Gene Gene information from NCBI Gene database.
Entrez ID 51768
Gene name Transmembrane 7 superfamily member 3
Gene symbol TM7SF3
Synonyms (NCBI Gene)
-
Chromosome 12
Chromosome location 12p11.23
miRNA miRNA information provided by mirtarbase database.
404
miRTarBase ID miRNA Experiments Reference
MIRT553624 hsa-miR-140-5p PAR-CLIP 21572407
MIRT553623 hsa-miR-107 PAR-CLIP 21572407
MIRT553622 hsa-miR-103a-3p PAR-CLIP 21572407
MIRT553621 hsa-miR-6838-5p PAR-CLIP 21572407
MIRT553620 hsa-miR-15a-5p PAR-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
9
GO ID Ontology Definition Evidence Reference
GO:0005886 Component Plasma membrane IBA
GO:0005886 Component Plasma membrane IDA 10828615
GO:0005886 Component Plasma membrane IEA
GO:0016020 Component Membrane IEA
GO:0032024 Process Positive regulation of insulin secretion IMP 21853325
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
605181 23049 ENSG00000064115
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9NS93
Protein name Transmembrane 7 superfamily member 3 (Seven span transmembrane protein)
Protein function Involved in the inhibition of cytokine-induced death of pancreatic beta cells. Involved in the promotion of insulin secretion from pancreatic beta cells (PubMed:21853325). Is a downstream transcriptional target of p53/TP53, and acts as a pro-sur
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13886 DUF4203 296 503 Domain of unknown function (DUF4203) Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed. Highly expressed in kidney and pancreas. {ECO:0000269|PubMed:10828615}.
Sequence
MGFLQLLVVAVLASEHRVAGAAEVFGNSSEGLIEFSVGKFRYFELNRPFPEEAILHDISS
NVTFLIFQIHSQYQNTTVSFSPTLLSNSSETGTASGLVFILRPEQSTCTWYLGTSGIQPV
QNMAILLSYSERDPVPGGCNLEFDLDIDPNIYLEYNFFETTIKFAPANLGYARGVDPPPC
DAGTDQDSRWRLQYDVYQYFLPENDLTEEMLLKHLQRMVSVPQVKASALKVVTLTANDKT
SVSFSSLPGQGVIYNVIVWDPFLNTSAAYIPAHTYACSFEAGEGSCASLGRVSSKVFFTL
FALLGFFICFFGHRFWKTELFFIGFIIMGFFFYILITRLTPIKYDVNLILTAVTGSVGGM
FLVAVWWRFGILSICMLCVGLVLGFLISSVTFFTPLGNLKIFHDDGVFWVTFSCIAILIP
VVFMGCLRILNILTCGVIGSYSVVLAIDSYWSTSLSYITLNVLKRALNKDFHRAFTNVPF
QTNDFIILAVWGMLAVSGITLQI
RRERGRPFFPPHPYKLWKQERERRVTNILDPSYHIPP
LRERLYGRLTQIKGLFQKEQPAGERTPLLL
Sequence length 570
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
HODGKINS LYMPHOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Developmental Disabilities Developmental disability Pubtator 37563198 Associate
★☆☆☆☆
Found in Text Mining only
Kallmann Syndrome Kallmann syndrome Pubtator 37563198 Associate
★☆☆☆☆
Found in Text Mining only