Gene Gene information from NCBI Gene database.
Entrez ID 51582
Gene name Antizyme inhibitor 1
Gene symbol AZIN1
Synonyms (NCBI Gene)
AZIAZI1AZIA1OAZIOAZINODC1L
Chromosome 8
Chromosome location 8q22.3
Summary The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key
miRNA miRNA information provided by mirtarbase database.
690
miRTarBase ID miRNA Experiments Reference
MIRT023440 hsa-miR-30b-5p Sequencing 20371350
MIRT050831 hsa-miR-17-5p CLASH 23622248
MIRT438553 hsa-miR-433-3p ChIP-seqImmunohistochemistryIn situ hybridizationLuciferase reporter assayqRT-PCRWestern blot 23868013
MIRT438553 hsa-miR-433-3p ChIP-seqImmunohistochemistryIn situ hybridizationLuciferase reporter assayqRT-PCRWestern blot 23868013
MIRT438553 hsa-miR-433-3p ChIP-seqImmunohistochemistryIn situ hybridizationLuciferase reporter assayqRT-PCRWestern blot 23868013
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
17
GO ID Ontology Definition Evidence Reference
GO:0003824 Function Catalytic activity IEA
GO:0004586 Function Ornithine decarboxylase activity IBA
GO:0005515 Function Protein binding IPI 25416956, 28514442, 31515488, 32296183, 33961781
GO:0005634 Component Nucleus IEA
GO:0005634 Component Nucleus ISS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
607909 16432 ENSG00000155096
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O14977
Protein name Antizyme inhibitor 1 (AZI) (AZI1) (Ornithine decarboxylase antizyme inhibitor)
Protein function Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3
PDB 4ZGZ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00278 Orn_DAP_Arg_deC 27 385 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Domain
PF02784 Orn_Arg_deC_N 45 278 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in liver. {ECO:0000269|PubMed:9349715}.
Sequence
MKGFIDDANYSVGLLDEGTNLGNVIDNYVYEHTLTGKNAFFVGDLGKIVKKHSQWQNVVA
QIKPFYTVKCNSAPAVLEILAALGTGFACSSKNEMALVQELGVPPENIIYISPCKQVSQI
KYAAKVGVNILTCDNEIELKKIARNHPNAKVLLHIATEDNIGGEEGNMKFGTTLKNCRHL
LECAKELDVQIIGVKFHVSSACKESQVYVHALSDARCVFDMAGEIGFTMNMLDIGGGFTG
TEFQLEEVNHVISPLLDIYFPEGSGVKIISEPGSYYVS
SAFTLAVNIIAKKVVENDKFPS
GVEKTGSDEPAFMYYMNDGVYGSFASKLSEDLNTIPEVHKKYKEDEPLFTSSLWGPSCDE
LDQIVESCLLPELNVGDWLIFDNMG
ADSFHEPSAFNDFQRPAIYYMMSFSDWYEMQDAGI
TSDSMMKNFFFVPSCIQLSQEDSFSAEA
Sequence length 448
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Regulation of ornithine decarboxylase (ODC)
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
LIVER CIRRHOSIS Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Bardet-Biedl Syndrome Bardet-Biedl Syndrome BEFREE 24550735
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 30463022
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 30463022 Associate
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Carcinogenesis Pubtator 28849733, 36528792, 37732519 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 37732519 Associate
★☆☆☆☆
Found in Text Mining only
Cirrhosis Cirrhosis BEFREE 23844940
★☆☆☆☆
Found in Text Mining only
Colitis Ulcerative Ulcerative colitis Pubtator 36528792 Associate
★☆☆☆☆
Found in Text Mining only
Colorectal Carcinoma Colorectal Cancer BEFREE 29925690, 30583079, 30768610
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Colorectal neoplasm Pubtator 30583079, 35365616 Associate
★☆☆☆☆
Found in Text Mining only
Hypoxia Hypoxia Pubtator 23122428 Inhibit
★☆☆☆☆
Found in Text Mining only