Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	54329
Gene name	G protein-coupled receptor 85
Gene symbol	GPR85
Synonyms (NCBI Gene)	SREBSREB2
Chromosome	7
Chromosome location	7q31.1
Summary	Members of the G protein-coupled receptor (GPCR) family, such as GPR85, have a similar structure characterized by 7 transmembrane domains. Activation of GPCRs by extracellular stimuli, such as neurotransmitters, hormones, or light, induces an intracellula

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miRTarBase ID	miRNA	Experiments	Reference
MIRT438267	hsa-miR-29a-3p	Luciferase reporter assay	24085298
MIRT438267	hsa-miR-29a-3p	Luciferase reporter assay	24085298
MIRT530915	hsa-miR-548aa	PAR-CLIP	22012620
MIRT530914	hsa-miR-548ap-3p	PAR-CLIP	22012620
MIRT530913	hsa-miR-548t-3p	PAR-CLIP	22012620
MIRT530912	hsa-miR-548e-5p	PAR-CLIP	22012620
MIRT530911	hsa-miR-548p	PAR-CLIP	22012620
MIRT530910	hsa-miR-3613-3p	PAR-CLIP	22012620
MIRT530909	hsa-miR-187-5p	PAR-CLIP	22012620
MIRT530915	hsa-miR-548aa	PAR-CLIP	22012620
MIRT530914	hsa-miR-548ap-3p	PAR-CLIP	22012620
MIRT530913	hsa-miR-548t-3p	PAR-CLIP	22012620
MIRT530912	hsa-miR-548e-5p	PAR-CLIP	22012620
MIRT530911	hsa-miR-548p	PAR-CLIP	22012620
MIRT530910	hsa-miR-3613-3p	PAR-CLIP	22012620
MIRT530909	hsa-miR-187-5p	PAR-CLIP	22012620
MIRT755607	mir-376a-1	Luciferase reporter assayqRT-PCR	36743290
MIRT1031928	hsa-miR-3653	CLIP-seq
MIRT1031929	hsa-miR-3658	CLIP-seq
MIRT1031930	hsa-miR-374c	CLIP-seq
MIRT1031931	hsa-miR-4312	CLIP-seq
MIRT1031932	hsa-miR-4719	CLIP-seq
MIRT1031933	hsa-miR-4727-5p	CLIP-seq
MIRT1031934	hsa-miR-513b	CLIP-seq
MIRT1031935	hsa-miR-544	CLIP-seq
MIRT1031936	hsa-miR-548ac	CLIP-seq
MIRT1031937	hsa-miR-548d-3p	CLIP-seq
MIRT1031938	hsa-miR-548z	CLIP-seq
MIRT1031939	hsa-miR-655	CLIP-seq
MIRT1031940	hsa-miR-1256	CLIP-seq
MIRT1031941	hsa-miR-135a	CLIP-seq
MIRT1031942	hsa-miR-135b	CLIP-seq
MIRT1031943	hsa-miR-193a-3p	CLIP-seq
MIRT1031944	hsa-miR-193b	CLIP-seq
MIRT1031945	hsa-miR-2355-5p	CLIP-seq
MIRT1031946	hsa-miR-302f	CLIP-seq
MIRT1031947	hsa-miR-3148	CLIP-seq
MIRT1031948	hsa-miR-3646	CLIP-seq
MIRT1031928	hsa-miR-3653	CLIP-seq
MIRT1031929	hsa-miR-3658	CLIP-seq
MIRT1031949	hsa-miR-4276	CLIP-seq
MIRT1031950	hsa-miR-4325	CLIP-seq
MIRT1031951	hsa-miR-4528	CLIP-seq
MIRT1031952	hsa-miR-4640-5p	CLIP-seq
MIRT1031953	hsa-miR-4720-5p	CLIP-seq
MIRT1031954	hsa-miR-4726-5p	CLIP-seq
MIRT1031955	hsa-miR-4773	CLIP-seq
MIRT1031956	hsa-miR-4799-3p	CLIP-seq
MIRT1031957	hsa-miR-548a-5p	CLIP-seq
MIRT1031958	hsa-miR-548ab	CLIP-seq
MIRT1031959	hsa-miR-548ak	CLIP-seq
MIRT1031960	hsa-miR-548b-5p	CLIP-seq
MIRT1031961	hsa-miR-548c-5p	CLIP-seq
MIRT1031962	hsa-miR-548d-5p	CLIP-seq
MIRT1031963	hsa-miR-548h	CLIP-seq
MIRT1031964	hsa-miR-548i	CLIP-seq
MIRT1031965	hsa-miR-548j	CLIP-seq
MIRT1031966	hsa-miR-548n	CLIP-seq
MIRT1031967	hsa-miR-548w	CLIP-seq
MIRT1031968	hsa-miR-548y	CLIP-seq
MIRT1031969	hsa-miR-559	CLIP-seq
MIRT1031970	hsa-miR-624	CLIP-seq
MIRT1031971	hsa-miR-892b	CLIP-seq
MIRT2006084	hsa-miR-142-3p	CLIP-seq
MIRT2006085	hsa-miR-3668	CLIP-seq
MIRT2006086	hsa-miR-4307	CLIP-seq
MIRT1031934	hsa-miR-513b	CLIP-seq
MIRT2006087	hsa-miR-548l	CLIP-seq
MIRT2006086	hsa-miR-4307	CLIP-seq
MIRT2238626	hsa-miR-548a-3p	CLIP-seq
MIRT2238627	hsa-miR-548e	CLIP-seq
MIRT2238628	hsa-miR-548f	CLIP-seq
MIRT1031932	hsa-miR-4719	CLIP-seq
MIRT1031934	hsa-miR-513b	CLIP-seq
MIRT1031936	hsa-miR-548ac	CLIP-seq
MIRT1031937	hsa-miR-548d-3p	CLIP-seq
MIRT1031938	hsa-miR-548z	CLIP-seq
MIRT2682051	hsa-miR-1263	CLIP-seq
MIRT2682052	hsa-miR-409-3p	CLIP-seq
MIRT2682053	hsa-miR-4438	CLIP-seq
MIRT2682054	hsa-miR-4504	CLIP-seq
MIRT2682055	hsa-miR-542-3p	CLIP-seq
MIRT2682056	hsa-miR-758	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IBA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	TAS	10833454
GO:0005515	Function	Protein binding	IPI	25780553
GO:0005783	Component	Endoplasmic reticulum	IDA	25780553
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007165	Process	Signal transduction	TAS	10833454
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0016020	Component	Membrane	IEA

MIM	HGNC	e!Ensembl
605188	4536	ENSG00000164604

P60893

Protein name

Probable G-protein coupled receptor 85 (Super conserved receptor expressed in brain 2)

Protein function

Orphan receptor.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	37 → 338	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in brain and testis. Lower levels in small intestine, placenta and spleen. In brain regions, detected in all regions tested, but somewhat lower levels in the corpus callosum, medulla and spinal cord. {ECO:0000269|PubMe

Sequence

MANYSHAADNILQNLSPLTAFLKLTSLGFIIGVSVVGNLLISILLVKDKTLHRAPYYFLL
DLCCSDILRSAICFPFVFNSVKNGSTWTYGTLTCKVIAFLGVLSCFHTAFMLFCISVTRY
LAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPVLDVGTYSFIREEDQCTFQHRSFR
ANDSLGFMLLLALILLATQLVYLKLIFFVHDRRKMKPVQFVAAVSQNWTFHGPGASGQAA
ANWLAGFGRGPTPPTLLGIRQNANTTGRRRLLVLDEFKMEKRISRMFYIMTFLFLTLWGP
YLVACYWRVFARGPVVPGGFLTAAVWMSFAQAGINPFVCIFSNRELRRCFSTTLLYCRKS
RLPREPYCVI

Sequence length

370

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CHOLELITHIASIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (2)

Disease Name	Disease (Merged)	Source	PMID	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Mental disorders	Mental Disorders	BEFREE	18413613	★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	18413613, 22968816	★★★★★ ★☆☆☆☆ Found in Text Mining only

GPR85 (G protein-coupled receptor 85)