Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	51593
Gene name	Serrate, RNA effector molecule
Gene symbol	SRRT
Synonyms (NCBI Gene)	ARS2ASR2serrate
Chromosome	7
Chromosome location	7q22.1

193

Show/Hide all (193)

miRTarBase ID	miRNA	Experiments	Reference
MIRT026028	hsa-miR-196a-5p	Sequencing	20371350
MIRT030477	hsa-miR-24-3p	Microarray	17686970
MIRT049730	hsa-miR-92a-3p	CLASH	23622248
MIRT026028	hsa-miR-196a-5p	CLASH	23622248
MIRT046768	hsa-miR-222-3p	CLASH	23622248
MIRT038543	hsa-miR-30c-1-3p	CLASH	23622248
MIRT035793	hsa-miR-1914-5p	CLASH	23622248
MIRT257947	hsa-miR-624-3p	PAR-CLIP	20371350
MIRT498811	hsa-miR-6882-5p	PAR-CLIP	20371350
MIRT102175	hsa-miR-4700-3p	PAR-CLIP	20371350
MIRT498810	hsa-miR-1197	PAR-CLIP	20371350
MIRT026028	hsa-miR-196a-5p	PAR-CLIP	20371350
MIRT102166	hsa-miR-196b-5p	PAR-CLIP	20371350
MIRT498809	hsa-miR-1246	PAR-CLIP	20371350
MIRT102170	hsa-miR-3682-3p	PAR-CLIP	20371350
MIRT102179	hsa-miR-6744-5p	PAR-CLIP	20371350
MIRT102167	hsa-miR-1255a	PAR-CLIP	20371350
MIRT102168	hsa-miR-1255b-5p	PAR-CLIP	20371350
MIRT257947	hsa-miR-624-3p	PAR-CLIP	20371350
MIRT498811	hsa-miR-6882-5p	PAR-CLIP	20371350
MIRT102175	hsa-miR-4700-3p	PAR-CLIP	20371350
MIRT498810	hsa-miR-1197	PAR-CLIP	20371350
MIRT026028	hsa-miR-196a-5p	PAR-CLIP	20371350
MIRT102166	hsa-miR-196b-5p	PAR-CLIP	20371350
MIRT498809	hsa-miR-1246	PAR-CLIP	20371350
MIRT102170	hsa-miR-3682-3p	PAR-CLIP	20371350
MIRT102179	hsa-miR-6744-5p	PAR-CLIP	20371350
MIRT102167	hsa-miR-1255a	PAR-CLIP	20371350
MIRT102168	hsa-miR-1255b-5p	PAR-CLIP	20371350
MIRT257947	hsa-miR-624-3p	PAR-CLIP	20371350
MIRT498811	hsa-miR-6882-5p	PAR-CLIP	20371350
MIRT102175	hsa-miR-4700-3p	PAR-CLIP	20371350
MIRT498810	hsa-miR-1197	PAR-CLIP	20371350
MIRT026028	hsa-miR-196a-5p	PAR-CLIP	20371350
MIRT102166	hsa-miR-196b-5p	PAR-CLIP	20371350
MIRT498809	hsa-miR-1246	PAR-CLIP	20371350
MIRT102170	hsa-miR-3682-3p	PAR-CLIP	20371350
MIRT102179	hsa-miR-6744-5p	PAR-CLIP	20371350
MIRT102167	hsa-miR-1255a	PAR-CLIP	20371350
MIRT102168	hsa-miR-1255b-5p	PAR-CLIP	20371350
MIRT257947	hsa-miR-624-3p	PAR-CLIP	21572407
MIRT498811	hsa-miR-6882-5p	PAR-CLIP	21572407
MIRT102175	hsa-miR-4700-3p	PAR-CLIP	21572407
MIRT498810	hsa-miR-1197	PAR-CLIP	21572407
MIRT026028	hsa-miR-196a-5p	PAR-CLIP	21572407
MIRT102166	hsa-miR-196b-5p	PAR-CLIP	21572407
MIRT498809	hsa-miR-1246	PAR-CLIP	21572407
MIRT102170	hsa-miR-3682-3p	PAR-CLIP	21572407
MIRT102179	hsa-miR-6744-5p	PAR-CLIP	21572407
MIRT102167	hsa-miR-1255a	PAR-CLIP	21572407
MIRT102168	hsa-miR-1255b-5p	PAR-CLIP	21572407
MIRT257947	hsa-miR-624-3p	PAR-CLIP	23446348
MIRT498811	hsa-miR-6882-5p	PAR-CLIP	23446348
MIRT102175	hsa-miR-4700-3p	PAR-CLIP	23446348
MIRT498810	hsa-miR-1197	PAR-CLIP	23446348
MIRT102169	hsa-miR-3169	PAR-CLIP	23446348
MIRT026028	hsa-miR-196a-5p	PAR-CLIP	23446348
MIRT102166	hsa-miR-196b-5p	PAR-CLIP	23446348
MIRT498809	hsa-miR-1246	PAR-CLIP	23446348
MIRT102181	hsa-miR-6857-3p	PAR-CLIP	23446348
MIRT102170	hsa-miR-3682-3p	PAR-CLIP	23446348
MIRT102176	hsa-miR-4740-5p	PAR-CLIP	23446348
MIRT102179	hsa-miR-6744-5p	PAR-CLIP	23446348
MIRT102167	hsa-miR-1255a	PAR-CLIP	23446348
MIRT102168	hsa-miR-1255b-5p	PAR-CLIP	23446348
MIRT514922	hsa-miR-376a-3p	PAR-CLIP	23446348
MIRT514921	hsa-miR-376b-3p	PAR-CLIP	23446348
MIRT257947	hsa-miR-624-3p	PAR-CLIP	24398324
MIRT498811	hsa-miR-6882-5p	PAR-CLIP	24398324
MIRT102175	hsa-miR-4700-3p	PAR-CLIP	24398324
MIRT498810	hsa-miR-1197	PAR-CLIP	24398324
MIRT026028	hsa-miR-196a-5p	PAR-CLIP	24398324
MIRT102166	hsa-miR-196b-5p	PAR-CLIP	24398324
MIRT498809	hsa-miR-1246	PAR-CLIP	24398324
MIRT102170	hsa-miR-3682-3p	PAR-CLIP	24398324
MIRT102179	hsa-miR-6744-5p	PAR-CLIP	24398324
MIRT102167	hsa-miR-1255a	PAR-CLIP	24398324
MIRT102168	hsa-miR-1255b-5p	PAR-CLIP	24398324
MIRT439544	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439544	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT257947	hsa-miR-624-3p	PAR-CLIP	20371350
MIRT498811	hsa-miR-6882-5p	PAR-CLIP	20371350
MIRT102175	hsa-miR-4700-3p	PAR-CLIP	20371350
MIRT498810	hsa-miR-1197	PAR-CLIP	20371350
MIRT026028	hsa-miR-196a-5p	PAR-CLIP	20371350
MIRT102166	hsa-miR-196b-5p	PAR-CLIP	20371350
MIRT498809	hsa-miR-1246	PAR-CLIP	20371350
MIRT102170	hsa-miR-3682-3p	PAR-CLIP	20371350
MIRT102179	hsa-miR-6744-5p	PAR-CLIP	20371350
MIRT102167	hsa-miR-1255a	PAR-CLIP	20371350
MIRT102168	hsa-miR-1255b-5p	PAR-CLIP	20371350
MIRT257947	hsa-miR-624-3p	PAR-CLIP	20371350
MIRT498811	hsa-miR-6882-5p	PAR-CLIP	20371350
MIRT102175	hsa-miR-4700-3p	PAR-CLIP	20371350
MIRT498810	hsa-miR-1197	PAR-CLIP	20371350
MIRT026028	hsa-miR-196a-5p	PAR-CLIP	20371350
MIRT102166	hsa-miR-196b-5p	PAR-CLIP	20371350
MIRT498809	hsa-miR-1246	PAR-CLIP	20371350
MIRT102170	hsa-miR-3682-3p	PAR-CLIP	20371350
MIRT102179	hsa-miR-6744-5p	PAR-CLIP	20371350
MIRT102167	hsa-miR-1255a	PAR-CLIP	20371350
MIRT102168	hsa-miR-1255b-5p	PAR-CLIP	20371350
MIRT257947	hsa-miR-624-3p	PAR-CLIP	20371350
MIRT498811	hsa-miR-6882-5p	PAR-CLIP	20371350
MIRT102175	hsa-miR-4700-3p	PAR-CLIP	20371350
MIRT498810	hsa-miR-1197	PAR-CLIP	20371350
MIRT026028	hsa-miR-196a-5p	PAR-CLIP	20371350
MIRT102166	hsa-miR-196b-5p	PAR-CLIP	20371350
MIRT498809	hsa-miR-1246	PAR-CLIP	20371350
MIRT102170	hsa-miR-3682-3p	PAR-CLIP	20371350
MIRT102179	hsa-miR-6744-5p	PAR-CLIP	20371350
MIRT102167	hsa-miR-1255a	PAR-CLIP	20371350
MIRT102168	hsa-miR-1255b-5p	PAR-CLIP	20371350
MIRT257947	hsa-miR-624-3p	PAR-CLIP	21572407
MIRT498811	hsa-miR-6882-5p	PAR-CLIP	21572407
MIRT102175	hsa-miR-4700-3p	PAR-CLIP	21572407
MIRT498810	hsa-miR-1197	PAR-CLIP	21572407
MIRT026028	hsa-miR-196a-5p	PAR-CLIP	21572407
MIRT102166	hsa-miR-196b-5p	PAR-CLIP	21572407
MIRT498809	hsa-miR-1246	PAR-CLIP	21572407
MIRT102170	hsa-miR-3682-3p	PAR-CLIP	21572407
MIRT102179	hsa-miR-6744-5p	PAR-CLIP	21572407
MIRT102167	hsa-miR-1255a	PAR-CLIP	21572407
MIRT102168	hsa-miR-1255b-5p	PAR-CLIP	21572407
MIRT257947	hsa-miR-624-3p	PAR-CLIP	23446348
MIRT498811	hsa-miR-6882-5p	PAR-CLIP	23446348
MIRT102175	hsa-miR-4700-3p	PAR-CLIP	23446348
MIRT498810	hsa-miR-1197	PAR-CLIP	23446348
MIRT102169	hsa-miR-3169	PAR-CLIP	23446348
MIRT026028	hsa-miR-196a-5p	PAR-CLIP	23446348
MIRT102166	hsa-miR-196b-5p	PAR-CLIP	23446348
MIRT498809	hsa-miR-1246	PAR-CLIP	23446348
MIRT102181	hsa-miR-6857-3p	PAR-CLIP	23446348
MIRT102170	hsa-miR-3682-3p	PAR-CLIP	23446348
MIRT102176	hsa-miR-4740-5p	PAR-CLIP	23446348
MIRT102179	hsa-miR-6744-5p	PAR-CLIP	23446348
MIRT102167	hsa-miR-1255a	PAR-CLIP	23446348
MIRT102168	hsa-miR-1255b-5p	PAR-CLIP	23446348
MIRT514922	hsa-miR-376a-3p	PAR-CLIP	23446348
MIRT514921	hsa-miR-376b-3p	PAR-CLIP	23446348
MIRT257947	hsa-miR-624-3p	PAR-CLIP	24398324
MIRT498811	hsa-miR-6882-5p	PAR-CLIP	24398324
MIRT102175	hsa-miR-4700-3p	PAR-CLIP	24398324
MIRT498810	hsa-miR-1197	PAR-CLIP	24398324
MIRT026028	hsa-miR-196a-5p	PAR-CLIP	24398324
MIRT102166	hsa-miR-196b-5p	PAR-CLIP	24398324
MIRT498809	hsa-miR-1246	PAR-CLIP	24398324
MIRT102170	hsa-miR-3682-3p	PAR-CLIP	24398324
MIRT102179	hsa-miR-6744-5p	PAR-CLIP	24398324
MIRT102167	hsa-miR-1255a	PAR-CLIP	24398324
MIRT102168	hsa-miR-1255b-5p	PAR-CLIP	24398324
MIRT1390053	hsa-miR-1255b	CLIP-seq
MIRT1390054	hsa-miR-196a	CLIP-seq
MIRT1390055	hsa-miR-196b	CLIP-seq
MIRT1390056	hsa-miR-3613-3p	CLIP-seq
MIRT1390057	hsa-miR-376a	CLIP-seq
MIRT1390058	hsa-miR-376b	CLIP-seq
MIRT1390059	hsa-miR-4330	CLIP-seq
MIRT1390060	hsa-miR-487b	CLIP-seq
MIRT1390061	hsa-miR-624	CLIP-seq
MIRT1390062	hsa-miR-3140-3p	CLIP-seq
MIRT1390063	hsa-miR-3929	CLIP-seq
MIRT1390064	hsa-miR-4274	CLIP-seq
MIRT1390065	hsa-miR-4419b	CLIP-seq
MIRT1390066	hsa-miR-4478	CLIP-seq
MIRT1390067	hsa-miR-4519	CLIP-seq
MIRT1390068	hsa-miR-4524	CLIP-seq
MIRT1390069	hsa-miR-302a	CLIP-seq
MIRT1390070	hsa-miR-302b	CLIP-seq
MIRT1390071	hsa-miR-302c	CLIP-seq
MIRT1390072	hsa-miR-302d	CLIP-seq
MIRT1390073	hsa-miR-302e	CLIP-seq
MIRT1390062	hsa-miR-3140-3p	CLIP-seq
MIRT1390074	hsa-miR-3190	CLIP-seq
MIRT1390075	hsa-miR-372	CLIP-seq
MIRT1390076	hsa-miR-373	CLIP-seq
MIRT1390064	hsa-miR-4274	CLIP-seq
MIRT1390067	hsa-miR-4519	CLIP-seq
MIRT1390068	hsa-miR-4524	CLIP-seq
MIRT1390077	hsa-miR-520a-3p	CLIP-seq
MIRT1390078	hsa-miR-520b	CLIP-seq
MIRT1390079	hsa-miR-520c-3p	CLIP-seq
MIRT1390080	hsa-miR-520d-3p	CLIP-seq
MIRT1390081	hsa-miR-520e	CLIP-seq
MIRT1390082	hsa-miR-520f	CLIP-seq
MIRT1390053	hsa-miR-1255b	CLIP-seq
MIRT1390054	hsa-miR-196a	CLIP-seq
MIRT1390055	hsa-miR-196b	CLIP-seq
MIRT1390056	hsa-miR-3613-3p	CLIP-seq
MIRT1390057	hsa-miR-376a	CLIP-seq
MIRT1390058	hsa-miR-376b	CLIP-seq
MIRT1390059	hsa-miR-4330	CLIP-seq
MIRT1390061	hsa-miR-624	CLIP-seq

Show/Hide all (27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003677	Function	DNA binding	ISS
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0005515	Function	Protein binding	IPI	17500595, 20858735, 23793891, 26382858, 32814053
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	ISS
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	ISS
GO:0016604	Component	Nuclear body	IBA
GO:0030674	Function	Protein-macromolecule adaptor activity	IDA	28297668
GO:0031047	Process	Regulatory ncRNA-mediated gene silencing	IEA
GO:0031053	Process	Primary miRNA processing	IBA
GO:0031053	Process	Primary miRNA processing	IEA
GO:0031053	Process	Primary miRNA processing	IMP	19632182
GO:0032991	Component	Protein-containing complex	IDA	23793891
GO:0046685	Process	Response to arsenic-containing substance	NAS	11239002
GO:0050769	Process	Positive regulation of neurogenesis	IEA
GO:0097150	Process	Neuronal stem cell population maintenance	IEA
GO:0097150	Process	Neuronal stem cell population maintenance	ISS
GO:0140262	Function	MRNA cap binding complex binding	IDA	28297668
GO:1990904	Component	Ribonucleoprotein complex	IDA	28297668

MIM	HGNC	e!Ensembl
614469	24101	ENSG00000087087

Q9BXP5

Protein name

Serrate RNA effector molecule homolog (Arsenite-resistance protein 2)

Protein function

Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA proces

PDB

5OO6 , 6F7J , 6F7P , 6F7S , 6F8D , 8PMP

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12066	SERRATE_Ars2_N	153 → 262	SERRATE/Ars2, N-terminal domain	Domain
PF04959	ARS2	646 → 851	Arsenite-resistance protein 2	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed. {ECO:0000269|PubMed:18086880}.

Sequence

MGDSDDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRGEYRDYDR
NRRERFSPPRHELSPPQKRMRRDWDEHSSDPYHSGYEMPYAGGGGGPTYGPPQPWGHPDV
HIMQHHVLPIQARLGSIAEIDLGVPPPVMKTFKEFLLSLDDSVDETEAVKRYNDYKLDFR
RQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQNRLRVFLSLMETGWFDNLLLDI
DKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGER
KTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDD
SFDEGSVSESESESESGQAEEEKEEAEEALKEKEKPKEEEWEKPKDAAGLECKPRPLHKT
CSLFMRNIAPNISRAEIISLCKRYPGFMRVALSEPQPERRFFRRGWVTFDRSVNIKEICW
NLQNIRLRECELSPGVNRDLTRRVRNINGITQHKQIVRNDIKLAAKLIHTLDDRTQLWAS
EPGTPPLPTSLPSQNPILKNITDYLIEEVSAEEEELLGSSGGAPPEEPPKEGNPAEINVE
RDEKLIKVLDKLLLYLRIVHSLDYYNTCEYPNEDEMPNRCGIIHVRGPMPPNRISHGEVL
EWQKTFEEKLTPLLSVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQELGKDKWLCPLSGK
KFKGPEFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQPPGPAQILPPG
LTPGLPYPHQTPQGLMPYGQPRPPILGYGAGAVRPAVPTGGPPYPHAPYGAGRGNYDAFR
GQGGYPGKPRNRMVRGDPRAIVEYRDLDAPDDVDFF

Sequence length

876

Interactions

View interactions

	Reactome
			RNA polymerase II transcribes snRNA genes mRNA Splicing - Major Pathway

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ANTI-GAD65 AUTOIMMUNE NEUROLOGICAL SYNDROMES	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UNIPOLAR DEPRESSION	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (19)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Bipolar Disorder	Bipolar Disorder	BEFREE	22373040		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bipolar Disorder	Bipolar Disorder	PSYGENET_DG	22373040		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cholangiocarcinoma	Cholangiocarcinoma	BEFREE	22213145		★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital contractural arachnodactyly	Congenital Contractural Arachnodactyly	BEFREE	22213145		★★★★★ ★☆☆☆☆ Found in Text Mining only
Dementia	Dementia	Pubtator	28600779	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Depressive Disorder Major	Major depressive disorder	Pubtator	22373040	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Giant Cell Glioblastoma	Giant Cell Glioblastoma	CTD_human_DG	30542699		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	30349053, 30542699		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Glioblastoma	Glioblastoma	CTD_human_DG	30542699		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Glioblastoma Multiforme	Glioblastoma	BEFREE	30349053, 30542699		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	CTD_human_DG	30542699		★★★★★ ★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Intellectual developmental disorder	Pubtator	28600779	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	30518811		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	24272391		★★★★★ ★☆☆☆☆ Found in Text Mining only
Major Depressive Disorder	Mental Depression	PSYGENET_DG	22373040		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Neoplasms	Neoplasms	BEFREE	30349053, 30542699		★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	22373040		★★★★★ ★☆☆☆☆ Found in Text Mining only
Unipolar Depression	Mental Depression	PSYGENET_DG	22373040		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	15919944	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

SRRT (serrate, RNA effector molecule)