ASB1 (ankyrin repeat and SOCS box containing 1)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 51665 |
| Gene name | Ankyrin repeat and SOCS box containing 1 |
| Gene symbol | ASB1 |
| Synonyms (NCBI Gene) |
ASB-1
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| Chromosome | 2 |
| Chromosome location | 2q37.3 |
| Summary | The protein encoded by this gene contains an ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, targeting them for ubiqu |
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miRNA
miRNA information provided by mirtarbase database.
631
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
14
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q9Y576 | ||||||||||||||||||||
| Protein name | Ankyrin repeat and SOCS box protein 1 (ASB-1) | ||||||||||||||||||||
| Protein function | Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:16325183). Mediates Notch-induced | ||||||||||||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 335 | ||||||||||||||||||||
| Interactions | View interactions | ||||||||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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