-4659b-5p	CLIP-seq
MIRT1248672	hsa-miR-4716-5p	CLIP-seq
MIRT1248683	hsa-miR-4776-3p	CLIP-seq
MIRT1248684	hsa-miR-4781-3p	CLIP-seq
MIRT1248686	hsa-miR-484	CLIP-seq
MIRT1922320	hsa-miR-507	CLIP-seq
MIRT1922321	hsa-miR-557	CLIP-seq
MIRT1248708	hsa-miR-764	CLIP-seq
MIRT1248609	hsa-miR-105	CLIP-seq
MIRT1248614	hsa-miR-1184	CLIP-seq
MIRT1248617	hsa-miR-1224-3p	CLIP-seq
MIRT1248618	hsa-miR-1234	CLIP-seq
MIRT2073428	hsa-miR-1257	CLIP-seq
MIRT1248619	hsa-miR-125a-3p	CLIP-seq
MIRT2073429	hsa-miR-1289	CLIP-seq
MIRT1248624	hsa-miR-1909	CLIP-seq
MIRT2073430	hsa-miR-2110	CLIP-seq
MIRT2073431	hsa-miR-2355-5p	CLIP-seq
MIRT1248634	hsa-miR-3135b	CLIP-seq
MIRT1248637	hsa-miR-3150a-3p	CLIP-seq
MIRT1248639	hsa-miR-3155	CLIP-seq
MIRT1248640	hsa-miR-3155b	CLIP-seq
MIRT1248641	hsa-miR-3175	CLIP-seq
MIRT2073432	hsa-miR-3180	CLIP-seq
MIRT2073433	hsa-miR-3180-3p	CLIP-seq
MIRT2073434	hsa-miR-3189-3p	CLIP-seq
MIRT2073435	hsa-miR-3196	CLIP-seq
MIRT1248642	hsa-miR-3202	CLIP-seq
MIRT2073436	hsa-miR-3612	CLIP-seq
MIRT1248643	hsa-miR-3663-5p	CLIP-seq
MIRT2073437	hsa-miR-3675-5p	CLIP-seq
MIRT1248647	hsa-miR-3934	CLIP-seq
MIRT2073438	hsa-miR-4312	CLIP-seq
MIRT1248651	hsa-miR-4418	CLIP-seq
MIRT2073439	hsa-miR-4443	CLIP-seq
MIRT1248657	hsa-miR-4454	CLIP-seq
MIRT2073440	hsa-miR-4492	CLIP-seq
MIRT2073441	hsa-miR-4498	CLIP-seq
MIRT2073442	hsa-miR-4640-5p	CLIP-seq
MIRT1248664	hsa-miR-4659a-5p	CLIP-seq
MIRT1248665	hsa-miR-4659b-5p	CLIP-seq
MIRT1248672	hsa-miR-4716-5p	CLIP-seq
MIRT2073443	hsa-miR-4726-5p	CLIP-seq
MIRT1248679	hsa-miR-4747-5p	CLIP-seq
MIRT1248683	hsa-miR-4776-3p	CLIP-seq
MIRT1248684	hsa-miR-4781-3p	CLIP-seq
MIRT2073444	hsa-miR-4790-3p	CLIP-seq
MIRT1248686	hsa-miR-484	CLIP-seq
MIRT1248689	hsa-miR-509-3-5p	CLIP-seq
MIRT1248691	hsa-miR-509-5p	CLIP-seq
MIRT1248702	hsa-miR-552	CLIP-seq
MIRT1248704	hsa-miR-574-3p	CLIP-seq
MIRT2073445	hsa-miR-650	CLIP-seq
MIRT2073446	hsa-miR-762	CLIP-seq
MIRT1248708	hsa-miR-764	CLIP-seq
MIRT1248711	hsa-miR-939	CLIP-seq
MIRT1248609	hsa-miR-105	CLIP-seq
MIRT1248610	hsa-miR-106a	CLIP-seq
MIRT1248611	hsa-miR-106b	CLIP-seq
MIRT1248616	hsa-miR-1207-5p	CLIP-seq
MIRT1248617	hsa-miR-1224-3p	CLIP-seq
MIRT1248618	hsa-miR-1234	CLIP-seq
MIRT1248619	hsa-miR-125a-3p	CLIP-seq
MIRT2300468	hsa-miR-1292	CLIP-seq
MIRT2300469	hsa-miR-1321	CLIP-seq
MIRT1248621	hsa-miR-1343	CLIP-seq
MIRT1248622	hsa-miR-150	CLIP-seq
MIRT2300470	hsa-miR-15a	CLIP-seq
MIRT2300471	hsa-miR-15b	CLIP-seq
MIRT2300472	hsa-miR-16	CLIP-seq
MIRT1248623	hsa-miR-17	CLIP-seq
MIRT1248624	hsa-miR-1909	CLIP-seq
MIRT2300473	hsa-miR-195	CLIP-seq
MIRT1248625	hsa-miR-20a	CLIP-seq
MIRT1248626	hsa-miR-20b	CLIP-seq
MIRT2073431	hsa-miR-2355-5p	CLIP-seq
MIRT1248628	hsa-miR-302a	CLIP-seq
MIRT1248629	hsa-miR-302b	CLIP-seq
MIRT1248630	hsa-miR-302c	CLIP-seq
MIRT1248631	hsa-miR-302d	CLIP-seq
MIRT1248632	hsa-miR-302e	CLIP-seq
MIRT1248633	hsa-miR-3128	CLIP-seq
MIRT1248636	hsa-miR-3147	CLIP-seq
MIRT1248637	hsa-miR-3150a-3p	CLIP-seq
MIRT1248639	hsa-miR-3155	CLIP-seq
MIRT1248640	hsa-miR-3155b	CLIP-seq
MIRT1248641	hsa-miR-3175	CLIP-seq
MIRT1248642	hsa-miR-3202	CLIP-seq
MIRT1248643	hsa-miR-3663-5p	CLIP-seq
MIRT1248645	hsa-miR-372	CLIP-seq
MIRT1248646	hsa-miR-373	CLIP-seq
MIRT2300474	hsa-miR-378g	CLIP-seq
MIRT1248647	hsa-miR-3934	CLIP-seq
MIRT2300475	hsa-miR-424	CLIP-seq
MIRT2300476	hsa-miR-4252	CLIP-seq
MIRT2300477	hsa-miR-4292	CLIP-seq
MIRT1248649	hsa-miR-4323	CLIP-seq
MIRT2300478	hsa-miR-4419a	CLIP-seq
MIRT1248652	hsa-miR-4425	CLIP-seq
MIRT1248653	hsa-miR-4436b-3p	CLIP-seq
MIRT2300479	hsa-miR-4437	CLIP-seq
MIRT1248657	hsa-miR-4454	CLIP-seq
MIRT2300480	hsa-miR-4471	CLIP-seq
MIRT1248660	hsa-miR-450b-3p	CLIP-seq
MIRT2300481	hsa-miR-4510	CLIP-seq
MIRT2300482	hsa-miR-4646-5p	CLIP-seq
MIRT2300483	hsa-miR-4667-3p	CLIP-seq
MIRT2300484	hsa-miR-4674	CLIP-seq
MIRT2300485	hsa-miR-4681	CLIP-seq
MIRT2300486	hsa-miR-4701-5p	CLIP-seq
MIRT2300487	hsa-miR-4717-3p	CLIP-seq
MIRT1248673	hsa-miR-4720-5p	CLIP-seq
MIRT2300488	hsa-miR-4728-5p	CLIP-seq
MIRT1248677	hsa-miR-4736	CLIP-seq
MIRT2300489	hsa-miR-4739	CLIP-seq
MIRT1248679	hsa-miR-4747-5p	CLIP-seq
MIRT2300490	hsa-miR-4756-5p	CLIP-seq
MIRT1248680	hsa-miR-4758-3p	CLIP-seq
MIRT1248681	hsa-miR-4763-3p	CLIP-seq
MIRT1248685	hsa-miR-4799-3p	CLIP-seq
MIRT1248686	hsa-miR-484	CLIP-seq
MIRT2300491	hsa-miR-497	CLIP-seq
MIRT1248690	hsa-miR-5095	CLIP-seq
MIRT1248693	hsa-miR-519d	CLIP-seq
MIRT1248694	hsa-miR-520a-3p	CLIP-seq
MIRT1248695	hsa-miR-520b	CLIP-seq
MIRT1248696	hsa-miR-520c-3p	CLIP-seq
MIRT1248697	hsa-miR-520d-3p	CLIP-seq
MIRT1248698	hsa-miR-520e	CLIP-seq
MIRT1248699	hsa-miR-520g	CLIP-seq
MIRT1248700	hsa-miR-520h	CLIP-seq
MIRT1248702	hsa-miR-552	CLIP-seq
MIRT1248704	hsa-miR-574-3p	CLIP-seq
MIRT2300492	hsa-miR-588	CLIP-seq
MIRT2300493	hsa-miR-7	CLIP-seq
MIRT1248708	hsa-miR-764	CLIP-seq
MIRT1248709	hsa-miR-769-3p	CLIP-seq
MIRT1248710	hsa-miR-93	CLIP-seq
MIRT1248711	hsa-miR-939	CLIP-seq
MIRT1248619	hsa-miR-125a-3p	CLIP-seq
MIRT1248639	hsa-miR-3155	CLIP-seq
MIRT1248640	hsa-miR-3155b	CLIP-seq
MIRT1248642	hsa-miR-3202	CLIP-seq
MIRT1248643	hsa-miR-3663-5p	CLIP-seq
MIRT1248647	hsa-miR-3934	CLIP-seq
MIRT1248664	hsa-miR-4659a-5p	CLIP-seq
MIRT1248665	hsa-miR-4659b-5p	CLIP-seq
MIRT1248672	hsa-miR-4716-5p	CLIP-seq
MIRT1248679	hsa-miR-4747-5p	CLIP-seq
MIRT1248683	hsa-miR-4776-3p	CLIP-seq
MIRT1248684	hsa-miR-4781-3p	CLIP-seq
MIRT1248686	hsa-miR-484	CLIP-seq
MIRT1248704	hsa-miR-574-3p	CLIP-seq
MIRT1248708	hsa-miR-764	CLIP-seq
MIRT2432212	hsa-miR-146a	CLIP-seq
MIRT2432213	hsa-miR-146b-5p	CLIP-seq
MIRT2432214	hsa-miR-4487	CLIP-seq
MIRT2432215	hsa-miR-4523	CLIP-seq
MIRT2432216	hsa-miR-4642	CLIP-seq
MIRT1248673	hsa-miR-4720-5p	CLIP-seq
MIRT1248685	hsa-miR-4799-3p	CLIP-seq
MIRT2432217	hsa-miR-508-5p	CLIP-seq
MIRT2432218	hsa-miR-520a-5p	CLIP-seq
MIRT2432219	hsa-miR-525-5p	CLIP-seq
MIRT2432212	hsa-miR-146a	CLIP-seq
MIRT2432213	hsa-miR-146b-5p	CLIP-seq
MIRT2432214	hsa-miR-4487	CLIP-seq
MIRT2432215	hsa-miR-4523	CLIP-seq
MIRT1248673	hsa-miR-4720-5p	CLIP-seq
MIRT1248685	hsa-miR-4799-3p	CLIP-seq
MIRT2432217	hsa-miR-508-5p	CLIP-seq
MIRT2432218	hsa-miR-520a-5p	CLIP-seq
MIRT2432219	hsa-miR-525-5p	CLIP-seq
MIRT2432212	hsa-miR-146a	CLIP-seq
MIRT2432213	hsa-miR-146b-5p	CLIP-seq
MIRT2432214	hsa-miR-4487	CLIP-seq
MIRT2432215	hsa-miR-4523	CLIP-seq
MIRT2432216	hsa-miR-4642	CLIP-seq
MIRT1248673	hsa-miR-4720-5p	CLIP-seq
MIRT1248685	hsa-miR-4799-3p	CLIP-seq
MIRT2432217	hsa-miR-508-5p	CLIP-seq
MIRT2432218	hsa-miR-520a-5p	CLIP-seq
MIRT2432219	hsa-miR-525-5p	CLIP-seq
MIRT1248610	hsa-miR-106a	CLIP-seq
MIRT1248611	hsa-miR-106b	CLIP-seq
MIRT1248617	hsa-miR-1224-3p	CLIP-seq
MIRT1248618	hsa-miR-1234	CLIP-seq
MIRT2597202	hsa-miR-1237	CLIP-seq
MIRT2597203	hsa-miR-1248	CLIP-seq
MIRT2073428	hsa-miR-1257	CLIP-seq
MIRT1248619	hsa-miR-125a-3p	CLIP-seq
MIRT2073429	hsa-miR-1289	CLIP-seq
MIRT1248622	hsa-miR-150	CLIP-seq
MIRT2300470	hsa-miR-15a	CLIP-seq
MIRT2300471	hsa-miR-15b	CLIP-seq
MIRT2300472	hsa-miR-16	CLIP-seq
MIRT1248623	hsa-miR-17	CLIP-seq
MIRT2300473	hsa-miR-195	CLIP-seq
MIRT2597204	hsa-miR-198	CLIP-seq
MIRT1248625	hsa-miR-20a	CLIP-seq
MIRT1248626	hsa-miR-20b	CLIP-seq
MIRT2073430	hsa-miR-2110	CLIP-seq
MIRT2597205	hsa-miR-2467-5p	CLIP-seq
MIRT1248628	hsa-miR-302a	CLIP-seq
MIRT1248629	hsa-miR-302b	CLIP-seq
MIRT1248630	hsa-miR-302c	CLIP-seq
MIRT1248631	hsa-miR-302d	CLIP-seq
MIRT1248632	hsa-miR-302e	CLIP-seq
MIRT1248636	hsa-miR-3147	CLIP-seq
MIRT1248637	hsa-miR-3150a-3p	CLIP-seq
MIRT1248641	hsa-miR-3175	CLIP-seq
MIRT2073432	hsa-miR-3180	CLIP-seq
MIRT2073433	hsa-miR-3180-3p	CLIP-seq
MIRT2597206	hsa-miR-3188	CLIP-seq
MIRT2073434	hsa-miR-3189-3p	CLIP-seq
MIRT2073435	hsa-miR-3196	CLIP-seq
MIRT2597207	hsa-miR-326	CLIP-seq
MIRT2597208	hsa-miR-330-5p	CLIP-seq
MIRT2073437	hsa-miR-3675-5p	CLIP-seq
MIRT1248645	hsa-miR-372	CLIP-seq
MIRT1248646	hsa-miR-373	CLIP-seq
MIRT1248647	hsa-miR-3934	CLIP-seq
MIRT2597209	hsa-miR-3975	CLIP-seq
MIRT2300475	hsa-miR-424	CLIP-seq
MIRT2597210	hsa-miR-4303	CLIP-seq
MIRT2073438	hsa-miR-4312	CLIP-seq
MIRT2597211	hsa-miR-4326	CLIP-seq
MIRT1248652	hsa-miR-4425	CLIP-seq
MIRT1248655	hsa-miR-4438	CLIP-seq
MIRT1248657	hsa-miR-4454	CLIP-seq
MIRT2597212	hsa-miR-4469	CLIP-seq
MIRT1248659	hsa-miR-4488	CLIP-seq
MIRT2073440	hsa-miR-4492	CLIP-seq
MIRT2073441	hsa-miR-4498	CLIP-seq
MIRT1248660	hsa-miR-450b-3p	CLIP-seq
MIRT2073442	hsa-miR-4640-5p	CLIP-seq
MIRT2597213	hsa-miR-4649-3p	CLIP-seq
MIRT1248666	hsa-miR-4667-5p	CLIP-seq
MIRT1248669	hsa-miR-4697-5p	CLIP-seq
MIRT1248671	hsa-miR-4700-5p	CLIP-seq
MIRT2597214	hsa-miR-4719	CLIP-seq
MIRT2073443	hsa-miR-4726-5p	CLIP-seq
MIRT1248676	hsa-miR-4731-5p	CLIP-seq
MIRT2073444	hsa-miR-4790-3p	CLIP-seq
MIRT2597215	hsa-miR-485-5p	CLIP-seq
MIRT2300491	hsa-miR-497	CLIP-seq
MIRT1248690	hsa-miR-5095	CLIP-seq
MIRT1248692	hsa-miR-512-3p	CLIP-seq
MIRT1248693	hsa-miR-519d	CLIP-seq
MIRT1248694	hsa-miR-520a-3p	CLIP-seq
MIRT2432218	hsa-miR-520a-5p	CLIP-seq
MIRT1248695	hsa-miR-520b	CLIP-seq
MIRT1248696	hsa-miR-520c-3p	CLIP-seq
MIRT1248697	hsa-miR-520d-3p	CLIP-seq
MIRT1248698	hsa-miR-520e	CLIP-seq
MIRT1248699	hsa-miR-520g	CLIP-seq
MIRT1248700	hsa-miR-520h	CLIP-seq
MIRT2432219	hsa-miR-525-5p	CLIP-seq
MIRT1248702	hsa-miR-552	CLIP-seq
MIRT2597216	hsa-miR-637	CLIP-seq
MIRT2597217	hsa-miR-642a	CLIP-seq
MIRT2597218	hsa-miR-671-5p	CLIP-seq
MIRT2073446	hsa-miR-762	CLIP-seq
MIRT1248708	hsa-miR-764	CLIP-seq
MIRT1248709	hsa-miR-769-3p	CLIP-seq
MIRT1248710	hsa-miR-93	CLIP-seq
MIRT1248711	hsa-miR-939	CLIP-seq
MIRT1248609	hsa-miR-105	CLIP-seq
MIRT1248610	hsa-miR-106a	CLIP-seq
MIRT1248611	hsa-miR-106b	CLIP-seq
MIRT1248617	hsa-miR-1224-3p	CLIP-seq
MIRT2688350	hsa-miR-1226	CLIP-seq
MIRT1248618	hsa-miR-1234	CLIP-seq
MIRT2597202	hsa-miR-1237	CLIP-seq
MIRT2597203	hsa-miR-1248	CLIP-seq
MIRT2073428	hsa-miR-1257	CLIP-seq
MIRT1248619	hsa-miR-125a-3p	CLIP-seq
MIRT1248621	hsa-miR-1343	CLIP-seq
MIRT1248622	hsa-miR-150	CLIP-seq
MIRT1248623	hsa-miR-17	CLIP-seq
MIRT2688351	hsa-miR-1913	CLIP-seq
MIRT1248625	hsa-miR-20a	CLIP-seq
MIRT1248626	hsa-miR-20b	CLIP-seq
MIRT2688352	hsa-miR-22	CLIP-seq
MIRT2597205	hsa-miR-2467-5p	CLIP-seq
MIRT2688353	hsa-miR-26a	CLIP-seq
MIRT2688354	hsa-miR-26b	CLIP-seq
MIRT1248628	hsa-miR-302a	CLIP-seq
MIRT1248629	hsa-miR-302b	CLIP-seq
MIRT1248630	hsa-miR-302c	CLIP-seq
MIRT1248631	hsa-miR-302d	CLIP-seq
MIRT1248632	hsa-miR-302e	CLIP-seq
MIRT1248636	hsa-miR-3147	CLIP-seq
MIRT2073432	hsa-miR-3180	CLIP-seq
MIRT2073433	hsa-miR-3180-3p	CLIP-seq
MIRT2597206	hsa-miR-3188	CLIP-seq
MIRT2073435	hsa-miR-3196	CLIP-seq
MIRT2688355	hsa-miR-324-3p	CLIP-seq
MIRT2597207	hsa-miR-326	CLIP-seq
MIRT2597208	hsa-miR-330-5p	CLIP-seq
MIRT2688356	hsa-miR-361-3p	CLIP-seq
MIRT2073437	hsa-miR-3675-5p	CLIP-seq
MIRT1248645	hsa-miR-372	CLIP-seq
MIRT1248646	hsa-miR-373	CLIP-seq
MIRT1248647	hsa-miR-3934	CLIP-seq
MIRT2597209	hsa-miR-3975	CLIP-seq
MIRT2597210	hsa-miR-4303	CLIP-seq
MIRT2073438	hsa-miR-4312	CLIP-seq
MIRT2688357	hsa-miR-4313	CLIP-seq
MIRT2597211	hsa-miR-4326	CLIP-seq
MIRT1248652	hsa-miR-4425	CLIP-seq
MIRT1248654	hsa-miR-4436b-5p	CLIP-seq
MIRT1248655	hsa-miR-4438	CLIP-seq
MIRT1248657	hsa-miR-4454	CLIP-seq
MIRT2597212	hsa-miR-4469	CLIP-seq
MIRT1248659	hsa-miR-4488	CLIP-seq
MIRT1248660	hsa-miR-450b-3p	CLIP-seq
MIRT2597213	hsa-miR-4649-3p	CLIP-seq
MIRT1248666	hsa-miR-4667-5p	CLIP-seq
MIRT1248668	hsa-miR-4691-5p	CLIP-seq
MIRT1248669	hsa-miR-4697-5p	CLIP-seq
MIRT1248671	hsa-miR-4700-5p	CLIP-seq
MIRT2597214	hsa-miR-4719	CLIP-seq
MIRT1248675	hsa-miR-4726-3p	CLIP-seq
MIRT1248676	hsa-miR-4731-5p	CLIP-seq
MIRT2073444	hsa-miR-4790-3p	CLIP-seq
MIRT2597215	hsa-miR-485-5p	CLIP-seq
MIRT1248690	hsa-miR-5095	CLIP-seq
MIRT1248692	hsa-miR-512-3p	CLIP-seq
MIRT1248693	hsa-miR-519d	CLIP-seq
MIRT1248694	hsa-miR-520a-3p	CLIP-seq
MIRT1248695	hsa-miR-520b	CLIP-seq
MIRT1248696	hsa-miR-520c-3p	CLIP-seq
MIRT1248697	hsa-miR-520d-3p	CLIP-seq
MIRT1248698	hsa-miR-520e	CLIP-seq
MIRT1248699	hsa-miR-520g	CLIP-seq
MIRT1248700	hsa-miR-520h	CLIP-seq
MIRT1248702	hsa-miR-552	CLIP-seq
MIRT2597216	hsa-miR-637	CLIP-seq
MIRT2597217	hsa-miR-642a	CLIP-seq
MIRT2597218	hsa-miR-671-5p	CLIP-seq
MIRT1248708	hsa-miR-764	CLIP-seq
MIRT1248709	hsa-miR-769-3p	CLIP-seq
MIRT1248710	hsa-miR-93	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000428	Component	DNA-directed RNA polymerase complex	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003899	Function	DNA-directed RNA polymerase activity	IBA
GO:0003899	Function	DNA-directed RNA polymerase activity	IEA
GO:0003899	Function	DNA-directed RNA polymerase activity	TAS	7828586
GO:0005515	Function	Protein binding	IPI	12737519, 15923622, 24981860, 27193682, 32296183, 32814053, 33961781, 35271311
GO:0005634	Component	Nucleus	IDA	9852112
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005665	Component	RNA polymerase II, core complex	IBA
GO:0005665	Component	RNA polymerase II, core complex	IDA	9852112
GO:0005666	Component	RNA polymerase III complex	IBA
GO:0005666	Component	RNA polymerase III complex	IDA	33335104, 34675218
GO:0005730	Component	Nucleolus	IEA
GO:0005736	Component	RNA polymerase I complex	IBA
GO:0005736	Component	RNA polymerase I complex	IDA	34671025, 36271492
GO:0005829	Component	Cytosol	TAS
GO:0006351	Process	DNA-templated transcription	IEA
GO:0006362	Process	Transcription elongation by RNA polymerase I	IBA
GO:0006366	Process	Transcription by RNA polymerase II	IBA
GO:0006366	Process	Transcription by RNA polymerase II	IDA	9852112
GO:0042797	Process	TRNA transcription by RNA polymerase III	IBA
GO:0050821	Process	Protein stabilization	NAS	31738558
GO:1990062	Component	RPAP3/R2TP/prefoldin-like complex	IPI	31738558

Other IDs

• MIM: 180664
• HGNC: 9192
• e!Ensembl: ENSG00000099817

Protein

• UniProt ID: P19388
• Protein name: DNA-directed RNA polymerases I, II, and III subunit RPABC1 (RNA polymerases I, II, and III subunit ABC1) (DNA-directed RNA polymerase II 23 kDa polypeptide) (DNA-directed RNA polymerase II subunit E) (RPB5 homolog) (XAP4)
• Protein function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and
• PDB: 5IY6, 5IY7, 5IY8, 5IY9, 5IYA, 5IYB, 5IYC, 5IYD, 6DRD, 6O9L, 6XRE, 7A6H, 7AE1, 7AE3, 7AEA, 7AST, 7D58, 7D59, 7DN3, 7DU2, 7FJI, 7FJJ, 7LBM, 7OB9, 7OBA, 7OBB, 7VBA, 7VBB, 7VBC, 8A43, 8ITY, 8IUE, 8IUH, 9EHZ, 9EI1, 9EI3, 9EI4, 9FSO, 9FSP, 9FSQ, 9FSR, 9FSS
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03871	RNA_pol_Rpb5_N	4 → 94	RNA polymerase Rpb5, N-terminal domain	Domain
  PF01191	RNA_pol_Rpb5_C	137 → 209	RNA polymerase Rpb5, C-terminal domain	Domain

• Sequence:

  MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQSGDKPSEGRPRRTDLTV
  LVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVD
  MAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVA
  RYFGIKRGQVVKIIRPSETAGRYITYRLVQ

• Sequence length: 210

Pathways

KEGG:

RNA polymerase
Nucleotide excision repair
Cytosolic DNA-sensing pathway
Huntington disease

Reactome:

Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV-1 elongation complex containing HIV-1 Tat
Viral Messenger RNA Synthesis
Cytosolic sensors of pathogen-associated DNA
MicroRNA (miRNA) biogenesis
B-WICH complex positively regulates rRNA expression
Transcriptional regulation by small RNAs
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
FGFR2 alternative splicing
RNA polymerase II transcribes snRNA genes
mRNA Capping
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase I Transcription Termination
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Polymerase III Transcription Initiation From Type 1 Promoter
RNA Polymerase III Transcription Initiation From Type 2 Promoter
RNA Polymerase III Transcription Initiation From Type 3 Promoter
RNA Pol II CTD phosphorylation and interaction with CE
Estrogen-dependent gene expression

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Short stature	Pathogenic	rs1297383239	RCV000736219	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SMALL VESSEL STROKE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
cervical cancer	Cervical Cancer	BEFREE	30846411		★☆☆☆☆ Found in Text Mining only
Cervix carcinoma	Cervix carcinoma	BEFREE	30846411		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	36811212	Associate	★☆☆☆☆ Found in Text Mining only
Esophageal carcinoma	Esophageal Carcinoma	BEFREE	25874495, 30846411		★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophagus Neoplasm	BEFREE	25874495, 30846411		★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophageal neoplasm	Pubtator	25874495, 38300349	Associate	★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	25874495	Inhibit	★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	25874495	Associate	★☆☆☆☆ Found in Text Mining only
Graves Ophthalmopathy	Graves ophthalmopathy	Pubtator	37884559	Associate	★☆☆☆☆ Found in Text Mining only
Hematologic Diseases	Hematologic disease	Pubtator	28260796	Associate	★☆☆☆☆ Found in Text Mining only
Interstitial Cystitis	Interstitial Cystitis	BEFREE	24704835		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	17497168		★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	28260796	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of esophagus	Esophagus Neoplasm	BEFREE	25874495, 30846411		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of liver	Liver Cancer	BEFREE	30846411		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	30587086, 30846411		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	28159929, 29724531, 30846411, 31333787		★☆☆☆☆ Found in Text Mining only
Malignant tumor of cervix	Cervical Tumor	BEFREE	30846411		★☆☆☆☆ Found in Text Mining only
Papillary thyroid carcinoma	Papillary thyroid carcinoma	BEFREE	29724531, 30846411		★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	30587086, 30846411		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	21856995	Associate	★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	25874495		★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	25921176	Associate	★☆☆☆☆ Found in Text Mining only