Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	51447
Gene name	Inositol hexakisphosphate kinase 2
Gene symbol	IP6K2
Synonyms (NCBI Gene)	IHPK2InsP6K2PIUS
Chromosome	3
Chromosome location	3p21.31
Summary	This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,

151

Show/Hide all (151)

miRTarBase ID	miRNA	Experiments	Reference
MIRT003850	hsa-miR-1-3p	Microarray	15685193
MIRT003850	hsa-miR-1-3p	Microarray;Other	15685193
MIRT003850	hsa-miR-1-3p	Microarray	18668037
MIRT027801	hsa-miR-98-5p	Microarray	19088304
MIRT040826	hsa-miR-18a-3p	CLASH	23622248
MIRT040826	hsa-miR-18a-3p	CLASH	23622248
MIRT038635	hsa-miR-125a-3p	CLASH	23622248
MIRT640457	hsa-miR-4668-3p	HITS-CLIP	19536157
MIRT640456	hsa-miR-1264	HITS-CLIP	19536157
MIRT640455	hsa-miR-186-3p	HITS-CLIP	19536157
MIRT640454	hsa-miR-361-3p	HITS-CLIP	19536157
MIRT640453	hsa-miR-150-5p	HITS-CLIP	19536157
MIRT640451	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT640452	hsa-miR-3679-3p	HITS-CLIP	19536157
MIRT640457	hsa-miR-4668-3p	HITS-CLIP	19536157
MIRT640456	hsa-miR-1264	HITS-CLIP	19536157
MIRT640455	hsa-miR-186-3p	HITS-CLIP	19536157
MIRT640454	hsa-miR-361-3p	HITS-CLIP	19536157
MIRT640453	hsa-miR-150-5p	HITS-CLIP	19536157
MIRT640451	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT640452	hsa-miR-3679-3p	HITS-CLIP	19536157
MIRT640457	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT640456	hsa-miR-1264	HITS-CLIP	23824327
MIRT640455	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT640454	hsa-miR-361-3p	HITS-CLIP	23824327
MIRT640453	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT640451	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT640452	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT640457	hsa-miR-4668-3p	HITS-CLIP	19536157
MIRT640456	hsa-miR-1264	HITS-CLIP	19536157
MIRT640455	hsa-miR-186-3p	HITS-CLIP	19536157
MIRT640454	hsa-miR-361-3p	HITS-CLIP	19536157
MIRT640453	hsa-miR-150-5p	HITS-CLIP	19536157
MIRT640451	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT640452	hsa-miR-3679-3p	HITS-CLIP	19536157
MIRT640457	hsa-miR-4668-3p	HITS-CLIP	19536157
MIRT640456	hsa-miR-1264	HITS-CLIP	19536157
MIRT640455	hsa-miR-186-3p	HITS-CLIP	19536157
MIRT640454	hsa-miR-361-3p	HITS-CLIP	19536157
MIRT640453	hsa-miR-150-5p	HITS-CLIP	19536157
MIRT640451	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT640452	hsa-miR-3679-3p	HITS-CLIP	19536157
MIRT640457	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT640456	hsa-miR-1264	HITS-CLIP	23824327
MIRT640455	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT640454	hsa-miR-361-3p	HITS-CLIP	23824327
MIRT640453	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT640451	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT640452	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT1068391	hsa-miR-2110	CLIP-seq
MIRT1068392	hsa-miR-2467-3p	CLIP-seq
MIRT1068393	hsa-miR-3117-5p	CLIP-seq
MIRT1068394	hsa-miR-3150a-3p	CLIP-seq
MIRT1068395	hsa-miR-3175	CLIP-seq
MIRT1068396	hsa-miR-326	CLIP-seq
MIRT1068397	hsa-miR-330-5p	CLIP-seq
MIRT1068398	hsa-miR-3678-3p	CLIP-seq
MIRT1068399	hsa-miR-380	CLIP-seq
MIRT1068400	hsa-miR-3924	CLIP-seq
MIRT1068401	hsa-miR-4267	CLIP-seq
MIRT1068402	hsa-miR-4303	CLIP-seq
MIRT1068403	hsa-miR-4495	CLIP-seq
MIRT1068404	hsa-miR-4649-3p	CLIP-seq
MIRT1068405	hsa-miR-4651	CLIP-seq
MIRT1068406	hsa-miR-4659a-3p	CLIP-seq
MIRT1068407	hsa-miR-4659b-3p	CLIP-seq
MIRT1068408	hsa-miR-4775	CLIP-seq
MIRT1068409	hsa-miR-576-5p	CLIP-seq
MIRT1068410	hsa-miR-590-3p	CLIP-seq
MIRT1068411	hsa-miR-608	CLIP-seq
MIRT1068412	hsa-miR-663b	CLIP-seq
MIRT1068413	hsa-miR-939	CLIP-seq
MIRT1068414	hsa-miR-214	CLIP-seq
MIRT1068415	hsa-miR-2392	CLIP-seq
MIRT1068416	hsa-miR-3605-5p	CLIP-seq
MIRT1068417	hsa-miR-3619-5p	CLIP-seq
MIRT1068418	hsa-miR-3665	CLIP-seq
MIRT1068419	hsa-miR-3675-5p	CLIP-seq
MIRT1068420	hsa-miR-3934	CLIP-seq
MIRT1068421	hsa-miR-4283	CLIP-seq
MIRT1068422	hsa-miR-4291	CLIP-seq
MIRT1068423	hsa-miR-4447	CLIP-seq
MIRT1068424	hsa-miR-4472	CLIP-seq
MIRT1068425	hsa-miR-4488	CLIP-seq
MIRT1068426	hsa-miR-4489	CLIP-seq
MIRT1068427	hsa-miR-4675	CLIP-seq
MIRT1068428	hsa-miR-4697-5p	CLIP-seq
MIRT1068429	hsa-miR-4719	CLIP-seq
MIRT1068430	hsa-miR-4741	CLIP-seq
MIRT1068431	hsa-miR-761	CLIP-seq
MIRT1068432	hsa-miR-764	CLIP-seq
MIRT1068433	hsa-miR-922	CLIP-seq
MIRT1068434	hsa-miR-124	CLIP-seq
MIRT1068435	hsa-miR-3130-5p	CLIP-seq
MIRT1068436	hsa-miR-3919	CLIP-seq
MIRT1068437	hsa-miR-4482	CLIP-seq
MIRT1068438	hsa-miR-4712-5p	CLIP-seq
MIRT1068439	hsa-miR-4797-5p	CLIP-seq
MIRT1068440	hsa-miR-506	CLIP-seq
MIRT1068441	hsa-miR-548an	CLIP-seq
MIRT1068442	hsa-miR-770-5p	CLIP-seq
MIRT2016658	hsa-miR-4446-5p	CLIP-seq
MIRT2016659	hsa-miR-488	CLIP-seq
MIRT2016660	hsa-miR-646	CLIP-seq
MIRT2016660	hsa-miR-646	CLIP-seq
MIRT2552514	hsa-miR-1913	CLIP-seq
MIRT2552515	hsa-miR-1915	CLIP-seq
MIRT1068392	hsa-miR-2467-3p	CLIP-seq
MIRT1068393	hsa-miR-3117-5p	CLIP-seq
MIRT2552516	hsa-miR-3127-3p	CLIP-seq
MIRT2552517	hsa-miR-3183	CLIP-seq
MIRT2552518	hsa-miR-3189-5p	CLIP-seq
MIRT2552519	hsa-miR-324-3p	CLIP-seq
MIRT1068396	hsa-miR-326	CLIP-seq
MIRT1068397	hsa-miR-330-5p	CLIP-seq
MIRT1068398	hsa-miR-3678-3p	CLIP-seq
MIRT1068401	hsa-miR-4267	CLIP-seq
MIRT1068402	hsa-miR-4303	CLIP-seq
MIRT2016658	hsa-miR-4446-5p	CLIP-seq
MIRT1068404	hsa-miR-4649-3p	CLIP-seq
MIRT2552520	hsa-miR-4650-5p	CLIP-seq
MIRT2552521	hsa-miR-4691-5p	CLIP-seq
MIRT2552522	hsa-miR-4723-3p	CLIP-seq
MIRT2552523	hsa-miR-4726-3p	CLIP-seq
MIRT2552524	hsa-miR-4757-5p	CLIP-seq
MIRT2552525	hsa-miR-4758-3p	CLIP-seq
MIRT2016659	hsa-miR-488	CLIP-seq
MIRT2016660	hsa-miR-646	CLIP-seq
MIRT1068412	hsa-miR-663b	CLIP-seq
MIRT2552514	hsa-miR-1913	CLIP-seq
MIRT2552515	hsa-miR-1915	CLIP-seq
MIRT1068392	hsa-miR-2467-3p	CLIP-seq
MIRT1068393	hsa-miR-3117-5p	CLIP-seq
MIRT2552517	hsa-miR-3183	CLIP-seq
MIRT2552518	hsa-miR-3189-5p	CLIP-seq
MIRT2552519	hsa-miR-324-3p	CLIP-seq
MIRT1068396	hsa-miR-326	CLIP-seq
MIRT1068397	hsa-miR-330-5p	CLIP-seq
MIRT1068398	hsa-miR-3678-3p	CLIP-seq
MIRT1068401	hsa-miR-4267	CLIP-seq
MIRT1068402	hsa-miR-4303	CLIP-seq
MIRT1068404	hsa-miR-4649-3p	CLIP-seq
MIRT2552520	hsa-miR-4650-5p	CLIP-seq
MIRT2552521	hsa-miR-4691-5p	CLIP-seq
MIRT2552522	hsa-miR-4723-3p	CLIP-seq
MIRT2552523	hsa-miR-4726-3p	CLIP-seq
MIRT2552524	hsa-miR-4757-5p	CLIP-seq
MIRT2552525	hsa-miR-4758-3p	CLIP-seq
MIRT2016659	hsa-miR-488	CLIP-seq
MIRT2016660	hsa-miR-646	CLIP-seq
MIRT1068412	hsa-miR-663b	CLIP-seq

Show/Hide all (42)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000827	Function	Inositol-1,3,4,5,6-pentakisphosphate kinase activity	IEA
GO:0000827	Function	Inositol-1,3,4,5,6-pentakisphosphate kinase activity	TAS
GO:0000828	Function	Inositol hexakisphosphate kinase activity	IBA
GO:0000828	Function	Inositol hexakisphosphate kinase activity	IDA	10574768
GO:0000828	Function	Inositol hexakisphosphate kinase activity	IEA
GO:0000828	Function	Inositol hexakisphosphate kinase activity	TAS
GO:0000829	Function	Diphosphoinositol pentakisphosphate kinase activity	IEA
GO:0000829	Function	Diphosphoinositol pentakisphosphate kinase activity	TAS
GO:0000832	Function	Inositol hexakisphosphate 5-kinase activity	IDA	30624931
GO:0000832	Function	Inositol hexakisphosphate 5-kinase activity	IEA
GO:0001650	Component	Fibrillar center	IDA
GO:0005515	Function	Protein binding	IPI	18195352, 21078964, 21516116, 25416956, 28514442, 29892012, 31515488, 32296183, 33961781
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	11502751
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030054	Component	Cell junction	IDA
GO:0030308	Process	Negative regulation of cell growth	IMP	11337497
GO:0032958	Process	Inositol phosphate biosynthetic process	IBA
GO:0032958	Process	Inositol phosphate biosynthetic process	IEA
GO:0043065	Process	Positive regulation of apoptotic process	IMP	11337497
GO:0043647	Process	Inositol phosphate metabolic process	IDA	30624931
GO:0043647	Process	Inositol phosphate metabolic process	IEA
GO:0043647	Process	Inositol phosphate metabolic process	TAS
GO:0046488	Process	Phosphatidylinositol metabolic process	IEA
GO:0046854	Process	Phosphatidylinositol phosphate biosynthetic process	IBA
GO:0046854	Process	Phosphatidylinositol phosphate biosynthetic process	IDA	10574768
GO:0050821	Process	Protein stabilization	IEA
GO:0052836	Function	Inositol 5-diphosphate pentakisphosphate 5-kinase activity	IEA
GO:0052836	Function	Inositol 5-diphosphate pentakisphosphate 5-kinase activity	TAS
GO:0052839	Function	Diphosphoinositol tetrakisphosphate kinase activity	IEA
GO:0052839	Function	Diphosphoinositol tetrakisphosphate kinase activity	TAS
GO:0090407	Process	Organophosphate biosynthetic process	IEA
GO:0097243	Function	Flavonoid binding	IDA	30624931
GO:1905396	Process	Cellular response to flavonoid	IMP	30624931

MIM	HGNC	e!Ensembl
606992	17313	ENSG00000068745

Q9UHH9

Protein name

Inositol hexakisphosphate kinase 2 (InsP6 kinase 2) (InsP6K2) (EC 2.7.4.-) (P(i)-uptake stimulator) (PiUS)

Protein function

Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03770	IPK	203 → 418	Inositol polyphosphate kinase	Family

Sequence

MSPAFRAMDVEPRAKGVLLEPFVHQVGGHSCVLRFNETTLCKPLVPREHQFYETLPAEMR
KFTPQYKGVVSVRFEEDEDRNLCLIAYPLKGDHGIVDIVDNSDCEPKSKLLRWTTNKKHH
VLETEKTPKDWVRQHRKEEKMKSHKLEEEFEWLKKSEVLYYTVEKKGNISSQLKHYNPWS
MKCHQQQLQRMKENAKHRNQYKFILLENLTSRYEVPCVLDLKMGTRQHGDDASEEKAANQ
IRKCQQSTSAVIGVRVCGMQVYQAGSGQLMFMNKYHGRKLSVQGFKEALFQFFHNGRYLR
RELLGPVLKKLTELKAVLERQESYRFYSSSLLVIYDGKERPEVVLDSDAEDLEDLSEESA
DESAGAYAYKPIGASSVDVRMIDFAHTTCRLYGEDTVVHEGQDAGYIFGLQSLIDIVTEI
SEESGE

Sequence length

426

Interactions

View interactions

	KEGG		Reactome
	Phosphatidylinositol signaling system		Synthesis of IPs in the nucleus Interferon alpha/beta signaling

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (9)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHILDHOOD ONSET ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HUNTINGTON DISEASE	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INFLAMMATORY BOWEL DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MENTAL OR BEHAVIOURAL DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PARKINSON DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (16)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Akinetic-Rigid Variant of Huntington Disease	Akinetic-Rigid Variant Of Huntington Disease	CTD_human_DG	21652713		★★★★★ ★☆☆☆☆ Found in Text Mining only
Anorexia Nervosa	Anorexia nervosa	Pubtator	39741260	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Autoimmune disease	Pubtator	22446964	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Autonomic Nervous System Diseases	Autonomic nervous system disease	Pubtator	34994165	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	31856847	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	21078964	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	32176627	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	35156508	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Huntington Disease	Huntington Disease	CTD_human_DG	21652713		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Huntington Disease, Late Onset	Huntington Disease	CTD_human_DG	21652713		★★★★★ ★☆☆☆☆ Found in Text Mining only
Juvenile Huntington Disease	Huntington Disease	CTD_human_DG	21652713		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	11896621		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	23018034		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	11337497, 11896621, 15634191	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	GWASCAT_DG	28892059		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Parkinson Disease	Parkinson disease	Pubtator	34994165	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

IP6K2 (inositol hexakisphosphate kinase 2)