PGA5 (pepsinogen A5)

Gene Gene information from NCBI Gene database.
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 5222
Gene name Pepsinogen A5
Gene symbol PGA5
Synonyms (NCBI Gene)
Pg5
Chromosome 11
Chromosome location 11q12.2
Summary This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the act
Transcription factors Transcription factors information provided by TRRUST V2 database.
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Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (1)
Transcription factor Regulation Reference
SOX2 Activation 17136346
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (10)
GO ID Ontology Definition Evidence Reference
GO:0004190 Function Aspartic-type endopeptidase activity IBA
GO:0004190 Function Aspartic-type endopeptidase activity IEA
GO:0005576 Component Extracellular region IEA
GO:0006508 Process Proteolysis IBA
GO:0006508 Process Proteolysis IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
169730 8887 ENSG00000256713
Protein Protein information from UniProt database.
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P0DJD9
Protein name Pepsin A-5 (EC 3.4.23.1) (Pepsinogen-5)
Protein function Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07966 A1_Propeptide 17 → 45 A1 Propeptide Motif
PF00026 Asp 75 → 387 Eukaryotic aspartyl protease Family
Sequence
Sequence length 388
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Protein digestion and absorption   Surfactant metabolism
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (1)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ESOPHAGITIS — CTD
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (10)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Barrett Epithelium Barrett Epithelium BEFREE 3305135
★★★★★
★☆☆☆☆
Found in Text Mining only
Chronic sinusitis Sinusitis BEFREE 28784015
★★★★★
★☆☆☆☆
Found in Text Mining only
Craniosynostosis Craniosynostosis BEFREE 28784015
★★★★★
★☆☆☆☆
Found in Text Mining only
Crohn Disease Crohn Disease BEFREE 2571544
★★★★★
★☆☆☆☆
Found in Text Mining only
Esophagitis Esophagitis CTD_human_DG 12928072
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Inflammatory Bowel Diseases Inflammatory Bowel Disease BEFREE 2571544
★★★★★
★☆☆☆☆
Found in Text Mining only
Lung Diseases, Interstitial Lung Diseases BEFREE 30405002
★★★★★
★☆☆☆☆
Found in Text Mining only
Nasal Polyps Nasal polyposis BEFREE 28784015
★★★★★
★☆☆☆☆
Found in Text Mining only
Prostatic Neoplasms Prostatic neoplasm Pubtator 30286759 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Ulcerative Colitis Ulcerative colitis BEFREE 2571544
★★★★★
★☆☆☆☆
Found in Text Mining only