Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	52
Gene name	Acid phosphatase 1
Gene symbol	ACP1
Synonyms (NCBI Gene)	HAAPLMW-PTPLMWPTP
Chromosome	2
Chromosome location	2p25.3
Summary	The product of this gene belongs to the phosphotyrosine protein phosphatase family of proteins. It functions as an acid phosphatase and a protein tyrosine phosphatase by hydrolyzing protein tyrosine phosphate to protein tyrosine and orthophosphate. This e

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miRTarBase ID	miRNA	Experiments	Reference
MIRT050258	hsa-miR-25-3p	CLASH	23622248
MIRT043619	hsa-miR-151a-3p	CLASH	23622248
MIRT043619	hsa-miR-151a-3p	CLASH	23622248
MIRT302322	hsa-miR-595	PAR-CLIP	21572407
MIRT551907	hsa-miR-6882-5p	PAR-CLIP	21572407
MIRT302329	hsa-miR-5680	PAR-CLIP	21572407
MIRT302323	hsa-miR-648	PAR-CLIP	21572407
MIRT551906	hsa-miR-300	PAR-CLIP	21572407
MIRT551905	hsa-miR-381-3p	PAR-CLIP	21572407
MIRT551904	hsa-miR-4666a-3p	PAR-CLIP	21572407
MIRT302330	hsa-miR-6513-3p	PAR-CLIP	21572407
MIRT551903	hsa-miR-6772-5p	PAR-CLIP	21572407
MIRT302327	hsa-miR-4455	PAR-CLIP	21572407
MIRT551902	hsa-miR-609	PAR-CLIP	21572407
MIRT302326	hsa-miR-3650	PAR-CLIP	21572407
MIRT551901	hsa-let-7a-3p	PAR-CLIP	21572407
MIRT551900	hsa-let-7b-3p	PAR-CLIP	21572407
MIRT551899	hsa-let-7f-1-3p	PAR-CLIP	21572407
MIRT551898	hsa-miR-98-3p	PAR-CLIP	21572407
MIRT302325	hsa-miR-3115	PAR-CLIP	21572407
MIRT531610	hsa-miR-205-5p	PAR-CLIP	22012620
MIRT531609	hsa-miR-371a-5p	PAR-CLIP	22012620
MIRT531608	hsa-miR-6868-3p	PAR-CLIP	22012620
MIRT302322	hsa-miR-595	PAR-CLIP	21572407
MIRT551907	hsa-miR-6882-5p	PAR-CLIP	21572407
MIRT302329	hsa-miR-5680	PAR-CLIP	21572407
MIRT302323	hsa-miR-648	PAR-CLIP	21572407
MIRT551906	hsa-miR-300	PAR-CLIP	21572407
MIRT551905	hsa-miR-381-3p	PAR-CLIP	21572407
MIRT551904	hsa-miR-4666a-3p	PAR-CLIP	21572407
MIRT302330	hsa-miR-6513-3p	PAR-CLIP	21572407
MIRT551903	hsa-miR-6772-5p	PAR-CLIP	21572407
MIRT302327	hsa-miR-4455	PAR-CLIP	21572407
MIRT551902	hsa-miR-609	PAR-CLIP	21572407
MIRT302326	hsa-miR-3650	PAR-CLIP	21572407
MIRT551901	hsa-let-7a-3p	PAR-CLIP	21572407
MIRT551900	hsa-let-7b-3p	PAR-CLIP	21572407
MIRT551899	hsa-let-7f-1-3p	PAR-CLIP	21572407
MIRT551898	hsa-miR-98-3p	PAR-CLIP	21572407
MIRT302325	hsa-miR-3115	PAR-CLIP	21572407
MIRT531610	hsa-miR-205-5p	PAR-CLIP	22012620
MIRT531609	hsa-miR-371a-5p	PAR-CLIP	22012620
MIRT531608	hsa-miR-6868-3p	PAR-CLIP	22012620
MIRT763155	hsa-miR-1236	CLIP-seq
MIRT763156	hsa-miR-1305	CLIP-seq
MIRT763157	hsa-miR-151-3p	CLIP-seq
MIRT763158	hsa-miR-3670	CLIP-seq
MIRT763159	hsa-miR-4305	CLIP-seq
MIRT763160	hsa-miR-4463	CLIP-seq
MIRT763161	hsa-miR-4499	CLIP-seq
MIRT763162	hsa-miR-4652-5p	CLIP-seq
MIRT763163	hsa-miR-4677-3p	CLIP-seq
MIRT763164	hsa-miR-4768-5p	CLIP-seq
MIRT763165	hsa-miR-576-5p	CLIP-seq
MIRT763166	hsa-miR-587	CLIP-seq
MIRT763155	hsa-miR-1236	CLIP-seq
MIRT763167	hsa-miR-1264	CLIP-seq
MIRT763168	hsa-miR-1266	CLIP-seq
MIRT763169	hsa-miR-1286	CLIP-seq
MIRT763170	hsa-miR-1294	CLIP-seq
MIRT763171	hsa-miR-1297	CLIP-seq
MIRT763156	hsa-miR-1305	CLIP-seq
MIRT763157	hsa-miR-151-3p	CLIP-seq
MIRT763172	hsa-miR-192	CLIP-seq
MIRT763173	hsa-miR-214	CLIP-seq
MIRT763174	hsa-miR-215	CLIP-seq
MIRT763175	hsa-miR-26a	CLIP-seq
MIRT763176	hsa-miR-26b	CLIP-seq
MIRT763177	hsa-miR-2861	CLIP-seq
MIRT763178	hsa-miR-3155	CLIP-seq
MIRT763179	hsa-miR-3155b	CLIP-seq
MIRT763180	hsa-miR-3619-5p	CLIP-seq
MIRT763181	hsa-miR-3661	CLIP-seq
MIRT763158	hsa-miR-3670	CLIP-seq
MIRT763182	hsa-miR-381	CLIP-seq
MIRT763183	hsa-miR-421	CLIP-seq
MIRT763184	hsa-miR-4251	CLIP-seq
MIRT763159	hsa-miR-4305	CLIP-seq
MIRT763185	hsa-miR-4438	CLIP-seq
MIRT763160	hsa-miR-4463	CLIP-seq
MIRT763186	hsa-miR-4465	CLIP-seq
MIRT763161	hsa-miR-4499	CLIP-seq
MIRT763187	hsa-miR-4518	CLIP-seq
MIRT763188	hsa-miR-4666-3p	CLIP-seq
MIRT763163	hsa-miR-4677-3p	CLIP-seq
MIRT763189	hsa-miR-4709-5p	CLIP-seq
MIRT763190	hsa-miR-4722-5p	CLIP-seq
MIRT763164	hsa-miR-4768-5p	CLIP-seq
MIRT763191	hsa-miR-484	CLIP-seq
MIRT763192	hsa-miR-539	CLIP-seq
MIRT763193	hsa-miR-554	CLIP-seq
MIRT763194	hsa-miR-576-3p	CLIP-seq
MIRT763165	hsa-miR-576-5p	CLIP-seq
MIRT763166	hsa-miR-587	CLIP-seq
MIRT763195	hsa-miR-601	CLIP-seq
MIRT763196	hsa-miR-615-5p	CLIP-seq
MIRT763197	hsa-miR-631	CLIP-seq
MIRT763198	hsa-miR-761	CLIP-seq
MIRT2166186	hsa-miR-1237	CLIP-seq
MIRT2166187	hsa-miR-1248	CLIP-seq
MIRT763168	hsa-miR-1266	CLIP-seq
MIRT2166188	hsa-miR-1283	CLIP-seq
MIRT763169	hsa-miR-1286	CLIP-seq
MIRT2166189	hsa-miR-1299	CLIP-seq
MIRT763157	hsa-miR-151-3p	CLIP-seq
MIRT2166190	hsa-miR-1976	CLIP-seq
MIRT763173	hsa-miR-214	CLIP-seq
MIRT763178	hsa-miR-3155	CLIP-seq
MIRT763179	hsa-miR-3155b	CLIP-seq
MIRT763180	hsa-miR-3619-5p	CLIP-seq
MIRT763158	hsa-miR-3670	CLIP-seq
MIRT2166191	hsa-miR-380	CLIP-seq
MIRT763182	hsa-miR-381	CLIP-seq
MIRT2166192	hsa-miR-4279	CLIP-seq
MIRT763159	hsa-miR-4305	CLIP-seq
MIRT763160	hsa-miR-4463	CLIP-seq
MIRT763161	hsa-miR-4499	CLIP-seq
MIRT763187	hsa-miR-4518	CLIP-seq
MIRT763162	hsa-miR-4652-5p	CLIP-seq
MIRT763163	hsa-miR-4677-3p	CLIP-seq
MIRT2166193	hsa-miR-4722-3p	CLIP-seq
MIRT763190	hsa-miR-4722-5p	CLIP-seq
MIRT2166194	hsa-miR-4764-5p	CLIP-seq
MIRT2166195	hsa-miR-4782-5p	CLIP-seq
MIRT763191	hsa-miR-484	CLIP-seq
MIRT2166196	hsa-miR-516b	CLIP-seq
MIRT763192	hsa-miR-539	CLIP-seq
MIRT763193	hsa-miR-554	CLIP-seq
MIRT763165	hsa-miR-576-5p	CLIP-seq
MIRT763166	hsa-miR-587	CLIP-seq
MIRT2166197	hsa-miR-591	CLIP-seq
MIRT763195	hsa-miR-601	CLIP-seq
MIRT763196	hsa-miR-615-5p	CLIP-seq
MIRT763198	hsa-miR-761	CLIP-seq
MIRT763157	hsa-miR-151-3p	CLIP-seq
MIRT763158	hsa-miR-3670	CLIP-seq
MIRT763159	hsa-miR-4305	CLIP-seq
MIRT763160	hsa-miR-4463	CLIP-seq
MIRT763161	hsa-miR-4499	CLIP-seq
MIRT763163	hsa-miR-4677-3p	CLIP-seq
MIRT2425899	hsa-let-7a	CLIP-seq
MIRT2425900	hsa-let-7b	CLIP-seq
MIRT2425901	hsa-let-7c	CLIP-seq
MIRT2425902	hsa-let-7d	CLIP-seq
MIRT2425903	hsa-let-7e	CLIP-seq
MIRT2425904	hsa-let-7f	CLIP-seq
MIRT2425905	hsa-let-7g	CLIP-seq
MIRT2425906	hsa-let-7i	CLIP-seq
MIRT763158	hsa-miR-3670	CLIP-seq
MIRT2425907	hsa-miR-4458	CLIP-seq
MIRT2425908	hsa-miR-4500	CLIP-seq
MIRT763162	hsa-miR-4652-5p	CLIP-seq
MIRT2425909	hsa-miR-98	CLIP-seq
MIRT2425899	hsa-let-7a	CLIP-seq
MIRT2425900	hsa-let-7b	CLIP-seq
MIRT2425901	hsa-let-7c	CLIP-seq
MIRT2425902	hsa-let-7d	CLIP-seq
MIRT2425903	hsa-let-7e	CLIP-seq
MIRT2425904	hsa-let-7f	CLIP-seq
MIRT2425905	hsa-let-7g	CLIP-seq
MIRT2425906	hsa-let-7i	CLIP-seq
MIRT763155	hsa-miR-1236	CLIP-seq
MIRT2166186	hsa-miR-1237	CLIP-seq
MIRT2166187	hsa-miR-1248	CLIP-seq
MIRT763168	hsa-miR-1266	CLIP-seq
MIRT763169	hsa-miR-1286	CLIP-seq
MIRT763170	hsa-miR-1294	CLIP-seq
MIRT763171	hsa-miR-1297	CLIP-seq
MIRT2166189	hsa-miR-1299	CLIP-seq
MIRT763156	hsa-miR-1305	CLIP-seq
MIRT763157	hsa-miR-151-3p	CLIP-seq
MIRT763172	hsa-miR-192	CLIP-seq
MIRT763173	hsa-miR-214	CLIP-seq
MIRT763174	hsa-miR-215	CLIP-seq
MIRT2468778	hsa-miR-2467-3p	CLIP-seq
MIRT763175	hsa-miR-26a	CLIP-seq
MIRT763176	hsa-miR-26b	CLIP-seq
MIRT763177	hsa-miR-2861	CLIP-seq
MIRT763178	hsa-miR-3155	CLIP-seq
MIRT763179	hsa-miR-3155b	CLIP-seq
MIRT2468779	hsa-miR-3529	CLIP-seq
MIRT2468780	hsa-miR-3616-3p	CLIP-seq
MIRT763180	hsa-miR-3619-5p	CLIP-seq
MIRT763181	hsa-miR-3661	CLIP-seq
MIRT763158	hsa-miR-3670	CLIP-seq
MIRT2468781	hsa-miR-379	CLIP-seq
MIRT2166191	hsa-miR-380	CLIP-seq
MIRT763182	hsa-miR-381	CLIP-seq
MIRT2468782	hsa-miR-3927	CLIP-seq
MIRT2468783	hsa-miR-3942-3p	CLIP-seq
MIRT2468784	hsa-miR-4257	CLIP-seq
MIRT2468785	hsa-miR-4290	CLIP-seq
MIRT763159	hsa-miR-4305	CLIP-seq
MIRT2425907	hsa-miR-4458	CLIP-seq
MIRT763160	hsa-miR-4463	CLIP-seq
MIRT763186	hsa-miR-4465	CLIP-seq
MIRT2468786	hsa-miR-4468	CLIP-seq
MIRT763161	hsa-miR-4499	CLIP-seq
MIRT2425908	hsa-miR-4500	CLIP-seq
MIRT763187	hsa-miR-4518	CLIP-seq
MIRT2468787	hsa-miR-4645-5p	CLIP-seq
MIRT763162	hsa-miR-4652-5p	CLIP-seq
MIRT763188	hsa-miR-4666-3p	CLIP-seq
MIRT2468788	hsa-miR-4673	CLIP-seq
MIRT763163	hsa-miR-4677-3p	CLIP-seq
MIRT2468789	hsa-miR-4709-3p	CLIP-seq
MIRT763190	hsa-miR-4722-5p	CLIP-seq
MIRT2468790	hsa-miR-4724-5p	CLIP-seq
MIRT2166194	hsa-miR-4764-5p	CLIP-seq
MIRT763164	hsa-miR-4768-5p	CLIP-seq
MIRT2166195	hsa-miR-4782-5p	CLIP-seq
MIRT763191	hsa-miR-484	CLIP-seq
MIRT2166196	hsa-miR-516b	CLIP-seq
MIRT2468791	hsa-miR-520g	CLIP-seq
MIRT2468792	hsa-miR-520h	CLIP-seq
MIRT763192	hsa-miR-539	CLIP-seq
MIRT763193	hsa-miR-554	CLIP-seq
MIRT763165	hsa-miR-576-5p	CLIP-seq
MIRT763166	hsa-miR-587	CLIP-seq
MIRT2166197	hsa-miR-591	CLIP-seq
MIRT763195	hsa-miR-601	CLIP-seq
MIRT763196	hsa-miR-615-5p	CLIP-seq
MIRT763197	hsa-miR-631	CLIP-seq
MIRT763198	hsa-miR-761	CLIP-seq
MIRT2425909	hsa-miR-98	CLIP-seq
MIRT763155	hsa-miR-1236	CLIP-seq
MIRT763168	hsa-miR-1266	CLIP-seq
MIRT763169	hsa-miR-1286	CLIP-seq
MIRT763156	hsa-miR-1305	CLIP-seq
MIRT763157	hsa-miR-151-3p	CLIP-seq
MIRT763173	hsa-miR-214	CLIP-seq
MIRT763178	hsa-miR-3155	CLIP-seq
MIRT763179	hsa-miR-3155b	CLIP-seq
MIRT763180	hsa-miR-3619-5p	CLIP-seq
MIRT763158	hsa-miR-3670	CLIP-seq
MIRT763182	hsa-miR-381	CLIP-seq
MIRT763159	hsa-miR-4305	CLIP-seq
MIRT763160	hsa-miR-4463	CLIP-seq
MIRT763161	hsa-miR-4499	CLIP-seq
MIRT763187	hsa-miR-4518	CLIP-seq
MIRT763162	hsa-miR-4652-5p	CLIP-seq
MIRT763188	hsa-miR-4666-3p	CLIP-seq
MIRT763163	hsa-miR-4677-3p	CLIP-seq
MIRT763190	hsa-miR-4722-5p	CLIP-seq
MIRT763164	hsa-miR-4768-5p	CLIP-seq
MIRT763191	hsa-miR-484	CLIP-seq
MIRT763192	hsa-miR-539	CLIP-seq
MIRT763193	hsa-miR-554	CLIP-seq
MIRT763165	hsa-miR-576-5p	CLIP-seq
MIRT763166	hsa-miR-587	CLIP-seq
MIRT2166197	hsa-miR-591	CLIP-seq
MIRT763195	hsa-miR-601	CLIP-seq
MIRT763196	hsa-miR-615-5p	CLIP-seq
MIRT763198	hsa-miR-761	CLIP-seq

Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003993	Function	Acid phosphatase activity	IDA	10336608
GO:0003993	Function	Acid phosphatase activity	IDA	9038134, 9705307, 10336608
GO:0003993	Function	Acid phosphatase activity	IEA
GO:0003993	Function	Acid phosphatase activity	TAS	1587862
GO:0004721	Function	Phosphoprotein phosphatase activity	IEA
GO:0004725	Function	Protein tyrosine phosphatase activity	IBA
GO:0004725	Function	Protein tyrosine phosphatase activity	IDA	9705307
GO:0004725	Function	Protein tyrosine phosphatase activity	IEA
GO:0004726	Function	Non-membrane spanning protein tyrosine phosphatase activity	IEA
GO:0005515	Function	Protein binding	IPI	9499402, 15846844, 25556234, 32814053
GO:0005737	Component	Cytoplasm	IDA	10940933
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IEA
GO:0007268	Process	Chemical synaptic transmission	IEA
GO:0009898	Component	Cytoplasmic side of plasma membrane	IDA	10940933
GO:0016787	Function	Hydrolase activity	IEA
GO:0016791	Function	Phosphatase activity	IEA
GO:0017124	Function	SH3 domain binding	IEA
GO:0042383	Component	Sarcolemma	IEA
GO:0045202	Component	Synapse	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145

MIM	HGNC	e!Ensembl
171500	122	ENSG00000143727

P24666

Protein name

Low molecular weight phosphotyrosine protein phosphatase (LMW-PTP) (LMW-PTPase) (EC 3.1.3.48) (Adipocyte acid phosphatase) (Low molecular weight cytosolic acid phosphatase) (EC 3.1.3.2) (Red cell acid phosphatase 1)

Protein function

Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates with differences in substrate specificity between isoform 1 and isoform 2. ; FUN

PDB

1XWW , 3N8I , 4Z99 , 4Z9A , 4Z9B , 5JNR , 5JNS , 5JNT , 5KQG , 5KQL , 5KQM , 5KQP , 5PNT , 6Y2V , 6Y2W , 7KH8 , 7UW6

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01451	LMWPc	9 → 154	Low molecular weight phosphotyrosine protein phosphatase	Domain

Tissue specificity

TISSUE SPECIFICITY: [Isoform 2]: Expressed in T-lymphocytes. {ECO:0000269|PubMed:9038134}.

Sequence

MAEQATKSVLFVCLGNICRSPIAEAVFRKLVTDQNISENWRVDSAATSGYEIGNPPDYRG
QSCMKRHGIPMSHVARQITKEDFATFDYILCMDESNLRDLNRKSNQVKTCKAKIELLGSY
DPQKQLIIEDPYYGNDSDFETVYQQCVRCCRAFLEKAH

Sequence length

158

Interactions

View interactions

	KEGG
	Thiamine metabolism Riboflavin metabolism Metabolic pathways Adherens junction Chemical carcinogenesis - reactive oxygen species

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (16)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ACP1 A/B POLYMORPHISM	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT DISORDER	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC ISCHEMIC HEART DISEASE	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CONDUCT DISORDER	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERIOSCLEROSIS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY HEART DISEASE	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS, INSULIN-DEPENDENT	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS, NON-INSULIN-DEPENDENT	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETIC RETINOPATHY	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LARGE ARTERY STROKE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL ISCHEMIA	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UNIPOLAR DEPRESSION	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

ACP1 (acid phosphatase 1)