PDYN (prodynorphin)

Gene

• Entrez ID: 5173
• Gene name: Prodynorphin
• Gene symbol: PDYN
• Synonyms (NCBI Gene): ADCA, PENKB, SCA23
• Chromosome: 20
• Chromosome location: 20p13
• Summary: The protein encoded by this gene is a preproprotein that is proteolytically processed to form the secreted opioid peptides beta-neoendorphin, dynorphin, leu-enkephalin, rimorphin, and leumorphin. These peptides are ligands for the kappa-type of opioid rec

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT608780	hsa-miR-548av-3p	HITS-CLIP	24906430
MIRT608779	hsa-miR-93-3p	HITS-CLIP	24906430
MIRT608778	hsa-miR-6743-3p	HITS-CLIP	24906430
MIRT608777	hsa-miR-8075	HITS-CLIP	24906430
MIRT608776	hsa-miR-6882-3p	HITS-CLIP	24906430
MIRT1223948	hsa-miR-2110	CLIP-seq
MIRT1223949	hsa-miR-3151	CLIP-seq
MIRT1223950	hsa-miR-3202	CLIP-seq
MIRT1223951	hsa-miR-4265	CLIP-seq
MIRT1223952	hsa-miR-4271	CLIP-seq
MIRT1223953	hsa-miR-4296	CLIP-seq
MIRT1223954	hsa-miR-4322	CLIP-seq
MIRT1223955	hsa-miR-4447	CLIP-seq
MIRT1223956	hsa-miR-4472	CLIP-seq
MIRT1223957	hsa-miR-4475	CLIP-seq
MIRT1223958	hsa-miR-4725-3p	CLIP-seq
MIRT1223959	hsa-miR-4747-5p	CLIP-seq
MIRT1223960	hsa-miR-491-5p	CLIP-seq
MIRT1223961	hsa-miR-1976	CLIP-seq
MIRT1223962	hsa-miR-3690	CLIP-seq
MIRT1223963	hsa-miR-4254	CLIP-seq
MIRT1223964	hsa-miR-711	CLIP-seq
MIRT2065272	hsa-miR-1261	CLIP-seq
MIRT2065273	hsa-miR-3145-3p	CLIP-seq
MIRT2065274	hsa-miR-3201	CLIP-seq
MIRT2065275	hsa-miR-3684	CLIP-seq
MIRT2065276	hsa-miR-376a	CLIP-seq
MIRT2065277	hsa-miR-376b	CLIP-seq
MIRT2065278	hsa-miR-378g	CLIP-seq
MIRT2065279	hsa-miR-3913-3p	CLIP-seq
MIRT2065280	hsa-miR-3929	CLIP-seq
MIRT2065281	hsa-miR-4419b	CLIP-seq
MIRT2065282	hsa-miR-4478	CLIP-seq
MIRT2065283	hsa-miR-4505	CLIP-seq
MIRT2065284	hsa-miR-4520a-3p	CLIP-seq
MIRT2065285	hsa-miR-4520b-3p	CLIP-seq
MIRT2065286	hsa-miR-4529-3p	CLIP-seq
MIRT2065287	hsa-miR-4791	CLIP-seq
MIRT2065288	hsa-miR-4803	CLIP-seq
MIRT2065289	hsa-miR-532-3p	CLIP-seq
MIRT2065290	hsa-miR-539	CLIP-seq
MIRT2065291	hsa-miR-662	CLIP-seq
MIRT2065275	hsa-miR-3684	CLIP-seq
MIRT2065276	hsa-miR-376a	CLIP-seq
MIRT2065277	hsa-miR-376b	CLIP-seq
MIRT2065272	hsa-miR-1261	CLIP-seq
MIRT2065273	hsa-miR-3145-3p	CLIP-seq
MIRT2065274	hsa-miR-3201	CLIP-seq
MIRT2065278	hsa-miR-378g	CLIP-seq
MIRT2065280	hsa-miR-3929	CLIP-seq
MIRT2065281	hsa-miR-4419b	CLIP-seq
MIRT2065282	hsa-miR-4478	CLIP-seq
MIRT2065283	hsa-miR-4505	CLIP-seq
MIRT2065287	hsa-miR-4791	CLIP-seq
MIRT2456195	hsa-miR-197	CLIP-seq
MIRT2456196	hsa-miR-3977	CLIP-seq
MIRT2456197	hsa-miR-4277	CLIP-seq
MIRT2456198	hsa-miR-4522	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001515	Function	Opioid peptide activity	IEA
GO:0005515	Function	Protein binding	IPI	28514442, 33961781
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	9047294
GO:0007218	Process	Neuropeptide signaling pathway	IBA
GO:0007218	Process	Neuropeptide signaling pathway	IEA
GO:0007268	Process	Chemical synaptic transmission	IBA
GO:0007268	Process	Chemical synaptic transmission	IEA
GO:0007600	Process	Sensory perception	IBA
GO:0030425	Component	Dendrite	IBA
GO:0031628	Function	Opioid receptor binding	IBA
GO:0043025	Component	Neuronal cell body	IBA
GO:0043679	Component	Axon terminus	IBA
GO:0098686	Component	Hippocampal mossy fiber to CA3 synapse	IDA	10098940
GO:0098992	Component	Neuronal dense core vesicle	IDA	10098940

Other IDs

• MIM: 131340
• HGNC: 8820
• e!Ensembl: ENSG00000101327

Protein

• UniProt ID: P01213
• Protein name: Proenkephalin-B (Beta-neoendorphin-dynorphin) (Preprodynorphin) [Cleaved into: Alpha-neoendorphin; Beta-neoendorphin; Big dynorphin (Big Dyn); Dynorphin A(1-17) (Dyn-A17) (Dynorphin A); Dynorphin A(1-13); Dynorphin A(1-8); Leu-enkephalin; Rimorphin (Dynor
• Protein function: Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity). ; Dynorphin peptides differenti
• PDB: 2N2F, 7Y1F, 8F7W, 8VJU, 8VJV
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01160	Opiods_neuropep	21 → 67	Vertebrate endogenous opioids neuropeptide	Family

• Sequence:

  MAWQGLVLAACLLMFPSTTADCLSRCSLCAVKTQDGPKPINPLICSLQCQAALLPSEEWE
  RCQSFLSFFTPSTLGLNDKEDLGSKSVGEGPYSELAKLSGSFLKELEKSKFLPSISTKEN
  TLSKSLEEKLRGLSDGFREGAESELMRDAQLNDGAMETGTLYLAEEDPKEQVKRYGGFLR
  KYPKRSSEVAGEGDGDSMGHEDLYKRYGGFLRRIRPKLKWDNQKRYGGFLRRQFKVVTRS
  QEDPNAYSGELFDA

• Sequence length: 254

Pathways

KEGG:

Neuroactive ligand-receptor interaction
Hormone signaling
Spinocerebellar ataxia
Pathways of neurodegeneration - multiple diseases
Cocaine addiction
Amphetamine addiction
Alcoholism

Reactome:

Opioid Signalling
G-protein activation
Peptide ligand-binding receptors
G alpha (i) signalling events

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Spinocerebellar ataxia type 23	Pathogenic; Likely pathogenic	rs267606939, rs201486601	RCV000018095 RCV000018097	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
AMNESIA	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AMNESTIC DISORDER	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AMPHETAMINE OR RELATED ACTING SYMPATHOMIMETIC ABUSE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AMPHETAMINE-RELATED DISORDERS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Autosomal dominant cerebellar ataxia	Uncertain significance; Likely benign; Benign	ClinVar Disgenet	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
BIPOLAR DISORDER	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BRADYCARDIA	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cholangiocarcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHOLESTASIS	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEPRESSIVE DISORDER	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DYSKINESIA, DRUG-INDUCED	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DYSKINESIAS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DYSKINETIC SYNDROME	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EPILEPSY, TEMPORAL LOBE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERALGESIA	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERCAPNIA	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPOTENSION	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPOXIA	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSION, SINGLE EPISODE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MENTAL DEPRESSION	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MOOD DISORDERS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MOVEMENT DISORDERS	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PARKINSONIAN DISORDERS	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PDYN-related disorder	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PRURITUS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RECURRENT MAJOR DEPRESSIVE EPISODES	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SEIZURES	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SPINOCEREBELLAR ATAXIA 23	—	CTD, Disgenet, HPO CTD, Disgenet, HPO CTD, Disgenet, HPO	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UNIPOLAR DEPRESSION	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adenocarcinoma	Adenocarcinoma	BEFREE	28038711		★☆☆☆☆ Found in Text Mining only
Adrenal Gland Pheochromocytoma	Adrenal Gland Pheochromocytoma	BEFREE	3596003		★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	33878365	Associate	★☆☆☆☆ Found in Text Mining only
Amnesia	Amnesia	CTD_human_DG	7768285		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ataxia	Ataxia	Pubtator	21035104	Associate	★☆☆☆☆ Found in Text Mining only
Ataxia, Spinocerebellar	Spinocerebellar Ataxia	BEFREE	20437544, 23108490, 23471613		★☆☆☆☆ Found in Text Mining only
Ataxias, Hereditary	Ataxia	BEFREE	16149098		★☆☆☆☆ Found in Text Mining only
Autosomal Dominant Juvenile Parkinson Disease	Parkinson Disease	CTD_human_DG	9930741		★☆☆☆☆ Found in Text Mining only
Autosomal Dominant Parkinsonism	Parkinsonian disease	CTD_human_DG	9930741		★☆☆☆☆ Found in Text Mining only
Autosomal Recessive Parkinsonism	Parkinsonian disease	CTD_human_DG	9930741		★☆☆☆☆ Found in Text Mining only
Ballismus	Ballismus	CTD_human_DG	21984936		★☆☆☆☆ Found in Text Mining only
Bipolar Disorder	Bipolar Disorder	PSYGENET_DG	11576758, 11803449		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bipolar Disorder	Bipolar Disorder	BEFREE	28830794		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bipolar Disorder	Bipolar disorder	Pubtator	28830794	Inhibit	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Brain Diseases	Brain disease	Pubtator	25220237	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	21035104	Associate	★☆☆☆☆ Found in Text Mining only
Central nervous system demyelination	Central Nervous System Demyelination	HPO_DG			★☆☆☆☆ Found in Text Mining only
CEREBELLAR ATAXIA, DEAFNESS, AND NARCOLEPSY, AUTOSOMAL DOMINANT	Cerebellar Ataxia, Deafness And Narcolepsy	BEFREE	27869457		★☆☆☆☆ Found in Text Mining only
Cerebellar atrophy	Cerebellar atrophy	HPO_DG			★☆☆☆☆ Found in Text Mining only
Cerebellar Diseases	Cerebellar Diseases	BEFREE	10417284, 7576727		★☆☆☆☆ Found in Text Mining only
Cholestasis	Cholestasis	CTD_human_DG	16919318		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clonic Seizures	Clonic Seizures	CTD_human_DG	1675896		★☆☆☆☆ Found in Text Mining only
Complex partial seizures	Seizure	CTD_human_DG	1675896		★☆☆☆☆ Found in Text Mining only
Degenerative polyarthritis	Arthritis	BEFREE	18507845		★☆☆☆☆ Found in Text Mining only
Dementia	Dementia	BEFREE	19468819, 27869457		★☆☆☆☆ Found in Text Mining only
Dentatorubral-Pallidoluysian Atrophy	Dentatorubral Pallidoluysian Atrophy	BEFREE	7573040		★☆☆☆☆ Found in Text Mining only
Depressive disorder	Mental Depression	BEFREE	23101464, 24231353, 28968778		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Depressive disorder	Mental Depression	PSYGENET_DG	23101464, 23293139, 23904614, 24231353, 24816773		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Dermatitis, Atopic	Dermatitis	BEFREE	19486061		★☆☆☆☆ Found in Text Mining only
Down Syndrome	Down Syndrome	BEFREE	8834106		★☆☆☆☆ Found in Text Mining only
Dysarthria	Dysarthria	HPO_DG			★☆☆☆☆ Found in Text Mining only
Dyskinesia, Drug-Induced	Dyskinesia	CTD_human_DG	21737418, 9767399		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Dyskinetic syndrome	Dyskinetic Syndrome	BEFREE	14552886		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Dyskinetic syndrome	Dyskinetic Syndrome	LHGDN	14552886		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Dyskinetic syndrome	Dyskinetic Syndrome	CTD_human_DG	21984936		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Dysphoric mood	Mood Disorder	PSYGENET_DG	22443215, 26335648		★☆☆☆☆ Found in Text Mining only
Eczema	Eczema	BEFREE	19486061		★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	Pubtator	10646497, 19437412	Associate	★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	BEFREE	19437412		★☆☆☆☆ Found in Text Mining only
Epilepsy Temporal Lobe	Temporal lobe epilepsy	Pubtator	19437412	Associate	★☆☆☆☆ Found in Text Mining only
Epilepsy, Temporal Lobe	Epilepsy	BEFREE	11835385, 18334734, 18355961, 19066720, 19437412, 31486590		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Epilepsy, Temporal Lobe	Epilepsy	LHGDN	18334734, 18355961		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Epileptic drop attack	Hypotonic seizures	CTD_human_DG	1675896		★☆☆☆☆ Found in Text Mining only
Etat Marbre	Status marmoratus	CTD_human_DG	20298714		★☆☆☆☆ Found in Text Mining only
Familial Juvenile Parkinsonism	Parkinsonian disease	CTD_human_DG	9930741		★☆☆☆☆ Found in Text Mining only
Friedreich Ataxia	Friedreich Ataxia	BEFREE	9758299		★☆☆☆☆ Found in Text Mining only
Frontotemporal Dementia	Frontotemporal dementia	Pubtator	32576262	Associate	★☆☆☆☆ Found in Text Mining only
Generalized seizures	Seizure	CTD_human_DG	1675896		★☆☆☆☆ Found in Text Mining only
Hemiballismus	Hemiballismus	CTD_human_DG	21984936		★☆☆☆☆ Found in Text Mining only
Impaired cognition	Impaired Cognition	BEFREE	27869457		★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory Bowel Disease	BEFREE	30391790		★☆☆☆☆ Found in Text Mining only
Jacksonian Seizure	Jacksonian Seizure	CTD_human_DG	1675896		★☆☆☆☆ Found in Text Mining only
Lewy Body Disease	Lewy body disease	Pubtator	32552841	Associate	★☆☆☆☆ Found in Text Mining only
Lingual-Facial-Buccal Dyskinesia	Orofacial dyskinesia	CTD_human_DG	21984936		★☆☆☆☆ Found in Text Mining only
Machado-Joseph Disease	Machado-Joseph Disease	BEFREE	7573040		★☆☆☆☆ Found in Text Mining only
Major Depressive Disorder	Mental Depression	PSYGENET_DG	11576758, 11803449, 19116947, 24231353		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Major Depressive Disorder	Mental Depression	BEFREE	11803449, 24231353		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	25399950		★☆☆☆☆ Found in Text Mining only
Mental Depression	Mental Depression	BEFREE	23101464, 24231353, 28968778		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Mental Depression	Mental Depression	PSYGENET_DG	23101464, 23293139, 23904614, 24231353, 24816773		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Mental disorders	Mental Disorders	BEFREE	25220237, 29713172		★☆☆☆☆ Found in Text Mining only
Mood Disorders	Mood Disorder	BEFREE	10646497, 11576758, 11803449		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Mood Disorders	Mood Disorder	PSYGENET_DG	10646497, 11576758, 11803449, 22002579, 22698692		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Mood Disorders	Mood disorder	Pubtator	10646497	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Mood Disorders	Mood Disorder	LHGDN	11803449		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Movement Disorders	Movement Disorders	CTD_human_DG	20298714		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Narcolepsy	Narcolepsy	BEFREE	25033457		★☆☆☆☆ Found in Text Mining only
nervous system disorder	Nervous System Disorder	BEFREE	10417284		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	11094064, 12676525, 1681570, 21106935, 25220237, 9819380		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	Pubtator	11094064	Associate	★☆☆☆☆ Found in Text Mining only
Neurodegenerative Diseases	Neurodegenerative disorder	Pubtator	21035104	Associate	★☆☆☆☆ Found in Text Mining only
Neurodegenerative Disorders	Neurodegenerative Disorders	BEFREE	21035104, 22531488, 7573040		★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	28038711		★☆☆☆☆ Found in Text Mining only
Oral Dyskinesia	Oral Dyskinesia	CTD_human_DG	21984936		★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	BEFREE	14552886, 17203488, 21737418		★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	LHGDN	14552886		★☆☆☆☆ Found in Text Mining only
PARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE	Parkinson Disease	CTD_human_DG	9930741		★☆☆☆☆ Found in Text Mining only
Parkinsonian Disorders	Parkinson Disease	CTD_human_DG	9930741		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Parkinsonism, Juvenile	Parkinsonian disease	CTD_human_DG	9930741		★☆☆☆☆ Found in Text Mining only
Pheochromocytoma	Pheochromocytoma	BEFREE	3596003		★☆☆☆☆ Found in Text Mining only
Polyneuropathy	Polyneuropathy	HPO_DG			★☆☆☆☆ Found in Text Mining only
Presenile dementia	Senile Dementia	BEFREE	19468819, 27869457		★☆☆☆☆ Found in Text Mining only
Progressive cerebellar ataxia	Cerebellar Ataxia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Ramsay Hunt Paralysis Syndrome	Ramsay Hunt Paralysis Syndrome	CTD_human_DG	9930741		★☆☆☆☆ Found in Text Mining only
Respiration Disorders	Respiration Disorders	CTD_human_DG	6131355		★☆☆☆☆ Found in Text Mining only
Respiratory Failure	Respiratory Failure	CTD_human_DG	6662192		★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	11576758, 12207142, 15301734		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	PSYGENET_DG	11576758, 12207142, 15301734		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sensation Disorders	Sensation Disorders	CTD_human_DG	19200067		★☆☆☆☆ Found in Text Mining only
Sensorimotor neuropathy	Sensorimotor neuropathy	HPO_DG			★☆☆☆☆ Found in Text Mining only
Sensory Disorders	Sensory Disorders	CTD_human_DG	19200067		★☆☆☆☆ Found in Text Mining only
Single Seizure	Seizure	CTD_human_DG	1675896		★☆☆☆☆ Found in Text Mining only
Small cell carcinoma of lung	Lung carcinoma	BEFREE	1681570, 7488056		★☆☆☆☆ Found in Text Mining only
Spinocerebellar Ataxia 11	Spinocerebellar ataxia	Pubtator	19089525	Associate	★☆☆☆☆ Found in Text Mining only
Spinocerebellar ataxia 23	Spinocerebellar ataxia	Pubtator	19089525, 21035104	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SPINOCEREBELLAR ATAXIA 23	Spinocerebellar Ataxia	BEFREE	21035104, 22531488, 23108490, 23471613		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SPINOCEREBELLAR ATAXIA 23	Spinocerebellar Ataxia	GENOMICS_ENGLAND_DG	21035104		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SPINOCEREBELLAR ATAXIA 23	Spinocerebellar Ataxia	UNIPROT_DG	21035104, 21712028, 23108490, 23471613		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SPINOCEREBELLAR ATAXIA 23	Spinocerebellar Ataxia	ORPHANET_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SPINOCEREBELLAR ATAXIA 23	Spinocerebellar Ataxia	CLINVAR_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SPINOCEREBELLAR ATAXIA 23	Spinocerebellar Ataxia	CTD_human_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SPINOCEREBELLAR ATAXIA 31 (disorder)	Spinocerebellar Ataxia	BEFREE	22287014		★☆☆☆☆ Found in Text Mining only
SPINOCEREBELLAR ATAXIA 8	Spinocerebellar Ataxia	BEFREE	10690991		★☆☆☆☆ Found in Text Mining only
Spinocerebellar Ataxia Type 1	Spinocerebellar Ataxia	BEFREE	10525976, 8931575, 9448569		★☆☆☆☆ Found in Text Mining only
Spinocerebellar ataxia type 23	Spinocerebellar Ataxia	Orphanet			★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Spinocerebellar Ataxia Type 6 (disorder)	Spinocerebellar Ataxia	BEFREE	18855094, 20181362, 9559993, 9600677		★☆☆☆☆ Found in Text Mining only
Spinocerebellar Ataxia Type 7	Spinocerebellar Ataxia	BEFREE	8940279		★☆☆☆☆ Found in Text Mining only
SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 23	Spinocerebellar Ataxia	BEFREE	31410782		★☆☆☆☆ Found in Text Mining only
Spinocerebellar Degeneration	Spinocerebellar Degeneration	BEFREE	9758299		★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	BEFREE	20206445		★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	25399950		★☆☆☆☆ Found in Text Mining only
Tonic - clonic seizures	Seizure	CTD_human_DG	1675896		★☆☆☆☆ Found in Text Mining only
Unipolar Depression	Mental Depression	PSYGENET_DG	11576758, 11803449, 19116947, 24231353		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Unipolar Depression	Mental Depression	BEFREE	11803449		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Visual seizure	Seizure	CTD_human_DG	1675896		★☆☆☆☆ Found in Text Mining only