GULP1 (GULP PTB domain containing engulfment adaptor 1)

Gene

• Entrez ID: 51454
• Gene name: GULP PTB domain containing engulfment adaptor 1
• Gene symbol: GULP1
• Synonyms (NCBI Gene): CED-6, CED6, GULP
• Chromosome: 2
• Chromosome location: 2q32.1-q32.2
• Summary: The protein encoded by this gene is an adapter protein necessary for the engulfment of apoptotic cells by phagocytes. Several transcript variants, some protein coding and some thought not to be protein coding, have been found for this gene. [provided by R

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016998	hsa-miR-335-5p	Microarray	18185580
MIRT024316	hsa-miR-215-5p	Microarray	19074876
MIRT026204	hsa-miR-192-5p	Microarray	19074876
MIRT527139	hsa-miR-1277-5p	PAR-CLIP	22012620
MIRT527138	hsa-miR-5011-5p	PAR-CLIP	22012620
MIRT527137	hsa-miR-25-3p	PAR-CLIP	22012620
MIRT527136	hsa-miR-32-5p	PAR-CLIP	22012620
MIRT527135	hsa-miR-363-3p	PAR-CLIP	22012620
MIRT527134	hsa-miR-367-3p	PAR-CLIP	22012620
MIRT527133	hsa-miR-92a-3p	PAR-CLIP	22012620
MIRT527132	hsa-miR-92b-3p	PAR-CLIP	22012620
MIRT512658	hsa-miR-627-3p	PAR-CLIP	22012620
MIRT512656	hsa-miR-3606-5p	PAR-CLIP	22012620
MIRT527131	hsa-miR-190a-3p	PAR-CLIP	22012620
MIRT512657	hsa-miR-5571-3p	PAR-CLIP	22012620
MIRT512655	hsa-miR-7975	PAR-CLIP	22012620
MIRT527130	hsa-miR-153-3p	PAR-CLIP	22012620
MIRT527129	hsa-miR-448	PAR-CLIP	22012620
MIRT512654	hsa-miR-3685	PAR-CLIP	22012620
MIRT512653	hsa-miR-384	PAR-CLIP	22012620
MIRT512658	hsa-miR-627-3p	PAR-CLIP	23446348
MIRT512656	hsa-miR-3606-5p	PAR-CLIP	23446348
MIRT512657	hsa-miR-5571-3p	PAR-CLIP	23446348
MIRT512655	hsa-miR-7975	PAR-CLIP	23446348
MIRT512654	hsa-miR-3685	PAR-CLIP	23446348
MIRT512653	hsa-miR-384	PAR-CLIP	23446348
MIRT527139	hsa-miR-1277-5p	PAR-CLIP	22012620
MIRT527138	hsa-miR-5011-5p	PAR-CLIP	22012620
MIRT527137	hsa-miR-25-3p	PAR-CLIP	22012620
MIRT527136	hsa-miR-32-5p	PAR-CLIP	22012620
MIRT527135	hsa-miR-363-3p	PAR-CLIP	22012620
MIRT527134	hsa-miR-367-3p	PAR-CLIP	22012620
MIRT527133	hsa-miR-92a-3p	PAR-CLIP	22012620
MIRT527132	hsa-miR-92b-3p	PAR-CLIP	22012620
MIRT512658	hsa-miR-627-3p	PAR-CLIP	22012620
MIRT512656	hsa-miR-3606-5p	PAR-CLIP	22012620
MIRT527131	hsa-miR-190a-3p	PAR-CLIP	22012620
MIRT512657	hsa-miR-5571-3p	PAR-CLIP	22012620
MIRT512655	hsa-miR-7975	PAR-CLIP	22012620
MIRT527130	hsa-miR-153-3p	PAR-CLIP	22012620
MIRT527129	hsa-miR-448	PAR-CLIP	22012620
MIRT512654	hsa-miR-3685	PAR-CLIP	22012620
MIRT512653	hsa-miR-384	PAR-CLIP	22012620
MIRT512658	hsa-miR-627-3p	PAR-CLIP	23446348
MIRT512656	hsa-miR-3606-5p	PAR-CLIP	23446348
MIRT512657	hsa-miR-5571-3p	PAR-CLIP	23446348
MIRT512655	hsa-miR-7975	PAR-CLIP	23446348
MIRT512654	hsa-miR-3685	PAR-CLIP	23446348
MIRT512653	hsa-miR-384	PAR-CLIP	23446348
MIRT1038516	hsa-miR-1305	CLIP-seq
MIRT1038517	hsa-miR-299-5p	CLIP-seq
MIRT1038518	hsa-miR-300	CLIP-seq
MIRT1038519	hsa-miR-3065-3p	CLIP-seq
MIRT1038520	hsa-miR-3129-3p	CLIP-seq
MIRT1038521	hsa-miR-3200-3p	CLIP-seq
MIRT1038522	hsa-miR-33a	CLIP-seq
MIRT1038523	hsa-miR-33b	CLIP-seq
MIRT1038524	hsa-miR-3646	CLIP-seq
MIRT1038525	hsa-miR-381	CLIP-seq
MIRT1038526	hsa-miR-4666-3p	CLIP-seq
MIRT1038527	hsa-miR-499-3p	CLIP-seq
MIRT1038528	hsa-miR-499a-3p	CLIP-seq
MIRT1038529	hsa-miR-548ac	CLIP-seq
MIRT1038530	hsa-miR-548ae	CLIP-seq
MIRT1038531	hsa-miR-548aj	CLIP-seq
MIRT1038532	hsa-miR-548am	CLIP-seq
MIRT1038533	hsa-miR-548d-3p	CLIP-seq
MIRT1038534	hsa-miR-548n	CLIP-seq
MIRT1038535	hsa-miR-548t	CLIP-seq
MIRT1038536	hsa-miR-548x	CLIP-seq
MIRT1038537	hsa-miR-548z	CLIP-seq
MIRT2007921	hsa-miR-1324	CLIP-seq
MIRT2007922	hsa-miR-142-5p	CLIP-seq
MIRT2007923	hsa-miR-219-1-3p	CLIP-seq
MIRT1038517	hsa-miR-299-5p	CLIP-seq
MIRT2007924	hsa-miR-340	CLIP-seq
MIRT2007925	hsa-miR-369-3p	CLIP-seq
MIRT2007926	hsa-miR-3714	CLIP-seq
MIRT2007927	hsa-miR-4457	CLIP-seq
MIRT2007928	hsa-miR-4643	CLIP-seq
MIRT2007929	hsa-miR-4678	CLIP-seq
MIRT2007930	hsa-miR-4731-3p	CLIP-seq
MIRT2007931	hsa-miR-4736	CLIP-seq
MIRT2007932	hsa-miR-4801	CLIP-seq
MIRT2007933	hsa-miR-514	CLIP-seq
MIRT2007934	hsa-miR-514b-3p	CLIP-seq
MIRT2007935	hsa-miR-548c-3p	CLIP-seq
MIRT2007936	hsa-miR-548l	CLIP-seq
MIRT2007937	hsa-miR-548u	CLIP-seq
MIRT2007938	hsa-miR-642b	CLIP-seq
MIRT2007939	hsa-miR-940	CLIP-seq
MIRT2240619	hsa-miR-1236	CLIP-seq
MIRT2240620	hsa-miR-144	CLIP-seq
MIRT2240621	hsa-miR-224	CLIP-seq
MIRT2240622	hsa-miR-23a	CLIP-seq
MIRT2240623	hsa-miR-23b	CLIP-seq
MIRT2240624	hsa-miR-23c	CLIP-seq
MIRT2240625	hsa-miR-3163	CLIP-seq
MIRT2240626	hsa-miR-3622b-5p	CLIP-seq
MIRT2240627	hsa-miR-4642	CLIP-seq
MIRT2240628	hsa-miR-4789-5p	CLIP-seq
MIRT2240629	hsa-miR-593	CLIP-seq
MIRT2388882	hsa-miR-101	CLIP-seq
MIRT2240620	hsa-miR-144	CLIP-seq
MIRT2544067	hsa-miR-1	CLIP-seq
MIRT2240619	hsa-miR-1236	CLIP-seq
MIRT2544068	hsa-miR-1245b-3p	CLIP-seq
MIRT2544069	hsa-miR-1253	CLIP-seq
MIRT2544070	hsa-miR-1299	CLIP-seq
MIRT2544071	hsa-miR-1322	CLIP-seq
MIRT2544072	hsa-miR-1323	CLIP-seq
MIRT2544073	hsa-miR-135a	CLIP-seq
MIRT2544074	hsa-miR-135b	CLIP-seq
MIRT2007922	hsa-miR-142-5p	CLIP-seq
MIRT2544075	hsa-miR-206	CLIP-seq
MIRT2544076	hsa-miR-2909	CLIP-seq
MIRT2544077	hsa-miR-3064-3p	CLIP-seq
MIRT2544078	hsa-miR-3119	CLIP-seq
MIRT2544079	hsa-miR-3122	CLIP-seq
MIRT2544080	hsa-miR-3140-3p	CLIP-seq
MIRT2544081	hsa-miR-3143	CLIP-seq
MIRT2544082	hsa-miR-3148	CLIP-seq
MIRT2544083	hsa-miR-3150b-3p	CLIP-seq
MIRT2544084	hsa-miR-3153	CLIP-seq
MIRT2544085	hsa-miR-3157-3p	CLIP-seq
MIRT2544086	hsa-miR-3162-5p	CLIP-seq
MIRT2007924	hsa-miR-340	CLIP-seq
MIRT2544087	hsa-miR-34c-3p	CLIP-seq
MIRT2544088	hsa-miR-3616-3p	CLIP-seq
MIRT2240626	hsa-miR-3622b-5p	CLIP-seq
MIRT1038524	hsa-miR-3646	CLIP-seq
MIRT2544089	hsa-miR-3662	CLIP-seq
MIRT2544090	hsa-miR-3673	CLIP-seq
MIRT2544091	hsa-miR-3913-5p	CLIP-seq
MIRT2544092	hsa-miR-409-3p	CLIP-seq
MIRT2544093	hsa-miR-410	CLIP-seq
MIRT2544094	hsa-miR-4290	CLIP-seq
MIRT2544095	hsa-miR-4307	CLIP-seq
MIRT2544096	hsa-miR-4432	CLIP-seq
MIRT2544097	hsa-miR-4477b	CLIP-seq
MIRT2544098	hsa-miR-4517	CLIP-seq
MIRT2544099	hsa-miR-4524	CLIP-seq
MIRT2544100	hsa-miR-4540	CLIP-seq
MIRT2240627	hsa-miR-4642	CLIP-seq
MIRT2544101	hsa-miR-4668-5p	CLIP-seq
MIRT2544102	hsa-miR-4689	CLIP-seq
MIRT2544103	hsa-miR-4712-3p	CLIP-seq
MIRT2544104	hsa-miR-4719	CLIP-seq
MIRT2544105	hsa-miR-4735-5p	CLIP-seq
MIRT2544106	hsa-miR-4761-3p	CLIP-seq
MIRT2544107	hsa-miR-4762-5p	CLIP-seq
MIRT2544108	hsa-miR-4778-3p	CLIP-seq
MIRT2544109	hsa-miR-4784	CLIP-seq
MIRT2544110	hsa-miR-491-3p	CLIP-seq
MIRT2544111	hsa-miR-494	CLIP-seq
MIRT2544112	hsa-miR-498	CLIP-seq
MIRT2544113	hsa-miR-513a-3p	CLIP-seq
MIRT2544114	hsa-miR-539	CLIP-seq
MIRT2544115	hsa-miR-543	CLIP-seq
MIRT2544116	hsa-miR-548a-5p	CLIP-seq
MIRT2544117	hsa-miR-548aa	CLIP-seq
MIRT2544118	hsa-miR-548ab	CLIP-seq
MIRT2544119	hsa-miR-548ag	CLIP-seq
MIRT2544120	hsa-miR-548ai	CLIP-seq
MIRT2544121	hsa-miR-548ak	CLIP-seq
MIRT2544122	hsa-miR-548b-5p	CLIP-seq
MIRT2544123	hsa-miR-548c-5p	CLIP-seq
MIRT2544124	hsa-miR-548d-5p	CLIP-seq
MIRT2544125	hsa-miR-548h	CLIP-seq
MIRT2544126	hsa-miR-548i	CLIP-seq
MIRT2544127	hsa-miR-548j	CLIP-seq
MIRT2544128	hsa-miR-548k	CLIP-seq
MIRT2007936	hsa-miR-548l	CLIP-seq
MIRT2544129	hsa-miR-548o	CLIP-seq
MIRT2007937	hsa-miR-548u	CLIP-seq
MIRT2544130	hsa-miR-548w	CLIP-seq
MIRT2544131	hsa-miR-548y	CLIP-seq
MIRT2544132	hsa-miR-559	CLIP-seq
MIRT2544133	hsa-miR-576-3p	CLIP-seq
MIRT2544134	hsa-miR-577	CLIP-seq
MIRT2544135	hsa-miR-579	CLIP-seq
MIRT2240629	hsa-miR-593	CLIP-seq
MIRT2544136	hsa-miR-613	CLIP-seq
MIRT2544137	hsa-miR-874	CLIP-seq
MIRT2544138	hsa-miR-875-3p	CLIP-seq
MIRT2544139	hsa-miR-889	CLIP-seq
MIRT2544140	hsa-miR-9	CLIP-seq
MIRT2544067	hsa-miR-1	CLIP-seq
MIRT2240619	hsa-miR-1236	CLIP-seq
MIRT2544068	hsa-miR-1245b-3p	CLIP-seq
MIRT2544069	hsa-miR-1253	CLIP-seq
MIRT2544070	hsa-miR-1299	CLIP-seq
MIRT2544071	hsa-miR-1322	CLIP-seq
MIRT2544072	hsa-miR-1323	CLIP-seq
MIRT2544073	hsa-miR-135a	CLIP-seq
MIRT2544074	hsa-miR-135b	CLIP-seq
MIRT2007922	hsa-miR-142-5p	CLIP-seq
MIRT2544075	hsa-miR-206	CLIP-seq
MIRT2544076	hsa-miR-2909	CLIP-seq
MIRT2544077	hsa-miR-3064-3p	CLIP-seq
MIRT2544078	hsa-miR-3119	CLIP-seq
MIRT2544079	hsa-miR-3122	CLIP-seq
MIRT2544080	hsa-miR-3140-3p	CLIP-seq
MIRT2544082	hsa-miR-3148	CLIP-seq
MIRT2544083	hsa-miR-3150b-3p	CLIP-seq
MIRT2544084	hsa-miR-3153	CLIP-seq
MIRT2544085	hsa-miR-3157-3p	CLIP-seq
MIRT2544086	hsa-miR-3162-5p	CLIP-seq
MIRT2007924	hsa-miR-340	CLIP-seq
MIRT2544087	hsa-miR-34c-3p	CLIP-seq
MIRT2544088	hsa-miR-3616-3p	CLIP-seq
MIRT2240626	hsa-miR-3622b-5p	CLIP-seq
MIRT1038524	hsa-miR-3646	CLIP-seq
MIRT2544089	hsa-miR-3662	CLIP-seq
MIRT2544090	hsa-miR-3673	CLIP-seq
MIRT2544091	hsa-miR-3913-5p	CLIP-seq
MIRT2544094	hsa-miR-4290	CLIP-seq
MIRT2544095	hsa-miR-4307	CLIP-seq
MIRT2544096	hsa-miR-4432	CLIP-seq
MIRT2544097	hsa-miR-4477b	CLIP-seq
MIRT2544098	hsa-miR-4517	CLIP-seq
MIRT2544099	hsa-miR-4524	CLIP-seq
MIRT2544100	hsa-miR-4540	CLIP-seq
MIRT2240627	hsa-miR-4642	CLIP-seq
MIRT2544101	hsa-miR-4668-5p	CLIP-seq
MIRT2544102	hsa-miR-4689	CLIP-seq
MIRT2544103	hsa-miR-4712-3p	CLIP-seq
MIRT2544104	hsa-miR-4719	CLIP-seq
MIRT2544105	hsa-miR-4735-5p	CLIP-seq
MIRT2544106	hsa-miR-4761-3p	CLIP-seq
MIRT2544107	hsa-miR-4762-5p	CLIP-seq
MIRT2544108	hsa-miR-4778-3p	CLIP-seq
MIRT2544109	hsa-miR-4784	CLIP-seq
MIRT2544110	hsa-miR-491-3p	CLIP-seq
MIRT2544111	hsa-miR-494	CLIP-seq
MIRT2544112	hsa-miR-498	CLIP-seq
MIRT2544113	hsa-miR-513a-3p	CLIP-seq
MIRT2544114	hsa-miR-539	CLIP-seq
MIRT2544116	hsa-miR-548a-5p	CLIP-seq
MIRT2544117	hsa-miR-548aa	CLIP-seq
MIRT2544118	hsa-miR-548ab	CLIP-seq
MIRT2544119	hsa-miR-548ag	CLIP-seq
MIRT2544120	hsa-miR-548ai	CLIP-seq
MIRT2544121	hsa-miR-548ak	CLIP-seq
MIRT2544122	hsa-miR-548b-5p	CLIP-seq
MIRT2544123	hsa-miR-548c-5p	CLIP-seq
MIRT2544124	hsa-miR-548d-5p	CLIP-seq
MIRT2544125	hsa-miR-548h	CLIP-seq
MIRT2544126	hsa-miR-548i	CLIP-seq
MIRT2544127	hsa-miR-548j	CLIP-seq
MIRT2544128	hsa-miR-548k	CLIP-seq
MIRT2007936	hsa-miR-548l	CLIP-seq
MIRT2544129	hsa-miR-548o	CLIP-seq
MIRT2007937	hsa-miR-548u	CLIP-seq
MIRT2544130	hsa-miR-548w	CLIP-seq
MIRT2544131	hsa-miR-548y	CLIP-seq
MIRT2544132	hsa-miR-559	CLIP-seq
MIRT2544133	hsa-miR-576-3p	CLIP-seq
MIRT2544134	hsa-miR-577	CLIP-seq
MIRT2544135	hsa-miR-579	CLIP-seq
MIRT2240629	hsa-miR-593	CLIP-seq
MIRT2544136	hsa-miR-613	CLIP-seq
MIRT2544137	hsa-miR-874	CLIP-seq
MIRT2544138	hsa-miR-875-3p	CLIP-seq
MIRT2544139	hsa-miR-889	CLIP-seq
MIRT2544140	hsa-miR-9	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005737	Component	Cytoplasm	IEA
GO:0006869	Process	Lipid transport	IEA
GO:0006909	Process	Phagocytosis	IEA
GO:0006911	Process	Phagocytosis, engulfment	IDA	11729193
GO:0006911	Process	Phagocytosis, engulfment	TAS	10574763
GO:0006915	Process	Apoptotic process	IEA
GO:0006915	Process	Apoptotic process	TAS	10574763

Other IDs

• MIM: 608165
• HGNC: 18649
• e!Ensembl: ENSG00000144366

Protein

• UniProt ID: Q9UBP9
• Protein name: PTB domain-containing engulfment adapter protein 1 (Cell death protein 6 homolog) (PTB domain adapter protein CED-6) (Protein GULP)
• Protein function: May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands,
• PDB: 6ITU
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00640	PID	27 → 155	Phosphotyrosine interaction domain (PTB/PID)	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. Detected in macrophages, pancreas, kidney, skeletal muscle, heart, colon, intestine, lung, placenta and ovary. {ECO:0000269|PubMed:10574763}.
• Sequence:

  MNRAFSRKKDKTWMHTPEALSKHFIPYNAKFLGSTEVEQPKGTEVVRDAVRKLKFARHIK
  KSEGQKIPKVELQISIYGVKILEPKTKEVQHNCQLHRISFCADDKTDKRIFTFICKDSES
  NKHLCYVFDSEKCAEEITLTIGQAFDLAYRKFLESGGKDVETRKQIAGLQKRIQDLETEN
  MELKNKVQDLENQLRITQVSAPPAGSMTPKSPSTDIFDMIPFSPISHQSSMPTRNGTQPP
  PVPSRSTEIKRDLFGAEPFDPFNCGAADFPPDIQSKLDEMQEGFKMGLTLEGTVFCLDPL
  DSRC

• Sequence length: 304

Pathways

KEGG:

Efferocytosis

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
LIVER CIRRHOSIS, EXPERIMENTAL	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
THYROID DISEASES	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UTERINE FIBROID	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adenocarcinoma	Adenocarcinoma	BEFREE	22451657		★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	29964205		★☆☆☆☆ Found in Text Mining only
Chronic Obstructive Airway Disease	Chronic Obstructive Pulmonary Disease	BEFREE	28284325		★☆☆☆☆ Found in Text Mining only
Emphysema	Emphysema	Pubtator	28284325	Associate	★☆☆☆☆ Found in Text Mining only
Episodic Kinesigenic Dyskinesia 1	Episodic Kinesigenic Dyskinesia	BEFREE	31373844		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	29964205		★☆☆☆☆ Found in Text Mining only
Niemann-Pick Disease, Type B	Niemann-Pick Disease	BEFREE	23415435		★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	28284325		★☆☆☆☆ Found in Text Mining only
Ovarian adenocarcinoma	Ovarian adenocarcinoma	BEFREE	22451657		★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	BEFREE	29964205		★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	40447753	Associate	★☆☆☆☆ Found in Text Mining only
Pulmonary Disease Chronic Obstructive	Chronic obstructive pulmonary disease	Pubtator	22829758, 28284325	Associate	★☆☆☆☆ Found in Text Mining only
Pulmonary Emphysema	Pulmonary Emphysema	BEFREE	28284325		★☆☆☆☆ Found in Text Mining only
Thyroid Diseases	Thyroid Diseases	CTD_human_DG	23397585		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	34576193	Associate	★☆☆☆☆ Found in Text Mining only