Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	51729
Gene name	WW domain binding protein 11
Gene symbol	WBP11
Synonyms (NCBI Gene)	BUG13CFAP90FAP90NPWBPPPP1R165SIPP1VCTERLVCTRLWBP-11
Chromosome	12
Chromosome location	12p12.3
Summary	This gene encodes a nuclear protein, which colocalizes with mRNA splicing factors and intermediate filament-containing perinuclear networks. This protein has 95% amino acid sequence identity to the mouse Wbp11 protein. It contains two proline-rich regions

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Show/Hide all (170)

miRTarBase ID	miRNA	Experiments	Reference
MIRT025244	hsa-miR-34a-5p	Proteomics	21566225
MIRT025244	hsa-miR-34a-5p	Proteomics	21566225
MIRT027410	hsa-miR-98-5p	Microarray	19088304
MIRT031437	hsa-miR-16-5p	Proteomics	18668040
MIRT052331	hsa-let-7b-5p	CLASH	23622248
MIRT051869	hsa-let-7c-5p	CLASH	23622248
MIRT037321	hsa-miR-877-5p	CLASH	23622248
MIRT571577	hsa-miR-496	PAR-CLIP	20371350
MIRT571576	hsa-miR-4496	PAR-CLIP	20371350
MIRT571575	hsa-miR-4722-3p	PAR-CLIP	20371350
MIRT571574	hsa-miR-6727-3p	PAR-CLIP	20371350
MIRT571573	hsa-miR-6747-3p	PAR-CLIP	20371350
MIRT571572	hsa-miR-643	PAR-CLIP	20371350
MIRT571571	hsa-miR-4312	PAR-CLIP	20371350
MIRT571569	hsa-miR-5093	PAR-CLIP	20371350
MIRT571570	hsa-miR-188-3p	PAR-CLIP	20371350
MIRT574383	hsa-miR-1260a	PAR-CLIP	20371350
MIRT574382	hsa-miR-1260b	PAR-CLIP	20371350
MIRT574381	hsa-miR-3156-3p	PAR-CLIP	20371350
MIRT571577	hsa-miR-496	PAR-CLIP	20371350
MIRT571576	hsa-miR-4496	PAR-CLIP	20371350
MIRT571575	hsa-miR-4722-3p	PAR-CLIP	20371350
MIRT571574	hsa-miR-6727-3p	PAR-CLIP	20371350
MIRT571573	hsa-miR-6747-3p	PAR-CLIP	20371350
MIRT571572	hsa-miR-643	PAR-CLIP	20371350
MIRT571571	hsa-miR-4312	PAR-CLIP	20371350
MIRT571569	hsa-miR-5093	PAR-CLIP	20371350
MIRT571570	hsa-miR-188-3p	PAR-CLIP	20371350
MIRT571577	hsa-miR-496	PAR-CLIP	20371350
MIRT571576	hsa-miR-4496	PAR-CLIP	20371350
MIRT571575	hsa-miR-4722-3p	PAR-CLIP	20371350
MIRT571574	hsa-miR-6727-3p	PAR-CLIP	20371350
MIRT571573	hsa-miR-6747-3p	PAR-CLIP	20371350
MIRT571572	hsa-miR-643	PAR-CLIP	20371350
MIRT571571	hsa-miR-4312	PAR-CLIP	20371350
MIRT571569	hsa-miR-5093	PAR-CLIP	20371350
MIRT571570	hsa-miR-188-3p	PAR-CLIP	20371350
MIRT574383	hsa-miR-1260a	PAR-CLIP	20371350
MIRT574382	hsa-miR-1260b	PAR-CLIP	20371350
MIRT574381	hsa-miR-3156-3p	PAR-CLIP	20371350
MIRT571577	hsa-miR-496	PAR-CLIP	20371350
MIRT571576	hsa-miR-4496	PAR-CLIP	20371350
MIRT571575	hsa-miR-4722-3p	PAR-CLIP	20371350
MIRT571574	hsa-miR-6727-3p	PAR-CLIP	20371350
MIRT571573	hsa-miR-6747-3p	PAR-CLIP	20371350
MIRT571572	hsa-miR-643	PAR-CLIP	20371350
MIRT571571	hsa-miR-4312	PAR-CLIP	20371350
MIRT571569	hsa-miR-5093	PAR-CLIP	20371350
MIRT571570	hsa-miR-188-3p	PAR-CLIP	20371350
MIRT1489071	hsa-miR-10a	CLIP-seq
MIRT1489072	hsa-miR-10b	CLIP-seq
MIRT1489073	hsa-miR-1255a	CLIP-seq
MIRT1489074	hsa-miR-1255b	CLIP-seq
MIRT1489075	hsa-miR-1260	CLIP-seq
MIRT1489076	hsa-miR-1299	CLIP-seq
MIRT1489077	hsa-miR-31	CLIP-seq
MIRT1489078	hsa-miR-3153	CLIP-seq
MIRT1489079	hsa-miR-3545-3p	CLIP-seq
MIRT1489080	hsa-miR-3671	CLIP-seq
MIRT1489081	hsa-miR-3944-5p	CLIP-seq
MIRT1489082	hsa-miR-452	CLIP-seq
MIRT1489083	hsa-miR-4539	CLIP-seq
MIRT1489084	hsa-miR-455-5p	CLIP-seq
MIRT1489085	hsa-miR-4660	CLIP-seq
MIRT1489086	hsa-miR-4668-5p	CLIP-seq
MIRT1489087	hsa-miR-4676-3p	CLIP-seq
MIRT1489088	hsa-miR-4697-3p	CLIP-seq
MIRT1489089	hsa-miR-4732-3p	CLIP-seq
MIRT1489090	hsa-miR-4766-5p	CLIP-seq
MIRT1489091	hsa-miR-4775	CLIP-seq
MIRT1489092	hsa-miR-4778-5p	CLIP-seq
MIRT1489093	hsa-miR-4782-5p	CLIP-seq
MIRT1489094	hsa-miR-502-5p	CLIP-seq
MIRT1489095	hsa-miR-516b	CLIP-seq
MIRT1489096	hsa-miR-548an	CLIP-seq
MIRT1489097	hsa-miR-548g	CLIP-seq
MIRT1489098	hsa-miR-561	CLIP-seq
MIRT1489099	hsa-miR-590-3p	CLIP-seq
MIRT1489100	hsa-miR-646	CLIP-seq
MIRT1489101	hsa-miR-671-5p	CLIP-seq
MIRT2147354	hsa-miR-15a	CLIP-seq
MIRT2147355	hsa-miR-15b	CLIP-seq
MIRT2147356	hsa-miR-16	CLIP-seq
MIRT2147357	hsa-miR-195	CLIP-seq
MIRT2147358	hsa-miR-3128	CLIP-seq
MIRT2147359	hsa-miR-323-5p	CLIP-seq
MIRT2147360	hsa-miR-3647-3p	CLIP-seq
MIRT2147361	hsa-miR-3925-3p	CLIP-seq
MIRT1489081	hsa-miR-3944-5p	CLIP-seq
MIRT2147362	hsa-miR-3977	CLIP-seq
MIRT2147363	hsa-miR-424	CLIP-seq
MIRT2147364	hsa-miR-4271	CLIP-seq
MIRT1489082	hsa-miR-452	CLIP-seq
MIRT2147365	hsa-miR-4524	CLIP-seq
MIRT1489084	hsa-miR-455-5p	CLIP-seq
MIRT2147366	hsa-miR-4642	CLIP-seq
MIRT1489087	hsa-miR-4676-3p	CLIP-seq
MIRT2147367	hsa-miR-4720-5p	CLIP-seq
MIRT2147368	hsa-miR-4725-3p	CLIP-seq
MIRT2147369	hsa-miR-4764-5p	CLIP-seq
MIRT2147370	hsa-miR-4779	CLIP-seq
MIRT2147371	hsa-miR-4799-3p	CLIP-seq
MIRT2147372	hsa-miR-488	CLIP-seq
MIRT2147373	hsa-miR-497	CLIP-seq
MIRT2147374	hsa-miR-503	CLIP-seq
MIRT2147375	hsa-miR-515-5p	CLIP-seq
MIRT2147376	hsa-miR-522	CLIP-seq
MIRT1489099	hsa-miR-590-3p	CLIP-seq
MIRT1489100	hsa-miR-646	CLIP-seq
MIRT2147377	hsa-miR-765	CLIP-seq
MIRT2147378	hsa-miR-766	CLIP-seq
MIRT2147379	hsa-miR-876-3p	CLIP-seq
MIRT1489075	hsa-miR-1260	CLIP-seq
MIRT2147354	hsa-miR-15a	CLIP-seq
MIRT2147355	hsa-miR-15b	CLIP-seq
MIRT2147356	hsa-miR-16	CLIP-seq
MIRT2147357	hsa-miR-195	CLIP-seq
MIRT2367769	hsa-miR-3133	CLIP-seq
MIRT2367770	hsa-miR-3611	CLIP-seq
MIRT1489081	hsa-miR-3944-5p	CLIP-seq
MIRT2147362	hsa-miR-3977	CLIP-seq
MIRT2147363	hsa-miR-424	CLIP-seq
MIRT2147364	hsa-miR-4271	CLIP-seq
MIRT2367771	hsa-miR-4511	CLIP-seq
MIRT2147365	hsa-miR-4524	CLIP-seq
MIRT1489084	hsa-miR-455-5p	CLIP-seq
MIRT2147368	hsa-miR-4725-3p	CLIP-seq
MIRT2147369	hsa-miR-4764-5p	CLIP-seq
MIRT1489092	hsa-miR-4778-5p	CLIP-seq
MIRT2147370	hsa-miR-4779	CLIP-seq
MIRT2147373	hsa-miR-497	CLIP-seq
MIRT2147374	hsa-miR-503	CLIP-seq
MIRT1489100	hsa-miR-646	CLIP-seq
MIRT2147377	hsa-miR-765	CLIP-seq
MIRT1489085	hsa-miR-4660	CLIP-seq
MIRT1489100	hsa-miR-646	CLIP-seq
MIRT1489101	hsa-miR-671-5p	CLIP-seq
MIRT2661309	hsa-miR-1208	CLIP-seq
MIRT2661310	hsa-miR-136	CLIP-seq
MIRT2147358	hsa-miR-3128	CLIP-seq
MIRT2661311	hsa-miR-320a	CLIP-seq
MIRT2661312	hsa-miR-320b	CLIP-seq
MIRT2661313	hsa-miR-320c	CLIP-seq
MIRT2661314	hsa-miR-320d	CLIP-seq
MIRT2367770	hsa-miR-3611	CLIP-seq
MIRT2661315	hsa-miR-4252	CLIP-seq
MIRT2661316	hsa-miR-4429	CLIP-seq
MIRT2661317	hsa-miR-4640-5p	CLIP-seq
MIRT2147366	hsa-miR-4642	CLIP-seq
MIRT1489085	hsa-miR-4660	CLIP-seq
MIRT2147367	hsa-miR-4720-5p	CLIP-seq
MIRT2661318	hsa-miR-4726-5p	CLIP-seq
MIRT2147371	hsa-miR-4799-3p	CLIP-seq
MIRT2147375	hsa-miR-515-5p	CLIP-seq
MIRT1489100	hsa-miR-646	CLIP-seq
MIRT1489101	hsa-miR-671-5p	CLIP-seq
MIRT2661309	hsa-miR-1208	CLIP-seq
MIRT2661310	hsa-miR-136	CLIP-seq
MIRT2147358	hsa-miR-3128	CLIP-seq
MIRT2367770	hsa-miR-3611	CLIP-seq
MIRT2661315	hsa-miR-4252	CLIP-seq
MIRT2661317	hsa-miR-4640-5p	CLIP-seq
MIRT2147366	hsa-miR-4642	CLIP-seq
MIRT1489085	hsa-miR-4660	CLIP-seq
MIRT2147367	hsa-miR-4720-5p	CLIP-seq
MIRT2661318	hsa-miR-4726-5p	CLIP-seq
MIRT2147371	hsa-miR-4799-3p	CLIP-seq
MIRT2147375	hsa-miR-515-5p	CLIP-seq
MIRT1489100	hsa-miR-646	CLIP-seq
MIRT1489101	hsa-miR-671-5p	CLIP-seq

Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003697	Function	Single-stranded DNA binding	TAS	10593949
GO:0003723	Function	RNA binding	HDA	22681889
GO:0005515	Function	Protein binding	IPI	16000308, 16189514, 16713569, 21988832, 22321011, 22365833, 24136289, 25416956, 27173435, 27314904, 28514442, 32296183, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	10593949
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0006364	Process	RRNA processing	IEA
GO:0006396	Process	RNA processing	IEA
GO:0006397	Process	MRNA processing	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0050699	Function	WW domain binding	IPI	19592703

MIM	HGNC	e!Ensembl
618083	16461	ENSG00000084463

Q9Y2W2

Protein name

WW domain-binding protein 11 (WBP-11) (Npw38-binding protein) (NpwBP) (SH3 domain-binding protein SNP70) (Splicing factor that interacts with PQBP-1 and PP1)

Protein function

Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity.

PDB

7ABF , 7ABG

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF09429	Wbp11	12 → 94	WW domain binding protein 11	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. Highly expressed in the heart, pancreas, kidney skeletal muscle, placenta and brain (at protein level). Weakly expressed in liver and lung. {ECO:0000269|PubMed:11375989}.

Sequence

MGRRSTSSTKSGKFMNPTDQARKEARKRELKKNKKQRMMVRAAVLKMKDPKQIIRDMEKL
DEMEFNPVQQPQLNEKVLKDKRKKLRETFERILRLYEKENPDIYKELRKLEVEYEQKRAQ
LSQYFDAVKNAQHVEVESIPLPDMPHAPSNILIQDIPLPGAQPPSILKKTSAYGPPTRAV
SILPLLGHGVPRLPPGRKPPGPPPGPPPPQVVQMYGRKVGFALDLPPRRRDEDMLYSPEL
AQRGHDDDVSSTSEDDGYPEDMDQDKHDDSTDDSDTDKSDGESDGDEFVHRDNGERDNNE
EKKSGLSVRFADMPGKSRKKKKNMKELTPLQAMMLRMAGQEIPEEGREVEEFSEDDDEDD
SDDSEAEKQSQKQHKEESHSDGTSTASSQQQAPPQSVPPSQIQAPPMPGPPPLGPPPAPP
LRPPGPPTGLPPGPPPGAPPFLRPPGMPGLRGPLPRLLPPGPPPGRPPGPPPGPPPGLPP
GPPPRGPPPRLPPPAPPGIPPPRPGMMRPPLVPPLGPAPPGLFPPAPLPNPGVLSAPPNL
IQRPKADDTSAATIEKKATATISAKPQITNPKAEITRFVPTALRVRRENKGATAAPQRKS
EDDSAVPLAKAAPKSGPSVPVSVQTKDDVYEAFMKEMEGLL

Sequence length

641

Interactions

View interactions

	KEGG		Reactome
	Spliceosome		mRNA Splicing - Major Pathway

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Vertebral, cardiac, tracheoesophageal, renal, and limb defects	Likely pathogenic; Pathogenic	rs2137238267, rs2498037109, rs2498067242, rs767139774, rs1949866551, rs1949868116, rs1949900423	RCV001754553 RCV003332931 RCV003388640 RCV003339526 RCV001312230 RCV001312231 RCV001312232 View all (2 more)	★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
WBP11 spliceosomopathy	Pathogenic; Likely pathogenic	rs767139774, rs1949866551, rs1949868116, rs1949874442, rs1949900423	RCV001199832 RCV001199833 RCV001199834 RCV001199831 RCV001199830	★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
WBP11-related disorder	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (8)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	34309201	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital Abnormalities	Congenital abnormalities	Pubtator	40089178	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Growth Disorders	Growth disorder	Pubtator	31874114	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	30626935		★★★★★ ★☆☆☆☆ Found in Text Mining only
Microcephaly	Microcephaly	Pubtator	31874114	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Spondylocostal dysostosis autosomal recessive	Spondylocostal dysostosis	Pubtator	40089178	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	30626935		★★★★★ ★☆☆☆☆ Found in Text Mining only
VACTERL association	Vacterl association	Pubtator	40089178	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

WBP11 (WW domain binding protein 11)