SHC3 (SHC adaptor protein 3)

Gene

• Entrez ID: 53358
• Gene name: SHC adaptor protein 3
• Gene symbol: SHC3
• Synonyms (NCBI Gene): N-Shc, NSHC, RAI, SHCC
• Chromosome: 9
• Chromosome location: 9q22.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018309	hsa-miR-335-5p	Microarray	18185580
MIRT002724	hsa-miR-124-3p	Microarray	15685193
MIRT049052	hsa-miR-92a-3p	CLASH	23622248
MIRT569213	hsa-miR-3120-3p	PAR-CLIP	20371350
MIRT569212	hsa-miR-1285-5p	PAR-CLIP	20371350
MIRT569211	hsa-miR-665	PAR-CLIP	20371350
MIRT569210	hsa-miR-342-3p	PAR-CLIP	20371350
MIRT569209	hsa-miR-3619-3p	PAR-CLIP	20371350
MIRT569208	hsa-miR-155-3p	PAR-CLIP	20371350
MIRT528190	hsa-miR-4733-5p	PAR-CLIP	22012620
MIRT528189	hsa-miR-885-5p	PAR-CLIP	22012620
MIRT528188	hsa-miR-376a-3p	PAR-CLIP	22012620
MIRT528187	hsa-miR-376b-3p	PAR-CLIP	22012620
MIRT528186	hsa-miR-3912-5p	PAR-CLIP	22012620
MIRT528185	hsa-miR-4646-3p	PAR-CLIP	22012620
MIRT528184	hsa-miR-2355-3p	PAR-CLIP	22012620
MIRT569213	hsa-miR-3120-3p	PAR-CLIP	20371350
MIRT569212	hsa-miR-1285-5p	PAR-CLIP	20371350
MIRT569211	hsa-miR-665	PAR-CLIP	20371350
MIRT569210	hsa-miR-342-3p	PAR-CLIP	20371350
MIRT569209	hsa-miR-3619-3p	PAR-CLIP	20371350
MIRT569208	hsa-miR-155-3p	PAR-CLIP	20371350
MIRT528190	hsa-miR-4733-5p	PAR-CLIP	22012620
MIRT528189	hsa-miR-885-5p	PAR-CLIP	22012620
MIRT528188	hsa-miR-376a-3p	PAR-CLIP	22012620
MIRT528187	hsa-miR-376b-3p	PAR-CLIP	22012620
MIRT528186	hsa-miR-3912-5p	PAR-CLIP	22012620
MIRT528185	hsa-miR-4646-3p	PAR-CLIP	22012620
MIRT528184	hsa-miR-2355-3p	PAR-CLIP	22012620
MIRT1346513	hsa-miR-103a	CLIP-seq
MIRT1346514	hsa-miR-105	CLIP-seq
MIRT1346515	hsa-miR-107	CLIP-seq
MIRT1346516	hsa-miR-1193	CLIP-seq
MIRT1346517	hsa-miR-1231	CLIP-seq
MIRT1346518	hsa-miR-1246	CLIP-seq
MIRT1346519	hsa-miR-1262	CLIP-seq
MIRT1346520	hsa-miR-1266	CLIP-seq
MIRT1346521	hsa-miR-1287	CLIP-seq
MIRT1346522	hsa-miR-1343	CLIP-seq
MIRT1346523	hsa-miR-145	CLIP-seq
MIRT1346524	hsa-miR-155	CLIP-seq
MIRT1346525	hsa-miR-181a	CLIP-seq
MIRT1346526	hsa-miR-181b	CLIP-seq
MIRT1346527	hsa-miR-181c	CLIP-seq
MIRT1346528	hsa-miR-181d	CLIP-seq
MIRT1346529	hsa-miR-182	CLIP-seq
MIRT1346530	hsa-miR-1825	CLIP-seq
MIRT1346531	hsa-miR-1827	CLIP-seq
MIRT1346532	hsa-miR-1908	CLIP-seq
MIRT1346533	hsa-miR-199a-5p	CLIP-seq
MIRT1346534	hsa-miR-199b-5p	CLIP-seq
MIRT1346535	hsa-miR-202	CLIP-seq
MIRT1346536	hsa-miR-2110	CLIP-seq
MIRT1346537	hsa-miR-2277-3p	CLIP-seq
MIRT1346538	hsa-miR-2278	CLIP-seq
MIRT1346539	hsa-miR-23a	CLIP-seq
MIRT1346540	hsa-miR-23b	CLIP-seq
MIRT1346541	hsa-miR-23c	CLIP-seq
MIRT1346542	hsa-miR-2682	CLIP-seq
MIRT1346543	hsa-miR-27a	CLIP-seq
MIRT1346544	hsa-miR-27b	CLIP-seq
MIRT1346545	hsa-miR-3065-5p	CLIP-seq
MIRT1346546	hsa-miR-3121-3p	CLIP-seq
MIRT1346547	hsa-miR-3136-5p	CLIP-seq
MIRT1346548	hsa-miR-3151	CLIP-seq
MIRT1346549	hsa-miR-3159	CLIP-seq
MIRT1346550	hsa-miR-3176	CLIP-seq
MIRT1346551	hsa-miR-3184	CLIP-seq
MIRT1346552	hsa-miR-3190	CLIP-seq
MIRT1346553	hsa-miR-335	CLIP-seq
MIRT1346554	hsa-miR-3591-3p	CLIP-seq
MIRT1346555	hsa-miR-3612	CLIP-seq
MIRT1346556	hsa-miR-3613-3p	CLIP-seq
MIRT1346557	hsa-miR-3617	CLIP-seq
MIRT1346558	hsa-miR-365	CLIP-seq
MIRT1346559	hsa-miR-3652	CLIP-seq
MIRT1346560	hsa-miR-3675-5p	CLIP-seq
MIRT1346561	hsa-miR-3689d	CLIP-seq
MIRT1346562	hsa-miR-3714	CLIP-seq
MIRT1346563	hsa-miR-376c	CLIP-seq
MIRT1346564	hsa-miR-3922-3p	CLIP-seq
MIRT1346565	hsa-miR-3925-3p	CLIP-seq
MIRT1346566	hsa-miR-3938	CLIP-seq
MIRT1346567	hsa-miR-3944-5p	CLIP-seq
MIRT1346568	hsa-miR-3977	CLIP-seq
MIRT1346569	hsa-miR-423-5p	CLIP-seq
MIRT1346570	hsa-miR-4262	CLIP-seq
MIRT1346571	hsa-miR-4267	CLIP-seq
MIRT1346572	hsa-miR-4270	CLIP-seq
MIRT1346573	hsa-miR-4271	CLIP-seq
MIRT1346574	hsa-miR-4280	CLIP-seq
MIRT1346575	hsa-miR-4283	CLIP-seq
MIRT1346576	hsa-miR-4288	CLIP-seq
MIRT1346577	hsa-miR-4310	CLIP-seq
MIRT1346578	hsa-miR-4320	CLIP-seq
MIRT1346579	hsa-miR-4427	CLIP-seq
MIRT1346580	hsa-miR-4430	CLIP-seq
MIRT1346581	hsa-miR-4437	CLIP-seq
MIRT1346582	hsa-miR-4439	CLIP-seq
MIRT1346583	hsa-miR-4441	CLIP-seq
MIRT1346584	hsa-miR-4443	CLIP-seq
MIRT1346585	hsa-miR-4447	CLIP-seq
MIRT1346586	hsa-miR-4457	CLIP-seq
MIRT1346587	hsa-miR-4472	CLIP-seq
MIRT1346588	hsa-miR-4474-5p	CLIP-seq
MIRT1346589	hsa-miR-4489	CLIP-seq
MIRT1346590	hsa-miR-449c	CLIP-seq
MIRT1346591	hsa-miR-4504	CLIP-seq
MIRT1346592	hsa-miR-4518	CLIP-seq
MIRT1346593	hsa-miR-451b	CLIP-seq
MIRT1346594	hsa-miR-4534	CLIP-seq
MIRT1346595	hsa-miR-4539	CLIP-seq
MIRT1346596	hsa-miR-4640-5p	CLIP-seq
MIRT1346597	hsa-miR-4651	CLIP-seq
MIRT1346598	hsa-miR-4652-3p	CLIP-seq
MIRT1346599	hsa-miR-4677-3p	CLIP-seq
MIRT1346600	hsa-miR-4679	CLIP-seq
MIRT1346601	hsa-miR-4680-3p	CLIP-seq
MIRT1346602	hsa-miR-4694-3p	CLIP-seq
MIRT1346603	hsa-miR-4701-3p	CLIP-seq
MIRT1346604	hsa-miR-4701-5p	CLIP-seq
MIRT1346605	hsa-miR-4725-3p	CLIP-seq
MIRT1346606	hsa-miR-4726-5p	CLIP-seq
MIRT1346607	hsa-miR-4730	CLIP-seq
MIRT1346608	hsa-miR-4732-5p	CLIP-seq
MIRT1346609	hsa-miR-4777-3p	CLIP-seq
MIRT1346610	hsa-miR-4802-5p	CLIP-seq
MIRT1346611	hsa-miR-483-3p	CLIP-seq
MIRT1346612	hsa-miR-485-5p	CLIP-seq
MIRT1346613	hsa-miR-488	CLIP-seq
MIRT1346614	hsa-miR-491-5p	CLIP-seq
MIRT1346615	hsa-miR-513a-5p	CLIP-seq
MIRT1346616	hsa-miR-513b	CLIP-seq
MIRT1346617	hsa-miR-515-5p	CLIP-seq
MIRT1346618	hsa-miR-519a	CLIP-seq
MIRT1346619	hsa-miR-519b-3p	CLIP-seq
MIRT1346620	hsa-miR-519c-3p	CLIP-seq
MIRT1346621	hsa-miR-542-3p	CLIP-seq
MIRT1346622	hsa-miR-579	CLIP-seq
MIRT1346623	hsa-miR-588	CLIP-seq
MIRT1346624	hsa-miR-595	CLIP-seq
MIRT1346625	hsa-miR-600	CLIP-seq
MIRT1346626	hsa-miR-608	CLIP-seq
MIRT1346627	hsa-miR-617	CLIP-seq
MIRT1346628	hsa-miR-627	CLIP-seq
MIRT1346629	hsa-miR-628-5p	CLIP-seq
MIRT1346630	hsa-miR-632	CLIP-seq
MIRT1346631	hsa-miR-641	CLIP-seq
MIRT1346632	hsa-miR-650	CLIP-seq
MIRT1346633	hsa-miR-663	CLIP-seq
MIRT1346634	hsa-miR-668	CLIP-seq
MIRT1346635	hsa-miR-744	CLIP-seq
MIRT1346636	hsa-miR-9	CLIP-seq
MIRT1346637	hsa-miR-943	CLIP-seq
MIRT1346586	hsa-miR-4457	CLIP-seq
MIRT1346616	hsa-miR-513b	CLIP-seq
MIRT2102563	hsa-miR-103b	CLIP-seq
MIRT2102564	hsa-miR-1260	CLIP-seq
MIRT2102565	hsa-miR-1260b	CLIP-seq
MIRT2102566	hsa-miR-146b-3p	CLIP-seq
MIRT2102567	hsa-miR-1909	CLIP-seq
MIRT2102568	hsa-miR-3140-3p	CLIP-seq
MIRT2102569	hsa-miR-3173-5p	CLIP-seq
MIRT1346559	hsa-miR-3652	CLIP-seq
MIRT2102570	hsa-miR-3918	CLIP-seq
MIRT2102571	hsa-miR-3942-3p	CLIP-seq
MIRT2102572	hsa-miR-412	CLIP-seq
MIRT2102573	hsa-miR-4261	CLIP-seq
MIRT1346579	hsa-miR-4427	CLIP-seq
MIRT1346580	hsa-miR-4430	CLIP-seq
MIRT2102574	hsa-miR-4492	CLIP-seq
MIRT2102575	hsa-miR-4498	CLIP-seq
MIRT2102576	hsa-miR-4638-3p	CLIP-seq
MIRT1346596	hsa-miR-4640-5p	CLIP-seq
MIRT2102577	hsa-miR-4691-5p	CLIP-seq
MIRT1346606	hsa-miR-4726-5p	CLIP-seq
MIRT1346611	hsa-miR-483-3p	CLIP-seq
MIRT2102578	hsa-miR-549	CLIP-seq
MIRT2102579	hsa-miR-593	CLIP-seq
MIRT2102580	hsa-miR-762	CLIP-seq
MIRT2102581	hsa-miR-874	CLIP-seq
MIRT2327019	hsa-miR-1184	CLIP-seq
MIRT2327020	hsa-miR-1294	CLIP-seq
MIRT2327021	hsa-miR-1321	CLIP-seq
MIRT2102566	hsa-miR-146b-3p	CLIP-seq
MIRT2327022	hsa-miR-2355-5p	CLIP-seq
MIRT2327023	hsa-miR-2467-5p	CLIP-seq
MIRT1346543	hsa-miR-27a	CLIP-seq
MIRT1346544	hsa-miR-27b	CLIP-seq
MIRT2327024	hsa-miR-3158-5p	CLIP-seq
MIRT2327025	hsa-miR-3166	CLIP-seq
MIRT2102569	hsa-miR-3173-5p	CLIP-seq
MIRT2327026	hsa-miR-3188	CLIP-seq
MIRT2327027	hsa-miR-3194-5p	CLIP-seq
MIRT2327028	hsa-miR-330-3p	CLIP-seq
MIRT2327029	hsa-miR-338-3p	CLIP-seq
MIRT2327030	hsa-miR-338-5p	CLIP-seq
MIRT1346559	hsa-miR-3652	CLIP-seq
MIRT2327031	hsa-miR-3975	CLIP-seq
MIRT1346572	hsa-miR-4270	CLIP-seq
MIRT2327032	hsa-miR-4284	CLIP-seq
MIRT2327033	hsa-miR-4305	CLIP-seq
MIRT2327034	hsa-miR-4308	CLIP-seq
MIRT2327035	hsa-miR-4316	CLIP-seq
MIRT2327036	hsa-miR-4420	CLIP-seq
MIRT1346580	hsa-miR-4430	CLIP-seq
MIRT2327037	hsa-miR-4436b-5p	CLIP-seq
MIRT2327038	hsa-miR-4438	CLIP-seq
MIRT1346583	hsa-miR-4441	CLIP-seq
MIRT2327039	hsa-miR-4530	CLIP-seq
MIRT1346598	hsa-miR-4652-3p	CLIP-seq
MIRT2327040	hsa-miR-4666-5p	CLIP-seq
MIRT1346599	hsa-miR-4677-3p	CLIP-seq
MIRT1346600	hsa-miR-4679	CLIP-seq
MIRT2102577	hsa-miR-4691-5p	CLIP-seq
MIRT2327041	hsa-miR-4727-5p	CLIP-seq
MIRT2327042	hsa-miR-4739	CLIP-seq
MIRT2327043	hsa-miR-4756-5p	CLIP-seq
MIRT2327044	hsa-miR-4763-5p	CLIP-seq
MIRT2327045	hsa-miR-4771	CLIP-seq
MIRT2327046	hsa-miR-4775	CLIP-seq
MIRT2327047	hsa-miR-4778-5p	CLIP-seq
MIRT1346612	hsa-miR-485-5p	CLIP-seq
MIRT2327048	hsa-miR-499a-5p	CLIP-seq
MIRT1346615	hsa-miR-513a-5p	CLIP-seq
MIRT2327049	hsa-miR-544b	CLIP-seq
MIRT2327050	hsa-miR-590-3p	CLIP-seq
MIRT2327051	hsa-miR-640	CLIP-seq
MIRT2102581	hsa-miR-874	CLIP-seq
MIRT2394452	hsa-miR-1202	CLIP-seq
MIRT2102566	hsa-miR-146b-3p	CLIP-seq
MIRT2394453	hsa-miR-22	CLIP-seq
MIRT2102569	hsa-miR-3173-5p	CLIP-seq
MIRT2394454	hsa-miR-3192	CLIP-seq
MIRT2327027	hsa-miR-3194-5p	CLIP-seq
MIRT2394455	hsa-miR-320e	CLIP-seq
MIRT2394456	hsa-miR-326	CLIP-seq
MIRT2394457	hsa-miR-330-5p	CLIP-seq
MIRT2394458	hsa-miR-3670	CLIP-seq
MIRT2394459	hsa-miR-3908	CLIP-seq
MIRT2394460	hsa-miR-3972	CLIP-seq
MIRT2394461	hsa-miR-4314	CLIP-seq
MIRT2394462	hsa-miR-4503	CLIP-seq
MIRT2394463	hsa-miR-4514	CLIP-seq
MIRT2394464	hsa-miR-4646-5p	CLIP-seq
MIRT2394465	hsa-miR-4692	CLIP-seq
MIRT2102581	hsa-miR-874	CLIP-seq
MIRT2433188	hsa-miR-3171	CLIP-seq
MIRT2433189	hsa-miR-331-5p	CLIP-seq
MIRT2433190	hsa-miR-4678	CLIP-seq
MIRT2394452	hsa-miR-1202	CLIP-seq
MIRT2459314	hsa-miR-3161	CLIP-seq
MIRT2327027	hsa-miR-3194-5p	CLIP-seq
MIRT2394460	hsa-miR-3972	CLIP-seq
MIRT1346585	hsa-miR-4447	CLIP-seq
MIRT1346587	hsa-miR-4472	CLIP-seq
MIRT2459315	hsa-miR-4481	CLIP-seq
MIRT2459316	hsa-miR-4488	CLIP-seq
MIRT1346602	hsa-miR-4694-3p	CLIP-seq
MIRT2459317	hsa-miR-4697-5p	CLIP-seq
MIRT2459318	hsa-miR-4745-5p	CLIP-seq
MIRT2459319	hsa-miR-486-3p	CLIP-seq
MIRT2622366	hsa-miR-1285	CLIP-seq
MIRT2622367	hsa-miR-1324	CLIP-seq
MIRT2622368	hsa-miR-138	CLIP-seq
MIRT1346524	hsa-miR-155	CLIP-seq
MIRT2622369	hsa-miR-1915	CLIP-seq
MIRT2327022	hsa-miR-2355-5p	CLIP-seq
MIRT2622370	hsa-miR-3179	CLIP-seq
MIRT2622371	hsa-miR-3187-5p	CLIP-seq
MIRT2622372	hsa-miR-3199	CLIP-seq
MIRT2394456	hsa-miR-326	CLIP-seq
MIRT2394457	hsa-miR-330-5p	CLIP-seq
MIRT2622373	hsa-miR-3614-5p	CLIP-seq
MIRT2622374	hsa-miR-3661	CLIP-seq
MIRT2394458	hsa-miR-3670	CLIP-seq
MIRT2622375	hsa-miR-3978	CLIP-seq
MIRT2622376	hsa-miR-4260	CLIP-seq
MIRT2102573	hsa-miR-4261	CLIP-seq
MIRT2622377	hsa-miR-431	CLIP-seq
MIRT2622378	hsa-miR-4325	CLIP-seq
MIRT2622379	hsa-miR-4450	CLIP-seq
MIRT2622380	hsa-miR-4494	CLIP-seq
MIRT2622381	hsa-miR-4499	CLIP-seq
MIRT2622382	hsa-miR-4513	CLIP-seq
MIRT2622383	hsa-miR-4667-5p	CLIP-seq
MIRT2622384	hsa-miR-4700-5p	CLIP-seq
MIRT2622385	hsa-miR-4722-5p	CLIP-seq
MIRT2622386	hsa-miR-4726-3p	CLIP-seq
MIRT2622387	hsa-miR-4728-3p	CLIP-seq
MIRT2622388	hsa-miR-4740-5p	CLIP-seq
MIRT2327044	hsa-miR-4763-5p	CLIP-seq
MIRT2622389	hsa-miR-4793-3p	CLIP-seq
MIRT2459319	hsa-miR-486-3p	CLIP-seq
MIRT2622390	hsa-miR-501-3p	CLIP-seq
MIRT2622391	hsa-miR-502-3p	CLIP-seq
MIRT739573	hsa-miR-520a-5p	CLIP-seq
MIRT739574	hsa-miR-525-5p	CLIP-seq
MIRT2622392	hsa-miR-550a	CLIP-seq
MIRT2622393	hsa-miR-612	CLIP-seq
MIRT2622394	hsa-miR-626	CLIP-seq
MIRT1346628	hsa-miR-627	CLIP-seq
MIRT2622395	hsa-miR-631	CLIP-seq
MIRT2622396	hsa-miR-635	CLIP-seq
MIRT2622397	hsa-miR-767-5p	CLIP-seq
MIRT2622398	hsa-miR-924	CLIP-seq
MIRT2690704	hsa-miR-1224-3p	CLIP-seq
MIRT2102564	hsa-miR-1260	CLIP-seq
MIRT2102565	hsa-miR-1260b	CLIP-seq
MIRT2690705	hsa-miR-1280	CLIP-seq
MIRT2622366	hsa-miR-1285	CLIP-seq
MIRT2622367	hsa-miR-1324	CLIP-seq
MIRT2622369	hsa-miR-1915	CLIP-seq
MIRT2327022	hsa-miR-2355-5p	CLIP-seq
MIRT2622370	hsa-miR-3179	CLIP-seq
MIRT2622371	hsa-miR-3187-5p	CLIP-seq
MIRT2622372	hsa-miR-3199	CLIP-seq
MIRT2394456	hsa-miR-326	CLIP-seq
MIRT2394457	hsa-miR-330-5p	CLIP-seq
MIRT2622373	hsa-miR-3614-5p	CLIP-seq
MIRT2622374	hsa-miR-3661	CLIP-seq
MIRT2394458	hsa-miR-3670	CLIP-seq
MIRT2622376	hsa-miR-4260	CLIP-seq
MIRT2622377	hsa-miR-431	CLIP-seq
MIRT2622378	hsa-miR-4325	CLIP-seq
MIRT2622379	hsa-miR-4450	CLIP-seq
MIRT2622380	hsa-miR-4494	CLIP-seq
MIRT2622381	hsa-miR-4499	CLIP-seq
MIRT2622382	hsa-miR-4513	CLIP-seq
MIRT2622383	hsa-miR-4667-5p	CLIP-seq
MIRT2622384	hsa-miR-4700-5p	CLIP-seq
MIRT2690706	hsa-miR-4712-5p	CLIP-seq
MIRT2622385	hsa-miR-4722-5p	CLIP-seq
MIRT2622386	hsa-miR-4726-3p	CLIP-seq
MIRT2622387	hsa-miR-4728-3p	CLIP-seq
MIRT2622388	hsa-miR-4740-5p	CLIP-seq
MIRT2327044	hsa-miR-4763-5p	CLIP-seq
MIRT2622389	hsa-miR-4793-3p	CLIP-seq
MIRT2459319	hsa-miR-486-3p	CLIP-seq
MIRT2622390	hsa-miR-501-3p	CLIP-seq
MIRT2622391	hsa-miR-502-3p	CLIP-seq
MIRT739573	hsa-miR-520a-5p	CLIP-seq
MIRT739574	hsa-miR-525-5p	CLIP-seq
MIRT2622392	hsa-miR-550a	CLIP-seq
MIRT2622393	hsa-miR-612	CLIP-seq
MIRT2622394	hsa-miR-626	CLIP-seq
MIRT1346628	hsa-miR-627	CLIP-seq
MIRT2622395	hsa-miR-631	CLIP-seq
MIRT2622396	hsa-miR-635	CLIP-seq
MIRT2622397	hsa-miR-767-5p	CLIP-seq
MIRT2690707	hsa-miR-770-5p	CLIP-seq
MIRT2622398	hsa-miR-924	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001784	Function	Phosphotyrosine residue binding	IPI	20624904
GO:0005515	Function	Protein binding	IPI	11877420, 16273093, 24728074, 25416956, 32296183, 32814053
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0007169	Process	Cell surface receptor protein tyrosine kinase signaling pathway	IBA
GO:0007169	Process	Cell surface receptor protein tyrosine kinase signaling pathway	TAS	8808684
GO:0007173	Process	Epidermal growth factor receptor signaling pathway	TAS	8808684
GO:0007417	Process	Central nervous system development	TAS	8808684
GO:0030971	Function	Receptor tyrosine kinase binding	IBA
GO:0035556	Process	Intracellular signal transduction	IEA

Other IDs

• MIM: 605263
• HGNC: 18181
• e!Ensembl: ENSG00000148082

Protein

• UniProt ID: Q92529
• Protein name: SHC-transforming protein 3 (Neuronal Shc) (N-Shc) (Protein Rai) (SHC-transforming protein C) (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3)
• Protein function: Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00640	PID	155 → 311	Phosphotyrosine interaction domain (PTB/PID)	Domain
  PF00017	SH2	499 → 570	SH2 domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level i
• Sequence:

  MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGEALRKAPDDG
  PGSLGHLLHKVSHLKLSSSGLRGLSSAARERAGARLSGSCSAPSLAAPDGSAPSAPRAPA
  MSAARKGRPGDEPLPRPPRGAPHASDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQI
  TREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPD
  SKQIIANHHMRSISFASGGDPDTTDYVAYVAKDPVNRRACHILECCDGLAQDVIGSIGQA
  FELRFKQYLQCPTKIPALHDRMQSLDEPWTEEEGDGSDHPYYNSIPSKMPPPGGFLDTRL
  KPRPHAPDTAQFAGKEQTYYQGRHLGDTFGEDWQQTPLRQGSSDIYSTPEGKLHVAPTGE
  APTYVNTQQIPPQAWPAAVSSAESSPRKDLFDMKPFEDALKNQPLGPVLSKAASVECISP
  VSPRAPDAKMLEELQAETWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQ
  AKHLLLVDPEGTIRTKDRVFDSISHLINHHLESSLPIVSAGSELCLQQPVERKQ

• Sequence length: 594

Pathways

KEGG:

EGFR tyrosine kinase inhibitor resistance
Endocrine resistance
ErbB signaling pathway
Ras signaling pathway
Chemokine signaling pathway
Phospholipase D signaling pathway
Focal adhesion
Natural killer cell mediated cytotoxicity
Neurotrophin signaling pathway
Insulin signaling pathway
Estrogen signaling pathway
Prolactin signaling pathway
Relaxin signaling pathway
Growth hormone synthesis, secretion and action
Alcoholism
Bacterial invasion of epithelial cells
Glioma
Chronic myeloid leukemia
Breast cancer
Hepatocellular carcinoma
Gastric cancer

Reactome:

Signalling to RAS
RAF/MAP kinase cascade
RET signaling

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PELVIC ORGAN PROLAPSE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SUBSTANCE ABUSE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adenoma	Adenoma	BEFREE	16817948		★☆☆☆☆ Found in Text Mining only
Adenoma of large intestine	Colorectal adenoma	BEFREE	16817948		★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	17170108	Associate	★☆☆☆☆ Found in Text Mining only
Anaplastic thyroid carcinoma	Anaplastic thyroid cancer	BEFREE	28318881		★☆☆☆☆ Found in Text Mining only
Astrocytoma	Astrocytoma	BEFREE	15870690		★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	12771034, 18289367, 18588689		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	36880347	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	16817948		★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	16054657, 16690207, 18289367		★☆☆☆☆ Found in Text Mining only
Carcinoma, Basal Cell	Carcinoma	BEFREE	12117772, 12433725, 15885892		★☆☆☆☆ Found in Text Mining only
Cerebral Aneurysm	Cerebral Aneurysm	BEFREE	15157303		★☆☆☆☆ Found in Text Mining only
Cerebral Infarction	Cerebral Infarction	BEFREE	29057481		★☆☆☆☆ Found in Text Mining only
Choroid Plexus Papilloma	Choroid Plexus Papilloma	BEFREE	19748727		★☆☆☆☆ Found in Text Mining only
Chronic Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	28603911, 7680734		★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	16817948, 18289367		★☆☆☆☆ Found in Text Mining only
Developmental Dysplasia of the Hip	Developmental dysplasia of the hip	Pubtator	36454308	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	29975575		★☆☆☆☆ Found in Text Mining only
Differentiated Thyroid Gland Carcinoma	Thyroid Carcinoma	BEFREE	28318881, 28510122, 28816536, 29144811, 29954369, 30015659, 30260898, 30584304, 30657361, 31626129		★☆☆☆☆ Found in Text Mining only
Early infantile epileptic encephalopathy with suppression bursts	Epileptic Encephalopathy	BEFREE	30184529		★☆☆☆☆ Found in Text Mining only
Ependymoma	Ependymoma	BEFREE	19748727		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	15870690, 25062668		★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	15870690, 25062668		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	LHGDN	15870690		★☆☆☆☆ Found in Text Mining only
Graves Disease	Graves Disease	BEFREE	31452116		★☆☆☆☆ Found in Text Mining only
Hairy Cell Leukemia	Hairy Cell Leukemia	BEFREE	7680734		★☆☆☆☆ Found in Text Mining only
Heart Defects Congenital	Congenital heart defect	Pubtator	31819021	Associate	★☆☆☆☆ Found in Text Mining only
Hyperthyroidism	Hyperthyroidism	BEFREE	28585680, 4632689		★☆☆☆☆ Found in Text Mining only
Hypoglycemia	Hypoglycemia	BEFREE	29975575, 31094068		★☆☆☆☆ Found in Text Mining only
Impaired cognition	Impaired Cognition	BEFREE	28407806		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	29330146		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	12771034, 18289367, 18588689		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	16054657, 16690207, 18289367		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of testis	Malignant Neoplasm Of Testis	BEFREE	15885892		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of thyroid	Thyroid cancer	BEFREE	20171085, 28008561, 28318881, 28585680		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	18588689, 27849386, 29330146		★☆☆☆☆ Found in Text Mining only
Malignant Testicular Germ Cell Tumor	Malignant testicular germ cell tumor	BEFREE	15885892		★☆☆☆☆ Found in Text Mining only
Medullary carcinoma of thyroid	Megalencephaly, Polymicrogyria, Polydactyly, Hydrocephalus Syndrome	BEFREE	27207700, 28318881, 30383218		★☆☆☆☆ Found in Text Mining only
Miscarriage	Miscarriage	BEFREE	29302874		★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	BEFREE	21046104		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	22790962, 28428267, 29330146, 29978374, 30654714		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	LHGDN	12185581, 18997821		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	18997821, 29057481		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	Pubtator	36419120	Associate	★☆☆☆☆ Found in Text Mining only
Opitz GBBB Syndrome, X-Linked	Opitz GBBB Syndrome, X-Linked	BEFREE	30184529		★☆☆☆☆ Found in Text Mining only
Osteoarthritis	Osteoarthritis	Pubtator	34494934	Associate	★☆☆☆☆ Found in Text Mining only
Papillary thyroid carcinoma	Papillary thyroid carcinoma	BEFREE	26285789, 28534687, 30396219		★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	BEFREE	28364501, 30184529		★☆☆☆☆ Found in Text Mining only
Right Atrial Isomerism	Atrial Isomerism	BEFREE	29057481		★☆☆☆☆ Found in Text Mining only
Smith-Magenis syndrome	Smith-Magenis Syndrome	BEFREE	27683195		★☆☆☆☆ Found in Text Mining only
Strabismus	Strabismus	BEFREE	30075294		★☆☆☆☆ Found in Text Mining only
SVEINSSON CHORIORETINAL ATROPHY	Sveinsson Chorioretinal Atrophy	BEFREE	30654714		★☆☆☆☆ Found in Text Mining only
Thyroid associated opthalmopathies	Thyroid eye disease	BEFREE	30075294		★☆☆☆☆ Found in Text Mining only
Thyroid carcinoma	Thyroid Carcinoma	BEFREE	20171085, 28008561, 28318881, 28585680, 30668525		★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasm	Thyroid Neoplasm	BEFREE	20171085, 27207700, 28008561, 28585680		★☆☆☆☆ Found in Text Mining only
Thyroid Nodule	Thyroid Nodule	BEFREE	28817605		★☆☆☆☆ Found in Text Mining only
Thyrotoxicosis	Thyrotoxicosis	BEFREE	28585680		★☆☆☆☆ Found in Text Mining only