Gene Gene information from NCBI Gene database.
Entrez ID 53944
Gene name Casein kinase 1 gamma 1
Gene symbol CSNK1G1
Synonyms (NCBI Gene)
CK1gamma1
Chromosome 15
Chromosome location 15q22.31
Summary This gene encodes a member of the casein kinase I gene family. This family is comprised of serine/threonine kinases that phosphorylate acidic proteins such as caseins. The encoded kinase plays a role in cell cycle checkpoint arrest in response to stalled
miRNA miRNA information provided by mirtarbase database.
1611
miRTarBase ID miRNA Experiments Reference
MIRT020171 hsa-miR-130b-3p Sequencing 20371350
MIRT028049 hsa-miR-93-5p Sequencing 20371350
MIRT028532 hsa-miR-30a-5p Proteomics 18668040
MIRT029209 hsa-miR-26b-5p Microarray 19088304
MIRT031148 hsa-miR-19b-3p Sequencing 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
19
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0004672 Function Protein kinase activity IEA
GO:0004674 Function Protein serine/threonine kinase activity IBA
GO:0004674 Function Protein serine/threonine kinase activity IDA 25500533
GO:0004674 Function Protein serine/threonine kinase activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
606274 2454 ENSG00000169118
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9HCP0
Protein name Casein kinase I isoform gamma-1 (CKI-gamma 1) (EC 2.7.11.1)
Protein function Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulat
PDB 2CMW
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 44 304 Protein kinase domain Domain
PF12605 CK1gamma_C 331 369 Casein kinase 1 gamma C terminal Family
PF12605 CK1gamma_C 367 392 Casein kinase 1 gamma C terminal Family
Sequence
Sequence length 422
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  Hedgehog signaling pathway  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
6
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
COMPLEX NEURODEVELOPMENTAL DISORDER GenCC
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MOOD DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
NEURODEVELOPMENTAL DISORDERS Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Carcinoma Basal Cell Basal cell carcinoma Pubtator 29967001 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Endometrioid Endometrioid carcinoma Pubtator 29967001 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Squamous Cell Squamous cell carcinoma Pubtator 37248471 Associate
★☆☆☆☆
Found in Text Mining only
Major Depressive Disorder Mental Depression GWASCAT_DG 29942085
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Mood Disorders Mood Disorder GWASCAT_DG 29942085
★☆☆☆☆
Found in Text Mining only