Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	51386
Gene name	Eukaryotic translation initiation factor 3 subunit L
Gene symbol	EIF3L
Synonyms (NCBI Gene)	EIF3EIPEIF3S11EIF3S6IPHSPC021HSPC025MSTP005
Chromosome	22
Chromosome location	22q13.1

Show/Hide all (77)

miRTarBase ID	miRNA	Experiments	Reference
MIRT023148	hsa-miR-124-3p	Proteomics	18668037
MIRT050632	hsa-miR-19b-3p	CLASH	23622248
MIRT047761	hsa-miR-7-5p	CLASH	23622248
MIRT044708	hsa-miR-320a	CLASH	23622248
MIRT043850	hsa-miR-340-3p	CLASH	23622248
MIRT039077	hsa-miR-769-3p	CLASH	23622248
MIRT683744	hsa-miR-490-3p	HITS-CLIP	23313552
MIRT683743	hsa-miR-5197-5p	HITS-CLIP	23313552
MIRT683742	hsa-miR-7851-3p	HITS-CLIP	23313552
MIRT683741	hsa-miR-3914	HITS-CLIP	23313552
MIRT683740	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT683739	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT683738	hsa-miR-940	HITS-CLIP	23313552
MIRT683734	hsa-miR-873-5p	HITS-CLIP	23313552
MIRT683737	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT683736	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT683735	hsa-miR-1827	HITS-CLIP	23313552
MIRT683734	hsa-miR-873-5p	HITS-CLIP	23313552
MIRT683733	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT683732	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT683731	hsa-miR-1207-5p	HITS-CLIP	23313552
MIRT683730	hsa-miR-4763-3p	HITS-CLIP	23313552
MIRT683729	hsa-miR-4736	HITS-CLIP	23313552
MIRT683728	hsa-miR-7150	HITS-CLIP	23313552
MIRT683727	hsa-miR-665	HITS-CLIP	23313552
MIRT683744	hsa-miR-490-3p	HITS-CLIP	23313552
MIRT683743	hsa-miR-5197-5p	HITS-CLIP	23313552
MIRT683742	hsa-miR-7851-3p	HITS-CLIP	23313552
MIRT683741	hsa-miR-3914	HITS-CLIP	23313552
MIRT683740	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT683739	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT683738	hsa-miR-940	HITS-CLIP	23313552
MIRT683734	hsa-miR-873-5p	HITS-CLIP	23313552
MIRT683737	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT683736	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT683735	hsa-miR-1827	HITS-CLIP	23313552
MIRT683734	hsa-miR-873-5p	HITS-CLIP	23313552
MIRT683733	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT683732	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT683731	hsa-miR-1207-5p	HITS-CLIP	23313552
MIRT683730	hsa-miR-4763-3p	HITS-CLIP	23313552
MIRT683729	hsa-miR-4736	HITS-CLIP	23313552
MIRT683728	hsa-miR-7150	HITS-CLIP	23313552
MIRT683727	hsa-miR-665	HITS-CLIP	23313552
MIRT957706	hsa-miR-1323	CLIP-seq
MIRT957707	hsa-miR-369-3p	CLIP-seq
MIRT957708	hsa-miR-374a	CLIP-seq
MIRT957709	hsa-miR-374b	CLIP-seq
MIRT957710	hsa-miR-374c	CLIP-seq
MIRT957711	hsa-miR-3929	CLIP-seq
MIRT957712	hsa-miR-4419b	CLIP-seq
MIRT957713	hsa-miR-4438	CLIP-seq
MIRT957714	hsa-miR-4478	CLIP-seq
MIRT957715	hsa-miR-499-3p	CLIP-seq
MIRT957716	hsa-miR-499a-3p	CLIP-seq
MIRT957717	hsa-miR-548m	CLIP-seq
MIRT957718	hsa-miR-548o	CLIP-seq
MIRT957719	hsa-miR-655	CLIP-seq
MIRT957711	hsa-miR-3929	CLIP-seq
MIRT957712	hsa-miR-4419b	CLIP-seq
MIRT957713	hsa-miR-4438	CLIP-seq
MIRT957714	hsa-miR-4478	CLIP-seq
MIRT2219022	hsa-miR-3140-5p	CLIP-seq
MIRT957717	hsa-miR-548m	CLIP-seq
MIRT2219023	hsa-miR-548p	CLIP-seq
MIRT957711	hsa-miR-3929	CLIP-seq
MIRT957712	hsa-miR-4419b	CLIP-seq
MIRT957713	hsa-miR-4438	CLIP-seq
MIRT957714	hsa-miR-4478	CLIP-seq
MIRT957717	hsa-miR-548m	CLIP-seq
MIRT2219023	hsa-miR-548p	CLIP-seq
MIRT957711	hsa-miR-3929	CLIP-seq
MIRT957712	hsa-miR-4419b	CLIP-seq
MIRT957713	hsa-miR-4438	CLIP-seq
MIRT957714	hsa-miR-4478	CLIP-seq
MIRT957717	hsa-miR-548m	CLIP-seq
MIRT2219023	hsa-miR-548p	CLIP-seq

Show/Hide all (29)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001650	Component	Fibrillar center	IEA
GO:0001732	Process	Formation of cytoplasmic translation initiation complex	IEA
GO:0001732	Process	Formation of cytoplasmic translation initiation complex	NAS	16920360
GO:0002183	Process	Cytoplasmic translational initiation	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003743	Function	Translation initiation factor activity	IC	17322308, 18599441
GO:0003743	Function	Translation initiation factor activity	IDA	17581632, 25849773
GO:0003743	Function	Translation initiation factor activity	IEA
GO:0003743	Function	Translation initiation factor activity	IEA
GO:0005515	Function	Protein binding	IPI	16189514, 18599441, 19748344, 21516116, 22190034, 23623729, 24965446, 25416956, 28514442, 32296183, 32814053, 33961781, 35271311
GO:0005654	Component	Nucleoplasm	IEA
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005852	Component	Eukaryotic translation initiation factor 3 complex	IBA
GO:0005852	Component	Eukaryotic translation initiation factor 3 complex	IDA	17322308, 17581632, 18599441, 25849773
GO:0005852	Component	Eukaryotic translation initiation factor 3 complex	IEA
GO:0005852	Component	Eukaryotic translation initiation factor 3 complex	IPI	17322308
GO:0006412	Process	Translation	IEA
GO:0006413	Process	Translational initiation	IBA
GO:0006413	Process	Translational initiation	IC	17322308, 18599441
GO:0006413	Process	Translational initiation	IDA	17581632
GO:0006413	Process	Translational initiation	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016282	Component	Eukaryotic 43S preinitiation complex	IEA
GO:0032991	Component	Protein-containing complex	IEA
GO:0033290	Component	Eukaryotic 48S preinitiation complex	IEA
GO:0045202	Component	Synapse	IEA
GO:0075525	Process	Viral translational termination-reinitiation	IDA	21347434

MIM	HGNC	e!Ensembl
619197	18138	ENSG00000100129

Q9Y262

Protein name

Eukaryotic translation initiation factor 3 subunit L (eIF3l) (Eukaryotic translation initiation factor 3 subunit 6-interacting protein) (Eukaryotic translation initiation factor 3 subunit E-interacting protein)

Protein function

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40

PDB

3J8B , 3J8C , 6FEC , 6YBD , 6ZMW , 6ZON , 6ZP4 , 6ZVJ , 7A09 , 7QP6 , 7QP7 , 8OZ0 , 8PJ1 , 8PJ2 , 8PJ3 , 8PJ4 , 8PJ5 , 8PJ6 , 8PPL , 8RG0 , 8XXN , 9BLN

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10255	Paf67	152 → 550	RNA polymerase I-associated factor PAF67	Family

Sequence

MSYPADDYESEAAYDPYAYPSDYDMHTGDPKQDLAYERQYEQQTYQVIPEVIKNFIQYFH
KTVSDLIDQKVYELQASRVSSDVIDQKVYEIQDIYENSWTKLTERFFKNTPWPEAEAIAP
QVGNDAVFLILYKELYYRHIYAKVSGGPSLEQRFESYYNYCNLFNYILNADGPAPLELPN
QWLWDIIDEFIYQFQSFSQYRCKTAKKSEEEIDFLRSNPKIWNVHSVLNVLHSLVDKSNI
NRQLEVYTSGGDPESVAGEYGRHSLYKMLGYFSLVGLLRLHSLLGDYYQAIKVLENIELN
KKSMYSRVPECQVTTYYYVGFAYLMMRRYQDAIRVFANILLYIQRTKSMFQRTTYKYEMI
NKQNEQMHALLAIALTMYPMRIDESIHLQLREKYGDKMLRMQKGDPQVYEELFSYSCPKF
LSPVVPNYDNVHPNYHKEPFLQQLKVFSDEVQQQAQLSTIRSFLKLYTTMPVAKLAGFLD
LTEQEFRIQLLVFKHKMKNLVWTSGISALDGEFQSASEVDFYIDKDMIHIADTKVARRYG
DFFIRQIHKFEELNRTLKKMGQRP

Sequence length

564

Interactions

View interactions

	Reactome
			L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
OPEN-ANGLE GLAUCOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (4)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Alzheimer Disease	Alzheimer disease	Pubtator	40183343	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	31239713		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	31239713		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	33758106	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

EIF3L (eukaryotic translation initiation factor 3 subunit L)