PFKFB2 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2)

Gene

• Entrez ID: 5208
• Gene name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
• Gene symbol: PFKFB2
• Synonyms (NCBI Gene): PFK-2/FBPase-2
• Chromosome: 1
• Chromosome location: 1q32.1
• Summary: The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the s

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT023270	hsa-miR-122-5p	Microarray	17612493
MIRT030745	hsa-miR-21-5p	Microarray	18591254
MIRT047308	hsa-miR-181a-5p	CLASH	23622248
MIRT456507	hsa-miR-552-3p	PAR-CLIP	23592263
MIRT456506	hsa-miR-1296-3p	PAR-CLIP	23592263
MIRT456505	hsa-miR-125a-3p	PAR-CLIP	23592263
MIRT456504	hsa-miR-4693-3p	PAR-CLIP	23592263
MIRT456503	hsa-miR-4481	PAR-CLIP	23592263
MIRT456502	hsa-miR-4745-5p	PAR-CLIP	23592263
MIRT456501	hsa-miR-4271	PAR-CLIP	23592263
MIRT456500	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT456499	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT456498	hsa-miR-491-5p	PAR-CLIP	23592263
MIRT456497	hsa-miR-585-5p	PAR-CLIP	23592263
MIRT456496	hsa-miR-2110	PAR-CLIP	23592263
MIRT441886	hsa-miR-548n	PAR-CLIP	22100165
MIRT441885	hsa-miR-548az-5p	PAR-CLIP	22100165
MIRT441884	hsa-miR-548t-5p	PAR-CLIP	22100165
MIRT441883	hsa-miR-106a-5p	PAR-CLIP	22100165
MIRT441882	hsa-miR-106b-5p	PAR-CLIP	22100165
MIRT441881	hsa-miR-17-5p	PAR-CLIP	22100165
MIRT441880	hsa-miR-20a-5p	PAR-CLIP	22100165
MIRT441879	hsa-miR-20b-5p	PAR-CLIP	22100165
MIRT441878	hsa-miR-519d-3p	PAR-CLIP	22100165
MIRT441877	hsa-miR-526b-3p	PAR-CLIP	22100165
MIRT441876	hsa-miR-93-5p	PAR-CLIP	22100165
MIRT441886	hsa-miR-548n	PAR-CLIP	22100165
MIRT441885	hsa-miR-548az-5p	PAR-CLIP	22100165
MIRT441884	hsa-miR-548t-5p	PAR-CLIP	22100165
MIRT441883	hsa-miR-106a-5p	PAR-CLIP	22100165
MIRT441882	hsa-miR-106b-5p	PAR-CLIP	22100165
MIRT441881	hsa-miR-17-5p	PAR-CLIP	22100165
MIRT441880	hsa-miR-20a-5p	PAR-CLIP	22100165
MIRT441879	hsa-miR-20b-5p	PAR-CLIP	22100165
MIRT441878	hsa-miR-519d-3p	PAR-CLIP	22100165
MIRT441877	hsa-miR-526b-3p	PAR-CLIP	22100165
MIRT441876	hsa-miR-93-5p	PAR-CLIP	22100165
MIRT440000	hsa-miR-376a-3p	HITS-CLIP	24374217
MIRT439996	hsa-miR-377-3p	HITS-CLIP	24374217
MIRT440000	hsa-miR-376a-3p	HITS-CLIP	24374217
MIRT439999	hsa-miR-382-5p	HITS-CLIP	24374217
MIRT439998	hsa-miR-1185-2-3p	HITS-CLIP	24374217
MIRT439996	hsa-miR-377-3p	HITS-CLIP	24374217
MIRT439997	hsa-miR-1185-1-3p	HITS-CLIP	24374217
MIRT440000	hsa-miR-376a-3p	HITS-CLIP	24374217
MIRT439996	hsa-miR-377-3p	HITS-CLIP	24374217
MIRT440000	hsa-miR-376a-3p	HITS-CLIP	24374217
MIRT439999	hsa-miR-382-5p	HITS-CLIP	24374217
MIRT439998	hsa-miR-1185-2-3p	HITS-CLIP	24374217
MIRT439996	hsa-miR-377-3p	HITS-CLIP	24374217
MIRT439997	hsa-miR-1185-1-3p	HITS-CLIP	24374217
MIRT456507	hsa-miR-552-3p	PAR-CLIP	23592263
MIRT456506	hsa-miR-1296-3p	PAR-CLIP	23592263
MIRT456505	hsa-miR-125a-3p	PAR-CLIP	23592263
MIRT456504	hsa-miR-4693-3p	PAR-CLIP	23592263
MIRT456503	hsa-miR-4481	PAR-CLIP	23592263
MIRT456502	hsa-miR-4745-5p	PAR-CLIP	23592263
MIRT456501	hsa-miR-4271	PAR-CLIP	23592263
MIRT456500	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT456499	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT456498	hsa-miR-491-5p	PAR-CLIP	23592263
MIRT456497	hsa-miR-585-5p	PAR-CLIP	23592263
MIRT456496	hsa-miR-2110	PAR-CLIP	23592263
MIRT441886	hsa-miR-548n	PAR-CLIP	22100165
MIRT441885	hsa-miR-548az-5p	PAR-CLIP	22100165
MIRT441884	hsa-miR-548t-5p	PAR-CLIP	22100165
MIRT441883	hsa-miR-106a-5p	PAR-CLIP	22100165
MIRT441882	hsa-miR-106b-5p	PAR-CLIP	22100165
MIRT441881	hsa-miR-17-5p	PAR-CLIP	22100165
MIRT441880	hsa-miR-20a-5p	PAR-CLIP	22100165
MIRT441879	hsa-miR-20b-5p	PAR-CLIP	22100165
MIRT441878	hsa-miR-519d-3p	PAR-CLIP	22100165
MIRT441877	hsa-miR-526b-3p	PAR-CLIP	22100165
MIRT441876	hsa-miR-93-5p	PAR-CLIP	22100165
MIRT441886	hsa-miR-548n	PAR-CLIP	22100165
MIRT441885	hsa-miR-548az-5p	PAR-CLIP	22100165
MIRT441884	hsa-miR-548t-5p	PAR-CLIP	22100165
MIRT441883	hsa-miR-106a-5p	PAR-CLIP	22100165
MIRT441882	hsa-miR-106b-5p	PAR-CLIP	22100165
MIRT441881	hsa-miR-17-5p	PAR-CLIP	22100165
MIRT441880	hsa-miR-20a-5p	PAR-CLIP	22100165
MIRT441879	hsa-miR-20b-5p	PAR-CLIP	22100165
MIRT441878	hsa-miR-519d-3p	PAR-CLIP	22100165
MIRT441877	hsa-miR-526b-3p	PAR-CLIP	22100165
MIRT441876	hsa-miR-93-5p	PAR-CLIP	22100165
MIRT030745	hsa-miR-21-5p	Luciferase reporter assay, Western blotting, qRT-PCR	37864733
MIRT1226165	hsa-miR-3925-3p	CLIP-seq
MIRT1226166	hsa-miR-515-5p	CLIP-seq
MIRT1226167	hsa-miR-766	CLIP-seq
MIRT1226168	hsa-miR-105	CLIP-seq
MIRT1226169	hsa-miR-1264	CLIP-seq
MIRT1226170	hsa-miR-1297	CLIP-seq
MIRT1226171	hsa-miR-1299	CLIP-seq
MIRT1226172	hsa-miR-1321	CLIP-seq
MIRT1226173	hsa-miR-1825	CLIP-seq
MIRT1226174	hsa-miR-26a	CLIP-seq
MIRT1226175	hsa-miR-26b	CLIP-seq
MIRT1226176	hsa-miR-298	CLIP-seq
MIRT1226177	hsa-miR-3065-5p	CLIP-seq
MIRT1226178	hsa-miR-3120-3p	CLIP-seq
MIRT1226179	hsa-miR-3121-5p	CLIP-seq
MIRT1226180	hsa-miR-3127-5p	CLIP-seq
MIRT1226181	hsa-miR-3148	CLIP-seq
MIRT1226182	hsa-miR-3153	CLIP-seq
MIRT1226183	hsa-miR-3158-5p	CLIP-seq
MIRT1226184	hsa-miR-3182	CLIP-seq
MIRT1226185	hsa-miR-3189-3p	CLIP-seq
MIRT1226186	hsa-miR-338-3p	CLIP-seq
MIRT1226187	hsa-miR-3591-5p	CLIP-seq
MIRT1226188	hsa-miR-3606	CLIP-seq
MIRT1226189	hsa-miR-3613-3p	CLIP-seq
MIRT1226190	hsa-miR-3646	CLIP-seq
MIRT1226191	hsa-miR-3654	CLIP-seq
MIRT1226192	hsa-miR-3667-3p	CLIP-seq
MIRT1226193	hsa-miR-3667-5p	CLIP-seq
MIRT1226194	hsa-miR-3913-3p	CLIP-seq
MIRT1226195	hsa-miR-3978	CLIP-seq
MIRT1226196	hsa-miR-409-3p	CLIP-seq
MIRT1226197	hsa-miR-4268	CLIP-seq
MIRT1226198	hsa-miR-4270	CLIP-seq
MIRT1226199	hsa-miR-4272	CLIP-seq
MIRT1226200	hsa-miR-4312	CLIP-seq
MIRT1226201	hsa-miR-4328	CLIP-seq
MIRT1226202	hsa-miR-4418	CLIP-seq
MIRT1226203	hsa-miR-4419a	CLIP-seq
MIRT1226204	hsa-miR-4422	CLIP-seq
MIRT1226205	hsa-miR-4434	CLIP-seq
MIRT1226206	hsa-miR-4441	CLIP-seq
MIRT1226207	hsa-miR-4465	CLIP-seq
MIRT1226208	hsa-miR-4495	CLIP-seq
MIRT1226209	hsa-miR-4510	CLIP-seq
MIRT1226210	hsa-miR-4516	CLIP-seq
MIRT1226211	hsa-miR-4531	CLIP-seq
MIRT1226212	hsa-miR-4638-3p	CLIP-seq
MIRT1226213	hsa-miR-4639-5p	CLIP-seq
MIRT1226214	hsa-miR-4640-5p	CLIP-seq
MIRT1226215	hsa-miR-4659a-5p	CLIP-seq
MIRT1226216	hsa-miR-4659b-5p	CLIP-seq
MIRT1226217	hsa-miR-4670-3p	CLIP-seq
MIRT1226218	hsa-miR-4680-5p	CLIP-seq
MIRT1226219	hsa-miR-4726-5p	CLIP-seq
MIRT1226220	hsa-miR-4739	CLIP-seq
MIRT1226221	hsa-miR-4744	CLIP-seq
MIRT1226222	hsa-miR-4756-5p	CLIP-seq
MIRT1226223	hsa-miR-4768-3p	CLIP-seq
MIRT1226224	hsa-miR-4772-3p	CLIP-seq
MIRT1226225	hsa-miR-4782-5p	CLIP-seq
MIRT1226226	hsa-miR-489	CLIP-seq
MIRT1226227	hsa-miR-509-3-5p	CLIP-seq
MIRT1226228	hsa-miR-509-5p	CLIP-seq
MIRT1226229	hsa-miR-512-3p	CLIP-seq
MIRT1226230	hsa-miR-516b	CLIP-seq
MIRT1226231	hsa-miR-545	CLIP-seq
MIRT1226232	hsa-miR-548a-3p	CLIP-seq
MIRT1226233	hsa-miR-548aa	CLIP-seq
MIRT1226234	hsa-miR-548c-3p	CLIP-seq
MIRT1226235	hsa-miR-548e	CLIP-seq
MIRT1226236	hsa-miR-548f	CLIP-seq
MIRT1226237	hsa-miR-548p	CLIP-seq
MIRT1226238	hsa-miR-548u	CLIP-seq
MIRT1226239	hsa-miR-569	CLIP-seq
MIRT1226240	hsa-miR-570	CLIP-seq
MIRT1226241	hsa-miR-582-3p	CLIP-seq
MIRT1226242	hsa-miR-586	CLIP-seq
MIRT1226243	hsa-miR-590-3p	CLIP-seq
MIRT1226244	hsa-miR-592	CLIP-seq
MIRT1226245	hsa-miR-597	CLIP-seq
MIRT1226246	hsa-miR-634	CLIP-seq
MIRT1226247	hsa-miR-642b	CLIP-seq
MIRT1226248	hsa-miR-665	CLIP-seq
MIRT1226249	hsa-miR-885-5p	CLIP-seq
MIRT1226250	hsa-miR-888	CLIP-seq
MIRT1226251	hsa-miR-921	CLIP-seq
MIRT1226252	hsa-miR-942	CLIP-seq
MIRT1226253	hsa-miR-944	CLIP-seq
MIRT1920754	hsa-miR-1305	CLIP-seq
MIRT1920755	hsa-miR-2278	CLIP-seq
MIRT1920756	hsa-miR-337-3p	CLIP-seq
MIRT1920757	hsa-miR-421	CLIP-seq
MIRT1920758	hsa-miR-4519	CLIP-seq
MIRT1920759	hsa-miR-4709-5p	CLIP-seq
MIRT1920760	hsa-miR-515-3p	CLIP-seq
MIRT1920761	hsa-miR-519e	CLIP-seq
MIRT1920754	hsa-miR-1305	CLIP-seq
MIRT1920755	hsa-miR-2278	CLIP-seq
MIRT1920756	hsa-miR-337-3p	CLIP-seq
MIRT1920757	hsa-miR-421	CLIP-seq
MIRT1920758	hsa-miR-4519	CLIP-seq
MIRT1920759	hsa-miR-4709-5p	CLIP-seq
MIRT1920760	hsa-miR-515-3p	CLIP-seq
MIRT1920761	hsa-miR-519e	CLIP-seq
MIRT1920754	hsa-miR-1305	CLIP-seq
MIRT1920755	hsa-miR-2278	CLIP-seq
MIRT1920756	hsa-miR-337-3p	CLIP-seq
MIRT1920757	hsa-miR-421	CLIP-seq
MIRT1920758	hsa-miR-4519	CLIP-seq
MIRT1920759	hsa-miR-4709-5p	CLIP-seq
MIRT1920760	hsa-miR-515-3p	CLIP-seq
MIRT1920761	hsa-miR-519e	CLIP-seq
MIRT2066108	hsa-miR-106a	CLIP-seq
MIRT2066109	hsa-miR-106b	CLIP-seq
MIRT2066110	hsa-miR-1184	CLIP-seq
MIRT2066111	hsa-miR-1205	CLIP-seq
MIRT2066112	hsa-miR-1207-5p	CLIP-seq
MIRT2066113	hsa-miR-122	CLIP-seq
MIRT2066114	hsa-miR-1225-5p	CLIP-seq
MIRT2066115	hsa-miR-1255a	CLIP-seq
MIRT2066116	hsa-miR-1255b	CLIP-seq
MIRT2066117	hsa-miR-1285	CLIP-seq
MIRT2066118	hsa-miR-1291	CLIP-seq
MIRT1920754	hsa-miR-1305	CLIP-seq
MIRT1226172	hsa-miR-1321	CLIP-seq
MIRT2066119	hsa-miR-150	CLIP-seq
MIRT2066120	hsa-miR-1587	CLIP-seq
MIRT2066121	hsa-miR-17	CLIP-seq
MIRT1226173	hsa-miR-1825	CLIP-seq
MIRT2066122	hsa-miR-1976	CLIP-seq
MIRT2066123	hsa-miR-2053	CLIP-seq
MIRT2066124	hsa-miR-20a	CLIP-seq
MIRT2066125	hsa-miR-20b	CLIP-seq
MIRT2066126	hsa-miR-2116	CLIP-seq
MIRT2066127	hsa-miR-223	CLIP-seq
MIRT2066128	hsa-miR-2964a-5p	CLIP-seq
MIRT2066129	hsa-miR-302a	CLIP-seq
MIRT2066130	hsa-miR-302b	CLIP-seq
MIRT2066131	hsa-miR-302c	CLIP-seq
MIRT2066132	hsa-miR-302d	CLIP-seq
MIRT2066133	hsa-miR-302e	CLIP-seq
MIRT2066134	hsa-miR-3065-3p	CLIP-seq
MIRT2066135	hsa-miR-3074-5p	CLIP-seq
MIRT2066136	hsa-miR-3117-5p	CLIP-seq
MIRT2066137	hsa-miR-3120-5p	CLIP-seq
MIRT2066138	hsa-miR-3126-3p	CLIP-seq
MIRT2066139	hsa-miR-3127-3p	CLIP-seq
MIRT2066140	hsa-miR-3135b	CLIP-seq
MIRT1226183	hsa-miR-3158-5p	CLIP-seq
MIRT2066141	hsa-miR-3166	CLIP-seq
MIRT2066142	hsa-miR-3179	CLIP-seq
MIRT1226184	hsa-miR-3182	CLIP-seq
MIRT2066143	hsa-miR-3187-5p	CLIP-seq
MIRT2066144	hsa-miR-3192	CLIP-seq
MIRT2066145	hsa-miR-3199	CLIP-seq
MIRT2066146	hsa-miR-328	CLIP-seq
MIRT1226190	hsa-miR-3646	CLIP-seq
MIRT2066147	hsa-miR-3652	CLIP-seq
MIRT2066148	hsa-miR-3661	CLIP-seq
MIRT2066149	hsa-miR-3663-5p	CLIP-seq
MIRT2066150	hsa-miR-3689a-5p	CLIP-seq
MIRT2066151	hsa-miR-3689b	CLIP-seq
MIRT2066152	hsa-miR-3689e	CLIP-seq
MIRT2066153	hsa-miR-3689f	CLIP-seq
MIRT2066154	hsa-miR-3691-5p	CLIP-seq
MIRT2066155	hsa-miR-3692	CLIP-seq
MIRT2066156	hsa-miR-370	CLIP-seq
MIRT2066157	hsa-miR-372	CLIP-seq
MIRT2066158	hsa-miR-373	CLIP-seq
MIRT2066159	hsa-miR-378g	CLIP-seq
MIRT2066160	hsa-miR-3921	CLIP-seq
MIRT2066161	hsa-miR-3945	CLIP-seq
MIRT2066162	hsa-miR-3973	CLIP-seq
MIRT2066163	hsa-miR-4253	CLIP-seq
MIRT2066164	hsa-miR-4279	CLIP-seq
MIRT2066165	hsa-miR-4286	CLIP-seq
MIRT2066166	hsa-miR-4314	CLIP-seq
MIRT2066167	hsa-miR-4323	CLIP-seq
MIRT1226203	hsa-miR-4419a	CLIP-seq
MIRT2066168	hsa-miR-4430	CLIP-seq
MIRT2066169	hsa-miR-4459	CLIP-seq
MIRT2066170	hsa-miR-4469	CLIP-seq
MIRT2066171	hsa-miR-4486	CLIP-seq
MIRT2066172	hsa-miR-4492	CLIP-seq
MIRT2066173	hsa-miR-4498	CLIP-seq
MIRT2066174	hsa-miR-4509	CLIP-seq
MIRT1226209	hsa-miR-4510	CLIP-seq
MIRT1226212	hsa-miR-4638-3p	CLIP-seq
MIRT2066175	hsa-miR-4646-5p	CLIP-seq
MIRT2066176	hsa-miR-4652-3p	CLIP-seq
MIRT2066177	hsa-miR-4652-5p	CLIP-seq
MIRT2066178	hsa-miR-4653-3p	CLIP-seq
MIRT2066179	hsa-miR-4653-5p	CLIP-seq
MIRT2066180	hsa-miR-4656	CLIP-seq
MIRT2066181	hsa-miR-4659a-3p	CLIP-seq
MIRT1226215	hsa-miR-4659a-5p	CLIP-seq
MIRT2066182	hsa-miR-4659b-3p	CLIP-seq
MIRT1226216	hsa-miR-4659b-5p	CLIP-seq
MIRT2066183	hsa-miR-4666-3p	CLIP-seq
MIRT1226217	hsa-miR-4670-3p	CLIP-seq
MIRT2066184	hsa-miR-4675	CLIP-seq
MIRT2066185	hsa-miR-4697-3p	CLIP-seq
MIRT2066186	hsa-miR-4704-3p	CLIP-seq
MIRT2066187	hsa-miR-4712-5p	CLIP-seq
MIRT2066188	hsa-miR-4722-3p	CLIP-seq
MIRT2066189	hsa-miR-4728-3p	CLIP-seq
MIRT2066190	hsa-miR-4736	CLIP-seq
MIRT1226220	hsa-miR-4739	CLIP-seq
MIRT2066191	hsa-miR-4741	CLIP-seq
MIRT2066192	hsa-miR-4752	CLIP-seq
MIRT2066193	hsa-miR-4756-3p	CLIP-seq
MIRT1226222	hsa-miR-4756-5p	CLIP-seq
MIRT2066194	hsa-miR-4763-3p	CLIP-seq
MIRT2066195	hsa-miR-4771	CLIP-seq
MIRT1226224	hsa-miR-4772-3p	CLIP-seq
MIRT2066196	hsa-miR-4777-3p	CLIP-seq
MIRT2066197	hsa-miR-4778-3p	CLIP-seq
MIRT2066198	hsa-miR-4799-5p	CLIP-seq
MIRT2066199	hsa-miR-486-5p	CLIP-seq
MIRT1226229	hsa-miR-512-3p	CLIP-seq
MIRT2066200	hsa-miR-513c	CLIP-seq
MIRT2066201	hsa-miR-514b-5p	CLIP-seq
MIRT2066202	hsa-miR-519d	CLIP-seq
MIRT2066203	hsa-miR-520a-3p	CLIP-seq
MIRT2066204	hsa-miR-520b	CLIP-seq
MIRT2066205	hsa-miR-520c-3p	CLIP-seq
MIRT2066206	hsa-miR-520d-3p	CLIP-seq
MIRT2066207	hsa-miR-520e	CLIP-seq
MIRT2066208	hsa-miR-520g	CLIP-seq
MIRT2066209	hsa-miR-520h	CLIP-seq
MIRT2066210	hsa-miR-541	CLIP-seq
MIRT1226239	hsa-miR-569	CLIP-seq
MIRT1226242	hsa-miR-586	CLIP-seq
MIRT2066211	hsa-miR-589	CLIP-seq
MIRT2066212	hsa-miR-606	CLIP-seq
MIRT2066213	hsa-miR-612	CLIP-seq
MIRT2066214	hsa-miR-631	CLIP-seq
MIRT2066215	hsa-miR-642a	CLIP-seq
MIRT2066216	hsa-miR-654-5p	CLIP-seq
MIRT2066217	hsa-miR-664	CLIP-seq
MIRT2066218	hsa-miR-762	CLIP-seq
MIRT2066219	hsa-miR-770-5p	CLIP-seq
MIRT2066220	hsa-miR-93	CLIP-seq
MIRT2066221	hsa-miR-938	CLIP-seq
MIRT1226252	hsa-miR-942	CLIP-seq
MIRT2066110	hsa-miR-1184	CLIP-seq
MIRT2066111	hsa-miR-1205	CLIP-seq
MIRT2293764	hsa-miR-1231	CLIP-seq
MIRT2293765	hsa-miR-1294	CLIP-seq
MIRT1226172	hsa-miR-1321	CLIP-seq
MIRT2293766	hsa-miR-188-3p	CLIP-seq
MIRT2066135	hsa-miR-3074-5p	CLIP-seq
MIRT2066136	hsa-miR-3117-5p	CLIP-seq
MIRT2066139	hsa-miR-3127-3p	CLIP-seq
MIRT1226183	hsa-miR-3158-5p	CLIP-seq
MIRT2066141	hsa-miR-3166	CLIP-seq
MIRT2066156	hsa-miR-370	CLIP-seq
MIRT2066160	hsa-miR-3921	CLIP-seq
MIRT2293767	hsa-miR-4251	CLIP-seq
MIRT2066163	hsa-miR-4253	CLIP-seq
MIRT2066165	hsa-miR-4286	CLIP-seq
MIRT2293768	hsa-miR-4288	CLIP-seq
MIRT2066167	hsa-miR-4323	CLIP-seq
MIRT2293769	hsa-miR-4329	CLIP-seq
MIRT1226203	hsa-miR-4419a	CLIP-seq
MIRT2293770	hsa-miR-4447	CLIP-seq
MIRT2293771	hsa-miR-4472	CLIP-seq
MIRT1226209	hsa-miR-4510	CLIP-seq
MIRT2066179	hsa-miR-4653-5p	CLIP-seq
MIRT1226217	hsa-miR-4670-3p	CLIP-seq
MIRT2293772	hsa-miR-4690-3p	CLIP-seq
MIRT2293773	hsa-miR-4710	CLIP-seq
MIRT2066187	hsa-miR-4712-5p	CLIP-seq
MIRT1226220	hsa-miR-4739	CLIP-seq
MIRT1226222	hsa-miR-4756-5p	CLIP-seq
MIRT2066195	hsa-miR-4771	CLIP-seq
MIRT2066197	hsa-miR-4778-3p	CLIP-seq
MIRT2293774	hsa-miR-4796-3p	CLIP-seq
MIRT2293775	hsa-miR-520a-5p	CLIP-seq
MIRT2293776	hsa-miR-525-5p	CLIP-seq
MIRT2293777	hsa-miR-539	CLIP-seq
MIRT1226239	hsa-miR-569	CLIP-seq
MIRT2066212	hsa-miR-606	CLIP-seq
MIRT2293778	hsa-miR-632	CLIP-seq
MIRT2066219	hsa-miR-770-5p	CLIP-seq
MIRT1226252	hsa-miR-942	CLIP-seq
MIRT1226172	hsa-miR-1321	CLIP-seq
MIRT2066161	hsa-miR-3945	CLIP-seq
MIRT2066163	hsa-miR-4253	CLIP-seq
MIRT1226203	hsa-miR-4419a	CLIP-seq
MIRT1226209	hsa-miR-4510	CLIP-seq
MIRT1226217	hsa-miR-4670-3p	CLIP-seq
MIRT1226220	hsa-miR-4739	CLIP-seq
MIRT1226222	hsa-miR-4756-5p	CLIP-seq
MIRT2066210	hsa-miR-541	CLIP-seq
MIRT1226239	hsa-miR-569	CLIP-seq
MIRT2066216	hsa-miR-654-5p	CLIP-seq
MIRT2432110	hsa-miR-1253	CLIP-seq
MIRT2432111	hsa-miR-2909	CLIP-seq
MIRT2432112	hsa-miR-3714	CLIP-seq
MIRT2432113	hsa-miR-3919	CLIP-seq
MIRT2432114	hsa-miR-3922-5p	CLIP-seq
MIRT2432115	hsa-miR-4307	CLIP-seq
MIRT2442463	hsa-miR-4691-5p	CLIP-seq
MIRT2591822	hsa-miR-1229	CLIP-seq
MIRT2591823	hsa-miR-1268	CLIP-seq
MIRT2591824	hsa-miR-1268b	CLIP-seq
MIRT2591825	hsa-miR-183	CLIP-seq
MIRT2591826	hsa-miR-187	CLIP-seq
MIRT2591827	hsa-miR-2681	CLIP-seq
MIRT2066137	hsa-miR-3120-5p	CLIP-seq
MIRT2591828	hsa-miR-3169	CLIP-seq
MIRT2591829	hsa-miR-3184	CLIP-seq
MIRT2591830	hsa-miR-3185	CLIP-seq
MIRT2591831	hsa-miR-3189-5p	CLIP-seq
MIRT2591832	hsa-miR-3614-5p	CLIP-seq
MIRT1226192	hsa-miR-3667-3p	CLIP-seq
MIRT2591833	hsa-miR-3680	CLIP-seq
MIRT2066150	hsa-miR-3689a-5p	CLIP-seq
MIRT2066151	hsa-miR-3689b	CLIP-seq
MIRT2066152	hsa-miR-3689e	CLIP-seq
MIRT2066153	hsa-miR-3689f	CLIP-seq
MIRT2591834	hsa-miR-423-5p	CLIP-seq
MIRT2591835	hsa-miR-4267	CLIP-seq
MIRT2066167	hsa-miR-4323	CLIP-seq
MIRT2066176	hsa-miR-4652-3p	CLIP-seq
MIRT2293772	hsa-miR-4690-3p	CLIP-seq
MIRT2591836	hsa-miR-4694-3p	CLIP-seq
MIRT2591837	hsa-miR-4724-3p	CLIP-seq
MIRT1226223	hsa-miR-4768-3p	CLIP-seq
MIRT2591838	hsa-miR-4786-3p	CLIP-seq
MIRT2591839	hsa-miR-4786-5p	CLIP-seq
MIRT2591840	hsa-miR-4798-3p	CLIP-seq
MIRT2591841	hsa-miR-507	CLIP-seq
MIRT2066200	hsa-miR-513c	CLIP-seq
MIRT2066201	hsa-miR-514b-5p	CLIP-seq
MIRT2591842	hsa-miR-519a	CLIP-seq
MIRT2591843	hsa-miR-519b-3p	CLIP-seq
MIRT2591844	hsa-miR-519c-3p	CLIP-seq
MIRT2591845	hsa-miR-522	CLIP-seq
MIRT2591846	hsa-miR-542-3p	CLIP-seq
MIRT2591847	hsa-miR-548a-5p	CLIP-seq
MIRT2591848	hsa-miR-548ab	CLIP-seq
MIRT2591849	hsa-miR-548ak	CLIP-seq
MIRT2591850	hsa-miR-548b-5p	CLIP-seq
MIRT2591851	hsa-miR-548c-5p	CLIP-seq
MIRT2591852	hsa-miR-548d-5p	CLIP-seq
MIRT2591853	hsa-miR-548h	CLIP-seq
MIRT2591854	hsa-miR-548i	CLIP-seq
MIRT2591855	hsa-miR-548j	CLIP-seq
MIRT2591856	hsa-miR-548w	CLIP-seq
MIRT2591857	hsa-miR-548y	CLIP-seq
MIRT2591858	hsa-miR-554	CLIP-seq
MIRT2591859	hsa-miR-557	CLIP-seq
MIRT2591860	hsa-miR-559	CLIP-seq
MIRT2066211	hsa-miR-589	CLIP-seq
MIRT1226248	hsa-miR-665	CLIP-seq
MIRT2687677	hsa-miR-129-3p	CLIP-seq
MIRT2687678	hsa-miR-1912	CLIP-seq
MIRT2066139	hsa-miR-3127-3p	CLIP-seq
MIRT2687679	hsa-miR-383	CLIP-seq
MIRT2687680	hsa-miR-3907	CLIP-seq
MIRT2687681	hsa-miR-4257	CLIP-seq
MIRT2687682	hsa-miR-4269	CLIP-seq
MIRT1226199	hsa-miR-4272	CLIP-seq
MIRT2066167	hsa-miR-4323	CLIP-seq
MIRT2687683	hsa-miR-4514	CLIP-seq
MIRT1226215	hsa-miR-4659a-5p	CLIP-seq
MIRT1226216	hsa-miR-4659b-5p	CLIP-seq
MIRT2293772	hsa-miR-4690-3p	CLIP-seq
MIRT2687684	hsa-miR-4692	CLIP-seq
MIRT2687685	hsa-miR-4742-5p	CLIP-seq
MIRT2687686	hsa-miR-4758-3p	CLIP-seq
MIRT2687687	hsa-miR-4772-5p	CLIP-seq
MIRT2687688	hsa-miR-4776-3p	CLIP-seq
MIRT1226233	hsa-miR-548aa	CLIP-seq
MIRT1226237	hsa-miR-548p	CLIP-seq
MIRT1226243	hsa-miR-590-3p	CLIP-seq
MIRT2687689	hsa-miR-600	CLIP-seq
MIRT2687690	hsa-miR-660	CLIP-seq
MIRT2687691	hsa-miR-767-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003824	Function	Catalytic activity	IEA
GO:0003873	Function	6-phosphofructo-2-kinase activity	IBA
GO:0003873	Function	6-phosphofructo-2-kinase activity	IDA	11069105
GO:0003873	Function	6-phosphofructo-2-kinase activity	IEA
GO:0003873	Function	6-phosphofructo-2-kinase activity	TAS	9652401
GO:0004331	Function	Fructose-2,6-bisphosphate 2-phosphatase activity	IBA
GO:0004331	Function	Fructose-2,6-bisphosphate 2-phosphatase activity	IEA
GO:0005515	Function	Protein binding	IPI	8387495, 15161933, 28514442, 33961781, 35271311, 36931259
GO:0005524	Function	ATP binding	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	TAS
GO:0006000	Process	Fructose metabolic process	IEA
GO:0006000	Process	Fructose metabolic process	TAS	9652401
GO:0006003	Process	Fructose 2,6-bisphosphate metabolic process	IBA
GO:0006003	Process	Fructose 2,6-bisphosphate metabolic process	IDA	27802586
GO:0006003	Process	Fructose 2,6-bisphosphate metabolic process	IEA
GO:0006007	Process	Glucose catabolic process	IEA
GO:0006089	Process	Lactate metabolic process	IEA
GO:0006094	Process	Gluconeogenesis	NAS	15581487
GO:0006096	Process	Glycolytic process	IDA	11069105
GO:0006096	Process	Glycolytic process	NAS	15581487
GO:0009749	Process	Response to glucose	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0019900	Function	Kinase binding	IEA
GO:0019901	Function	Protein kinase binding	IPI	11069105
GO:0032024	Process	Positive regulation of insulin secretion	IEA
GO:0043540	Component	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex	IPI	27802586
GO:0046835	Process	Carbohydrate phosphorylation	IEA

Other IDs

• MIM: 171835
• HGNC: 8873
• e!Ensembl: ENSG00000123836

Protein

• UniProt ID: O60825
• Protein name: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (6PF-2-K/Fru-2,6-P2ase 2) (PFK/FBPase 2) (6PF-2-K/Fru-2,6-P2ase heart-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]
• Protein function: Synthesis and degradation of fructose 2,6-bisphosphate.
• PDB: 5HTK
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01591	6PF2K	26 → 249	6-phosphofructo-2-kinase	Domain
  PF00300	His_Phos_1	252 → 438	Histidine phosphatase superfamily (branch 1)	Domain

• Tissue specificity: TISSUE SPECIFICITY: Heart.
• Sequence:

  MSGASSSEQNNNSYETKTPNLRMSEKKCSWASYMTNSPTLIVMIGLPARGKTYVSKKLTR
  YLNWIGVPTKVFNLGVYRREAVKSYKSYDFFRHDNEEAMKIRKQCALVALEDVKAYLTEE
  NGQIAVFDATNTTRERRDMILNFAEQNSFKVFFVESVCDDPDVIAANILEVKVSSPDYPE
  RNRENVMEDFLKRIECYKVTYRPLDPDNYDKDLSFIKVINVGQRFLVNRVQDYIQSKIVY
  YLMNIHVQPRTIYLCRHGESEFNLLGKIGGDSGLSVRGKQFAQALRKFLEEQEITDLKVW
  TSQLKRTIQTAESLGVPYEQWKILNEIDAGVCEEMTYAEIEKRYPEEFALRDQEKYLYRY
  PGGESYQDLVQRLEPVIMELERQGNVLVISHQAVMRCLLAYFLDKGADELPYLRCPLHTI
  FKLTPVAYGCKVETIKLNVEAVNTHRDKPTNNFPKNQTPVRMRRNSFTPLSSSNTIRRPR
  NYSVGSRPLKPLSPLRAQDMQEGAD

• Sequence length: 505

Pathways

KEGG:

Fructose and mannose metabolism
Metabolic pathways
AMPK signaling pathway
Thyroid hormone signaling pathway

Reactome:

Regulation of glycolysis by fructose 2,6-bisphosphate metabolism

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ATRIAL FIBRILLATION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SUBSTANCE ABUSE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Astrocytoma	Astrocytoma	Pubtator	31170943	Associate	★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	35184643	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	24568531	Associate	★☆☆☆☆ Found in Text Mining only
Childhood Acute Lymphoblastic Leukemia	Lymphoblastic Leukemia	BEFREE	21092265		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	25662186	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	25662186		★☆☆☆☆ Found in Text Mining only
Diabetic Nephropathies	Diabetic neuropathy	Pubtator	25662186	Associate	★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	29655792		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	38098117	Associate	★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	29655792		★☆☆☆☆ Found in Text Mining only
Intervertebral Disc Degeneration	Intervertebral disc disease	Pubtator	33676464	Associate	★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	34109434	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	31391192		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	15474002, 29440170		★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	29440170		★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	29523788		★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	37986397	Associate	★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	32718270	Associate	★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	35242214	Associate	★☆☆☆☆ Found in Text Mining only
Retinoblastoma	Retinoblastoma	Pubtator	35184643	Associate	★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach Neoplasms	BEFREE	17143338		★☆☆☆☆ Found in Text Mining only
Tetralogy of Fallot	Tetralogy of fallot	Pubtator	23571024	Stimulate	★☆☆☆☆ Found in Text Mining only
Thyroid Cancer Papillary	Papillary thyroid cancer	Pubtator	20824721	Associate	★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	26980488	Associate	★☆☆☆☆ Found in Text Mining only
Ventricular Remodeling	Ventricular remodeling	Pubtator	23571024	Associate	★☆☆☆☆ Found in Text Mining only