CLIC5 (chloride intracellular channel 5)

Gene

• Entrez ID: 53405
• Gene name: Chloride intracellular channel 5
• Gene symbol: CLIC5
• Synonyms (NCBI Gene): DFNB102, DFNB103, MST130, MSTP130
• Chromosome: 6
• Chromosome location: 6p21.1
• Summary: This gene encodes a member of the chloride intracellular channel (CLIC) family of chloride ion channels. The encoded protein associates with actin-based cytoskeletal structures and may play a role in multiple processes including hair cell stereocilia form

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs189893797	C>T	Likely-benign, conflicting-interpretations-of-pathogenicity	Genic upstream transcript variant, coding sequence variant, non coding transcript variant, intron variant, missense variant
rs199808624	C>T	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, genic upstream transcript variant, non coding transcript variant, missense variant
rs606231308	A>T	Pathogenic	5 prime UTR variant, coding sequence variant, non coding transcript variant, genic upstream transcript variant, stop gained
rs1043716893	C>G,T	Likely-pathogenic	Genic downstream transcript variant, coding sequence variant, stop gained, missense variant, non coding transcript variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT718083	hsa-miR-500b-3p	HITS-CLIP	19536157
MIRT718082	hsa-miR-4301	HITS-CLIP	19536157
MIRT718081	hsa-miR-5193	HITS-CLIP	19536157
MIRT718080	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT718079	hsa-miR-532-3p	HITS-CLIP	19536157
MIRT718078	hsa-miR-6845-3p	HITS-CLIP	19536157
MIRT718077	hsa-miR-412-3p	HITS-CLIP	19536157
MIRT718076	hsa-miR-6754-3p	HITS-CLIP	19536157
MIRT718075	hsa-miR-6837-3p	HITS-CLIP	19536157
MIRT718074	hsa-miR-6802-3p	HITS-CLIP	19536157
MIRT718073	hsa-miR-3156-3p	HITS-CLIP	19536157
MIRT624321	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT718072	hsa-miR-4279	HITS-CLIP	19536157
MIRT718083	hsa-miR-500b-3p	HITS-CLIP	19536157
MIRT718082	hsa-miR-4301	HITS-CLIP	19536157
MIRT718081	hsa-miR-5193	HITS-CLIP	19536157
MIRT718080	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT718079	hsa-miR-532-3p	HITS-CLIP	19536157
MIRT718078	hsa-miR-6845-3p	HITS-CLIP	19536157
MIRT718077	hsa-miR-412-3p	HITS-CLIP	19536157
MIRT718076	hsa-miR-6754-3p	HITS-CLIP	19536157
MIRT718075	hsa-miR-6837-3p	HITS-CLIP	19536157
MIRT718074	hsa-miR-6802-3p	HITS-CLIP	19536157
MIRT718073	hsa-miR-3156-3p	HITS-CLIP	19536157
MIRT624321	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT718072	hsa-miR-4279	HITS-CLIP	19536157
MIRT624332	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT624331	hsa-miR-105-5p	HITS-CLIP	23824327
MIRT624330	hsa-miR-7853-5p	HITS-CLIP	23824327
MIRT624329	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT624328	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT624326	hsa-miR-4469	HITS-CLIP	23824327
MIRT624324	hsa-miR-3671	HITS-CLIP	23824327
MIRT624322	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT624321	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT624320	hsa-miR-3686	HITS-CLIP	23824327
MIRT624319	hsa-miR-607	HITS-CLIP	23824327
MIRT624323	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT636614	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT636613	hsa-miR-4282	HITS-CLIP	23824327
MIRT636612	hsa-miR-3622a-3p	HITS-CLIP	23824327
MIRT636611	hsa-miR-3622b-3p	HITS-CLIP	23824327
MIRT636610	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT636609	hsa-miR-221-5p	HITS-CLIP	23824327
MIRT636608	hsa-miR-8073	HITS-CLIP	23824327
MIRT636607	hsa-miR-6868-5p	HITS-CLIP	23824327
MIRT636606	hsa-miR-34a-5p	HITS-CLIP	23824327
MIRT636605	hsa-miR-34c-5p	HITS-CLIP	23824327
MIRT636604	hsa-miR-449a	HITS-CLIP	23824327
MIRT636603	hsa-miR-449b-5p	HITS-CLIP	23824327
MIRT636602	hsa-miR-548au-3p	HITS-CLIP	23824327
MIRT659473	hsa-miR-5579-3p	HITS-CLIP	23824327
MIRT636601	hsa-miR-5096	HITS-CLIP	23824327
MIRT636600	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT624332	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT624331	hsa-miR-105-5p	HITS-CLIP	23824327
MIRT624330	hsa-miR-7853-5p	HITS-CLIP	23824327
MIRT624329	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT624328	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT624326	hsa-miR-4469	HITS-CLIP	23824327
MIRT624324	hsa-miR-3671	HITS-CLIP	23824327
MIRT624322	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT624321	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT659472	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT624320	hsa-miR-3686	HITS-CLIP	23824327
MIRT624319	hsa-miR-607	HITS-CLIP	23824327
MIRT624323	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT636612	hsa-miR-3622a-3p	HITS-CLIP	23824327
MIRT636611	hsa-miR-3622b-3p	HITS-CLIP	23824327
MIRT636610	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT636609	hsa-miR-221-5p	HITS-CLIP	23824327
MIRT636608	hsa-miR-8073	HITS-CLIP	23824327
MIRT636607	hsa-miR-6868-5p	HITS-CLIP	23824327
MIRT636606	hsa-miR-34a-5p	HITS-CLIP	23824327
MIRT636605	hsa-miR-34c-5p	HITS-CLIP	23824327
MIRT636604	hsa-miR-449a	HITS-CLIP	23824327
MIRT636603	hsa-miR-449b-5p	HITS-CLIP	23824327
MIRT636602	hsa-miR-548au-3p	HITS-CLIP	23824327
MIRT636601	hsa-miR-5096	HITS-CLIP	23824327
MIRT636600	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT636614	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT636613	hsa-miR-4282	HITS-CLIP	23824327
MIRT636612	hsa-miR-3622a-3p	HITS-CLIP	23824327
MIRT636611	hsa-miR-3622b-3p	HITS-CLIP	23824327
MIRT636610	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT636609	hsa-miR-221-5p	HITS-CLIP	23824327
MIRT636608	hsa-miR-8073	HITS-CLIP	23824327
MIRT636607	hsa-miR-6868-5p	HITS-CLIP	23824327
MIRT636606	hsa-miR-34a-5p	HITS-CLIP	23824327
MIRT636605	hsa-miR-34c-5p	HITS-CLIP	23824327
MIRT636604	hsa-miR-449a	HITS-CLIP	23824327
MIRT636603	hsa-miR-449b-5p	HITS-CLIP	23824327
MIRT636602	hsa-miR-548au-3p	HITS-CLIP	23824327
MIRT636601	hsa-miR-5096	HITS-CLIP	23824327
MIRT636600	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT624332	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT624331	hsa-miR-105-5p	HITS-CLIP	23824327
MIRT624330	hsa-miR-7853-5p	HITS-CLIP	23824327
MIRT624329	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT624328	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT624327	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT624326	hsa-miR-4469	HITS-CLIP	23824327
MIRT624325	hsa-miR-3182	HITS-CLIP	23824327
MIRT624324	hsa-miR-3671	HITS-CLIP	23824327
MIRT624323	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT624322	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT624321	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT624320	hsa-miR-3686	HITS-CLIP	23824327
MIRT624319	hsa-miR-607	HITS-CLIP	23824327
MIRT443457	hsa-miR-1252-3p	PAR-CLIP	22100165
MIRT443456	hsa-miR-5680	PAR-CLIP	22100165
MIRT443455	hsa-miR-3691-3p	PAR-CLIP	22100165
MIRT443453	hsa-miR-4251	PAR-CLIP	22100165
MIRT443454	hsa-miR-539-5p	PAR-CLIP	22100165
MIRT443452	hsa-miR-4480	PAR-CLIP	22100165
MIRT443451	hsa-miR-4663	PAR-CLIP	22100165
MIRT443450	hsa-miR-7160-5p	PAR-CLIP	22100165
MIRT443449	hsa-miR-8077	PAR-CLIP	22100165
MIRT443448	hsa-miR-6807-5p	PAR-CLIP	22100165
MIRT443447	hsa-miR-628-5p	PAR-CLIP	22100165
MIRT718083	hsa-miR-500b-3p	HITS-CLIP	19536157
MIRT718082	hsa-miR-4301	HITS-CLIP	19536157
MIRT718081	hsa-miR-5193	HITS-CLIP	19536157
MIRT718080	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT718079	hsa-miR-532-3p	HITS-CLIP	19536157
MIRT718078	hsa-miR-6845-3p	HITS-CLIP	19536157
MIRT718077	hsa-miR-412-3p	HITS-CLIP	19536157
MIRT718076	hsa-miR-6754-3p	HITS-CLIP	19536157
MIRT718075	hsa-miR-6837-3p	HITS-CLIP	19536157
MIRT718074	hsa-miR-6802-3p	HITS-CLIP	19536157
MIRT718073	hsa-miR-3156-3p	HITS-CLIP	19536157
MIRT624321	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT718072	hsa-miR-4279	HITS-CLIP	19536157
MIRT718083	hsa-miR-500b-3p	HITS-CLIP	19536157
MIRT718082	hsa-miR-4301	HITS-CLIP	19536157
MIRT718081	hsa-miR-5193	HITS-CLIP	19536157
MIRT718080	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT718079	hsa-miR-532-3p	HITS-CLIP	19536157
MIRT718078	hsa-miR-6845-3p	HITS-CLIP	19536157
MIRT718077	hsa-miR-412-3p	HITS-CLIP	19536157
MIRT718076	hsa-miR-6754-3p	HITS-CLIP	19536157
MIRT718075	hsa-miR-6837-3p	HITS-CLIP	19536157
MIRT718074	hsa-miR-6802-3p	HITS-CLIP	19536157
MIRT718073	hsa-miR-3156-3p	HITS-CLIP	19536157
MIRT624321	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT718072	hsa-miR-4279	HITS-CLIP	19536157
MIRT624332	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT624331	hsa-miR-105-5p	HITS-CLIP	23824327
MIRT624330	hsa-miR-7853-5p	HITS-CLIP	23824327
MIRT624329	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT624328	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT624326	hsa-miR-4469	HITS-CLIP	23824327
MIRT624324	hsa-miR-3671	HITS-CLIP	23824327
MIRT624322	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT624321	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT624320	hsa-miR-3686	HITS-CLIP	23824327
MIRT624319	hsa-miR-607	HITS-CLIP	23824327
MIRT624323	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT636614	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT636613	hsa-miR-4282	HITS-CLIP	23824327
MIRT636612	hsa-miR-3622a-3p	HITS-CLIP	23824327
MIRT636611	hsa-miR-3622b-3p	HITS-CLIP	23824327
MIRT636610	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT636609	hsa-miR-221-5p	HITS-CLIP	23824327
MIRT636608	hsa-miR-8073	HITS-CLIP	23824327
MIRT636607	hsa-miR-6868-5p	HITS-CLIP	23824327
MIRT636606	hsa-miR-34a-5p	HITS-CLIP	23824327
MIRT636605	hsa-miR-34c-5p	HITS-CLIP	23824327
MIRT636604	hsa-miR-449a	HITS-CLIP	23824327
MIRT636603	hsa-miR-449b-5p	HITS-CLIP	23824327
MIRT636602	hsa-miR-548au-3p	HITS-CLIP	23824327
MIRT659473	hsa-miR-5579-3p	HITS-CLIP	23824327
MIRT636601	hsa-miR-5096	HITS-CLIP	23824327
MIRT636600	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT624332	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT624331	hsa-miR-105-5p	HITS-CLIP	23824327
MIRT624330	hsa-miR-7853-5p	HITS-CLIP	23824327
MIRT624329	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT624328	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT624326	hsa-miR-4469	HITS-CLIP	23824327
MIRT624324	hsa-miR-3671	HITS-CLIP	23824327
MIRT624322	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT624321	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT659472	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT624320	hsa-miR-3686	HITS-CLIP	23824327
MIRT624319	hsa-miR-607	HITS-CLIP	23824327
MIRT624323	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT636612	hsa-miR-3622a-3p	HITS-CLIP	23824327
MIRT636611	hsa-miR-3622b-3p	HITS-CLIP	23824327
MIRT636610	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT636609	hsa-miR-221-5p	HITS-CLIP	23824327
MIRT636608	hsa-miR-8073	HITS-CLIP	23824327
MIRT636607	hsa-miR-6868-5p	HITS-CLIP	23824327
MIRT636606	hsa-miR-34a-5p	HITS-CLIP	23824327
MIRT636605	hsa-miR-34c-5p	HITS-CLIP	23824327
MIRT636604	hsa-miR-449a	HITS-CLIP	23824327
MIRT636603	hsa-miR-449b-5p	HITS-CLIP	23824327
MIRT636602	hsa-miR-548au-3p	HITS-CLIP	23824327
MIRT636601	hsa-miR-5096	HITS-CLIP	23824327
MIRT636600	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT636614	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT636613	hsa-miR-4282	HITS-CLIP	23824327
MIRT636612	hsa-miR-3622a-3p	HITS-CLIP	23824327
MIRT636611	hsa-miR-3622b-3p	HITS-CLIP	23824327
MIRT636610	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT636609	hsa-miR-221-5p	HITS-CLIP	23824327
MIRT636608	hsa-miR-8073	HITS-CLIP	23824327
MIRT636607	hsa-miR-6868-5p	HITS-CLIP	23824327
MIRT636606	hsa-miR-34a-5p	HITS-CLIP	23824327
MIRT636605	hsa-miR-34c-5p	HITS-CLIP	23824327
MIRT636604	hsa-miR-449a	HITS-CLIP	23824327
MIRT636603	hsa-miR-449b-5p	HITS-CLIP	23824327
MIRT636602	hsa-miR-548au-3p	HITS-CLIP	23824327
MIRT636601	hsa-miR-5096	HITS-CLIP	23824327
MIRT636600	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT624332	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT624331	hsa-miR-105-5p	HITS-CLIP	23824327
MIRT624330	hsa-miR-7853-5p	HITS-CLIP	23824327
MIRT624329	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT624328	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT624327	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT624326	hsa-miR-4469	HITS-CLIP	23824327
MIRT624325	hsa-miR-3182	HITS-CLIP	23824327
MIRT624324	hsa-miR-3671	HITS-CLIP	23824327
MIRT624323	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT624322	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT624321	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT624320	hsa-miR-3686	HITS-CLIP	23824327
MIRT624319	hsa-miR-607	HITS-CLIP	23824327
MIRT443457	hsa-miR-1252-3p	PAR-CLIP	22100165
MIRT443456	hsa-miR-5680	PAR-CLIP	22100165
MIRT443455	hsa-miR-3691-3p	PAR-CLIP	22100165
MIRT443453	hsa-miR-4251	PAR-CLIP	22100165
MIRT443454	hsa-miR-539-5p	PAR-CLIP	22100165
MIRT443452	hsa-miR-4480	PAR-CLIP	22100165
MIRT443451	hsa-miR-4663	PAR-CLIP	22100165
MIRT443450	hsa-miR-7160-5p	PAR-CLIP	22100165
MIRT443449	hsa-miR-8077	PAR-CLIP	22100165
MIRT443448	hsa-miR-6807-5p	PAR-CLIP	22100165
MIRT443447	hsa-miR-628-5p	PAR-CLIP	22100165
MIRT896366	hsa-miR-122	CLIP-seq
MIRT896367	hsa-miR-216b	CLIP-seq
MIRT896368	hsa-miR-3074-5p	CLIP-seq
MIRT896369	hsa-miR-3180-5p	CLIP-seq
MIRT896370	hsa-miR-342-5p	CLIP-seq
MIRT896371	hsa-miR-3611	CLIP-seq
MIRT896372	hsa-miR-3675-3p	CLIP-seq
MIRT896373	hsa-miR-3677-5p	CLIP-seq
MIRT896374	hsa-miR-432	CLIP-seq
MIRT896375	hsa-miR-4453	CLIP-seq
MIRT896376	hsa-miR-4506	CLIP-seq
MIRT896377	hsa-miR-4538	CLIP-seq
MIRT896378	hsa-miR-4651	CLIP-seq
MIRT896379	hsa-miR-4664-5p	CLIP-seq
MIRT896380	hsa-miR-4722-3p	CLIP-seq
MIRT896381	hsa-miR-4757-5p	CLIP-seq
MIRT896382	hsa-miR-516a-3p	CLIP-seq
MIRT896383	hsa-miR-520a-5p	CLIP-seq
MIRT896384	hsa-miR-525-5p	CLIP-seq
MIRT896385	hsa-miR-608	CLIP-seq
MIRT896386	hsa-miR-618	CLIP-seq
MIRT896387	hsa-miR-646	CLIP-seq
MIRT896388	hsa-miR-1178	CLIP-seq
MIRT896389	hsa-miR-1227	CLIP-seq
MIRT896390	hsa-miR-134	CLIP-seq
MIRT896391	hsa-miR-298	CLIP-seq
MIRT896368	hsa-miR-3074-5p	CLIP-seq
MIRT896392	hsa-miR-3118	CLIP-seq
MIRT896393	hsa-miR-3145-3p	CLIP-seq
MIRT896394	hsa-miR-3155	CLIP-seq
MIRT896395	hsa-miR-3155b	CLIP-seq
MIRT896396	hsa-miR-3160-5p	CLIP-seq
MIRT896397	hsa-miR-3164	CLIP-seq
MIRT896398	hsa-miR-3185	CLIP-seq
MIRT896399	hsa-miR-4303	CLIP-seq
MIRT896400	hsa-miR-4522	CLIP-seq
MIRT896401	hsa-miR-4677-3p	CLIP-seq
MIRT896402	hsa-miR-4678	CLIP-seq
MIRT896403	hsa-miR-4679	CLIP-seq
MIRT896404	hsa-miR-4698	CLIP-seq
MIRT896405	hsa-miR-4714-5p	CLIP-seq
MIRT896406	hsa-miR-4715-3p	CLIP-seq
MIRT896380	hsa-miR-4722-3p	CLIP-seq
MIRT896407	hsa-miR-4743	CLIP-seq
MIRT896408	hsa-miR-4762-3p	CLIP-seq
MIRT896409	hsa-miR-4772-5p	CLIP-seq
MIRT896410	hsa-miR-484	CLIP-seq
MIRT896382	hsa-miR-516a-3p	CLIP-seq
MIRT896382	hsa-miR-516a-3p	CLIP-seq
MIRT1965780	hsa-miR-3192	CLIP-seq
MIRT2201709	hsa-miR-103a	CLIP-seq
MIRT2201710	hsa-miR-107	CLIP-seq
MIRT2201711	hsa-miR-1179	CLIP-seq
MIRT2201712	hsa-miR-1184	CLIP-seq
MIRT2201713	hsa-miR-4269	CLIP-seq
MIRT2201714	hsa-miR-4310	CLIP-seq
MIRT2201715	hsa-miR-4420	CLIP-seq
MIRT2201716	hsa-miR-4514	CLIP-seq
MIRT2201717	hsa-miR-4692	CLIP-seq
MIRT2201718	hsa-miR-4742-5p	CLIP-seq
MIRT2201719	hsa-miR-503	CLIP-seq
MIRT2201720	hsa-miR-511	CLIP-seq
MIRT2201721	hsa-miR-634	CLIP-seq
MIRT2201722	hsa-miR-940	CLIP-seq
MIRT2386175	hsa-miR-4271	CLIP-seq
MIRT2386176	hsa-miR-4725-3p	CLIP-seq
MIRT2442083	hsa-miR-3977	CLIP-seq
MIRT2447176	hsa-miR-1245b-5p	CLIP-seq
MIRT2447177	hsa-miR-3142	CLIP-seq
MIRT2447178	hsa-miR-3620	CLIP-seq
MIRT2447179	hsa-miR-3653	CLIP-seq
MIRT2447180	hsa-miR-4263	CLIP-seq
MIRT2447181	hsa-miR-4426	CLIP-seq
MIRT2447182	hsa-miR-4493	CLIP-seq
MIRT2447183	hsa-miR-4647	CLIP-seq
MIRT2447184	hsa-miR-4662b	CLIP-seq
MIRT2447185	hsa-miR-4699-5p	CLIP-seq
MIRT2447186	hsa-miR-548n	CLIP-seq
MIRT2447187	hsa-miR-548t	CLIP-seq
MIRT2447188	hsa-miR-561	CLIP-seq
MIRT2447189	hsa-miR-576-5p	CLIP-seq
MIRT2201721	hsa-miR-634	CLIP-seq
MIRT2504629	hsa-miR-127-5p	CLIP-seq
MIRT2504630	hsa-miR-1289	CLIP-seq
MIRT2504631	hsa-miR-23a	CLIP-seq
MIRT2504632	hsa-miR-23b	CLIP-seq
MIRT2504633	hsa-miR-23c	CLIP-seq
MIRT2504634	hsa-miR-3135b	CLIP-seq
MIRT2504635	hsa-miR-3198	CLIP-seq
MIRT2504636	hsa-miR-320e	CLIP-seq
MIRT2447178	hsa-miR-3620	CLIP-seq
MIRT2442083	hsa-miR-3977	CLIP-seq
MIRT2504637	hsa-miR-4294	CLIP-seq
MIRT2504638	hsa-miR-4309	CLIP-seq
MIRT2504639	hsa-miR-4717-3p	CLIP-seq
MIRT2201720	hsa-miR-511	CLIP-seq
MIRT2201721	hsa-miR-634	CLIP-seq
MIRT2504640	hsa-miR-924	CLIP-seq
MIRT2504631	hsa-miR-23a	CLIP-seq
MIRT2504632	hsa-miR-23b	CLIP-seq
MIRT2504633	hsa-miR-23c	CLIP-seq
MIRT2447178	hsa-miR-3620	CLIP-seq
MIRT2442083	hsa-miR-3977	CLIP-seq
MIRT2504639	hsa-miR-4717-3p	CLIP-seq
MIRT2201720	hsa-miR-511	CLIP-seq
MIRT2201721	hsa-miR-634	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005254	Function	Chloride channel activity	IEA
GO:0005515	Function	Protein binding	IPI	10793131, 12163479, 16831863, 24285636, 28514442, 32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IEA
GO:0005794	Component	Golgi apparatus	IDA	12163479
GO:0005794	Component	Golgi apparatus	IEA
GO:0005813	Component	Centrosome	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005938	Component	Cell cortex	IEA
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006821	Process	Chloride transport	IDA	10793131
GO:0006821	Process	Chloride transport	IEA
GO:0007565	Process	Female pregnancy	TAS	10793131
GO:0007601	Process	Visual perception	IEA
GO:0007605	Process	Sensory perception of sound	IEA
GO:0007605	Process	Sensory perception of sound	IMP	24781754
GO:0015629	Component	Actin cytoskeleton	IDA	10793131
GO:0016020	Component	Membrane	IEA
GO:0016324	Component	Apical plasma membrane	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0032420	Component	Stereocilium	IEA
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0034702	Component	Monoatomic ion channel complex	IEA
GO:0034707	Component	Chloride channel complex	IEA
GO:0042995	Component	Cell projection	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:1902476	Process	Chloride transmembrane transport	IEA

Other IDs

• MIM: 607293
• HGNC: 13517
• e!Ensembl: ENSG00000112782

Protein

• UniProt ID: Q9NZA1
• Protein name: Chloride intracellular channel protein 5 (Glutaredoxin-like oxidoreductase CLIC5) (EC 1.8.-.-)
• Protein function: In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (By similarity). Can insert into membranes and form non-selective ion channels almost equally permeable to Na(+), K(+
• PDB: 6Y2H, 8Q4I, 8Q4J
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13409	GST_N_2	190 → 254	Glutathione S-transferase, N-terminal domain	Domain
  PF13410	GST_C_2	273 → 379		Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed in both fetal and adult human tissues (PubMed:24781754). Isoform 1 is expressed in renal glomeruli endothelial cells and podocytes (at protein level). {ECO:0000269|PubMed:20335315, ECO:0000269|PubMed:24781754}.
• Sequence:

  MNDEDYSTIYDTIQNERTYEVPDQPEENESPHYDDVHEYLRPENDLYATQLNTHEYDFVS
  VYTIKGEETSLASVQSEDRGYLLPDEIYSELQEAHPGEPQEDRGISMEGLYSSTQDQQLC
  AAELQENGSVMKEDLPSPSSFTIQHSKAFSTTKYSCYSDAEGLEEKEGAHMNPEIYLFVK
  AGIDGESIGNCPFSQRLFMILWLKGVVFNVTTVDLKRKPADLHNLAPGTHPPFLTFNGDV
  KTDVNKIEEFLEETLTPEKYPKLAAKHRESNTAGIDIFSKFSAYIKNTKQQNNAALERGL
  TKALKKLDDYLNTPLPEEIDANTCGEDKGSRRKFLDGDELTLADCNLLPKLHVVKIVAKK
  YRNYDIPAEMTGLWRYLKNAYARDEFTNTCAADSEIELAYADVAKRLSRS

• Sequence length: 410

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Autosomal recessive nonsyndromic hearing loss 103	Pathogenic	rs606231308	RCV000148034	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Hearing loss, autosomal recessive	Likely pathogenic	rs1043716893	RCV000855670	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ANDROGENETIC ALOPECIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTOSOMAL RECESSIVE ISOLATED SENSORINEURAL DEAFNESS TYPE DFNB	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CLIC5-related disorder	Benign; Likely benign; Conflicting classifications of pathogenicity	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEAFNESS, AUTOSOMAL RECESSIVE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEAFNESS, AUTOSOMAL RECESSIVE 103	—	CTD, Disgenet, HPO CTD, Disgenet, HPO CTD, Disgenet, HPO	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLAUCOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hearing impairment	Uncertain significance	ClinVar Disgenet	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
HODGKINS LYMPHOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MENTAL OR BEHAVIOURAL DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OPEN-ANGLE GLAUCOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS, HIP	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PERIODONTITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSYCHOSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SENSORINEURAL HEARING LOSS OF BILATERAL EARS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
STROKE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Conflicting classifications of pathogenicity	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Autosomal recessive non-syndromic sensorineural deafness type DFNB	Non-Syndromic Sensorineural Deafness	Orphanet			★☆☆☆☆ Found in Text Mining only
Bilateral Vestibulopathy	Bilateral Vestibulopathy	HPO_DG			★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	24172169	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	34766585	Associate	★☆☆☆☆ Found in Text Mining only
Cataract	Cataract	Pubtator	37511188	Associate	★☆☆☆☆ Found in Text Mining only
Childhood Acute Lymphoblastic Leukemia	Lymphoblastic Leukemia	BEFREE	27540136		★☆☆☆☆ Found in Text Mining only
DEAFNESS, AUTOSOMAL RECESSIVE (disorder)	Deafness	CLINGEN_DG	17021174, 24285636, 24781754		★☆☆☆☆ Found in Text Mining only
DEAFNESS, AUTOSOMAL RECESSIVE 103	Deafness	GENOMICS_ENGLAND_DG	24781754		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEAFNESS, AUTOSOMAL RECESSIVE 103	Deafness	CTD_human_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEAFNESS, AUTOSOMAL RECESSIVE 103	Deafness	CLINVAR_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Diabetic Nephropathies	Diabetic neuropathy	Pubtator	36092962, 37492198	Associate	★☆☆☆☆ Found in Text Mining only
Diabetic Nephropathies	Diabetic neuropathy	Pubtator	37916327	Inhibit	★☆☆☆☆ Found in Text Mining only
Hearing Loss	Hearing loss	Pubtator	24781754, 33114113	Associate	★☆☆☆☆ Found in Text Mining only
Kidney Diseases	Kidney disease	Pubtator	24781754	Associate	★☆☆☆☆ Found in Text Mining only
Nonsyndromic Deafness	Nonsyndromic Deafness	BEFREE	24781754		★☆☆☆☆ Found in Text Mining only
Renal Insufficiency	Renal Insufficiency	BEFREE	24781754		★☆☆☆☆ Found in Text Mining only
Sensorineural Deafness With Mild Renal Dysfunction	Sensorineural deafness with renal dysfunction	Pubtator	24781754	Associate	★☆☆☆☆ Found in Text Mining only
Sensorineural Hearing Loss (disorder)	Hearing Loss	HPO_DG			★☆☆☆☆ Found in Text Mining only
Small Cell Lung Carcinoma	Small cell lung carcinoma	Pubtator	35845940	Associate	★☆☆☆☆ Found in Text Mining only
Vestibular Diseases	Vestibular disease	Pubtator	24781754	Associate	★☆☆☆☆ Found in Text Mining only