Gene Gene information from NCBI Gene database.
Entrez ID 51696
Gene name Hdc homolog, cell cycle regulator
Gene symbol HECA
Synonyms (NCBI Gene)
HDCHDCLHHDCdJ225E12.1
Chromosome 6
Chromosome location 6q24.1
Summary This gene encodes the homolog of the Drosophila headcase protein, a highly basic, cytoplasmic protein that regulates the re-entry of imaginal cells into the mitotic cycle during adult morphogenesis. In Drosophila, the encoded protein also inhibits termina
miRNA miRNA information provided by mirtarbase database.
427
miRTarBase ID miRNA Experiments Reference
MIRT029329 hsa-miR-26b-5p Microarray 19088304
MIRT523318 hsa-miR-485-5p PAR-CLIP 23446348
MIRT523316 hsa-miR-6884-5p PAR-CLIP 23446348
MIRT523317 hsa-miR-4505 PAR-CLIP 23446348
MIRT523315 hsa-miR-5787 PAR-CLIP 23446348
Transcription factors Transcription factors information provided by TRRUST V2 database.
2
Transcription factor Regulation Reference
TCF4 Repression 22100912
TCF7L2 Repression 22100912
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
6
GO ID Ontology Definition Evidence Reference
GO:0005634 Component Nucleus IDA 19643820, 22100912
GO:0005737 Component Cytoplasm IDA 19643820
GO:0016020 Component Membrane HDA 19946888
GO:0030323 Process Respiratory tube development NAS 11696983
GO:0045930 Process Negative regulation of mitotic cell cycle IDA 19643820
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
607977 21041 ENSG00000112406
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9UBI9
Protein name Headcase protein homolog (hHDC)
Protein function May play an important role in some human cancers. May be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system and lungs.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15353 HECA 93 191 Headcase protein family homologue Family
PF16002 Headcase 335 534 Headcase protein Family
Tissue specificity TISSUE SPECIFICITY: Expressed in all tissues examined. Highest levels are in the spleen, thymus, peripheral blood and heart. Lowest in the kidney and pancreas. {ECO:0000269|PubMed:11696983}.
Sequence
MPNPKNSKGGRKNKRANSSGDEQENGAGALAAAGAAGAAAGGALAAAAGCGAAAAGAPGA
GGAAGAGGAGTGAANAAAAAGAAAAGDAKNEAPCATPLICSFGRPVDLEKDDYQKVVCNN
EHCPCSTWMHLQCFYEWESSILVQFNCIGRARSWNEKQCRQNMWTKKGYDLAFRFCSCRC
GQGHLKKDTDW
YQVKRMQDEKKKKSGSEKNTGRPPGEAAEEAKKCRPPNKPQKGPSHDLP
RRHSMDRQNSQEKAVGAAAYGARSPGGSPGQSPPTGYSILSPAHFSGPRSSRYLGEFLKN
AIHLEPHKKAMAGGHVFRNAHFDYSPAGLAVHRGGHFDTPVQFLRRLDLSELLTHIPRHK
LNTFHVRMEDDAQVGQGEDLRKFILAALSASHRNVVNCALCHRALPVFEQFPLVDGTLFL
SPSRHDEIEYDVPCHLQGRLMHLYAVCVDCLEGVHKIICIKCKSRWDGSWHQLGTMYTYD
ILAASPCCQARLNCKHCGKPVIDVRIGMQYFSEYSNVQQCPHCGNLDYHFVKPF
SSFKVL
EAY
Sequence length 543
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CORONARY ARTERY DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
OBSESSIVE-COMPULSIVE DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma Uncertain significance ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute leukemia Leukemia BEFREE 29883599
★☆☆☆☆
Found in Text Mining only
Acute lymphocytic leukemia Lymphocytic Leukemia BEFREE 8636717
★☆☆☆☆
Found in Text Mining only
Agenesis of corpus callosum Agenesis Of Corpus Callosum BEFREE 19568768
★☆☆☆☆
Found in Text Mining only
Allergic rhinitis (disorder) Allergic rhinitis BEFREE 20608921
★☆☆☆☆
Found in Text Mining only
Anxiety Disorders Anxiety disorder Pubtator 36292569 Associate
★☆☆☆☆
Found in Text Mining only
Aplasia Cutis Congenita Aplasia Cutis Congenita BEFREE 19568768
★☆☆☆☆
Found in Text Mining only
Arteriosclerosis Arteriosclerosis BEFREE 28600950
★☆☆☆☆
Found in Text Mining only
Asthma Asthma Pubtator 32460303, 33878997, 37271320 Associate
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Atherosclerosis BEFREE 28600950
★☆☆☆☆
Found in Text Mining only
Attention deficit hyperactivity disorder Attention Deficit Hyperactivity Disorder HPO_DG
★☆☆☆☆
Found in Text Mining only