TRPV2 (transient receptor potential cation channel subfamily V member 2)

Gene

• Entrez ID: 51393
• Gene name: Transient receptor potential cation channel subfamily V member 2
• Gene symbol: TRPV2
• Synonyms (NCBI Gene): VRL, VRL-1, VRL1
• Chromosome: 17
• Chromosome location: 17p11.2
• Summary: This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be act

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT707055	hsa-miR-202-5p	HITS-CLIP	21572407
MIRT707054	hsa-miR-223-3p	HITS-CLIP	21572407
MIRT707053	hsa-miR-4524b-3p	HITS-CLIP	21572407
MIRT707052	hsa-miR-1245a	HITS-CLIP	21572407
MIRT707051	hsa-miR-8079	HITS-CLIP	21572407
MIRT707049	hsa-miR-8062	HITS-CLIP	21572407
MIRT707050	hsa-miR-1324	HITS-CLIP	21572407
MIRT707048	hsa-miR-4433a-3p	HITS-CLIP	21572407
MIRT707047	hsa-miR-5002-3p	HITS-CLIP	21572407
MIRT707046	hsa-miR-3606-5p	HITS-CLIP	21572407
MIRT707045	hsa-miR-921	HITS-CLIP	21572407
MIRT707044	hsa-miR-337-3p	HITS-CLIP	21572407
MIRT707043	hsa-miR-4256	HITS-CLIP	21572407
MIRT707042	hsa-miR-3136-5p	HITS-CLIP	21572407
MIRT707041	hsa-miR-4439	HITS-CLIP	21572407
MIRT707040	hsa-miR-943	HITS-CLIP	21572407
MIRT698032	hsa-miR-382-5p	HITS-CLIP	23313552
MIRT698031	hsa-miR-6801-5p	HITS-CLIP	23313552
MIRT520457	hsa-miR-6832-5p	HITS-CLIP	23313552
MIRT698030	hsa-miR-4732-5p	HITS-CLIP	23313552
MIRT698029	hsa-miR-3674	HITS-CLIP	23313552
MIRT628752	hsa-miR-6819-3p	HITS-CLIP	23824327
MIRT628751	hsa-miR-6877-3p	HITS-CLIP	23824327
MIRT628750	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT663595	hsa-miR-764	HITS-CLIP	23824327
MIRT663594	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT663593	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT628749	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT663592	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT628748	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT628747	hsa-miR-640	HITS-CLIP	23824327
MIRT628752	hsa-miR-6819-3p	HITS-CLIP	23824327
MIRT628751	hsa-miR-6877-3p	HITS-CLIP	23824327
MIRT628750	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT628749	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT628748	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT628747	hsa-miR-640	HITS-CLIP	23824327
MIRT465178	hsa-miR-5580-3p	PAR-CLIP	20371350
MIRT465176	hsa-miR-4464	PAR-CLIP	20371350
MIRT465175	hsa-miR-4748	PAR-CLIP	20371350
MIRT465173	hsa-miR-3665	PAR-CLIP	20371350
MIRT465172	hsa-miR-657	PAR-CLIP	20371350
MIRT465171	hsa-miR-5087	PAR-CLIP	20371350
MIRT465170	hsa-miR-8068	PAR-CLIP	20371350
MIRT465169	hsa-miR-4666a-5p	PAR-CLIP	20371350
MIRT465168	hsa-miR-3924	PAR-CLIP	20371350
MIRT529682	hsa-miR-5092	PAR-CLIP	22012620
MIRT529683	hsa-miR-205-3p	PAR-CLIP	22012620
MIRT529681	hsa-miR-4508	PAR-CLIP	22012620
MIRT529680	hsa-miR-138-2-3p	PAR-CLIP	22012620
MIRT520456	hsa-miR-197-3p	PAR-CLIP	22012620
MIRT520453	hsa-miR-5096	PAR-CLIP	22012620
MIRT529679	hsa-miR-548aa	PAR-CLIP	22012620
MIRT529678	hsa-miR-548ap-3p	PAR-CLIP	22012620
MIRT529677	hsa-miR-548t-3p	PAR-CLIP	22012620
MIRT529676	hsa-miR-4731-3p	PAR-CLIP	22012620
MIRT529675	hsa-miR-4801	PAR-CLIP	22012620
MIRT529674	hsa-miR-141-5p	PAR-CLIP	22012620
MIRT520464	hsa-miR-6890-5p	PAR-CLIP	23446348
MIRT520463	hsa-miR-3194-5p	PAR-CLIP	23446348
MIRT520462	hsa-miR-193b-5p	PAR-CLIP	23446348
MIRT520461	hsa-miR-4650-3p	PAR-CLIP	23446348
MIRT520460	hsa-miR-3529-5p	PAR-CLIP	23446348
MIRT520459	hsa-miR-379-5p	PAR-CLIP	23446348
MIRT520458	hsa-miR-4451	PAR-CLIP	23446348
MIRT520457	hsa-miR-6832-5p	PAR-CLIP	23446348
MIRT520456	hsa-miR-197-3p	PAR-CLIP	23446348
MIRT520455	hsa-miR-3170	PAR-CLIP	23446348
MIRT520454	hsa-miR-6855-5p	PAR-CLIP	23446348
MIRT520453	hsa-miR-5096	PAR-CLIP	23446348
MIRT488997	hsa-miR-3186-3p	PAR-CLIP	23592263
MIRT488995	hsa-miR-6499-5p	PAR-CLIP	23592263
MIRT488994	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT488993	hsa-miR-4767	PAR-CLIP	23592263
MIRT465178	hsa-miR-5580-3p	PAR-CLIP	23592263
MIRT465177	hsa-miR-6841-5p	PAR-CLIP	23592263
MIRT465176	hsa-miR-4464	PAR-CLIP	23592263
MIRT465175	hsa-miR-4748	PAR-CLIP	23592263
MIRT465174	hsa-miR-455-5p	PAR-CLIP	23592263
MIRT465173	hsa-miR-3665	PAR-CLIP	23592263
MIRT465172	hsa-miR-657	PAR-CLIP	23592263
MIRT465171	hsa-miR-5087	PAR-CLIP	23592263
MIRT465170	hsa-miR-8068	PAR-CLIP	23592263
MIRT465169	hsa-miR-4666a-5p	PAR-CLIP	23592263
MIRT465168	hsa-miR-3924	PAR-CLIP	23592263
MIRT442042	hsa-miR-495-5p	PAR-CLIP	22100165
MIRT442041	hsa-miR-1277-5p	PAR-CLIP	22100165
MIRT442040	hsa-miR-6508-5p	PAR-CLIP	22100165
MIRT442039	hsa-miR-8067	PAR-CLIP	22100165
MIRT442038	hsa-miR-627-3p	PAR-CLIP	22100165
MIRT442037	hsa-miR-6501-5p	PAR-CLIP	22100165
MIRT442036	hsa-miR-518d-5p	PAR-CLIP	22100165
MIRT442035	hsa-miR-518e-5p	PAR-CLIP	22100165
MIRT442033	hsa-miR-518f-5p	PAR-CLIP	22100165
MIRT442034	hsa-miR-519a-5p	PAR-CLIP	22100165
MIRT442032	hsa-miR-519b-5p	PAR-CLIP	22100165
MIRT442031	hsa-miR-519c-5p	PAR-CLIP	22100165
MIRT442030	hsa-miR-520c-5p	PAR-CLIP	22100165
MIRT442029	hsa-miR-522-5p	PAR-CLIP	22100165
MIRT442028	hsa-miR-523-5p	PAR-CLIP	22100165
MIRT442027	hsa-miR-526a	PAR-CLIP	22100165
MIRT442026	hsa-miR-4777-5p	PAR-CLIP	22100165
MIRT442025	hsa-miR-192-3p	PAR-CLIP	22100165
MIRT707055	hsa-miR-202-5p	HITS-CLIP	21572407
MIRT707054	hsa-miR-223-3p	HITS-CLIP	21572407
MIRT707053	hsa-miR-4524b-3p	HITS-CLIP	21572407
MIRT707052	hsa-miR-1245a	HITS-CLIP	21572407
MIRT707051	hsa-miR-8079	HITS-CLIP	21572407
MIRT707049	hsa-miR-8062	HITS-CLIP	21572407
MIRT707050	hsa-miR-1324	HITS-CLIP	21572407
MIRT707048	hsa-miR-4433a-3p	HITS-CLIP	21572407
MIRT707047	hsa-miR-5002-3p	HITS-CLIP	21572407
MIRT707046	hsa-miR-3606-5p	HITS-CLIP	21572407
MIRT707045	hsa-miR-921	HITS-CLIP	21572407
MIRT707044	hsa-miR-337-3p	HITS-CLIP	21572407
MIRT707043	hsa-miR-4256	HITS-CLIP	21572407
MIRT707042	hsa-miR-3136-5p	HITS-CLIP	21572407
MIRT707041	hsa-miR-4439	HITS-CLIP	21572407
MIRT707040	hsa-miR-943	HITS-CLIP	21572407
MIRT698032	hsa-miR-382-5p	HITS-CLIP	23313552
MIRT698031	hsa-miR-6801-5p	HITS-CLIP	23313552
MIRT520457	hsa-miR-6832-5p	HITS-CLIP	23313552
MIRT698030	hsa-miR-4732-5p	HITS-CLIP	23313552
MIRT698029	hsa-miR-3674	HITS-CLIP	23313552
MIRT628752	hsa-miR-6819-3p	HITS-CLIP	23824327
MIRT628751	hsa-miR-6877-3p	HITS-CLIP	23824327
MIRT628750	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT663595	hsa-miR-764	HITS-CLIP	23824327
MIRT663594	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT663593	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT628749	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT663592	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT628748	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT628747	hsa-miR-640	HITS-CLIP	23824327
MIRT628752	hsa-miR-6819-3p	HITS-CLIP	23824327
MIRT628751	hsa-miR-6877-3p	HITS-CLIP	23824327
MIRT628750	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT628749	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT628748	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT628747	hsa-miR-640	HITS-CLIP	23824327
MIRT465178	hsa-miR-5580-3p	PAR-CLIP	20371350
MIRT465176	hsa-miR-4464	PAR-CLIP	20371350
MIRT465175	hsa-miR-4748	PAR-CLIP	20371350
MIRT465173	hsa-miR-3665	PAR-CLIP	20371350
MIRT465172	hsa-miR-657	PAR-CLIP	20371350
MIRT465171	hsa-miR-5087	PAR-CLIP	20371350
MIRT465170	hsa-miR-8068	PAR-CLIP	20371350
MIRT465169	hsa-miR-4666a-5p	PAR-CLIP	20371350
MIRT465168	hsa-miR-3924	PAR-CLIP	20371350
MIRT529682	hsa-miR-5092	PAR-CLIP	22012620
MIRT529683	hsa-miR-205-3p	PAR-CLIP	22012620
MIRT529681	hsa-miR-4508	PAR-CLIP	22012620
MIRT529680	hsa-miR-138-2-3p	PAR-CLIP	22012620
MIRT520456	hsa-miR-197-3p	PAR-CLIP	22012620
MIRT520453	hsa-miR-5096	PAR-CLIP	22012620
MIRT529679	hsa-miR-548aa	PAR-CLIP	22012620
MIRT529678	hsa-miR-548ap-3p	PAR-CLIP	22012620
MIRT529677	hsa-miR-548t-3p	PAR-CLIP	22012620
MIRT529676	hsa-miR-4731-3p	PAR-CLIP	22012620
MIRT529675	hsa-miR-4801	PAR-CLIP	22012620
MIRT529674	hsa-miR-141-5p	PAR-CLIP	22012620
MIRT520464	hsa-miR-6890-5p	PAR-CLIP	23446348
MIRT520463	hsa-miR-3194-5p	PAR-CLIP	23446348
MIRT520462	hsa-miR-193b-5p	PAR-CLIP	23446348
MIRT520461	hsa-miR-4650-3p	PAR-CLIP	23446348
MIRT520460	hsa-miR-3529-5p	PAR-CLIP	23446348
MIRT520459	hsa-miR-379-5p	PAR-CLIP	23446348
MIRT520458	hsa-miR-4451	PAR-CLIP	23446348
MIRT520457	hsa-miR-6832-5p	PAR-CLIP	23446348
MIRT520456	hsa-miR-197-3p	PAR-CLIP	23446348
MIRT520455	hsa-miR-3170	PAR-CLIP	23446348
MIRT520454	hsa-miR-6855-5p	PAR-CLIP	23446348
MIRT520453	hsa-miR-5096	PAR-CLIP	23446348
MIRT488997	hsa-miR-3186-3p	PAR-CLIP	23592263
MIRT488995	hsa-miR-6499-5p	PAR-CLIP	23592263
MIRT488994	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT488993	hsa-miR-4767	PAR-CLIP	23592263
MIRT465178	hsa-miR-5580-3p	PAR-CLIP	23592263
MIRT465177	hsa-miR-6841-5p	PAR-CLIP	23592263
MIRT465176	hsa-miR-4464	PAR-CLIP	23592263
MIRT465175	hsa-miR-4748	PAR-CLIP	23592263
MIRT465174	hsa-miR-455-5p	PAR-CLIP	23592263
MIRT465173	hsa-miR-3665	PAR-CLIP	23592263
MIRT465172	hsa-miR-657	PAR-CLIP	23592263
MIRT465171	hsa-miR-5087	PAR-CLIP	23592263
MIRT465170	hsa-miR-8068	PAR-CLIP	23592263
MIRT465169	hsa-miR-4666a-5p	PAR-CLIP	23592263
MIRT465168	hsa-miR-3924	PAR-CLIP	23592263
MIRT442042	hsa-miR-495-5p	PAR-CLIP	22100165
MIRT442041	hsa-miR-1277-5p	PAR-CLIP	22100165
MIRT442040	hsa-miR-6508-5p	PAR-CLIP	22100165
MIRT442039	hsa-miR-8067	PAR-CLIP	22100165
MIRT442038	hsa-miR-627-3p	PAR-CLIP	22100165
MIRT442037	hsa-miR-6501-5p	PAR-CLIP	22100165
MIRT442036	hsa-miR-518d-5p	PAR-CLIP	22100165
MIRT442035	hsa-miR-518e-5p	PAR-CLIP	22100165
MIRT442033	hsa-miR-518f-5p	PAR-CLIP	22100165
MIRT442034	hsa-miR-519a-5p	PAR-CLIP	22100165
MIRT442032	hsa-miR-519b-5p	PAR-CLIP	22100165
MIRT442031	hsa-miR-519c-5p	PAR-CLIP	22100165
MIRT442030	hsa-miR-520c-5p	PAR-CLIP	22100165
MIRT442029	hsa-miR-522-5p	PAR-CLIP	22100165
MIRT442028	hsa-miR-523-5p	PAR-CLIP	22100165
MIRT442027	hsa-miR-526a	PAR-CLIP	22100165
MIRT442026	hsa-miR-4777-5p	PAR-CLIP	22100165
MIRT442025	hsa-miR-192-3p	PAR-CLIP	22100165

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005216	Function	Monoatomic ion channel activity	IEA
GO:0005216	Function	Monoatomic ion channel activity	TAS	10201375
GO:0005261	Function	Monoatomic cation channel activity	IDA	10201375
GO:0005261	Function	Monoatomic cation channel activity	IEA
GO:0005262	Function	Calcium channel activity	IBA
GO:0005262	Function	Calcium channel activity	IEA
GO:0005262	Function	Calcium channel activity	TAS
GO:0005515	Function	Protein binding	IPI	34158856
GO:0005737	Component	Cytoplasm	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	10201375
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	10201375
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006816	Process	Calcium ion transport	IEA
GO:0007600	Process	Sensory perception	TAS	10201375
GO:0009266	Process	Response to temperature stimulus	IDA	10201375
GO:0009986	Component	Cell surface	IEA
GO:0015075	Function	Monoatomic ion transmembrane transporter activity	TAS	10201375
GO:0016020	Component	Membrane	IEA
GO:0030424	Component	Axon	IEA
GO:0032584	Component	Growth cone membrane	IEA
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0042470	Component	Melanosome	IEA
GO:0044295	Component	Axonal growth cone	IEA
GO:0044297	Component	Cell body	IEA
GO:0045773	Process	Positive regulation of axon extension	IEA
GO:0055085	Process	Transmembrane transport	IEA
GO:0070588	Process	Calcium ion transmembrane transport	IEA
GO:0070588	Process	Calcium ion transmembrane transport	TAS
GO:0090280	Process	Positive regulation of calcium ion import	IEA
GO:0098703	Process	Calcium ion import across plasma membrane	IBA
GO:0120162	Process	Positive regulation of cold-induced thermogenesis	IEA
GO:0120162	Process	Positive regulation of cold-induced thermogenesis	ISS	26882545

Other IDs

• MIM: 606676
• HGNC: 18082
• e!Ensembl: ENSG00000187688

Protein

• UniProt ID: Q9Y5S1
• Protein name: Transient receptor potential cation channel subfamily V member 2 (TrpV2) (Osm-9-like TRP channel 2) (OTRPC2) (Vanilloid receptor-like protein 1) (VRL-1)
• Protein function: Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF1, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher
• PDB: 2F37
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF12796	Ank_2	67 → 193	Ankyrin repeats (3 copies)	Repeat
  PF00520	Ion_trans	389 → 657	Ion transport protein	Family

• Sequence:

  MTSPSSSPVFRLETLDGGQEDGSEADRGKLDFGSGLPPMESQFQGEDRKFAPQIRVNLNY
  RKGTGASQPDPNRFDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCL
  MKAVLNLKDGVNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVK
  LLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQA
  TDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKL
  AAKEGKIEIFRHILQREFSGLSHLSRKFTEWCYGPVRVSLYDLASVDSCEENSVLEIIAF
  HCKSPHRHRMVVLEPLNKLLQAKWDLLIPKFFLNFLCNLIYMFIFTAVAYHQPTLKKQAA
  PHLKAEVGNSMLLTGHILILLGGIYLLVGQLWYFWRRHVFIWISFIDSYFEILFLFQALL
  TVVSQVLCFLAIEWYLPLLVSALVLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLL
  IYLVFLFGFAVALVSLSQEAWRPEAPTGPNATESVQPMEGQEDEGNGAQYRGILEASLEL
  FKFTIGMGELAFQEQLHFRGMVLLLLLAYVLLTYILLLNMLIALMSETVNSVATDSWSIW
  KLQKAISVLEMENGYWWCRKKQRAGVMLTVGTKPDGSPDERWCFRVEEVNWASWEQTLPT
  LCEDPSGAGVPRTLENPVLASPPKEDEDGASEENYVPVQLLQSN

• Sequence length: 764

Pathways

KEGG:

NOD-like receptor signaling pathway
Inflammatory mediator regulation of TRP channels

Reactome:

TRP channels

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ENDOMETRIAL NEOPLASMS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adult Acute Myeloblastic Leukemia	Myeloblastic Leukemia	BEFREE	25903924		★☆☆☆☆ Found in Text Mining only
Arthritis	Arthritis	BEFREE	25869297, 30851707		★☆☆☆☆ Found in Text Mining only
Atrial Fibrillation	Atrial fibrillation	Pubtator	28839241	Associate	★☆☆☆☆ Found in Text Mining only
Atrial Fibrillation	Atrial fibrillation	Pubtator	36513971	Stimulate	★☆☆☆☆ Found in Text Mining only
B-Cell Lymphomas	B-Cell Lymphoma	BEFREE	23862671		★☆☆☆☆ Found in Text Mining only
Bladder Neoplasm	Bladder Neoplasm	BEFREE	23741410		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	31547381	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Basal Cell	Basal cell carcinoma	Pubtator	31690728	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma of bladder	Bladder carcinoma	BEFREE	23741410		★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	35558077	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Squamous cell carcinoma	Pubtator	28081185	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma, Basal Cell	Carcinoma	BEFREE	31690728		★☆☆☆☆ Found in Text Mining only
Cardiomyopathies	Cardiomyopathy	BEFREE	23453732, 28546113, 29581825, 31394715		★☆☆☆☆ Found in Text Mining only
Cardiomyopathies	Cardiomyopathy	Pubtator	29093384	Associate	★☆☆☆☆ Found in Text Mining only
Cardiomyopathy, Dilated	Cardiomyopathy	BEFREE	29581825		★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular Diseases	BEFREE	23453732		★☆☆☆☆ Found in Text Mining only
Childhood Acute Myeloid Leukemia	Acute Myeloid Leukemia	BEFREE	25903924		★☆☆☆☆ Found in Text Mining only
Childhood asthma	Asthma	BEFREE	23294145		★☆☆☆☆ Found in Text Mining only
Chronic interstitial cystitis	Interstitial Cystitis	BEFREE	23727186		★☆☆☆☆ Found in Text Mining only
Chronic kidney disease stage 5	Kidney Disease	BEFREE	19619644		★☆☆☆☆ Found in Text Mining only
Chronic Obstructive Airway Disease	Chronic Obstructive Pulmonary Disease	BEFREE	30914062		★☆☆☆☆ Found in Text Mining only
Cirrhosis	Cirrhosis	BEFREE	20113837		★☆☆☆☆ Found in Text Mining only
Colitis Ulcerative	Ulcerative colitis	Pubtator	32455137	Associate	★☆☆☆☆ Found in Text Mining only
Congestive heart failure	Congestive Heart Failure	BEFREE	31394715		★☆☆☆☆ Found in Text Mining only
Cystic Fibrosis	Cystic Fibrosis	BEFREE	29523858		★☆☆☆☆ Found in Text Mining only
Deuteranomaly	Deuteranomaly	BEFREE	25903924, 30323891		★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Endometrial neoplasm	Pubtator	32751388	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Endometrial Neoplasms	Endometrial neoplasm	Pubtator	34936030	Stimulate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Endometriosis	Endometriosis	Pubtator	30134548	Associate	★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	30761248	Stimulate	★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	31690728, 35813298	Associate	★☆☆☆☆ Found in Text Mining only
Familial cold urticaria	Cold urticaria	BEFREE	29505690		★☆☆☆☆ Found in Text Mining only
Fatigue Syndrome Chronic	Fatigue syndrome	Pubtator	27834303	Associate	★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	26088448, 29719613, 30845786, 31653969		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	26088448	Associate	★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	26088448, 29719613, 30845786, 31653969		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	20093382, 22492283		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	25903924	Associate	★☆☆☆☆ Found in Text Mining only
Heart Diseases	Heart Diseases	BEFREE	28546113		★☆☆☆☆ Found in Text Mining only
Heart Failure	Heart failure	Pubtator	29093384	Associate	★☆☆☆☆ Found in Text Mining only
Heart failure	Heart Failure	BEFREE	31394715		★☆☆☆☆ Found in Text Mining only
Hepatocellular Adenoma	Hepatocellular adenoma	BEFREE	31653969		★☆☆☆☆ Found in Text Mining only
Interstitial Cystitis	Interstitial Cystitis	BEFREE	23727186		★☆☆☆☆ Found in Text Mining only
Kidney Failure Chronic	Kidney failure	Pubtator	19619644	Inhibit	★☆☆☆☆ Found in Text Mining only
Kidney Failure, Chronic	Kidney Failure	BEFREE	19619644		★☆☆☆☆ Found in Text Mining only
Left Ventricular Hypertrophy	Left Ventricular Hypertrophy	BEFREE	28009703		★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	25268680, 30733502	Associate	★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	30733502		★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	25903924		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	20113837, 26456053, 29906748		★☆☆☆☆ Found in Text Mining only
Liver Cirrhosis	Liver Cirrhosis	BEFREE	20113837		★☆☆☆☆ Found in Text Mining only
Liver neoplasms	Liver neoplasms	BEFREE	26456053		★☆☆☆☆ Found in Text Mining only
Lymphoid leukemia	Lymphoid leukemia	BEFREE	23862671		★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	BEFREE	30688042		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of liver	Liver Cancer	BEFREE	29906748		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	20103638, 30620187		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of urinary bladder	Urinary bladder cancer	BEFREE	23741410		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	20103638, 24878697, 25001513, 30688042, 30851707, 31566564, 31653969		★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	30881453		★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	36744297	Associate	★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	BEFREE	23862671, 24293211, 30326911		★☆☆☆☆ Found in Text Mining only
Muscular Dystrophy	Muscular dystrophy	BEFREE	19050039, 29581825, 31394715		★☆☆☆☆ Found in Text Mining only
Muscular Dystrophy Duchenne	Duchenne muscular dystrophy	Pubtator	23426965	Associate	★☆☆☆☆ Found in Text Mining only
Muscular Dystrophy, Duchenne	Duchenne Muscular Dystrophy	BEFREE	23426965		★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial Infarction	BEFREE	28481959		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	20113837, 29719613, 29906748		★☆☆☆☆ Found in Text Mining only
nervous system disorder	Nervous System Disorder	BEFREE	29719613		★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	20103638, 30620187		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic Neoplasms	BEFREE	20103638		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	21623387	Associate	★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	25869297, 30851707		★☆☆☆☆ Found in Text Mining only
Rosacea	Rosacea	Pubtator	22189789	Associate	★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	24878697, 25001513, 28389731, 30761248, 31653969, 31690728		★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	28081185	Stimulate	★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple Negative Breast Neoplasms	BEFREE	30323891, 31653969		★☆☆☆☆ Found in Text Mining only
Ulcerative Colitis	Ulcerative colitis	BEFREE	29914124		★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	35836291	Associate	★☆☆☆☆ Found in Text Mining only
Urothelial Carcinoma	Urothelial Carcinoma	BEFREE	17977643		★☆☆☆☆ Found in Text Mining only
Uveitis	Uveitis	BEFREE	30688042		★☆☆☆☆ Found in Text Mining only
Varicosity	Vulval varices	BEFREE	27553072		★☆☆☆☆ Found in Text Mining only