Gene Gene information from NCBI Gene database.
Entrez ID 5267
Gene name Serpin family A member 4
Gene symbol SERPINA4
Synonyms (NCBI Gene)
KALKLSTKSTPI-4PI4kallistatin
Chromosome 14
Chromosome location 14q32.13
miRNA miRNA information provided by mirtarbase database.
394
miRTarBase ID miRNA Experiments Reference
MIRT609249 hsa-miR-141-5p HITS-CLIP 23824327
MIRT609246 hsa-miR-5088-3p HITS-CLIP 23824327
MIRT609245 hsa-miR-1237-3p HITS-CLIP 23824327
MIRT609244 hsa-miR-4287 HITS-CLIP 23824327
MIRT609243 hsa-miR-4685-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
13
GO ID Ontology Definition Evidence Reference
GO:0004867 Function Serine-type endopeptidase inhibitor activity IBA
GO:0004867 Function Serine-type endopeptidase inhibitor activity IEA
GO:0004867 Function Serine-type endopeptidase inhibitor activity TAS 1334488
GO:0005515 Function Protein binding IPI 28514442, 33961781
GO:0005576 Component Extracellular region HDA 27068509
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
147935 8948 ENSG00000100665
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P29622
Protein name Kallistatin (Kallikrein inhibitor) (Peptidase inhibitor 4) (PI-4) (Serpin A4)
Protein function Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of
PDB 6F02
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00079 Serpin 53 424 Serpin (serine protease inhibitor) Domain
Tissue specificity TISSUE SPECIFICITY: Expressed by the liver and secreted in plasma.
Sequence
Sequence length 427
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Platelet degranulation
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
5
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CARCINOMA, HEPATOCELLULAR CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Gastric cancer Uncertain significance ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, EXPERIMENTAL CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MESOTHELIOMA, MALIGNANT CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Amyotrophic Lateral Sclerosis Amyotrophic lateral sclerosis Pubtator 37646115 Associate
★☆☆☆☆
Found in Text Mining only
Angina Stable Angina pectoris Pubtator 32712615 Inhibit
★☆☆☆☆
Found in Text Mining only
Angioedemas, Hereditary Angioedema BEFREE 16916274, 17559913, 22149337, 23634741, 28225674, 30044938, 30952698, 31234673, 31635497
★☆☆☆☆
Found in Text Mining only
Aortic Aneurysm Abdominal Aortic aneurysm Pubtator 22163325 Associate
★☆☆☆☆
Found in Text Mining only
Arthritis Arthritis BEFREE 15818689
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Atherosclerosis Pubtator 32712615 Associate
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 23666756 Inhibit
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 26790955 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 31322260 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma of lung Lung carcinoma BEFREE 20509975
★☆☆☆☆
Found in Text Mining only