POLK (DNA polymerase kappa)

Gene

• Entrez ID: 51426
• Gene name: DNA polymerase kappa
• Gene symbol: POLK
• Synonyms (NCBI Gene): DINB1, DINP, POLQ
• Chromosome: 5
• Chromosome location: 5q13.3
• Summary: This gene encodes a member of the DNA polymerase type-Y family of proteins. The encoded protein is a specialized DNA polymerase that catalyzes translesion DNA synthesis, which allows DNA replication in the presence of DNA lesions. Human cell lines lacking

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs111584802	A>G	Pathogenic	Coding sequence variant, non coding transcript variant, missense variant
rs139591993	A>C,T	Pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs148960463	G>A	Pathogenic	5 prime UTR variant, non coding transcript variant, coding sequence variant, missense variant, genic upstream transcript variant, intron variant
rs749804502	G>A,T	Pathogenic	Non coding transcript variant, genic upstream transcript variant, coding sequence variant, missense variant
rs770984846	G>A	Pathogenic	Synonymous variant, coding sequence variant, non coding transcript variant
rs781194178	G>A,T	Pathogenic	Downstream transcript variant, genic downstream transcript variant, missense variant, coding sequence variant, non coding transcript variant, synonymous variant
rs786205688	T>C	Pathogenic	Genic downstream transcript variant, non coding transcript variant, 3 prime UTR variant
rs863225454	C>T	Uncertain-significance, pathogenic	Coding sequence variant, missense variant, non coding transcript variant, genic upstream transcript variant
rs863225455	C>T	Pathogenic	Non coding transcript variant, genic downstream transcript variant, missense variant, downstream transcript variant, coding sequence variant
rs863225456	T>A	Pathogenic	Coding sequence variant, non coding transcript variant, missense variant, genic downstream transcript variant
rs863225457	G>A	Pathogenic	Non coding transcript variant, genic downstream transcript variant, missense variant, downstream transcript variant, coding sequence variant
rs1304454699	G>A	Pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs1554059550	T>C	Pathogenic	Coding sequence variant, non coding transcript variant, missense variant, genic upstream transcript variant
rs1554059573	T>C	Pathogenic	Coding sequence variant, non coding transcript variant, missense variant, genic upstream transcript variant
rs1554062741	A>G	Pathogenic	Coding sequence variant, non coding transcript variant, missense variant
rs1554062789	C>T	Pathogenic	Coding sequence variant, non coding transcript variant, missense variant
rs1554062804	G>A	Pathogenic	Coding sequence variant, non coding transcript variant, synonymous variant
rs1554063600	A>G	Pathogenic	Coding sequence variant, intron variant, missense variant
rs1554063656	T>C	Pathogenic	Coding sequence variant, non coding transcript variant, intron variant, missense variant
rs1554064175	A>T	Pathogenic	Coding sequence variant, non coding transcript variant, missense variant
rs1554064740	T>G	Pathogenic	Coding sequence variant, non coding transcript variant, missense variant, genic downstream transcript variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017418	hsa-miR-335-5p	Microarray	18185580
MIRT021743	hsa-miR-132-3p	Microarray	17612493
MIRT1247981	hsa-miR-1185	CLIP-seq
MIRT1247982	hsa-miR-1224-5p	CLIP-seq
MIRT1247983	hsa-miR-1237	CLIP-seq
MIRT1247984	hsa-miR-1248	CLIP-seq
MIRT1247985	hsa-miR-1270	CLIP-seq
MIRT1247986	hsa-miR-1297	CLIP-seq
MIRT1247987	hsa-miR-135a	CLIP-seq
MIRT1247988	hsa-miR-135b	CLIP-seq
MIRT1247989	hsa-miR-186	CLIP-seq
MIRT1247990	hsa-miR-194	CLIP-seq
MIRT1247991	hsa-miR-26a	CLIP-seq
MIRT1247992	hsa-miR-26b	CLIP-seq
MIRT1247993	hsa-miR-302a	CLIP-seq
MIRT1247994	hsa-miR-302b	CLIP-seq
MIRT1247995	hsa-miR-302c	CLIP-seq
MIRT1247996	hsa-miR-302d	CLIP-seq
MIRT1247997	hsa-miR-302e	CLIP-seq
MIRT1247998	hsa-miR-31	CLIP-seq
MIRT1247999	hsa-miR-3133	CLIP-seq
MIRT1248000	hsa-miR-3135b	CLIP-seq
MIRT1248001	hsa-miR-3155	CLIP-seq
MIRT1248002	hsa-miR-3155b	CLIP-seq
MIRT1248003	hsa-miR-3159	CLIP-seq
MIRT1248004	hsa-miR-3163	CLIP-seq
MIRT1248005	hsa-miR-3190	CLIP-seq
MIRT1248006	hsa-miR-3605-5p	CLIP-seq
MIRT1248007	hsa-miR-362-5p	CLIP-seq
MIRT1248008	hsa-miR-3652	CLIP-seq
MIRT1248009	hsa-miR-3662	CLIP-seq
MIRT1248010	hsa-miR-3679-5p	CLIP-seq
MIRT1248011	hsa-miR-3688-5p	CLIP-seq
MIRT1248012	hsa-miR-369-3p	CLIP-seq
MIRT1248013	hsa-miR-372	CLIP-seq
MIRT1248014	hsa-miR-373	CLIP-seq
MIRT1248015	hsa-miR-374a	CLIP-seq
MIRT1248016	hsa-miR-374b	CLIP-seq
MIRT1248017	hsa-miR-3915	CLIP-seq
MIRT1248018	hsa-miR-3978	CLIP-seq
MIRT1248019	hsa-miR-432	CLIP-seq
MIRT1248020	hsa-miR-4430	CLIP-seq
MIRT1248021	hsa-miR-4434	CLIP-seq
MIRT1248022	hsa-miR-4465	CLIP-seq
MIRT1248023	hsa-miR-4516	CLIP-seq
MIRT1248024	hsa-miR-4531	CLIP-seq
MIRT1248025	hsa-miR-4689	CLIP-seq
MIRT1248026	hsa-miR-4752	CLIP-seq
MIRT1248027	hsa-miR-484	CLIP-seq
MIRT1248028	hsa-miR-500b	CLIP-seq
MIRT1248029	hsa-miR-501-5p	CLIP-seq
MIRT1248030	hsa-miR-520a-3p	CLIP-seq
MIRT1248031	hsa-miR-520b	CLIP-seq
MIRT1248032	hsa-miR-520c-3p	CLIP-seq
MIRT1248033	hsa-miR-520d-3p	CLIP-seq
MIRT1248034	hsa-miR-520e	CLIP-seq
MIRT1248035	hsa-miR-520f	CLIP-seq
MIRT1248036	hsa-miR-526b	CLIP-seq
MIRT1248037	hsa-miR-548k	CLIP-seq
MIRT1248038	hsa-miR-606	CLIP-seq
MIRT1248039	hsa-miR-620	CLIP-seq
MIRT1248040	hsa-miR-664	CLIP-seq
MIRT1248041	hsa-miR-802	CLIP-seq
MIRT1248042	hsa-miR-890	CLIP-seq
MIRT2073189	hsa-miR-1244	CLIP-seq
MIRT1247984	hsa-miR-1248	CLIP-seq
MIRT2073190	hsa-miR-137	CLIP-seq
MIRT2073191	hsa-miR-25	CLIP-seq
MIRT1247993	hsa-miR-302a	CLIP-seq
MIRT1247994	hsa-miR-302b	CLIP-seq
MIRT1247995	hsa-miR-302c	CLIP-seq
MIRT1247996	hsa-miR-302d	CLIP-seq
MIRT1247997	hsa-miR-302e	CLIP-seq
MIRT1247998	hsa-miR-31	CLIP-seq
MIRT1248000	hsa-miR-3135b	CLIP-seq
MIRT1248001	hsa-miR-3155	CLIP-seq
MIRT1248002	hsa-miR-3155b	CLIP-seq
MIRT2073192	hsa-miR-3156-5p	CLIP-seq
MIRT1248003	hsa-miR-3159	CLIP-seq
MIRT2073193	hsa-miR-32	CLIP-seq
MIRT2073194	hsa-miR-363	CLIP-seq
MIRT1248008	hsa-miR-3652	CLIP-seq
MIRT2073195	hsa-miR-367	CLIP-seq
MIRT1248013	hsa-miR-372	CLIP-seq
MIRT1248014	hsa-miR-373	CLIP-seq
MIRT2073196	hsa-miR-3973	CLIP-seq
MIRT2073197	hsa-miR-4297	CLIP-seq
MIRT2073198	hsa-miR-4325	CLIP-seq
MIRT1248020	hsa-miR-4430	CLIP-seq
MIRT2073199	hsa-miR-4461	CLIP-seq
MIRT2073200	hsa-miR-4704-3p	CLIP-seq
MIRT2073201	hsa-miR-4733-5p	CLIP-seq
MIRT2073202	hsa-miR-4735-5p	CLIP-seq
MIRT1248027	hsa-miR-484	CLIP-seq
MIRT2073203	hsa-miR-512-3p	CLIP-seq
MIRT2073204	hsa-miR-519a	CLIP-seq
MIRT2073205	hsa-miR-519b-3p	CLIP-seq
MIRT2073206	hsa-miR-519c-3p	CLIP-seq
MIRT1248030	hsa-miR-520a-3p	CLIP-seq
MIRT1248031	hsa-miR-520b	CLIP-seq
MIRT1248032	hsa-miR-520c-3p	CLIP-seq
MIRT1248033	hsa-miR-520d-3p	CLIP-seq
MIRT1248034	hsa-miR-520e	CLIP-seq
MIRT2073207	hsa-miR-548c-3p	CLIP-seq
MIRT2073208	hsa-miR-92a	CLIP-seq
MIRT2073209	hsa-miR-92b	CLIP-seq
MIRT2300311	hsa-miR-1184	CLIP-seq
MIRT2073189	hsa-miR-1244	CLIP-seq
MIRT2300312	hsa-miR-1301	CLIP-seq
MIRT2300313	hsa-miR-1915	CLIP-seq
MIRT2300314	hsa-miR-192	CLIP-seq
MIRT2300315	hsa-miR-200b	CLIP-seq
MIRT2300316	hsa-miR-200c	CLIP-seq
MIRT2300317	hsa-miR-215	CLIP-seq
MIRT1247993	hsa-miR-302a	CLIP-seq
MIRT1247994	hsa-miR-302b	CLIP-seq
MIRT1247995	hsa-miR-302c	CLIP-seq
MIRT1247996	hsa-miR-302d	CLIP-seq
MIRT1247997	hsa-miR-302e	CLIP-seq
MIRT2300318	hsa-miR-3065-5p	CLIP-seq
MIRT1247998	hsa-miR-31	CLIP-seq
MIRT1248000	hsa-miR-3135b	CLIP-seq
MIRT2300319	hsa-miR-3149	CLIP-seq
MIRT1248001	hsa-miR-3155	CLIP-seq
MIRT1248002	hsa-miR-3155b	CLIP-seq
MIRT2073192	hsa-miR-3156-5p	CLIP-seq
MIRT2300320	hsa-miR-3157-5p	CLIP-seq
MIRT1248004	hsa-miR-3163	CLIP-seq
MIRT2300321	hsa-miR-3200-5p	CLIP-seq
MIRT2300322	hsa-miR-323-3p	CLIP-seq
MIRT1248008	hsa-miR-3652	CLIP-seq
MIRT1248011	hsa-miR-3688-5p	CLIP-seq
MIRT1248012	hsa-miR-369-3p	CLIP-seq
MIRT1248013	hsa-miR-372	CLIP-seq
MIRT1248014	hsa-miR-373	CLIP-seq
MIRT1248015	hsa-miR-374a	CLIP-seq
MIRT1248016	hsa-miR-374b	CLIP-seq
MIRT2073196	hsa-miR-3973	CLIP-seq
MIRT2300323	hsa-miR-4280	CLIP-seq
MIRT2300324	hsa-miR-429	CLIP-seq
MIRT2300325	hsa-miR-4302	CLIP-seq
MIRT2300326	hsa-miR-4418	CLIP-seq
MIRT1248020	hsa-miR-4430	CLIP-seq
MIRT2300327	hsa-miR-4438	CLIP-seq
MIRT2300328	hsa-miR-4659a-5p	CLIP-seq
MIRT2300329	hsa-miR-4659b-5p	CLIP-seq
MIRT2300330	hsa-miR-4660	CLIP-seq
MIRT2300331	hsa-miR-4682	CLIP-seq
MIRT2300332	hsa-miR-4691-3p	CLIP-seq
MIRT2300333	hsa-miR-4699-3p	CLIP-seq
MIRT2300334	hsa-miR-4724-3p	CLIP-seq
MIRT2300335	hsa-miR-4726-3p	CLIP-seq
MIRT2300336	hsa-miR-4776-3p	CLIP-seq
MIRT1248027	hsa-miR-484	CLIP-seq
MIRT2300337	hsa-miR-5047	CLIP-seq
MIRT2300338	hsa-miR-509-3-5p	CLIP-seq
MIRT2300339	hsa-miR-5095	CLIP-seq
MIRT2300340	hsa-miR-509-5p	CLIP-seq
MIRT2073203	hsa-miR-512-3p	CLIP-seq
MIRT2073204	hsa-miR-519a	CLIP-seq
MIRT2073205	hsa-miR-519b-3p	CLIP-seq
MIRT2073206	hsa-miR-519c-3p	CLIP-seq
MIRT1248030	hsa-miR-520a-3p	CLIP-seq
MIRT1248031	hsa-miR-520b	CLIP-seq
MIRT1248032	hsa-miR-520c-3p	CLIP-seq
MIRT1248033	hsa-miR-520d-3p	CLIP-seq
MIRT1248034	hsa-miR-520e	CLIP-seq
MIRT2300341	hsa-miR-568	CLIP-seq
MIRT2392810	hsa-miR-1179	CLIP-seq
MIRT1247998	hsa-miR-31	CLIP-seq
MIRT1248000	hsa-miR-3135b	CLIP-seq
MIRT1248001	hsa-miR-3155	CLIP-seq
MIRT1248002	hsa-miR-3155b	CLIP-seq
MIRT2073192	hsa-miR-3156-5p	CLIP-seq
MIRT2300321	hsa-miR-3200-5p	CLIP-seq
MIRT1248008	hsa-miR-3652	CLIP-seq
MIRT1248011	hsa-miR-3688-5p	CLIP-seq
MIRT1248020	hsa-miR-4430	CLIP-seq
MIRT2392811	hsa-miR-4729	CLIP-seq
MIRT1248027	hsa-miR-484	CLIP-seq
MIRT2392812	hsa-miR-576-5p	CLIP-seq
MIRT1247998	hsa-miR-31	CLIP-seq
MIRT1248000	hsa-miR-3135b	CLIP-seq
MIRT1248001	hsa-miR-3155	CLIP-seq
MIRT1248002	hsa-miR-3155b	CLIP-seq
MIRT1248008	hsa-miR-3652	CLIP-seq
MIRT1248011	hsa-miR-3688-5p	CLIP-seq
MIRT1248020	hsa-miR-4430	CLIP-seq
MIRT1248027	hsa-miR-484	CLIP-seq
MIRT1247981	hsa-miR-1185	CLIP-seq
MIRT1247982	hsa-miR-1224-5p	CLIP-seq
MIRT2597059	hsa-miR-1227	CLIP-seq
MIRT2597060	hsa-miR-1228	CLIP-seq
MIRT1247983	hsa-miR-1237	CLIP-seq
MIRT1247984	hsa-miR-1248	CLIP-seq
MIRT1247986	hsa-miR-1297	CLIP-seq
MIRT2300315	hsa-miR-200b	CLIP-seq
MIRT2300316	hsa-miR-200c	CLIP-seq
MIRT1247991	hsa-miR-26a	CLIP-seq
MIRT1247992	hsa-miR-26b	CLIP-seq
MIRT1247993	hsa-miR-302a	CLIP-seq
MIRT1247994	hsa-miR-302b	CLIP-seq
MIRT1247995	hsa-miR-302c	CLIP-seq
MIRT1247996	hsa-miR-302d	CLIP-seq
MIRT1247997	hsa-miR-302e	CLIP-seq
MIRT2597061	hsa-miR-3129-3p	CLIP-seq
MIRT2597062	hsa-miR-3146	CLIP-seq
MIRT2300319	hsa-miR-3149	CLIP-seq
MIRT1248003	hsa-miR-3159	CLIP-seq
MIRT1248004	hsa-miR-3163	CLIP-seq
MIRT2597063	hsa-miR-3185	CLIP-seq
MIRT1248005	hsa-miR-3190	CLIP-seq
MIRT2597064	hsa-miR-325	CLIP-seq
MIRT1248006	hsa-miR-3605-5p	CLIP-seq
MIRT2597065	hsa-miR-3622b-5p	CLIP-seq
MIRT1248007	hsa-miR-362-5p	CLIP-seq
MIRT2597066	hsa-miR-3646	CLIP-seq
MIRT1248009	hsa-miR-3662	CLIP-seq
MIRT1248010	hsa-miR-3679-5p	CLIP-seq
MIRT1248012	hsa-miR-369-3p	CLIP-seq
MIRT1248013	hsa-miR-372	CLIP-seq
MIRT1248014	hsa-miR-373	CLIP-seq
MIRT1248015	hsa-miR-374a	CLIP-seq
MIRT1248016	hsa-miR-374b	CLIP-seq
MIRT1248017	hsa-miR-3915	CLIP-seq
MIRT2597067	hsa-miR-3941	CLIP-seq
MIRT1248018	hsa-miR-3978	CLIP-seq
MIRT2300323	hsa-miR-4280	CLIP-seq
MIRT2300324	hsa-miR-429	CLIP-seq
MIRT2597068	hsa-miR-4307	CLIP-seq
MIRT1248022	hsa-miR-4465	CLIP-seq
MIRT2597069	hsa-miR-4642	CLIP-seq
MIRT2597070	hsa-miR-4643	CLIP-seq
MIRT2300328	hsa-miR-4659a-5p	CLIP-seq
MIRT2300329	hsa-miR-4659b-5p	CLIP-seq
MIRT2597071	hsa-miR-466	CLIP-seq
MIRT2597072	hsa-miR-4662a-3p	CLIP-seq
MIRT2597073	hsa-miR-4672	CLIP-seq
MIRT1248025	hsa-miR-4689	CLIP-seq
MIRT2597074	hsa-miR-4690-5p	CLIP-seq
MIRT2073200	hsa-miR-4704-3p	CLIP-seq
MIRT2597075	hsa-miR-4709-3p	CLIP-seq
MIRT2597076	hsa-miR-4715-3p	CLIP-seq
MIRT2073202	hsa-miR-4735-5p	CLIP-seq
MIRT2597077	hsa-miR-4742-3p	CLIP-seq
MIRT1248026	hsa-miR-4752	CLIP-seq
MIRT2597078	hsa-miR-4753-3p	CLIP-seq
MIRT2597079	hsa-miR-4768-5p	CLIP-seq
MIRT2597080	hsa-miR-4769-3p	CLIP-seq
MIRT2597081	hsa-miR-4775	CLIP-seq
MIRT2300336	hsa-miR-4776-3p	CLIP-seq
MIRT2597082	hsa-miR-4789-3p	CLIP-seq
MIRT2597083	hsa-miR-4794	CLIP-seq
MIRT2597084	hsa-miR-4803	CLIP-seq
MIRT2597085	hsa-miR-486-5p	CLIP-seq
MIRT1248028	hsa-miR-500b	CLIP-seq
MIRT1248029	hsa-miR-501-5p	CLIP-seq
MIRT1248030	hsa-miR-520a-3p	CLIP-seq
MIRT1248031	hsa-miR-520b	CLIP-seq
MIRT1248032	hsa-miR-520c-3p	CLIP-seq
MIRT1248033	hsa-miR-520d-3p	CLIP-seq
MIRT2597086	hsa-miR-520d-5p	CLIP-seq
MIRT1248034	hsa-miR-520e	CLIP-seq
MIRT1248035	hsa-miR-520f	CLIP-seq
MIRT2597087	hsa-miR-524-5p	CLIP-seq
MIRT1248036	hsa-miR-526b	CLIP-seq
MIRT2597088	hsa-miR-548a-3p	CLIP-seq
MIRT2597089	hsa-miR-548b-3p	CLIP-seq
MIRT2597090	hsa-miR-548e	CLIP-seq
MIRT2597091	hsa-miR-548f	CLIP-seq
MIRT1248037	hsa-miR-548k	CLIP-seq
MIRT2597092	hsa-miR-548n	CLIP-seq
MIRT2597093	hsa-miR-548t	CLIP-seq
MIRT2300341	hsa-miR-568	CLIP-seq
MIRT2597094	hsa-miR-590-3p	CLIP-seq
MIRT1248038	hsa-miR-606	CLIP-seq
MIRT2597095	hsa-miR-621	CLIP-seq
MIRT2597096	hsa-miR-628-3p	CLIP-seq
MIRT1248040	hsa-miR-664	CLIP-seq
MIRT1247981	hsa-miR-1185	CLIP-seq
MIRT1247982	hsa-miR-1224-5p	CLIP-seq
MIRT2597059	hsa-miR-1227	CLIP-seq
MIRT2597060	hsa-miR-1228	CLIP-seq
MIRT1247983	hsa-miR-1237	CLIP-seq
MIRT1247984	hsa-miR-1248	CLIP-seq
MIRT1247986	hsa-miR-1297	CLIP-seq
MIRT2300315	hsa-miR-200b	CLIP-seq
MIRT2300316	hsa-miR-200c	CLIP-seq
MIRT1247991	hsa-miR-26a	CLIP-seq
MIRT1247992	hsa-miR-26b	CLIP-seq
MIRT1247993	hsa-miR-302a	CLIP-seq
MIRT1247994	hsa-miR-302b	CLIP-seq
MIRT1247995	hsa-miR-302c	CLIP-seq
MIRT1247996	hsa-miR-302d	CLIP-seq
MIRT1247997	hsa-miR-302e	CLIP-seq
MIRT2597062	hsa-miR-3146	CLIP-seq
MIRT2300319	hsa-miR-3149	CLIP-seq
MIRT1248003	hsa-miR-3159	CLIP-seq
MIRT1248004	hsa-miR-3163	CLIP-seq
MIRT1248005	hsa-miR-3190	CLIP-seq
MIRT1248006	hsa-miR-3605-5p	CLIP-seq
MIRT2597065	hsa-miR-3622b-5p	CLIP-seq
MIRT1248007	hsa-miR-362-5p	CLIP-seq
MIRT1248009	hsa-miR-3662	CLIP-seq
MIRT1248010	hsa-miR-3679-5p	CLIP-seq
MIRT1248012	hsa-miR-369-3p	CLIP-seq
MIRT1248013	hsa-miR-372	CLIP-seq
MIRT1248014	hsa-miR-373	CLIP-seq
MIRT1248015	hsa-miR-374a	CLIP-seq
MIRT1248016	hsa-miR-374b	CLIP-seq
MIRT1248017	hsa-miR-3915	CLIP-seq
MIRT2597067	hsa-miR-3941	CLIP-seq
MIRT1248018	hsa-miR-3978	CLIP-seq
MIRT2300323	hsa-miR-4280	CLIP-seq
MIRT2300324	hsa-miR-429	CLIP-seq
MIRT2597068	hsa-miR-4307	CLIP-seq
MIRT1248022	hsa-miR-4465	CLIP-seq
MIRT2597069	hsa-miR-4642	CLIP-seq
MIRT2597070	hsa-miR-4643	CLIP-seq
MIRT2300328	hsa-miR-4659a-5p	CLIP-seq
MIRT2300329	hsa-miR-4659b-5p	CLIP-seq
MIRT2597071	hsa-miR-466	CLIP-seq
MIRT2597072	hsa-miR-4662a-3p	CLIP-seq
MIRT2597073	hsa-miR-4672	CLIP-seq
MIRT1248025	hsa-miR-4689	CLIP-seq
MIRT2597074	hsa-miR-4690-5p	CLIP-seq
MIRT2073200	hsa-miR-4704-3p	CLIP-seq
MIRT2597076	hsa-miR-4715-3p	CLIP-seq
MIRT2073202	hsa-miR-4735-5p	CLIP-seq
MIRT1248026	hsa-miR-4752	CLIP-seq
MIRT2597078	hsa-miR-4753-3p	CLIP-seq
MIRT2597079	hsa-miR-4768-5p	CLIP-seq
MIRT2597081	hsa-miR-4775	CLIP-seq
MIRT2300336	hsa-miR-4776-3p	CLIP-seq
MIRT2597082	hsa-miR-4789-3p	CLIP-seq
MIRT2597083	hsa-miR-4794	CLIP-seq
MIRT2597084	hsa-miR-4803	CLIP-seq
MIRT1248028	hsa-miR-500b	CLIP-seq
MIRT1248029	hsa-miR-501-5p	CLIP-seq
MIRT1248030	hsa-miR-520a-3p	CLIP-seq
MIRT1248031	hsa-miR-520b	CLIP-seq
MIRT1248032	hsa-miR-520c-3p	CLIP-seq
MIRT1248033	hsa-miR-520d-3p	CLIP-seq
MIRT2597086	hsa-miR-520d-5p	CLIP-seq
MIRT1248034	hsa-miR-520e	CLIP-seq
MIRT1248035	hsa-miR-520f	CLIP-seq
MIRT2597087	hsa-miR-524-5p	CLIP-seq
MIRT1248036	hsa-miR-526b	CLIP-seq
MIRT2597089	hsa-miR-548b-3p	CLIP-seq
MIRT1248037	hsa-miR-548k	CLIP-seq
MIRT2597092	hsa-miR-548n	CLIP-seq
MIRT2597093	hsa-miR-548t	CLIP-seq
MIRT2300341	hsa-miR-568	CLIP-seq
MIRT2597094	hsa-miR-590-3p	CLIP-seq
MIRT2597095	hsa-miR-621	CLIP-seq
MIRT1248040	hsa-miR-664	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
HSF1	Activation	22227292

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003677	Function	DNA binding	IEA
GO:0003684	Function	Damaged DNA binding	IEA
GO:0003887	Function	DNA-directed DNA polymerase activity	IBA
GO:0003887	Function	DNA-directed DNA polymerase activity	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	12414988
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006260	Process	DNA replication	IEA
GO:0006281	Process	DNA repair	IDA	28297716
GO:0006281	Process	DNA repair	IEA
GO:0006281	Process	DNA repair	IEA
GO:0006281	Process	DNA repair	TAS	10620008
GO:0006297	Process	Nucleotide-excision repair, DNA gap filling	IMP	20227374
GO:0006974	Process	DNA damage response	IDA	28297716
GO:0006974	Process	DNA damage response	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016604	Component	Nuclear body	IDA
GO:0016740	Function	Transferase activity	IEA
GO:0016779	Function	Nucleotidyltransferase activity	IEA
GO:0034061	Function	DNA polymerase activity	IEA
GO:0034644	Process	Cellular response to UV	IDA	28297716
GO:0042276	Process	Error-prone translesion synthesis	IBA
GO:0042276	Process	Error-prone translesion synthesis	IDA	28297716
GO:0046872	Function	Metal ion binding	IEA
GO:0071897	Process	DNA biosynthetic process	IEA
GO:0090734	Component	Site of DNA damage	IDA	28297716

Other IDs

• MIM: 605650
• HGNC: 9183
• e!Ensembl: ENSG00000122008

Protein

• UniProt ID: Q9UBT6
• Protein name: DNA polymerase kappa (EC 2.7.7.7) (DINB protein) (DINP)
• Protein function: DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base,
• PDB: 1T94, 2LSI, 2OH2, 2W7O, 2W7P, 3IN5, 3PZP, 4BA9, 4GK5, 4U6P, 4U7C, 5T14, 5W2A, 5W2C, 6BRX, 6BS1, 6CST, 7NV0, 7NV1
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00817	IMS	106 → 325	impB/mucB/samB family	Family
  PF11798	IMS_HHH	339 → 370	IMS family HHH motif	Motif
  PF11799	IMS_C	407 → 526	impB/mucB/samB family C-terminal domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Detected at low levels in testis, spleen, prostate and ovary. Detected at very low levels in kidney, colon, brain, heart, liver, lung, placenta, pancreas and peripheral blood leukocytes. {ECO:0000269|PubMed:10518552, ECO:0000269|PubMed
• Sequence:

  MDSTKEKCDSYKDDLLLRMGLNDNKAGMEGLDKEKINKIIMEATKGSRFYGNELKKEKQV
  NQRIENMMQQKAQITSQQLRKAQLQVDRFAMELEQSRNLSNTIVHIDMDAFYAAVEMRDN
  PELKDKPIAVGSMSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKE
  VKEILADYDPNFMAMSLDEAYLNITKHLEERQNWPEDKRRYFIKMGSSVENDNPGKEVNK
  LSEHERSISPLLFEESPSDVQPPGDPFQVNFEEQNNPQILQNSVVFGTSAQEVVKEIRFR
  IEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPNRQAVMDFIKDLPIRKVSGIGKV
  TEKMLKALGIITCTELYQQRALLSLLFSETSWHYFLHISLGLGSTHLTRDGERKSMSVER
  TFSEINKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVST
  AEEIFAIAKELLKTEIDADFPHPLRLRLMGVRISSFPNEEDRKHQQRSIIGFLQAGNQAL
  SATECTLEKTDKDKFVKPLEMSHKKSFFDKKRSERKWSHQDTFKCEAVNKQSFQTSQPFQ
  VLKKKMNENLEISENSDDCQILTCPVCFRAQGCISLEALNKHVDECLDGPSISENFKMFS
  CSHVSATKVNKKENVPASSLCEKQDYEAHPKIKEISSVDCIALVDTIDNSSKAESIDALS
  NKHSKEECSSLPSKSFNIEHCHQNSSSTVSLENEDVGSFRQEYRQPYLCEVKTGQALVCP
  VCNVEQKTSDLTLFNVHVDVCLNKSFIQELRKDKFNPVNQPKESSRSTGSSSGVQKAVTR
  TKRPGLMTKYSTSKKIKPNNPKHTLDIFFK

• Sequence length: 870

Pathways

KEGG:

Fanconi anemia pathway
Epstein-Barr virus infection
Pathways in cancer
Transcriptional misregulation in cancer
Colorectal cancer
Pancreatic cancer
Endometrial cancer
Glioma
Thyroid cancer
Basal cell carcinoma
Melanoma
Chronic myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Breast cancer
Hepatocellular carcinoma
Gastric cancer

Reactome:

Translesion synthesis by POLK
Termination of translesion DNA synthesis
HDR through Homologous Recombination (HRR)
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Prostate cancer	Pathogenic	rs786205688, rs749804502, rs1554059550, rs1554059573, rs111584802, rs770984846, rs1554062741, rs1554062789, rs1554062804, rs1304454699, rs1554063600, rs1554063656, rs139591993, rs1554064175, rs781194178, rs863225457, rs863225455, rs863225456, rs1554064740	RCV000170553 RCV000170548 RCV000170545 RCV000170549 RCV000170550 RCV000170551 RCV000170552 RCV000170547 RCV000170564 RCV000170565 RCV000170561 RCV000170562 RCV000170557 RCV000170558 RCV000170559 RCV000170560 RCV000170555 RCV000170556 RCV000170563	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ATRIAL FIBRILLATION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEART FAILURE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INTELLECTUAL DEVELOPMENTAL DISORDER, AUTOSOMAL DOMINANT 34	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Neurodevelopmental delay	Conflicting classifications of pathogenicity	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATIC NEOPLASMS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Seizure	Conflicting classifications of pathogenicity	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
STROKE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	31137743		★☆☆☆☆ Found in Text Mining only
Adult T-Cell Lymphoma/Leukemia	T-Cell Lymphoma/Leukemia	BEFREE	30097855		★☆☆☆☆ Found in Text Mining only
Atrial Fibrillation	Atrial Fibrillation	GWASCAT_DG	27790247		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Azoospermia Nonobstructive	Nonobstructive azoospermia	Pubtator	38403804	Associate	★☆☆☆☆ Found in Text Mining only
Biliary Tract Neoplasms	Biliary tract neoplasms	Pubtator	33182492	Associate	★☆☆☆☆ Found in Text Mining only
Breast Cancer, Familial	Breast Cancer	BEFREE	25409685		★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	18281469, 20624954, 20700469, 25409685, 25417172, 26765445, 27264557, 30655289		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	20624954, 20700469, 25409685, 25417172, 26765445, 29879995, 30655289	Associate	★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	36642785	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	12036445		★☆☆☆☆ Found in Text Mining only
Carcinoma Lobular	Lobular carcinoma	Pubtator	35477749	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	11454676, 15202001, 31137743		★☆☆☆☆ Found in Text Mining only
Carcinoma Pancreatic Ductal	Pancreatic ductal carcinoma	Pubtator	32113160	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	37095444, 38270643	Associate	★☆☆☆☆ Found in Text Mining only
Cerebrovascular accident	Stroke	GWASCAT_DG	27790247		★☆☆☆☆ Found in Text Mining only
Cleft Palate	Cleft palate	Pubtator	36896836	Associate	★☆☆☆☆ Found in Text Mining only
Cockayne Syndrome, Type I	Cockayne Syndrome	BEFREE	20215648		★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	17099721, 23219161, 31650563		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	30591675	Associate	★☆☆☆☆ Found in Text Mining only
Congenital chromosomal disease	Congenital Chromosomal Disease	BEFREE	31294882		★☆☆☆☆ Found in Text Mining only
Coronary heart disease	Coronary Heart Disease	GWASCAT_DG	27790247		★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	GWASCAT_DG	27790247		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	GWASCAT_DG	27790247		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	23504502, 36803971	Associate	★☆☆☆☆ Found in Text Mining only
Giant Cell Glioblastoma	Giant Cell Glioblastoma	CTD_human_DG	26651356		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	26651356, 31082191		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Glioblastoma	Glioblastoma	CTD_human_DG	26651356		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Glioblastoma	Glioblastoma	Pubtator	26651356, 31082191	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Glioblastoma Multiforme	Glioblastoma	BEFREE	26651356, 31082191		★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	CTD_human_DG	26651356		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	23056190, 31595696	Associate	★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	31595696		★☆☆☆☆ Found in Text Mining only
Heart failure	Heart Failure	GWASCAT_DG	27790247		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hereditary Breast and Ovarian Cancer Syndrome	Hereditary breast and ovarian cancer syndrome	Pubtator	25409685, 32039725	Associate	★☆☆☆☆ Found in Text Mining only
Huntington Disease	Huntington disease	Pubtator	34473992	Associate	★☆☆☆☆ Found in Text Mining only
Kidney Neoplasms	Kidney neoplasm	Pubtator	37095444	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	33911081, 37358557	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	39768855	Associate	★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	24012694, 27533083, 36642785	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	18281469, 20624954, 20700469, 25409685, 25417172, 26765445, 27264557, 30655289		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	11454676, 15202001, 15665310, 31137743		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	18281469		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	26046662		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	CTD_human_DG	26046662		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	CLINVAR_DG			★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of skin	Skin cancer	BEFREE	19564618, 20577207, 21640722, 29859927, 30362123, 30535880, 30773314		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	11113193, 25851856, 26765445, 27264557, 29139326, 30655289		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	GWASCAT_DG	27790247		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	25409685		★☆☆☆☆ Found in Text Mining only
Mesothelioma Malignant	Mesothelioma	Pubtator	34008015	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	11032022, 18281469, 20233878, 20700469, 22987617, 25766642, 29691900, 30297532, 30362123, 31381562, 31650563		★☆☆☆☆ Found in Text Mining only
Nijmegen Breakage Syndrome	Nijmegen Breakage Syndrome	BEFREE	28430587		★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	24948471		★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	28591191, 32546565	Associate	★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	18281469		★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	32113160, 36896836	Associate	★☆☆☆☆ Found in Text Mining only
Papillary thyroid carcinoma	Papillary thyroid carcinoma	BEFREE	31439400		★☆☆☆☆ Found in Text Mining only
Peripheral T-Cell Lymphoma	T-Cell Lymphoma	BEFREE	30097855		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic Neoplasms	BEFREE	26046662		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostatic Neoplasms	Prostatic Neoplasms	CTD_human_DG	26046662		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	26046662, 32300177, 35606411	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Skin Neoplasms	Skin Neoplasms	BEFREE	29859927		★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	31396961		★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of skin	Skin carcinoma	BEFREE	16823845		★☆☆☆☆ Found in Text Mining only
Stomach Diseases	Stomach disease	Pubtator	32838755	Associate	★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	23504502, 32838755, 36578802	Associate	★☆☆☆☆ Found in Text Mining only
Xeroderma Pigmentosum	Xeroderma Pigmentosum	BEFREE	10385124, 10556591, 10871396, 11113193, 11157773, 11376341, 11773631, 12082017, 12405351, 12546696, 16449651, 19564618, 21640722, 22217736, 25435364, 29859927		★☆☆☆☆ Found in Text Mining only
Xeroderma pigmentosum, variant type	Xeroderma Pigmentosum	BEFREE	17344931		★☆☆☆☆ Found in Text Mining only