YPEL5 (yippee like 5)

Gene

• Entrez ID: 51646
• Gene name: Yippee like 5
• Gene symbol: YPEL5
• Synonyms (NCBI Gene): CGI-127
• Chromosome: 2
• Chromosome location: 2p23.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016964	hsa-miR-335-5p	Microarray	18185580
MIRT1499534	hsa-miR-1246	CLIP-seq
MIRT1499535	hsa-miR-1290	CLIP-seq
MIRT1499536	hsa-miR-3134	CLIP-seq
MIRT1499537	hsa-miR-3167	CLIP-seq
MIRT1499538	hsa-miR-4426	CLIP-seq
MIRT1499539	hsa-miR-4647	CLIP-seq
MIRT1499540	hsa-miR-4662b	CLIP-seq
MIRT1499541	hsa-miR-4696	CLIP-seq
MIRT1499542	hsa-miR-4742-3p	CLIP-seq
MIRT1499543	hsa-miR-4768-5p	CLIP-seq
MIRT1499544	hsa-miR-876-5p	CLIP-seq
MIRT1499545	hsa-miR-1253	CLIP-seq
MIRT1499546	hsa-miR-139-5p	CLIP-seq
MIRT1499547	hsa-miR-183	CLIP-seq
MIRT1499548	hsa-miR-3160-3p	CLIP-seq
MIRT1499549	hsa-miR-3591-3p	CLIP-seq
MIRT1499550	hsa-miR-3613-3p	CLIP-seq
MIRT1499551	hsa-miR-3907	CLIP-seq
MIRT1499552	hsa-miR-4251	CLIP-seq
MIRT1499553	hsa-miR-4260	CLIP-seq
MIRT1499554	hsa-miR-4283	CLIP-seq
MIRT1499555	hsa-miR-4299	CLIP-seq
MIRT1499556	hsa-miR-4303	CLIP-seq
MIRT1499557	hsa-miR-4329	CLIP-seq
MIRT1499558	hsa-miR-4437	CLIP-seq
MIRT1499559	hsa-miR-4456	CLIP-seq
MIRT1499560	hsa-miR-4489	CLIP-seq
MIRT1499561	hsa-miR-4674	CLIP-seq
MIRT1499562	hsa-miR-4733-3p	CLIP-seq
MIRT1499563	hsa-miR-499a-5p	CLIP-seq
MIRT1499564	hsa-miR-515-5p	CLIP-seq
MIRT1499565	hsa-miR-548c-3p	CLIP-seq
MIRT1499566	hsa-miR-548q	CLIP-seq
MIRT1499567	hsa-miR-760	CLIP-seq
MIRT2150416	hsa-miR-141	CLIP-seq
MIRT2150417	hsa-miR-200a	CLIP-seq
MIRT2150418	hsa-miR-542-3p	CLIP-seq
MIRT2370929	hsa-miR-4277	CLIP-seq
MIRT2370930	hsa-miR-489	CLIP-seq
MIRT2370931	hsa-miR-513b	CLIP-seq
MIRT2664399	hsa-miR-105	CLIP-seq
MIRT2664400	hsa-miR-1193	CLIP-seq
MIRT2664401	hsa-miR-1229	CLIP-seq
MIRT2664402	hsa-miR-1236	CLIP-seq
MIRT2664403	hsa-miR-124	CLIP-seq
MIRT1499534	hsa-miR-1246	CLIP-seq
MIRT2664404	hsa-miR-127-3p	CLIP-seq
MIRT2664405	hsa-miR-127-5p	CLIP-seq
MIRT2664406	hsa-miR-1285	CLIP-seq
MIRT1499535	hsa-miR-1290	CLIP-seq
MIRT2664407	hsa-miR-1298	CLIP-seq
MIRT2150416	hsa-miR-141	CLIP-seq
MIRT2664408	hsa-miR-1827	CLIP-seq
MIRT1499547	hsa-miR-183	CLIP-seq
MIRT2150417	hsa-miR-200a	CLIP-seq
MIRT2664409	hsa-miR-2277-3p	CLIP-seq
MIRT2664410	hsa-miR-297	CLIP-seq
MIRT2664411	hsa-miR-30a	CLIP-seq
MIRT2664412	hsa-miR-30b	CLIP-seq
MIRT2664413	hsa-miR-30c	CLIP-seq
MIRT2664414	hsa-miR-30d	CLIP-seq
MIRT2664415	hsa-miR-30e	CLIP-seq
MIRT2664416	hsa-miR-3120-3p	CLIP-seq
MIRT1499536	hsa-miR-3134	CLIP-seq
MIRT2664417	hsa-miR-3143	CLIP-seq
MIRT2664418	hsa-miR-3148	CLIP-seq
MIRT2664419	hsa-miR-3153	CLIP-seq
MIRT1499537	hsa-miR-3167	CLIP-seq
MIRT2664420	hsa-miR-3187-5p	CLIP-seq
MIRT2664421	hsa-miR-329	CLIP-seq
MIRT2664422	hsa-miR-337-5p	CLIP-seq
MIRT2664423	hsa-miR-342-3p	CLIP-seq
MIRT2664424	hsa-miR-362-3p	CLIP-seq
MIRT2664425	hsa-miR-3646	CLIP-seq
MIRT2664426	hsa-miR-3661	CLIP-seq
MIRT2664427	hsa-miR-3662	CLIP-seq
MIRT2664428	hsa-miR-3671	CLIP-seq
MIRT2664429	hsa-miR-3688-3p	CLIP-seq
MIRT2664430	hsa-miR-3714	CLIP-seq
MIRT2664431	hsa-miR-380	CLIP-seq
MIRT1499551	hsa-miR-3907	CLIP-seq
MIRT2664432	hsa-miR-3910	CLIP-seq
MIRT2664433	hsa-miR-3913-3p	CLIP-seq
MIRT2664434	hsa-miR-3921	CLIP-seq
MIRT2664435	hsa-miR-3941	CLIP-seq
MIRT2664436	hsa-miR-4263	CLIP-seq
MIRT2664437	hsa-miR-4276	CLIP-seq
MIRT2664438	hsa-miR-4282	CLIP-seq
MIRT1499555	hsa-miR-4299	CLIP-seq
MIRT2664439	hsa-miR-4305	CLIP-seq
MIRT1499538	hsa-miR-4426	CLIP-seq
MIRT1499558	hsa-miR-4437	CLIP-seq
MIRT1499559	hsa-miR-4456	CLIP-seq
MIRT2664440	hsa-miR-4473	CLIP-seq
MIRT2664441	hsa-miR-4485	CLIP-seq
MIRT2664442	hsa-miR-4495	CLIP-seq
MIRT2664443	hsa-miR-452	CLIP-seq
MIRT2664444	hsa-miR-4522	CLIP-seq
MIRT2664445	hsa-miR-4645-3p	CLIP-seq
MIRT2664446	hsa-miR-4646-5p	CLIP-seq
MIRT1499539	hsa-miR-4647	CLIP-seq
MIRT2664447	hsa-miR-4652-3p	CLIP-seq
MIRT2664448	hsa-miR-4653-5p	CLIP-seq
MIRT2664449	hsa-miR-4662a-5p	CLIP-seq
MIRT1499540	hsa-miR-4662b	CLIP-seq
MIRT2664450	hsa-miR-4668-5p	CLIP-seq
MIRT1499561	hsa-miR-4674	CLIP-seq
MIRT2664451	hsa-miR-4676-3p	CLIP-seq
MIRT2664452	hsa-miR-4684-5p	CLIP-seq
MIRT2664453	hsa-miR-4718	CLIP-seq
MIRT2664454	hsa-miR-4729	CLIP-seq
MIRT1499542	hsa-miR-4742-3p	CLIP-seq
MIRT2664455	hsa-miR-4760-5p	CLIP-seq
MIRT1499543	hsa-miR-4768-5p	CLIP-seq
MIRT2664456	hsa-miR-4777-5p	CLIP-seq
MIRT2664457	hsa-miR-4778-5p	CLIP-seq
MIRT2664458	hsa-miR-4786-3p	CLIP-seq
MIRT2664459	hsa-miR-4790-3p	CLIP-seq
MIRT2664460	hsa-miR-4799-5p	CLIP-seq
MIRT2370930	hsa-miR-489	CLIP-seq
MIRT2664461	hsa-miR-506	CLIP-seq
MIRT2664462	hsa-miR-512-3p	CLIP-seq
MIRT2664463	hsa-miR-513a-3p	CLIP-seq
MIRT2370931	hsa-miR-513b	CLIP-seq
MIRT1499564	hsa-miR-515-5p	CLIP-seq
MIRT2664464	hsa-miR-518d-5p	CLIP-seq
MIRT2664465	hsa-miR-519b-5p	CLIP-seq
MIRT2664466	hsa-miR-519c-5p	CLIP-seq
MIRT2664467	hsa-miR-520c-5p	CLIP-seq
MIRT2664468	hsa-miR-520f	CLIP-seq
MIRT2664469	hsa-miR-526a	CLIP-seq
MIRT2664470	hsa-miR-543	CLIP-seq
MIRT2664471	hsa-miR-545	CLIP-seq
MIRT2664472	hsa-miR-548aa	CLIP-seq
MIRT2664473	hsa-miR-548ac	CLIP-seq
MIRT2664474	hsa-miR-548ae	CLIP-seq
MIRT2664475	hsa-miR-548aj	CLIP-seq
MIRT2664476	hsa-miR-548am	CLIP-seq
MIRT2664477	hsa-miR-548d-3p	CLIP-seq
MIRT2664478	hsa-miR-548p	CLIP-seq
MIRT1499566	hsa-miR-548q	CLIP-seq
MIRT2664479	hsa-miR-548x	CLIP-seq
MIRT2664480	hsa-miR-548z	CLIP-seq
MIRT2664481	hsa-miR-561	CLIP-seq
MIRT2664482	hsa-miR-562	CLIP-seq
MIRT2664483	hsa-miR-567	CLIP-seq
MIRT2664484	hsa-miR-576-5p	CLIP-seq
MIRT2664485	hsa-miR-582-3p	CLIP-seq
MIRT2664486	hsa-miR-590-3p	CLIP-seq
MIRT2664487	hsa-miR-603	CLIP-seq
MIRT2664488	hsa-miR-607	CLIP-seq
MIRT2664489	hsa-miR-612	CLIP-seq
MIRT2664490	hsa-miR-621	CLIP-seq
MIRT2664491	hsa-miR-629	CLIP-seq
MIRT2664492	hsa-miR-631	CLIP-seq
MIRT2664493	hsa-miR-664	CLIP-seq
MIRT1499567	hsa-miR-760	CLIP-seq
MIRT2664494	hsa-miR-769-5p	CLIP-seq
MIRT1499544	hsa-miR-876-5p	CLIP-seq
MIRT2664495	hsa-miR-942	CLIP-seq
MIRT2664399	hsa-miR-105	CLIP-seq
MIRT2664400	hsa-miR-1193	CLIP-seq
MIRT2664402	hsa-miR-1236	CLIP-seq
MIRT2664403	hsa-miR-124	CLIP-seq
MIRT1499534	hsa-miR-1246	CLIP-seq
MIRT2664404	hsa-miR-127-3p	CLIP-seq
MIRT2664405	hsa-miR-127-5p	CLIP-seq
MIRT2664406	hsa-miR-1285	CLIP-seq
MIRT1499535	hsa-miR-1290	CLIP-seq
MIRT2664407	hsa-miR-1298	CLIP-seq
MIRT2150416	hsa-miR-141	CLIP-seq
MIRT2664408	hsa-miR-1827	CLIP-seq
MIRT1499547	hsa-miR-183	CLIP-seq
MIRT2150417	hsa-miR-200a	CLIP-seq
MIRT2664409	hsa-miR-2277-3p	CLIP-seq
MIRT2695431	hsa-miR-28-3p	CLIP-seq
MIRT2664410	hsa-miR-297	CLIP-seq
MIRT2664411	hsa-miR-30a	CLIP-seq
MIRT2664412	hsa-miR-30b	CLIP-seq
MIRT2664413	hsa-miR-30c	CLIP-seq
MIRT2664414	hsa-miR-30d	CLIP-seq
MIRT2664415	hsa-miR-30e	CLIP-seq
MIRT2664416	hsa-miR-3120-3p	CLIP-seq
MIRT1499536	hsa-miR-3134	CLIP-seq
MIRT2664417	hsa-miR-3143	CLIP-seq
MIRT2664418	hsa-miR-3148	CLIP-seq
MIRT2664419	hsa-miR-3153	CLIP-seq
MIRT1499537	hsa-miR-3167	CLIP-seq
MIRT2664420	hsa-miR-3187-5p	CLIP-seq
MIRT2664421	hsa-miR-329	CLIP-seq
MIRT2664422	hsa-miR-337-5p	CLIP-seq
MIRT2664424	hsa-miR-362-3p	CLIP-seq
MIRT2664425	hsa-miR-3646	CLIP-seq
MIRT2664426	hsa-miR-3661	CLIP-seq
MIRT2664427	hsa-miR-3662	CLIP-seq
MIRT2664428	hsa-miR-3671	CLIP-seq
MIRT2664429	hsa-miR-3688-3p	CLIP-seq
MIRT2664430	hsa-miR-3714	CLIP-seq
MIRT2664431	hsa-miR-380	CLIP-seq
MIRT1499551	hsa-miR-3907	CLIP-seq
MIRT2664432	hsa-miR-3910	CLIP-seq
MIRT2664434	hsa-miR-3921	CLIP-seq
MIRT2664435	hsa-miR-3941	CLIP-seq
MIRT2664436	hsa-miR-4263	CLIP-seq
MIRT2664438	hsa-miR-4282	CLIP-seq
MIRT1499555	hsa-miR-4299	CLIP-seq
MIRT2664439	hsa-miR-4305	CLIP-seq
MIRT1499538	hsa-miR-4426	CLIP-seq
MIRT1499558	hsa-miR-4437	CLIP-seq
MIRT1499559	hsa-miR-4456	CLIP-seq
MIRT2664440	hsa-miR-4473	CLIP-seq
MIRT2695432	hsa-miR-448	CLIP-seq
MIRT2664441	hsa-miR-4485	CLIP-seq
MIRT2664442	hsa-miR-4495	CLIP-seq
MIRT2664443	hsa-miR-452	CLIP-seq
MIRT2664444	hsa-miR-4522	CLIP-seq
MIRT2664445	hsa-miR-4645-3p	CLIP-seq
MIRT2664446	hsa-miR-4646-5p	CLIP-seq
MIRT1499539	hsa-miR-4647	CLIP-seq
MIRT2664447	hsa-miR-4652-3p	CLIP-seq
MIRT2664448	hsa-miR-4653-5p	CLIP-seq
MIRT2664449	hsa-miR-4662a-5p	CLIP-seq
MIRT1499540	hsa-miR-4662b	CLIP-seq
MIRT2664450	hsa-miR-4668-5p	CLIP-seq
MIRT1499561	hsa-miR-4674	CLIP-seq
MIRT2664451	hsa-miR-4676-3p	CLIP-seq
MIRT2695433	hsa-miR-4676-5p	CLIP-seq
MIRT2664452	hsa-miR-4684-5p	CLIP-seq
MIRT2664453	hsa-miR-4718	CLIP-seq
MIRT2664454	hsa-miR-4729	CLIP-seq
MIRT1499542	hsa-miR-4742-3p	CLIP-seq
MIRT2664455	hsa-miR-4760-5p	CLIP-seq
MIRT1499543	hsa-miR-4768-5p	CLIP-seq
MIRT2664456	hsa-miR-4777-5p	CLIP-seq
MIRT2664457	hsa-miR-4778-5p	CLIP-seq
MIRT2664458	hsa-miR-4786-3p	CLIP-seq
MIRT2664460	hsa-miR-4799-5p	CLIP-seq
MIRT2370930	hsa-miR-489	CLIP-seq
MIRT2664461	hsa-miR-506	CLIP-seq
MIRT2664462	hsa-miR-512-3p	CLIP-seq
MIRT2664463	hsa-miR-513a-3p	CLIP-seq
MIRT2370931	hsa-miR-513b	CLIP-seq
MIRT1499564	hsa-miR-515-5p	CLIP-seq
MIRT2664464	hsa-miR-518d-5p	CLIP-seq
MIRT2664465	hsa-miR-519b-5p	CLIP-seq
MIRT2664466	hsa-miR-519c-5p	CLIP-seq
MIRT2664467	hsa-miR-520c-5p	CLIP-seq
MIRT2664468	hsa-miR-520f	CLIP-seq
MIRT2664469	hsa-miR-526a	CLIP-seq
MIRT2664470	hsa-miR-543	CLIP-seq
MIRT2664471	hsa-miR-545	CLIP-seq
MIRT2664472	hsa-miR-548aa	CLIP-seq
MIRT2664473	hsa-miR-548ac	CLIP-seq
MIRT2664474	hsa-miR-548ae	CLIP-seq
MIRT2664475	hsa-miR-548aj	CLIP-seq
MIRT2664476	hsa-miR-548am	CLIP-seq
MIRT2664477	hsa-miR-548d-3p	CLIP-seq
MIRT2664478	hsa-miR-548p	CLIP-seq
MIRT1499566	hsa-miR-548q	CLIP-seq
MIRT2664479	hsa-miR-548x	CLIP-seq
MIRT2664480	hsa-miR-548z	CLIP-seq
MIRT2664481	hsa-miR-561	CLIP-seq
MIRT2664482	hsa-miR-562	CLIP-seq
MIRT2664483	hsa-miR-567	CLIP-seq
MIRT2695434	hsa-miR-575	CLIP-seq
MIRT2664484	hsa-miR-576-5p	CLIP-seq
MIRT2664485	hsa-miR-582-3p	CLIP-seq
MIRT2664486	hsa-miR-590-3p	CLIP-seq
MIRT2664487	hsa-miR-603	CLIP-seq
MIRT2664488	hsa-miR-607	CLIP-seq
MIRT2664489	hsa-miR-612	CLIP-seq
MIRT2664490	hsa-miR-621	CLIP-seq
MIRT2664491	hsa-miR-629	CLIP-seq
MIRT2664492	hsa-miR-631	CLIP-seq
MIRT2664493	hsa-miR-664	CLIP-seq
MIRT1499567	hsa-miR-760	CLIP-seq
MIRT2664494	hsa-miR-769-5p	CLIP-seq
MIRT1499544	hsa-miR-876-5p	CLIP-seq
MIRT2664495	hsa-miR-942	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000151	Component	Ubiquitin ligase complex	IBA
GO:0000151	Component	Ubiquitin ligase complex	IDA	29911972
GO:0000922	Component	Spindle pole	IEA
GO:0005515	Function	Protein binding	IPI	20580816, 32296183
GO:0005576	Component	Extracellular region	TAS
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IEA
GO:0005813	Component	Centrosome	ISS
GO:0005856	Component	Cytoskeleton	IEA
GO:0008283	Process	Cell population proliferation	ISS
GO:0030496	Component	Midbody	IEA
GO:0030496	Component	Midbody	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0097431	Component	Mitotic spindle pole	ISS
GO:1904724	Component	Tertiary granule lumen	TAS
GO:1904813	Component	Ficolin-1-rich granule lumen	TAS

Other IDs

• MIM: 609726
• HGNC: 18329
• e!Ensembl: ENSG00000119801

Protein

• UniProt ID: P62699
• Protein name: Protein yippee-like 5
• Protein function: Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Required for normal ce
• PDB: 8QBN
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03226	Yippee-Mis18	13 → 118	Yippee zinc-binding/DNA-binding /Mis18, centromere assembly	Domain

• Sequence:

  MGRIFLDHIGGTRLFSCANCDTILTNRSELISTRFTGATGRAFLFNKVVNLQYSEVQDRV
  MLTGRHMVRDVSCKNCNSKLGWIYEFATEDSQRYKEGRVILERALVRESEGFEEHVPSDN
  S

• Sequence length: 121

Pathways

Reactome:

Neutrophil degranulation

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ATOPIC ECZEMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CENTRAL NERVOUS SYSTEM CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GASTRIC ULCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Amyotrophic Lateral Sclerosis	Amyotrophic lateral sclerosis	Pubtator	36418457	Associate	★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	33411363	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	35674183	Associate	★☆☆☆☆ Found in Text Mining only
Chronic Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	23382248		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	33411363	Associate	★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	29221754		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	36045381	Associate	★☆☆☆☆ Found in Text Mining only