Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	51400
Gene name	Protein phosphatase methylesterase 1
Gene symbol	PPME1
Synonyms (NCBI Gene)	ABDH19PME-1
Chromosome	11
Chromosome location	11q13.4
Summary	This gene encodes a protein phosphatase methylesterase localized to the nucleus. The encoded protein acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. It plays a role in mal

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miRTarBase ID	miRNA	Experiments
MIRT1254721	hsa-miR-103a	CLIP-seq
MIRT1254722	hsa-miR-107	CLIP-seq
MIRT1254723	hsa-miR-1197	CLIP-seq
MIRT1254724	hsa-miR-1271	CLIP-seq
MIRT1254725	hsa-miR-128	CLIP-seq
MIRT1254726	hsa-miR-1286	CLIP-seq
MIRT1254727	hsa-miR-135a	CLIP-seq
MIRT1254728	hsa-miR-135b	CLIP-seq
MIRT1254729	hsa-miR-147	CLIP-seq
MIRT1254730	hsa-miR-182	CLIP-seq
MIRT1254731	hsa-miR-185	CLIP-seq
MIRT1254732	hsa-miR-1913	CLIP-seq
MIRT1254733	hsa-miR-193a-5p	CLIP-seq
MIRT1254734	hsa-miR-199a-5p	CLIP-seq
MIRT1254735	hsa-miR-199b-5p	CLIP-seq
MIRT1254736	hsa-miR-214	CLIP-seq
MIRT1254737	hsa-miR-216a	CLIP-seq
MIRT1254738	hsa-miR-2392	CLIP-seq
MIRT1254739	hsa-miR-27a	CLIP-seq
MIRT1254740	hsa-miR-27b	CLIP-seq
MIRT1254741	hsa-miR-3074-5p	CLIP-seq
MIRT1254742	hsa-miR-3127-3p	CLIP-seq
MIRT1254743	hsa-miR-3140-3p	CLIP-seq
MIRT1254744	hsa-miR-3150b-3p	CLIP-seq
MIRT1254745	hsa-miR-3183	CLIP-seq
MIRT1254746	hsa-miR-324-3p	CLIP-seq
MIRT1254747	hsa-miR-326	CLIP-seq
MIRT1254748	hsa-miR-330-5p	CLIP-seq
MIRT1254749	hsa-miR-3617	CLIP-seq
MIRT1254750	hsa-miR-3619-3p	CLIP-seq
MIRT1254751	hsa-miR-3619-5p	CLIP-seq
MIRT1254752	hsa-miR-3652	CLIP-seq
MIRT1254753	hsa-miR-3667-3p	CLIP-seq
MIRT1254754	hsa-miR-3677-5p	CLIP-seq
MIRT1254755	hsa-miR-3687	CLIP-seq
MIRT1254756	hsa-miR-3689a-3p	CLIP-seq
MIRT1254757	hsa-miR-3689c	CLIP-seq
MIRT1254758	hsa-miR-3911	CLIP-seq
MIRT1254759	hsa-miR-3973	CLIP-seq
MIRT1254760	hsa-miR-3978	CLIP-seq
MIRT1254761	hsa-miR-409-3p	CLIP-seq
MIRT1254762	hsa-miR-4299	CLIP-seq
MIRT1254763	hsa-miR-4306	CLIP-seq
MIRT1254764	hsa-miR-4311	CLIP-seq
MIRT1254765	hsa-miR-4426	CLIP-seq
MIRT1254766	hsa-miR-4430	CLIP-seq
MIRT1254767	hsa-miR-4436a	CLIP-seq
MIRT1254768	hsa-miR-4442	CLIP-seq
MIRT1254769	hsa-miR-4450	CLIP-seq
MIRT1254770	hsa-miR-4456	CLIP-seq
MIRT1254771	hsa-miR-4463	CLIP-seq
MIRT1254772	hsa-miR-4464	CLIP-seq
MIRT1254773	hsa-miR-4466	CLIP-seq
MIRT1254774	hsa-miR-4470	CLIP-seq
MIRT1254775	hsa-miR-4480	CLIP-seq
MIRT1254776	hsa-miR-4481	CLIP-seq
MIRT1254777	hsa-miR-4486	CLIP-seq
MIRT1254778	hsa-miR-4489	CLIP-seq
MIRT1254779	hsa-miR-4492	CLIP-seq
MIRT1254780	hsa-miR-4498	CLIP-seq
MIRT1254781	hsa-miR-4505	CLIP-seq
MIRT1254782	hsa-miR-450b-3p	CLIP-seq
MIRT1254783	hsa-miR-4521	CLIP-seq
MIRT1254784	hsa-miR-4534	CLIP-seq
MIRT1254785	hsa-miR-4640-5p	CLIP-seq
MIRT1254786	hsa-miR-4642	CLIP-seq
MIRT1254787	hsa-miR-4643	CLIP-seq
MIRT1254788	hsa-miR-4644	CLIP-seq
MIRT1254789	hsa-miR-4647	CLIP-seq
MIRT1254790	hsa-miR-4651	CLIP-seq
MIRT1254791	hsa-miR-4652-3p	CLIP-seq
MIRT1254792	hsa-miR-4655-5p	CLIP-seq
MIRT1254793	hsa-miR-4658	CLIP-seq
MIRT1254794	hsa-miR-466	CLIP-seq
MIRT1254795	hsa-miR-4662b	CLIP-seq
MIRT1254796	hsa-miR-4667-5p	CLIP-seq
MIRT1254797	hsa-miR-4676-5p	CLIP-seq
MIRT1254798	hsa-miR-4699-3p	CLIP-seq
MIRT1254799	hsa-miR-4700-5p	CLIP-seq
MIRT1254800	hsa-miR-4704-3p	CLIP-seq
MIRT1254801	hsa-miR-4709-3p	CLIP-seq
MIRT1254802	hsa-miR-4713-3p	CLIP-seq
MIRT1254803	hsa-miR-4717-3p	CLIP-seq
MIRT1254804	hsa-miR-4719	CLIP-seq
MIRT1254805	hsa-miR-4722-3p	CLIP-seq
MIRT1254806	hsa-miR-4723-3p	CLIP-seq
MIRT1254807	hsa-miR-4726-5p	CLIP-seq
MIRT1254808	hsa-miR-4728-5p	CLIP-seq
MIRT1254809	hsa-miR-4745-5p	CLIP-seq
MIRT1254810	hsa-miR-4748	CLIP-seq
MIRT1254811	hsa-miR-4749-3p	CLIP-seq
MIRT1254812	hsa-miR-4755-3p	CLIP-seq
MIRT1254813	hsa-miR-4757-5p	CLIP-seq
MIRT1254814	hsa-miR-4758-5p	CLIP-seq
MIRT1254815	hsa-miR-4765	CLIP-seq
MIRT1254816	hsa-miR-4784	CLIP-seq
MIRT1254817	hsa-miR-4789-3p	CLIP-seq
MIRT1254818	hsa-miR-548q	CLIP-seq
MIRT1254819	hsa-miR-548u	CLIP-seq
MIRT1254820	hsa-miR-570	CLIP-seq
MIRT1254821	hsa-miR-575	CLIP-seq
MIRT1254822	hsa-miR-591	CLIP-seq
MIRT1254823	hsa-miR-597	CLIP-seq
MIRT1254824	hsa-miR-608	CLIP-seq
MIRT1254825	hsa-miR-638	CLIP-seq
MIRT1254826	hsa-miR-641	CLIP-seq
MIRT1254827	hsa-miR-644	CLIP-seq
MIRT1254828	hsa-miR-653	CLIP-seq
MIRT1254829	hsa-miR-675	CLIP-seq
MIRT1254830	hsa-miR-761	CLIP-seq
MIRT1254831	hsa-miR-762	CLIP-seq
MIRT1254832	hsa-miR-769-3p	CLIP-seq
MIRT1254833	hsa-miR-938	CLIP-seq
MIRT1254834	hsa-miR-96	CLIP-seq
MIRT1254721	hsa-miR-103a	CLIP-seq
MIRT1254722	hsa-miR-107	CLIP-seq
MIRT2075164	hsa-miR-1207-3p	CLIP-seq
MIRT1254725	hsa-miR-128	CLIP-seq
MIRT1254726	hsa-miR-1286	CLIP-seq
MIRT2075165	hsa-miR-1302	CLIP-seq
MIRT2075166	hsa-miR-1827	CLIP-seq
MIRT2075167	hsa-miR-1972	CLIP-seq
MIRT1254734	hsa-miR-199a-5p	CLIP-seq
MIRT1254735	hsa-miR-199b-5p	CLIP-seq
MIRT1254736	hsa-miR-214	CLIP-seq
MIRT2075168	hsa-miR-299-3p	CLIP-seq
MIRT2075169	hsa-miR-3185	CLIP-seq
MIRT1254750	hsa-miR-3619-3p	CLIP-seq
MIRT1254751	hsa-miR-3619-5p	CLIP-seq
MIRT1254755	hsa-miR-3687	CLIP-seq
MIRT1254756	hsa-miR-3689a-3p	CLIP-seq
MIRT1254757	hsa-miR-3689c	CLIP-seq
MIRT2075170	hsa-miR-4298	CLIP-seq
MIRT1254767	hsa-miR-4436a	CLIP-seq
MIRT1254768	hsa-miR-4442	CLIP-seq
MIRT1254776	hsa-miR-4481	CLIP-seq
MIRT2075171	hsa-miR-4648	CLIP-seq
MIRT1254790	hsa-miR-4651	CLIP-seq
MIRT2075172	hsa-miR-4654	CLIP-seq
MIRT1254803	hsa-miR-4717-3p	CLIP-seq
MIRT2075173	hsa-miR-4717-5p	CLIP-seq
MIRT1254808	hsa-miR-4728-5p	CLIP-seq
MIRT1254809	hsa-miR-4745-5p	CLIP-seq
MIRT2075174	hsa-miR-4769-5p	CLIP-seq
MIRT2075175	hsa-miR-512-3p	CLIP-seq
MIRT1254819	hsa-miR-548u	CLIP-seq
MIRT1254822	hsa-miR-591	CLIP-seq
MIRT1254823	hsa-miR-597	CLIP-seq
MIRT1254824	hsa-miR-608	CLIP-seq
MIRT1254828	hsa-miR-653	CLIP-seq
MIRT2075176	hsa-miR-7	CLIP-seq
MIRT1254830	hsa-miR-761	CLIP-seq
MIRT1254721	hsa-miR-103a	CLIP-seq
MIRT1254722	hsa-miR-107	CLIP-seq
MIRT2301787	hsa-miR-1228	CLIP-seq
MIRT1254725	hsa-miR-128	CLIP-seq
MIRT1254726	hsa-miR-1286	CLIP-seq
MIRT2075165	hsa-miR-1302	CLIP-seq
MIRT2075166	hsa-miR-1827	CLIP-seq
MIRT1254731	hsa-miR-185	CLIP-seq
MIRT1254734	hsa-miR-199a-5p	CLIP-seq
MIRT1254735	hsa-miR-199b-5p	CLIP-seq
MIRT1254736	hsa-miR-214	CLIP-seq
MIRT1254739	hsa-miR-27a	CLIP-seq
MIRT1254740	hsa-miR-27b	CLIP-seq
MIRT1254744	hsa-miR-3150b-3p	CLIP-seq
MIRT2301788	hsa-miR-342-5p	CLIP-seq
MIRT1254749	hsa-miR-3617	CLIP-seq
MIRT1254750	hsa-miR-3619-3p	CLIP-seq
MIRT1254751	hsa-miR-3619-5p	CLIP-seq
MIRT1254752	hsa-miR-3652	CLIP-seq
MIRT1254754	hsa-miR-3677-5p	CLIP-seq
MIRT1254755	hsa-miR-3687	CLIP-seq
MIRT1254756	hsa-miR-3689a-3p	CLIP-seq
MIRT1254757	hsa-miR-3689c	CLIP-seq
MIRT2301789	hsa-miR-3914	CLIP-seq
MIRT1254760	hsa-miR-3978	CLIP-seq
MIRT2075170	hsa-miR-4298	CLIP-seq
MIRT1254763	hsa-miR-4306	CLIP-seq
MIRT1254765	hsa-miR-4426	CLIP-seq
MIRT1254766	hsa-miR-4430	CLIP-seq
MIRT1254767	hsa-miR-4436a	CLIP-seq
MIRT1254768	hsa-miR-4442	CLIP-seq
MIRT1254772	hsa-miR-4464	CLIP-seq
MIRT1254776	hsa-miR-4481	CLIP-seq
MIRT1254777	hsa-miR-4486	CLIP-seq
MIRT1254778	hsa-miR-4489	CLIP-seq
MIRT1254781	hsa-miR-4505	CLIP-seq
MIRT1254784	hsa-miR-4534	CLIP-seq
MIRT1254786	hsa-miR-4642	CLIP-seq
MIRT1254787	hsa-miR-4643	CLIP-seq
MIRT1254788	hsa-miR-4644	CLIP-seq
MIRT1254789	hsa-miR-4647	CLIP-seq
MIRT2075171	hsa-miR-4648	CLIP-seq
MIRT1254790	hsa-miR-4651	CLIP-seq
MIRT1254792	hsa-miR-4655-5p	CLIP-seq
MIRT1254793	hsa-miR-4658	CLIP-seq
MIRT1254794	hsa-miR-466	CLIP-seq
MIRT1254795	hsa-miR-4662b	CLIP-seq
MIRT2301790	hsa-miR-4664-5p	CLIP-seq
MIRT1254797	hsa-miR-4676-5p	CLIP-seq
MIRT2301791	hsa-miR-4690-3p	CLIP-seq
MIRT1254798	hsa-miR-4699-3p	CLIP-seq
MIRT1254800	hsa-miR-4704-3p	CLIP-seq
MIRT1254801	hsa-miR-4709-3p	CLIP-seq
MIRT1254803	hsa-miR-4717-3p	CLIP-seq
MIRT1254808	hsa-miR-4728-5p	CLIP-seq
MIRT1254809	hsa-miR-4745-5p	CLIP-seq
MIRT1254810	hsa-miR-4748	CLIP-seq
MIRT1254813	hsa-miR-4757-5p	CLIP-seq
MIRT1254814	hsa-miR-4758-5p	CLIP-seq
MIRT1254816	hsa-miR-4784	CLIP-seq
MIRT1254817	hsa-miR-4789-3p	CLIP-seq
MIRT2301792	hsa-miR-499-3p	CLIP-seq
MIRT2301793	hsa-miR-499a-3p	CLIP-seq
MIRT1254821	hsa-miR-575	CLIP-seq
MIRT1254822	hsa-miR-591	CLIP-seq
MIRT1254823	hsa-miR-597	CLIP-seq
MIRT1254824	hsa-miR-608	CLIP-seq
MIRT1254826	hsa-miR-641	CLIP-seq
MIRT1254828	hsa-miR-653	CLIP-seq
MIRT2301794	hsa-miR-665	CLIP-seq
MIRT1254830	hsa-miR-761	CLIP-seq
MIRT2301795	hsa-miR-873	CLIP-seq
MIRT2392912	hsa-miR-150	CLIP-seq
MIRT2392913	hsa-miR-218	CLIP-seq
MIRT1254756	hsa-miR-3689a-3p	CLIP-seq
MIRT1254757	hsa-miR-3689c	CLIP-seq
MIRT1254760	hsa-miR-3978	CLIP-seq
MIRT1254776	hsa-miR-4481	CLIP-seq
MIRT1254778	hsa-miR-4489	CLIP-seq
MIRT1254787	hsa-miR-4643	CLIP-seq
MIRT1254794	hsa-miR-466	CLIP-seq
MIRT2392914	hsa-miR-4713-5p	CLIP-seq
MIRT1254808	hsa-miR-4728-5p	CLIP-seq
MIRT1254809	hsa-miR-4745-5p	CLIP-seq
MIRT1254817	hsa-miR-4789-3p	CLIP-seq
MIRT2301792	hsa-miR-499-3p	CLIP-seq
MIRT2301793	hsa-miR-499a-3p	CLIP-seq
MIRT2392915	hsa-miR-532-3p	CLIP-seq
MIRT2392916	hsa-miR-636	CLIP-seq
MIRT1254723	hsa-miR-1197	CLIP-seq
MIRT2075164	hsa-miR-1207-3p	CLIP-seq
MIRT2598515	hsa-miR-1254	CLIP-seq
MIRT1254725	hsa-miR-128	CLIP-seq
MIRT2598516	hsa-miR-1285	CLIP-seq
MIRT2075166	hsa-miR-1827	CLIP-seq
MIRT2075167	hsa-miR-1972	CLIP-seq
MIRT1254741	hsa-miR-3074-5p	CLIP-seq
MIRT2598517	hsa-miR-3116	CLIP-seq
MIRT1254742	hsa-miR-3127-3p	CLIP-seq
MIRT2598518	hsa-miR-3153	CLIP-seq
MIRT2075169	hsa-miR-3185	CLIP-seq
MIRT2598519	hsa-miR-3187-5p	CLIP-seq
MIRT2598520	hsa-miR-3202	CLIP-seq
MIRT1254753	hsa-miR-3667-3p	CLIP-seq
MIRT1254760	hsa-miR-3978	CLIP-seq
MIRT1254765	hsa-miR-4426	CLIP-seq
MIRT1254767	hsa-miR-4436a	CLIP-seq
MIRT1254769	hsa-miR-4450	CLIP-seq
MIRT1254771	hsa-miR-4463	CLIP-seq
MIRT1254789	hsa-miR-4647	CLIP-seq
MIRT1254795	hsa-miR-4662b	CLIP-seq
MIRT1254796	hsa-miR-4667-5p	CLIP-seq
MIRT1254799	hsa-miR-4700-5p	CLIP-seq
MIRT2598521	hsa-miR-4712-5p	CLIP-seq
MIRT2075173	hsa-miR-4717-5p	CLIP-seq
MIRT1254805	hsa-miR-4722-3p	CLIP-seq
MIRT2598522	hsa-miR-4747-5p	CLIP-seq
MIRT1254811	hsa-miR-4749-3p	CLIP-seq
MIRT1254812	hsa-miR-4755-3p	CLIP-seq
MIRT2075175	hsa-miR-512-3p	CLIP-seq
MIRT1254819	hsa-miR-548u	CLIP-seq
MIRT2598523	hsa-miR-550a	CLIP-seq
MIRT2598524	hsa-miR-612	CLIP-seq
MIRT2598525	hsa-miR-661	CLIP-seq
MIRT2075176	hsa-miR-7	CLIP-seq
MIRT2598526	hsa-miR-770-5p	CLIP-seq
MIRT1254833	hsa-miR-938	CLIP-seq
MIRT1254723	hsa-miR-1197	CLIP-seq
MIRT1254765	hsa-miR-4426	CLIP-seq
MIRT1254767	hsa-miR-4436a	CLIP-seq
MIRT1254789	hsa-miR-4647	CLIP-seq
MIRT1254795	hsa-miR-4662b	CLIP-seq

Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000086	Process	G2/M transition of mitotic cell cycle	TAS
GO:0004864	Function	Protein phosphatase inhibitor activity	IDA	10318862
GO:0005515	Function	Protein binding	IPI	22167190, 28514442, 33961781
GO:0005654	Component	Nucleoplasm	TAS
GO:0016787	Function	Hydrolase activity	IEA
GO:0019901	Function	Protein kinase binding	IEA
GO:0019903	Function	Protein phosphatase binding	IDA	10318862
GO:0019903	Function	Protein phosphatase binding	IPI	10318862
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0051721	Function	Protein phosphatase 2A binding	IDA	10318862
GO:0051723	Function	Protein methylesterase activity	IBA
GO:0051723	Function	Protein methylesterase activity	IDA	10318862
GO:0051723	Function	Protein methylesterase activity	IEA
GO:0051723	Function	Protein methylesterase activity	TAS
GO:0052689	Function	Carboxylic ester hydrolase activity	IEA
GO:0106222	Function	LncRNA binding	IEA

MIM	HGNC	e!Ensembl
611117	30178	ENSG00000214517

Q9Y570

Protein name

Protein phosphatase methylesterase 1 (PME-1) (EC 3.1.1.89)

Protein function

Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme.

PDB

3C5V , 3C5W , 7SOY

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12697	Abhydrolase_6	79 → 362	Alpha/beta hydrolase family	Domain

Sequence

MSALEKSMHLGRLPSRPPLPGSGGSQSGAKMRMGPGRKRDFSPVPWSQYFESMEDVEVEN
ETGKDTFRVYKSGSEGPVLLLLHGGGHSALSWAVFTAAIISRVQCRIVALDLRSHGETKV
KNPEDLSAETMAKDVGNVVEAMYGDLPPPIMLIGHSMGGAIAVHTASSNLVPSLLGLCMI
DVVEGTAMDALNSMQNFLRGRPKTFKSLENAIEWSVKSGQIRNLESARVSMVGQVKQCEG
ITSPEGSKSIVEGIIEEEEEDEEGSESISKRKKEDDMETKKDHPYTWRIELAKTEKYWDG
WFRGLSNLFLSCPIPKLLLLAGVDRLDKDLTIGQMQGKFQMQVLPQCGHAVHEDAPDKVA
EAVATFLIRHRFAEPIGGFQCVFPGC

Sequence length

386

Interactions

View interactions

	Reactome
			Cyclin A/B1/B2 associated events during G2/M transition

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
PSORIASIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (24)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma of rectum	Adenocarcinoma Of Rectum	BEFREE	26377365		★★★★★ ★☆☆☆☆ Found in Text Mining only
Astrocytoma	Astrocytoma	BEFREE	19293187		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	24253382		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic neoplasm	Pubtator	26377365	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	26377365	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometrial adenocarcinoma	Endometrial Adenocarcinoma	BEFREE	24928782		★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometrial Carcinoma	Endometrial carcinoma	BEFREE	24928782, 27048286		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	24253382	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	31717978		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	24253382	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus Systemic	Systemic lupus erythematosus	Pubtator	31137925	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Glioma	Glioma	BEFREE	19293187		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of endometrium	Endometrial Cancer	BEFREE	24928782, 27048286		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	24253382		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	24253382		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	31214504		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	24928782, 27048286		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurodegenerative Diseases	Neurodegenerative disorder	Pubtator	38588804	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	32351291	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Progressive supranuclear palsy	Progressive Supranuclear Palsy	BEFREE	29281045		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	24253382		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	24253382	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Tauopathies	Tauopathies	BEFREE	29281045		★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Cancer Papillary	Papillary thyroid cancer	Pubtator	26810418	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

PPME1 (protein phosphatase methylesterase 1)