Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	53353
Gene name	LDL receptor related protein 1B
Gene symbol	LRP1B
Synonyms (NCBI Gene)	LRP-1BLRP-DITLRPDIT
Chromosome	2
Chromosome location	2q22.1-q22.2
Summary	This gene encodes a member of the low density lipoprotein (LDL) receptor family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands. Disruption of this gene has been reporte

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miRTarBase ID	miRNA	Experiments	Reference
MIRT016828	hsa-miR-335-5p	Microarray	18185580
MIRT020555	hsa-miR-155-5p	Other	20584899
MIRT028914	hsa-miR-26b-5p	Microarray	19088304
MIRT053461	hsa-miR-200c-3p	Microarray	23807165
MIRT713286	hsa-miR-5692a	HITS-CLIP	19536157
MIRT713285	hsa-miR-106b-3p	HITS-CLIP	19536157
MIRT713286	hsa-miR-5692a	HITS-CLIP	19536157
MIRT713285	hsa-miR-106b-3p	HITS-CLIP	19536157
MIRT1117869	hsa-miR-103a	CLIP-seq
MIRT1117870	hsa-miR-106a	CLIP-seq
MIRT1117871	hsa-miR-106b	CLIP-seq
MIRT1117872	hsa-miR-107	CLIP-seq
MIRT1117873	hsa-miR-1323	CLIP-seq
MIRT1117874	hsa-miR-15a	CLIP-seq
MIRT1117875	hsa-miR-15b	CLIP-seq
MIRT1117876	hsa-miR-16	CLIP-seq
MIRT1117877	hsa-miR-17	CLIP-seq
MIRT1117878	hsa-miR-195	CLIP-seq
MIRT1117879	hsa-miR-20a	CLIP-seq
MIRT1117880	hsa-miR-20b	CLIP-seq
MIRT1117881	hsa-miR-214	CLIP-seq
MIRT1117882	hsa-miR-2467-3p	CLIP-seq
MIRT1117883	hsa-miR-25	CLIP-seq
MIRT1117884	hsa-miR-3074-3p	CLIP-seq
MIRT1117885	hsa-miR-3117-5p	CLIP-seq
MIRT1117886	hsa-miR-3125	CLIP-seq
MIRT1117887	hsa-miR-3143	CLIP-seq
MIRT1117888	hsa-miR-3148	CLIP-seq
MIRT1117889	hsa-miR-32	CLIP-seq
MIRT1117890	hsa-miR-3613-5p	CLIP-seq
MIRT1117891	hsa-miR-3614-3p	CLIP-seq
MIRT1117892	hsa-miR-3619-5p	CLIP-seq
MIRT1117893	hsa-miR-363	CLIP-seq
MIRT1117894	hsa-miR-367	CLIP-seq
MIRT1117895	hsa-miR-3678-3p	CLIP-seq
MIRT1117896	hsa-miR-3688-3p	CLIP-seq
MIRT1117897	hsa-miR-3916	CLIP-seq
MIRT1117898	hsa-miR-3923	CLIP-seq
MIRT1117899	hsa-miR-3928	CLIP-seq
MIRT1117900	hsa-miR-424	CLIP-seq
MIRT1117901	hsa-miR-425	CLIP-seq
MIRT1117902	hsa-miR-4279	CLIP-seq
MIRT1117903	hsa-miR-4290	CLIP-seq
MIRT1117904	hsa-miR-4291	CLIP-seq
MIRT1117905	hsa-miR-4310	CLIP-seq
MIRT1117906	hsa-miR-4325	CLIP-seq
MIRT1117907	hsa-miR-4517	CLIP-seq
MIRT1117908	hsa-miR-4687-5p	CLIP-seq
MIRT1117909	hsa-miR-4699-5p	CLIP-seq
MIRT1117910	hsa-miR-4709-3p	CLIP-seq
MIRT1117911	hsa-miR-4742-3p	CLIP-seq
MIRT1117912	hsa-miR-4756-3p	CLIP-seq
MIRT1117913	hsa-miR-495	CLIP-seq
MIRT1117914	hsa-miR-497	CLIP-seq
MIRT1117915	hsa-miR-498	CLIP-seq
MIRT1117916	hsa-miR-519a	CLIP-seq
MIRT1117917	hsa-miR-519b-3p	CLIP-seq
MIRT1117918	hsa-miR-519c-3p	CLIP-seq
MIRT1117919	hsa-miR-519d	CLIP-seq
MIRT1117920	hsa-miR-543	CLIP-seq
MIRT1117921	hsa-miR-548o	CLIP-seq
MIRT1117922	hsa-miR-548p	CLIP-seq
MIRT1117923	hsa-miR-548t	CLIP-seq
MIRT1117924	hsa-miR-577	CLIP-seq
MIRT1117925	hsa-miR-592	CLIP-seq
MIRT1117926	hsa-miR-597	CLIP-seq
MIRT1117927	hsa-miR-761	CLIP-seq
MIRT1117928	hsa-miR-922	CLIP-seq
MIRT1117929	hsa-miR-92a	CLIP-seq
MIRT1117930	hsa-miR-92b	CLIP-seq
MIRT1117931	hsa-miR-93	CLIP-seq
MIRT1117883	hsa-miR-25	CLIP-seq
MIRT1117889	hsa-miR-32	CLIP-seq
MIRT1117893	hsa-miR-363	CLIP-seq
MIRT1117894	hsa-miR-367	CLIP-seq
MIRT1117898	hsa-miR-3923	CLIP-seq
MIRT1117906	hsa-miR-4325	CLIP-seq
MIRT1117915	hsa-miR-498	CLIP-seq
MIRT1117922	hsa-miR-548p	CLIP-seq
MIRT1117929	hsa-miR-92a	CLIP-seq
MIRT1117930	hsa-miR-92b	CLIP-seq
MIRT1117883	hsa-miR-25	CLIP-seq
MIRT1117889	hsa-miR-32	CLIP-seq
MIRT1117893	hsa-miR-363	CLIP-seq
MIRT1117894	hsa-miR-367	CLIP-seq
MIRT1117898	hsa-miR-3923	CLIP-seq
MIRT1117906	hsa-miR-4325	CLIP-seq
MIRT2033345	hsa-miR-4704-3p	CLIP-seq
MIRT1117915	hsa-miR-498	CLIP-seq
MIRT2033346	hsa-miR-548n	CLIP-seq
MIRT1117922	hsa-miR-548p	CLIP-seq
MIRT1117923	hsa-miR-548t	CLIP-seq
MIRT1117929	hsa-miR-92a	CLIP-seq
MIRT1117930	hsa-miR-92b	CLIP-seq
MIRT2263680	hsa-miR-1283	CLIP-seq
MIRT2263681	hsa-miR-2116	CLIP-seq
MIRT1117883	hsa-miR-25	CLIP-seq
MIRT1117889	hsa-miR-32	CLIP-seq
MIRT2263682	hsa-miR-3202	CLIP-seq
MIRT2263683	hsa-miR-361-5p	CLIP-seq
MIRT1117893	hsa-miR-363	CLIP-seq
MIRT1117894	hsa-miR-367	CLIP-seq
MIRT1117898	hsa-miR-3923	CLIP-seq
MIRT2263684	hsa-miR-4273	CLIP-seq
MIRT2263685	hsa-miR-4277	CLIP-seq
MIRT1117906	hsa-miR-4325	CLIP-seq
MIRT2263686	hsa-miR-4493	CLIP-seq
MIRT2263687	hsa-miR-4533	CLIP-seq
MIRT2263688	hsa-miR-4659a-3p	CLIP-seq
MIRT2263689	hsa-miR-4659b-3p	CLIP-seq
MIRT2263690	hsa-miR-4677-5p	CLIP-seq
MIRT2033345	hsa-miR-4704-3p	CLIP-seq
MIRT2263691	hsa-miR-4796-5p	CLIP-seq
MIRT1117915	hsa-miR-498	CLIP-seq
MIRT2263692	hsa-miR-548c-3p	CLIP-seq
MIRT2033346	hsa-miR-548n	CLIP-seq
MIRT1117922	hsa-miR-548p	CLIP-seq
MIRT1117923	hsa-miR-548t	CLIP-seq
MIRT2263693	hsa-miR-890	CLIP-seq
MIRT1117929	hsa-miR-92a	CLIP-seq
MIRT1117930	hsa-miR-92b	CLIP-seq
MIRT1117883	hsa-miR-25	CLIP-seq
MIRT1117889	hsa-miR-32	CLIP-seq
MIRT1117893	hsa-miR-363	CLIP-seq
MIRT1117894	hsa-miR-367	CLIP-seq
MIRT1117898	hsa-miR-3923	CLIP-seq
MIRT1117906	hsa-miR-4325	CLIP-seq
MIRT1117915	hsa-miR-498	CLIP-seq
MIRT1117922	hsa-miR-548p	CLIP-seq
MIRT1117929	hsa-miR-92a	CLIP-seq
MIRT1117930	hsa-miR-92b	CLIP-seq
MIRT2563023	hsa-miR-452	CLIP-seq
MIRT2563024	hsa-miR-4676-3p	CLIP-seq
MIRT2563025	hsa-miR-548a-5p	CLIP-seq
MIRT2563026	hsa-miR-548ab	CLIP-seq
MIRT2563027	hsa-miR-548ak	CLIP-seq
MIRT2563028	hsa-miR-548b-5p	CLIP-seq
MIRT2563029	hsa-miR-548c-5p	CLIP-seq
MIRT2563030	hsa-miR-548d-5p	CLIP-seq
MIRT2563031	hsa-miR-548h	CLIP-seq
MIRT2563032	hsa-miR-548i	CLIP-seq
MIRT2563033	hsa-miR-548j	CLIP-seq
MIRT2033346	hsa-miR-548n	CLIP-seq
MIRT2563034	hsa-miR-548w	CLIP-seq
MIRT2563035	hsa-miR-548y	CLIP-seq
MIRT2563036	hsa-miR-559	CLIP-seq
MIRT2563023	hsa-miR-452	CLIP-seq
MIRT2563024	hsa-miR-4676-3p	CLIP-seq
MIRT2563025	hsa-miR-548a-5p	CLIP-seq
MIRT2563026	hsa-miR-548ab	CLIP-seq
MIRT2563027	hsa-miR-548ak	CLIP-seq
MIRT2563028	hsa-miR-548b-5p	CLIP-seq
MIRT2563029	hsa-miR-548c-5p	CLIP-seq
MIRT2563030	hsa-miR-548d-5p	CLIP-seq
MIRT2563031	hsa-miR-548h	CLIP-seq
MIRT2563032	hsa-miR-548i	CLIP-seq
MIRT2563033	hsa-miR-548j	CLIP-seq
MIRT2033346	hsa-miR-548n	CLIP-seq
MIRT2563034	hsa-miR-548w	CLIP-seq
MIRT2563035	hsa-miR-548y	CLIP-seq
MIRT2563036	hsa-miR-559	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005041	Function	Low-density lipoprotein particle receptor activity	IBA
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005886	Component	Plasma membrane	IBA
GO:0006897	Process	Endocytosis	IEA
GO:0006898	Process	Receptor-mediated endocytosis	IEA
GO:0006898	Process	Receptor-mediated endocytosis	TAS	10766186
GO:0015031	Process	Protein transport	TAS	10766186
GO:0016020	Component	Membrane	IEA
GO:0043235	Component	Receptor complex	IBA
GO:0043235	Component	Receptor complex	IDA	23382219

MIM	HGNC	e!Ensembl
608766	6693	ENSG00000168702

Q9NZR2

Protein name

Low-density lipoprotein receptor-related protein 1B (LRP-1B) (Low-density lipoprotein receptor-related protein-deleted in tumor) (LRP-DIT)

Protein function

Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00057	Ldl_recept_a	30 → 69	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	75 → 113	Low-density lipoprotein receptor domain class A	Repeat
PF07645	EGF_CA	155 → 193	Calcium-binding EGF domain	Domain
PF00058	Ldl_recept_b	295 → 335	Low-density lipoprotein receptor repeat class B	Repeat
PF00058	Ldl_recept_b	568 → 608	Low-density lipoprotein receptor repeat class B	Repeat
PF00058	Ldl_recept_b	611 → 654	Low-density lipoprotein receptor repeat class B	Repeat
PF00058	Ldl_recept_b	657 → 704	Low-density lipoprotein receptor repeat class B	Repeat
PF14670	FXa_inhibition	798 → 833		Domain
PF00057	Ldl_recept_a	843 → 881	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	884 → 922	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	925 → 962	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	965 → 1002	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	1004 → 1042	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	1051 → 1088	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	1093 → 1131	Low-density lipoprotein receptor domain class A	Repeat
PF14670	FXa_inhibition	1176 → 1212		Domain
PF00058	Ldl_recept_b	1347 → 1387	Low-density lipoprotein receptor repeat class B	Repeat
PF00058	Ldl_recept_b	1390 → 1434	Low-density lipoprotein receptor repeat class B	Repeat
PF00058	Ldl_recept_b	1618 → 1658	Low-density lipoprotein receptor repeat class B	Repeat
PF14670	FXa_inhibition	1838 → 1874		Domain
PF00058	Ldl_recept_b	1965 → 2005	Low-density lipoprotein receptor repeat class B	Repeat
PF00058	Ldl_recept_b	2008 → 2049	Low-density lipoprotein receptor repeat class B	Repeat
PF00058	Ldl_recept_b	2330 → 2372	Low-density lipoprotein receptor repeat class B	Repeat
PF00057	Ldl_recept_a	2508 → 2547	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	2550 → 2586	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	2589 → 2625	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	2641 → 2674	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	2680 → 2716	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	2718 → 2756	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	2759 → 2799	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	2803 → 2840	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	2843 → 2884	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	2889 → 2925	Low-density lipoprotein receptor domain class A	Repeat
PF12662	cEGF	2948 → 2971	Complement Clr-like EGF-like	Domain
PF16472	DUF5050	3007 → 3241	Domain of unknown function (DUF5050)	Domain
PF14670	FXa_inhibition	3277 → 3313		Domain
PF00057	Ldl_recept_a	3315 → 3352	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	3355 → 3391	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	3394 → 3431	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	3434 → 3471	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	3474 → 3510	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	3513 → 3549	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	3551 → 3587	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	3592 → 3628	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	3630 → 3667	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	3672 → 3710	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	3760 → 3796	Low-density lipoprotein receptor domain class A	Repeat
PF07645	EGF_CA	3844 → 3880	Calcium-binding EGF domain	Domain
PF00058	Ldl_recept_b	4039 → 4080	Low-density lipoprotein receptor repeat class B	Repeat
PF00008	EGF	4253 → 4283	EGF-like domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in thyroid gland and in salivary gland, as well as in adult and fetal brain. {ECO:0000269|PubMed:11384978}.

Sequence

MSEFLLALLTLSGLLPIARVLTVGADRDQQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPD
DSDESLDTCPEEVEIKCPLNHIACLGTNKCVHLSQLCNGVLDCPDGYDEGVHCQELLSNC
QQLNCQYKCTMVRNSTRCYCEDGFEITEDGRSCKDQDECAVYGTCSQTCRNTHGSYTCSC
VEGYLMQPDNRSCKAKIEPTDRPPILLIANFETIEVFYLNGSKMATLSSVNGNEIHTLDF
IYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTINILQSFHNVQQMAIDWLTRNLYFV
DHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGKLFFTDYGNVAKVERCDMDGMN
RTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVDYQGKNRHTVIQGRQVRHLYGIT
VFEDYLYATNSDNYNIVRINRFNGTDIHSLIKIENAWGIRIYQKRTQPTVRSHACEVDPY
GMPGGCSHICLLSSSYKTRTCRCRTGFNLGSDGRSCKRPKNELFLFYGKGRPGIVRGMDL
NTKIADEYMIPIENLVNPRALDFHAETNYIYFADTTSFLIGRQKIDGTERETILKDDLDN
VEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRGIVVDPVNGWMY
WTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTLYWCDAYYDHIE
KVFLNGTHRKIVYSGRELNHPFGLSHHGNYVFWTDYMNGSIFQLDLITSEVTLLRHERPP
LFGLQIYDPRKQQGDNMCRVNNGGCSTLCLAIPGGRVCACADNQLLDENGTTCTFNPGEA
LPHICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIP
KRWLCDGANDCGSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEMA
SCEFPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVHSCFDNQFRCSSGRCIP
GHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCVPDLWRCDGEKDCE
DGSDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCDSFLCGPPK
HPCANDTSVCLQPEKLCNGKKDCPDGSDEGYLCDECSLNNGGCSNHCSVVPGRGIVCSCP
EGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKHTVKCSCYEGWKLDVDGESCTSVDPFEA
FIIFSIRHEIRRIDLHKRDYSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSES
GGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHP
RAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIV
WTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSKANKWTG
QNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAANDGKGPCSHMCLINHNRSAACACPHLM
KLSSDKKTCYEMKKFLLYARRSEIRGVDIDNPYFNFITAFTVPDIDDVTVIDFDASEERL
YWTDIKTQTIKRAFINGTGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQINVARL
DGSLKTSIIHGIDKPQCLAAHPVRGKLYWTDGNTINMANMDGSNSKILFQNQKEPVGLSI
DYVENKLYWISSGNGTINRCNLDGGNLEVIESMKEELTKATALTIMDKKLWWADQNLAQL
GTCSKRDGRNPTILRNKTSGVVHMKVYDKEAQQGSNSCQLNNGGCSQLCLPTSETTRTCM
CTVGYYLQKNRMSCQGIESFLMYSVHEGIRGIPLEPSDKMDALMPISGTSFAVGIDFHAE
NDTIYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVA
RLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQMPCIGKARLDGSEKVVLVSMGIA
WPNGISIDYEENKLYWCDARTDKIERIDLETGGNREMVLSGSNVDMFSVAVFGAYIYWSD
RAHANGSVRRGHKNDATETITMRTGLGVNLKEVKIFNRVREKGTNVCARDNGGCKQLCLY
RGNSRRTCACAHGYLAEDGVTCLRHEGYLLYSGRTILKSIHLSDETNLNSPIRPYENPRY
FKNVIALAFDYNQRRKGTNRIFYSDAHFGNIQLIKDNWEDRQVIVENVGSVEGLAYHRAW
DTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDDHPHVLALDECQNLMFWTNWNEQ
HPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGSLGKIERCEYDGSQRHVI
VKSGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGDTKILRSDIPHQPMGIIAVANDT
NSCELSPCALLNGGCHDLCLLTPNGRVNCSCRGDRILLEDNRCVTKNSSCNAYSEFECGN
GECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLCDGENDCGDN
SDELDCKVSTCATVEFRCADGTCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKT
TGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPSGRCILNTWI
CDGQKDCEDGRDEFHCDSSCSWNQFACSAQKCISKHWICDGEDDCGDGLDESDSICGAIT
CAADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHNKVCIPK
QFVCDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDEAPL
NPKCKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNCHINECLSKKVSGCSQ
DCQDLPVSYKCKCWPGFQLKDDGKTCVDIDECSSGFPCSQQCINTYGTYKCLCTDGYEIQ
PDNPNGCKSLSDEEPFLILADHHEIRKISTDGSNYTLLKQGLNNVIAIDFDYREEFIYWI
DSSRPNGSRINRMCLNGSDIKVVHNTAVPNALAVDWIGKNLYWSDTEKRIIEVSKLNGLY
PTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALT
IDYVNRRLYWADENHIEFSNMDGSHRHKVPNQDIPGVIALTLFEDYIYWTDGKTKSLSRA
HKTSGADRLSLIYSWHAITDIQVYHSYRQPDVSKHLCMINNGGCSHLCLLAPGKTHTCAC
PTNFYLAADNRTCLSNCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPG
RFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQD
DCGDEEDERDCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPHE
FQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFWCDGDFDC
ADGSDERNCETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYI
CASDGCISASLKCNGEYDCADGSDEMDCVTECKEDQFRCKNKAHCIPIRWLCDGIHDCVD
GSDEENCERGGNICRADEFLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMCVKFLCPSTRP
HRCRNNRICLQSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKKDEFACSNKKCIPMDLQ
CDRLDDCGDGSDEQGCRIAPTEYTCEDNVNPCGDDAYCNQIKTSVFCRCKPGFQRNMKNR
QCEDLNECLVFGTCSHQCINVEGSYKCVCDQNFQERNNTCIAEGSEDQVLYIANDTDILG
FIYPFNYSGDHQQISHIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHGREKRQAN
SGLICPEFKRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTR
LLTNMAGEPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDY
FSERIYWADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAGPKNGVFRV
QKFGHGSVEYLALNIDKTKGVLISHRYKQLDLPNPCLDLACEFLCLLNPSGATCVCPEGK
YLINGTCNDDSLLDDSCKLTCENGGRCILNEKGDLRCHCWPSYSGERCEVNHCSNYCQNG
GTCVPSVLGRPTCSCALGFTGPNCGKTVCEDFCQNGGTCIVTAGNQPYCHCQPEYTGDRC
QYYVCHHYCVNSESCTIGDDGSVECVCPTRYEGPKCEVDKCVRCHGGHCIINKDSEDIFC
NCTNGKIASSCQLCDGYCYNGGTCQLDPETNVPVCLCSTNWSGTQCERPAPKSSKSDHIS
TRSIAIIVPLVLLVTLITTLVIGLVLCKRKRRTKTIRRQPIINGGINVEIGNPSYNMYEV
DHDHNDGGLLDPGFMIDPTKARYIGGGPSAFKLPHTAPPIYLNSDLKGPLTAGPTNYSNP
VYAKLYMDGQNCRNSLGSVDERKELLPKKIEIGIRETVA

Sequence length

4599

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (55)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Adrenocortical carcinoma, hereditary	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BONE NEOPLASM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA, RENAL CELL	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CATARACT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CENTRAL NERVOUS SYSTEM CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHILDHOOD ONSET ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC KIDNEY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC OBSTRUCTIVE AIRWAY DISEASE	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CONGENITAL HEART DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CONNECTIVE TISSUE NEOPLASM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORNEAL DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOMETRIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ERECTILE DYSFUNCTION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLAUCOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
High myopia	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
KERATOCONUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
KIDNEY FAILURE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LRP1B-associated developmental disorder	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LRP1B-related disorder	Conflicting classifications of pathogenicity; Uncertain significance; Likely benign; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant lymphoma, large B-cell, diffuse	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant neoplastic disease	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of urinary bladder	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MELANOMA	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MIGRAINE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PARKINSON DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PERIODONTITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PERIPHERAL VASCULAR DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostate cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATIC NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RECTUM CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SEVERE MYOPIA	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 1 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine carcinosarcoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UVEAL MELANOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (91)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	28522810, 30121391		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adrenocortical Carcinoma	Adrenocortical carcinoma	Pubtator	25078331, 34410225	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	26621834, 36951251	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Anodontia	Anodontia	Pubtator	31270961	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Biliary Tract Neoplasms	Biliary tract neoplasms	Pubtator	33754015	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Brain Tumor, Primary	Brain Neoplasms	BEFREE	26428308		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	30607440		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	33653800	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	16918994, 35069585	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	30607440		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	Pubtator	37115272	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Basal Cell	Basal cell carcinoma	Pubtator	33928395	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	34386813, 35150083, 35389768, 35651292, 35777027, 36153509	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Intraductal Noninfiltrating	Intraductal noninfiltrating carcinoma	Pubtator	26718977	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Merkel Cell	Merkel cell carcinoma	Pubtator	36736454	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	28522810		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Pancreatic Ductal	Pancreatic ductal carcinoma	Pubtator	33255265, 34313325	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	23521319	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinosarcoma	Carcinoma	Pubtator	32209061	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular disease	Pubtator	23420841	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Childhood asthma	Asthma	GWASCAT_DG	29551627		★★★★★ ★☆☆☆☆ Found in Text Mining only
Chromophobe Renal Cell Carcinoma	Chromophobe Carcinoma	CTD_human_DG	22138691		★★★★★ ★☆☆☆☆ Found in Text Mining only
Collecting Duct Carcinoma of the Kidney	Renal Carcinoma	CTD_human_DG	22138691		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	28408316		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	29575536, 33836681, 36520636, 37394872, 37992266	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital Heart Defects	Congenital heart defects	GWASCAT_DG	28468790		★★★★★ ★☆☆☆☆ Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma	Renal Carcinoma	CTD_human_DG	22138691		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 1	Diabetes mellitus, type 1	Pubtator	22069270	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	GWASCAT_DG	29221444		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ductal Carcinoma	Ductal Carcinoma	BEFREE	30607440		★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Endometrial neoplasm	Pubtator	39686583	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophageal neoplasm	Pubtator	28548104	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	16918994	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	19435819, 34875133, 37511044	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	26428308		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	26428308		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Glioma	Glioma	Pubtator	16247447, 37511044	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hemihyperplasia Isolated	Hemihyperplasia	Pubtator	12004004	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Keratoconus	Keratoconus	Pubtator	33729517	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Kidney Neoplasms	Kidney neoplasm	Pubtator	23521319	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Laryngeal Neoplasms	Laryngeal neoplasm	Pubtator	35911687	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	32011516, 38019014	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Diseases	Lung disease	Pubtator	33653800	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	28522810, 33200540	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus, Systemic	Lupus Erythematosus	BEFREE	20483040		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	34152098, 39686583	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	Pubtator	37657032	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma Follicular	Lymphoma	Pubtator	30802265	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma Primary Cutaneous Anaplastic Large Cell	Primary cutaneous anaplastic large cell lymphoma	Pubtator	34382383	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	30607440		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	28522810		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	22896685		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	CTD_human_DG	29662167		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	31270961		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	12004004, 21057533, 27626682		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	28408316		★★★★★ ★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	CTD_human_DG	22197931		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Melanoma	Melanoma	Pubtator	33653800	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Motion Sickness	Motion Sickness	GWASCAT_DG	25628336		★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	Pubtator	29895955	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	12004004, 16857411, 21057533, 21947875, 26428308, 27006499, 27626682		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	31164891		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	30755693		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	30755693	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	33432021, 34689147, 36721777, 37525498, 37742945	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	25945796	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Papillary Renal Cell Carcinoma	Papillary Renal Carcinoma	CTD_human_DG	22138691		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pediatric Obesity	Childhood obesity	BEFREE	30755693		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	GWASCAT_DG	31095341		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostate carcinoma	Prostate cancer	BEFREE	31270961		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostatic Neoplasms	Prostatic Neoplasms	CTD_human_DG	29662167		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	30877185, 31270961, 33115829, 33214693	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Pulmonary Disease Chronic Obstructive	Chronic obstructive pulmonary disease	Pubtator	28522810	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pulmonary Disease Chronic Obstructive	Chronic obstructive pulmonary disease	Pubtator	35860812	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Renal Cell Carcinoma	Renal Carcinoma	CTD_human_DG	22138691		★★★★★ ★☆☆☆☆ Found in Text Mining only
Rhabdomyosarcoma Embryonal	Rhabdomyosarcoma	Pubtator	39379998	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Sarcoma	Sarcoma	Pubtator	33653800	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Sarcomatoid Renal Cell Carcinoma	Renal Carcinoma	CTD_human_DG	22138691		★★★★★ ★☆☆☆☆ Found in Text Mining only
Sarcopenia	Sarcopenia	Pubtator	36573383	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	23553203		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	GWASCAT_DG	31374203		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Small Cell Lung Carcinoma	Small cell lung carcinoma	Pubtator	31199602, 35596192	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	LHGDN	16918994		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	16918994		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	16918994, 33994859, 37340028, 37373553	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	31312661, 32034058, 33511732, 33827485, 33900127, 33933102, 34551773, 34603481, 36823311	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	36606427	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasms	Thyroid cancer	Pubtator	36916542, 40184130	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	35841413	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	17504382, 33994859, 36333792	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Uveal melanoma	Uveal Melanoma	GWASCAT_DG	31626034		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

LRP1B (LDL receptor related protein 1B)