PDE7A (phosphodiesterase 7A)

Gene

• Entrez ID: 5150
• Gene name: Phosphodiesterase 7A
• Gene symbol: PDE7A
• Synonyms (NCBI Gene): HCP1, PDE7
• Chromosome: 8
• Chromosome location: 8q13.1
• Summary: The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE7 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular sign

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT632617	hsa-miR-6871-5p	HITS-CLIP	23824327
MIRT632616	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT634447	hsa-miR-4284	HITS-CLIP	23824327
MIRT634446	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT634445	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT634444	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT634443	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT634442	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT634441	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT634440	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT632615	hsa-miR-7977	HITS-CLIP	23824327
MIRT634439	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT634438	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT634437	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT634436	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT634435	hsa-miR-3689c	HITS-CLIP	23824327
MIRT634434	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT634433	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT632617	hsa-miR-6871-5p	HITS-CLIP	23824327
MIRT632616	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT632615	hsa-miR-7977	HITS-CLIP	23824327
MIRT622870	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT622869	hsa-miR-764	HITS-CLIP	23824327
MIRT622868	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT622867	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT622866	hsa-miR-640	HITS-CLIP	23824327
MIRT225511	hsa-miR-409-3p	PAR-CLIP	22100165
MIRT443013	hsa-miR-345-3p	PAR-CLIP	22100165
MIRT443012	hsa-miR-203a-3p	PAR-CLIP	22100165
MIRT443011	hsa-miR-210-5p	PAR-CLIP	22100165
MIRT443010	hsa-miR-6807-5p	PAR-CLIP	22100165
MIRT632617	hsa-miR-6871-5p	HITS-CLIP	23824327
MIRT632616	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT634447	hsa-miR-4284	HITS-CLIP	23824327
MIRT634446	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT634445	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT634444	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT634443	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT634442	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT634441	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT634440	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT632615	hsa-miR-7977	HITS-CLIP	23824327
MIRT634439	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT634438	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT634437	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT634436	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT634435	hsa-miR-3689c	HITS-CLIP	23824327
MIRT634434	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT634433	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT632617	hsa-miR-6871-5p	HITS-CLIP	23824327
MIRT632616	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT632615	hsa-miR-7977	HITS-CLIP	23824327
MIRT622870	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT622869	hsa-miR-764	HITS-CLIP	23824327
MIRT622868	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT622867	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT622866	hsa-miR-640	HITS-CLIP	23824327
MIRT225511	hsa-miR-409-3p	PAR-CLIP	22100165
MIRT443013	hsa-miR-345-3p	PAR-CLIP	22100165
MIRT443012	hsa-miR-203a-3p	PAR-CLIP	22100165
MIRT443011	hsa-miR-210-5p	PAR-CLIP	22100165
MIRT443010	hsa-miR-6807-5p	PAR-CLIP	22100165
MIRT1220884	hsa-miR-1184	CLIP-seq
MIRT1220885	hsa-miR-1197	CLIP-seq
MIRT1220886	hsa-miR-1202	CLIP-seq
MIRT1220887	hsa-miR-1252	CLIP-seq
MIRT1220888	hsa-miR-1276	CLIP-seq
MIRT1220889	hsa-miR-1285	CLIP-seq
MIRT1220890	hsa-miR-145	CLIP-seq
MIRT1220891	hsa-miR-148a	CLIP-seq
MIRT1220892	hsa-miR-148b	CLIP-seq
MIRT1220893	hsa-miR-150	CLIP-seq
MIRT1220894	hsa-miR-152	CLIP-seq
MIRT1220895	hsa-miR-1825	CLIP-seq
MIRT1220896	hsa-miR-1827	CLIP-seq
MIRT1220897	hsa-miR-199a-5p	CLIP-seq
MIRT1220898	hsa-miR-199b-5p	CLIP-seq
MIRT1220899	hsa-miR-205	CLIP-seq
MIRT1220900	hsa-miR-219-1-3p	CLIP-seq
MIRT1220901	hsa-miR-2467-3p	CLIP-seq
MIRT1220902	hsa-miR-30a	CLIP-seq
MIRT1220903	hsa-miR-30b	CLIP-seq
MIRT1220904	hsa-miR-30c	CLIP-seq
MIRT1220905	hsa-miR-30d	CLIP-seq
MIRT1220906	hsa-miR-30e	CLIP-seq
MIRT1220907	hsa-miR-3153	CLIP-seq
MIRT1220908	hsa-miR-3156-3p	CLIP-seq
MIRT1220909	hsa-miR-3180-5p	CLIP-seq
MIRT1220910	hsa-miR-3187-5p	CLIP-seq
MIRT1220911	hsa-miR-3188	CLIP-seq
MIRT1220912	hsa-miR-3942-3p	CLIP-seq
MIRT1220913	hsa-miR-3972	CLIP-seq
MIRT1220914	hsa-miR-4301	CLIP-seq
MIRT1220915	hsa-miR-431	CLIP-seq
MIRT1220916	hsa-miR-4328	CLIP-seq
MIRT1220917	hsa-miR-4418	CLIP-seq
MIRT1220918	hsa-miR-4470	CLIP-seq
MIRT1220919	hsa-miR-4475	CLIP-seq
MIRT1220920	hsa-miR-4505	CLIP-seq
MIRT1220921	hsa-miR-4639-3p	CLIP-seq
MIRT1220922	hsa-miR-4713-5p	CLIP-seq
MIRT1220923	hsa-miR-4716-3p	CLIP-seq
MIRT1220924	hsa-miR-4780	CLIP-seq
MIRT1220925	hsa-miR-485-5p	CLIP-seq
MIRT1220926	hsa-miR-509-3-5p	CLIP-seq
MIRT1220927	hsa-miR-509-5p	CLIP-seq
MIRT1220928	hsa-miR-511	CLIP-seq
MIRT1220929	hsa-miR-513b	CLIP-seq
MIRT1220930	hsa-miR-532-3p	CLIP-seq
MIRT1220931	hsa-miR-548a-3p	CLIP-seq
MIRT1220932	hsa-miR-548an	CLIP-seq
MIRT1220933	hsa-miR-548e	CLIP-seq
MIRT1220934	hsa-miR-548f	CLIP-seq
MIRT1220935	hsa-miR-548p	CLIP-seq
MIRT1220936	hsa-miR-558	CLIP-seq
MIRT1220937	hsa-miR-603	CLIP-seq
MIRT1220938	hsa-miR-612	CLIP-seq
MIRT1220939	hsa-miR-625	CLIP-seq
MIRT1220940	hsa-miR-759	CLIP-seq
MIRT1220941	hsa-miR-922	CLIP-seq
MIRT1220886	hsa-miR-1202	CLIP-seq
MIRT1220889	hsa-miR-1285	CLIP-seq
MIRT1220942	hsa-miR-140-5p	CLIP-seq
MIRT1220890	hsa-miR-145	CLIP-seq
MIRT1220943	hsa-miR-146a	CLIP-seq
MIRT1220944	hsa-miR-146b-5p	CLIP-seq
MIRT1220891	hsa-miR-148a	CLIP-seq
MIRT1220892	hsa-miR-148b	CLIP-seq
MIRT1220894	hsa-miR-152	CLIP-seq
MIRT1220945	hsa-miR-181a	CLIP-seq
MIRT1220946	hsa-miR-181b	CLIP-seq
MIRT1220947	hsa-miR-181c	CLIP-seq
MIRT1220948	hsa-miR-181d	CLIP-seq
MIRT1220895	hsa-miR-1825	CLIP-seq
MIRT1220896	hsa-miR-1827	CLIP-seq
MIRT1220897	hsa-miR-199a-5p	CLIP-seq
MIRT1220898	hsa-miR-199b-5p	CLIP-seq
MIRT1220899	hsa-miR-205	CLIP-seq
MIRT1220900	hsa-miR-219-1-3p	CLIP-seq
MIRT1220949	hsa-miR-23a	CLIP-seq
MIRT1220950	hsa-miR-23b	CLIP-seq
MIRT1220951	hsa-miR-23c	CLIP-seq
MIRT1220901	hsa-miR-2467-3p	CLIP-seq
MIRT1220902	hsa-miR-30a	CLIP-seq
MIRT1220903	hsa-miR-30b	CLIP-seq
MIRT1220904	hsa-miR-30c	CLIP-seq
MIRT1220905	hsa-miR-30d	CLIP-seq
MIRT1220906	hsa-miR-30e	CLIP-seq
MIRT1220909	hsa-miR-3180-5p	CLIP-seq
MIRT1220910	hsa-miR-3187-5p	CLIP-seq
MIRT1220911	hsa-miR-3188	CLIP-seq
MIRT1220952	hsa-miR-3190	CLIP-seq
MIRT1220953	hsa-miR-3202	CLIP-seq
MIRT1220954	hsa-miR-3678-5p	CLIP-seq
MIRT1220955	hsa-miR-3681	CLIP-seq
MIRT1220956	hsa-miR-377	CLIP-seq
MIRT1220957	hsa-miR-3919	CLIP-seq
MIRT1220958	hsa-miR-3925-5p	CLIP-seq
MIRT1220912	hsa-miR-3942-3p	CLIP-seq
MIRT1220913	hsa-miR-3972	CLIP-seq
MIRT1220959	hsa-miR-4262	CLIP-seq
MIRT1220915	hsa-miR-431	CLIP-seq
MIRT1220960	hsa-miR-4330	CLIP-seq
MIRT1220961	hsa-miR-4460	CLIP-seq
MIRT1220962	hsa-miR-4481	CLIP-seq
MIRT1220920	hsa-miR-4505	CLIP-seq
MIRT1220963	hsa-miR-4533	CLIP-seq
MIRT1220964	hsa-miR-4642	CLIP-seq
MIRT1220965	hsa-miR-4658	CLIP-seq
MIRT1220966	hsa-miR-4727-3p	CLIP-seq
MIRT1220967	hsa-miR-4745-5p	CLIP-seq
MIRT1220968	hsa-miR-4747-3p	CLIP-seq
MIRT1220969	hsa-miR-4756-3p	CLIP-seq
MIRT1220970	hsa-miR-4758-5p	CLIP-seq
MIRT1220925	hsa-miR-485-5p	CLIP-seq
MIRT1220928	hsa-miR-511	CLIP-seq
MIRT1220929	hsa-miR-513b	CLIP-seq
MIRT1220931	hsa-miR-548a-3p	CLIP-seq
MIRT1220933	hsa-miR-548e	CLIP-seq
MIRT1220934	hsa-miR-548f	CLIP-seq
MIRT1220935	hsa-miR-548p	CLIP-seq
MIRT1220971	hsa-miR-587	CLIP-seq
MIRT1220938	hsa-miR-612	CLIP-seq
MIRT1220940	hsa-miR-759	CLIP-seq
MIRT1220972	hsa-miR-875-5p	CLIP-seq
MIRT1220973	hsa-miR-9	CLIP-seq
MIRT1220941	hsa-miR-922	CLIP-seq
MIRT1920739	hsa-miR-298	CLIP-seq
MIRT1920740	hsa-miR-3158-5p	CLIP-seq
MIRT1920741	hsa-miR-412	CLIP-seq
MIRT1220917	hsa-miR-4418	CLIP-seq
MIRT1920742	hsa-miR-4420	CLIP-seq
MIRT1220926	hsa-miR-509-3-5p	CLIP-seq
MIRT1220927	hsa-miR-509-5p	CLIP-seq
MIRT1920739	hsa-miR-298	CLIP-seq
MIRT1920740	hsa-miR-3158-5p	CLIP-seq
MIRT1920741	hsa-miR-412	CLIP-seq
MIRT1220917	hsa-miR-4418	CLIP-seq
MIRT1920742	hsa-miR-4420	CLIP-seq
MIRT1220926	hsa-miR-509-3-5p	CLIP-seq
MIRT1220927	hsa-miR-509-5p	CLIP-seq
MIRT1220896	hsa-miR-1827	CLIP-seq
MIRT1220949	hsa-miR-23a	CLIP-seq
MIRT1220950	hsa-miR-23b	CLIP-seq
MIRT1220951	hsa-miR-23c	CLIP-seq
MIRT2063748	hsa-miR-3680	CLIP-seq
MIRT1220917	hsa-miR-4418	CLIP-seq
MIRT1220926	hsa-miR-509-3-5p	CLIP-seq
MIRT1220927	hsa-miR-509-5p	CLIP-seq
MIRT2063749	hsa-miR-582-5p	CLIP-seq
MIRT2063750	hsa-miR-124	CLIP-seq
MIRT1220949	hsa-miR-23a	CLIP-seq
MIRT1220950	hsa-miR-23b	CLIP-seq
MIRT1220951	hsa-miR-23c	CLIP-seq
MIRT2063751	hsa-miR-3714	CLIP-seq
MIRT2063752	hsa-miR-3910	CLIP-seq
MIRT2063753	hsa-miR-506	CLIP-seq
MIRT1220893	hsa-miR-150	CLIP-seq
MIRT2292170	hsa-miR-153	CLIP-seq
MIRT1220896	hsa-miR-1827	CLIP-seq
MIRT2292171	hsa-miR-2355-3p	CLIP-seq
MIRT1220949	hsa-miR-23a	CLIP-seq
MIRT1220950	hsa-miR-23b	CLIP-seq
MIRT1220951	hsa-miR-23c	CLIP-seq
MIRT1220908	hsa-miR-3156-3p	CLIP-seq
MIRT1220912	hsa-miR-3942-3p	CLIP-seq
MIRT1220914	hsa-miR-4301	CLIP-seq
MIRT1220917	hsa-miR-4418	CLIP-seq
MIRT1220921	hsa-miR-4639-3p	CLIP-seq
MIRT2292172	hsa-miR-4684-3p	CLIP-seq
MIRT1220922	hsa-miR-4713-5p	CLIP-seq
MIRT1220924	hsa-miR-4780	CLIP-seq
MIRT1220926	hsa-miR-509-3-5p	CLIP-seq
MIRT1220927	hsa-miR-509-5p	CLIP-seq
MIRT1220930	hsa-miR-532-3p	CLIP-seq
MIRT2292173	hsa-miR-570	CLIP-seq
MIRT2063749	hsa-miR-582-5p	CLIP-seq
MIRT1220937	hsa-miR-603	CLIP-seq
MIRT2292174	hsa-miR-101	CLIP-seq
MIRT1220886	hsa-miR-1202	CLIP-seq
MIRT2292175	hsa-miR-1260	CLIP-seq
MIRT2292176	hsa-miR-1260b	CLIP-seq
MIRT1220888	hsa-miR-1276	CLIP-seq
MIRT2292177	hsa-miR-1280	CLIP-seq
MIRT2292178	hsa-miR-1284	CLIP-seq
MIRT1220889	hsa-miR-1285	CLIP-seq
MIRT2292179	hsa-miR-1297	CLIP-seq
MIRT2292180	hsa-miR-144	CLIP-seq
MIRT1220891	hsa-miR-148a	CLIP-seq
MIRT1220892	hsa-miR-148b	CLIP-seq
MIRT1220894	hsa-miR-152	CLIP-seq
MIRT1220895	hsa-miR-1825	CLIP-seq
MIRT1220896	hsa-miR-1827	CLIP-seq
MIRT2292181	hsa-miR-199a-3p	CLIP-seq
MIRT2292182	hsa-miR-199b-3p	CLIP-seq
MIRT2292183	hsa-miR-2116	CLIP-seq
MIRT2292184	hsa-miR-218	CLIP-seq
MIRT1220900	hsa-miR-219-1-3p	CLIP-seq
MIRT1220949	hsa-miR-23a	CLIP-seq
MIRT1220950	hsa-miR-23b	CLIP-seq
MIRT1220951	hsa-miR-23c	CLIP-seq
MIRT1220901	hsa-miR-2467-3p	CLIP-seq
MIRT2292185	hsa-miR-26a	CLIP-seq
MIRT2292186	hsa-miR-26b	CLIP-seq
MIRT1920739	hsa-miR-298	CLIP-seq
MIRT2292187	hsa-miR-3064-5p	CLIP-seq
MIRT1220902	hsa-miR-30a	CLIP-seq
MIRT1220903	hsa-miR-30b	CLIP-seq
MIRT1220904	hsa-miR-30c	CLIP-seq
MIRT1220905	hsa-miR-30d	CLIP-seq
MIRT1220906	hsa-miR-30e	CLIP-seq
MIRT2292188	hsa-miR-3129-5p	CLIP-seq
MIRT1220907	hsa-miR-3153	CLIP-seq
MIRT1920740	hsa-miR-3158-5p	CLIP-seq
MIRT1220910	hsa-miR-3187-5p	CLIP-seq
MIRT1220911	hsa-miR-3188	CLIP-seq
MIRT2292189	hsa-miR-3606	CLIP-seq
MIRT2292190	hsa-miR-3652	CLIP-seq
MIRT1220954	hsa-miR-3678-5p	CLIP-seq
MIRT2063748	hsa-miR-3680	CLIP-seq
MIRT1220913	hsa-miR-3972	CLIP-seq
MIRT1920741	hsa-miR-412	CLIP-seq
MIRT1220915	hsa-miR-431	CLIP-seq
MIRT1220916	hsa-miR-4328	CLIP-seq
MIRT1220917	hsa-miR-4418	CLIP-seq
MIRT1920742	hsa-miR-4420	CLIP-seq
MIRT2292191	hsa-miR-4430	CLIP-seq
MIRT2292192	hsa-miR-4445	CLIP-seq
MIRT2292193	hsa-miR-4463	CLIP-seq
MIRT2292194	hsa-miR-4465	CLIP-seq
MIRT1220918	hsa-miR-4470	CLIP-seq
MIRT2292195	hsa-miR-4494	CLIP-seq
MIRT1220920	hsa-miR-4505	CLIP-seq
MIRT2292196	hsa-miR-4509	CLIP-seq
MIRT1220964	hsa-miR-4642	CLIP-seq
MIRT2292197	hsa-miR-4677-5p	CLIP-seq
MIRT2292172	hsa-miR-4684-3p	CLIP-seq
MIRT2292198	hsa-miR-4694-5p	CLIP-seq
MIRT1220923	hsa-miR-4716-3p	CLIP-seq
MIRT2292199	hsa-miR-4717-3p	CLIP-seq
MIRT2292200	hsa-miR-4720-5p	CLIP-seq
MIRT2292201	hsa-miR-4744	CLIP-seq
MIRT2292202	hsa-miR-4799-3p	CLIP-seq
MIRT2292203	hsa-miR-4802-3p	CLIP-seq
MIRT1220925	hsa-miR-485-5p	CLIP-seq
MIRT2292204	hsa-miR-499a-5p	CLIP-seq
MIRT1220926	hsa-miR-509-3-5p	CLIP-seq
MIRT1220927	hsa-miR-509-5p	CLIP-seq
MIRT1220928	hsa-miR-511	CLIP-seq
MIRT1220930	hsa-miR-532-3p	CLIP-seq
MIRT1220931	hsa-miR-548a-3p	CLIP-seq
MIRT1220932	hsa-miR-548an	CLIP-seq
MIRT1220933	hsa-miR-548e	CLIP-seq
MIRT1220934	hsa-miR-548f	CLIP-seq
MIRT1220935	hsa-miR-548p	CLIP-seq
MIRT1220936	hsa-miR-558	CLIP-seq
MIRT2292205	hsa-miR-561	CLIP-seq
MIRT2292173	hsa-miR-570	CLIP-seq
MIRT2063749	hsa-miR-582-5p	CLIP-seq
MIRT1220938	hsa-miR-612	CLIP-seq
MIRT1220939	hsa-miR-625	CLIP-seq
MIRT2292206	hsa-miR-628-5p	CLIP-seq
MIRT2292207	hsa-miR-636	CLIP-seq
MIRT1220940	hsa-miR-759	CLIP-seq
MIRT1220941	hsa-miR-922	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
ETS2	Unknown	12737631
NFKB1	Unknown	12737631

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004112	Function	Cyclic-nucleotide phosphodiesterase activity	IEA
GO:0004114	Function	3',5'-cyclic-nucleotide phosphodiesterase activity	IEA
GO:0004115	Function	3',5'-cyclic-AMP phosphodiesterase activity	IBA
GO:0004115	Function	3',5'-cyclic-AMP phosphodiesterase activity	IDA	8389765, 8943082, 9195912
GO:0004115	Function	3',5'-cyclic-AMP phosphodiesterase activity	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006198	Process	CAMP catabolic process	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0008081	Function	Phosphoric diester hydrolase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0047555	Function	3',5'-cyclic-GMP phosphodiesterase activity	IBA
GO:0141162	Process	Negative regulation of cAMP/PKA signal transduction	IBA

Other IDs

• MIM: 171885
• HGNC: 8791
• e!Ensembl: ENSG00000205268

Protein

• UniProt ID: Q13946
• Protein name: High affinity 3',5'-cyclic-AMP phosphodiesterase 7A (EC 3.1.4.53) (HCP1) (TM22) (cAMP-specific phosphodiesterase 7A)
• Protein function: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:19350606, PubMed:8389765, PubMed:9195912). May have a role in muscle signal transduction (PubMed:9195912). {ECO:0000269|PubMed:19350
• PDB: 1ZKL, 3G3N, 4PM0, 4Y2B
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00233	PDEase_I	211 → 444		Domain

• Tissue specificity: TISSUE SPECIFICITY: [Isoform PDE7A1]: Found at high levels in skeletal muscle and at low levels in a variety of tissues including brain and heart (PubMed:9195912). It is expressed as well in two T-cell lines (PubMed:9195912). {ECO:0000269|PubMed:9195912}.
• Sequence:

  MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTA
  LYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRS
  SRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSL
  HGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPW
  DILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFS
  HLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKC
  ADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYL
  VEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQENR
  LS

• Sequence length: 482

Pathways

KEGG:

Purine metabolism
Metabolic pathways
Morphine addiction

Reactome:

G alpha (s) signalling events

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SUBSTANCE ABUSE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Alzheimer Disease	Alzheimer disease	Pubtator	31123752	Associate	★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	BEFREE	16427796		★☆☆☆☆ Found in Text Mining only
Brain Neoplasms	Brain neoplasms	Pubtator	31123752	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	29339250		★☆☆☆☆ Found in Text Mining only
Chronic Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	11812656, 19033455, 28867658		★☆☆☆☆ Found in Text Mining only
Chronic Obstructive Airway Disease	Chronic Obstructive Pulmonary Disease	BEFREE	16427796, 17020529		★☆☆☆☆ Found in Text Mining only
Cognition Disorders	Cognition disorder	Pubtator	22054870	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	29293549		★☆☆☆☆ Found in Text Mining only
Cystic Fibrosis	Cystic Fibrosis	BEFREE	16763151		★☆☆☆☆ Found in Text Mining only
Dermatitis, Atopic	Dermatitis	BEFREE	17020529		★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	BEFREE	28358816		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	28358816		★☆☆☆☆ Found in Text Mining only
Eczema	Eczema	BEFREE	17020529		★☆☆☆☆ Found in Text Mining only
Endometrial Carcinoma	Endometrial carcinoma	BEFREE	25955017		★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus	Lupus Erythematosus	BEFREE	17020529		★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus, Discoid	Lupus Erythematosus	BEFREE	17020529		★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus, Systemic	Lupus Erythematosus	BEFREE	17020529		★☆☆☆☆ Found in Text Mining only
Lupus Vulgaris	Lupus Vulgaris	BEFREE	17020529		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of endometrium	Endometrial Cancer	BEFREE	25955017		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	29339250		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	11812656, 25955017		★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Multiple Sclerosis	BEFREE	17020529, 28007551, 28256546		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	25281617		★☆☆☆☆ Found in Text Mining only
nervous system disorder	Nervous System Disorder	BEFREE	28093982		★☆☆☆☆ Found in Text Mining only
Neurodegenerative Disorders	Neurodegenerative Disorders	BEFREE	28007551, 31473904		★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	BEFREE	31473904		★☆☆☆☆ Found in Text Mining only
Psoriasis	Psoriasis	BEFREE	17020529		★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	17020529, 28826660		★☆☆☆☆ Found in Text Mining only