Gene Gene information from NCBI Gene database.
Entrez ID 51378
Gene name Angiopoietin 4
Gene symbol ANGPT4
Synonyms (NCBI Gene)
ANG3ANG4
Chromosome 20
Chromosome location 20p13
Summary Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis
miRNA miRNA information provided by mirtarbase database.
182
miRTarBase ID miRNA Experiments Reference
MIRT016991 hsa-miR-335-5p Microarray 18185580
MIRT709498 hsa-miR-6716-5p HITS-CLIP 19536157
MIRT709497 hsa-miR-5587-5p HITS-CLIP 19536157
MIRT709496 hsa-miR-133a-3p HITS-CLIP 19536157
MIRT709495 hsa-miR-133b HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
21
GO ID Ontology Definition Evidence Reference
GO:0001525 Process Angiogenesis IEA
GO:0001935 Process Endothelial cell proliferation IDA 10025962
GO:0005576 Component Extracellular region IEA
GO:0005576 Component Extracellular region TAS
GO:0005615 Component Extracellular space IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603705 487 ENSG00000101280
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9Y264
Protein name Angiopoietin-4 (ANG-4) (Angiopoietin-3) (ANG-3)
Protein function Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00147 Fibrinogen_C 287 501 Fibrinogen beta and gamma chains, C-terminal globular domain Domain
Tissue specificity TISSUE SPECIFICITY: Highly expressed in the lung with much lower levels found in other tissues.
Sequence
MLSQLAMLQGSLLLVVATMSVAQQTRQEADRGCETLVVQHGHCSYTFLLPKSEPCPPGPE
VSRDSNTLQRESLANPLHLGKLPTQQVKQLEQALQNNTQWLKKLERAIKTILRSKLEQVQ
QQMAQNQTAPMLELGTSLLNQTTAQIRKLTDMEAQLLNQTSRMDAQMPETFLSTNKLENQ
LLLQRQKLQQLQGQNSALEKRLQALETKQQEELASILSKKAKLLNTLSRQSAALTNIERG
LRGVRHNSSLLQDQQHSLRQLLVLLRHLVQERANASAPAFIMAGEQVFQDCAEIQRSGAS
ASGVYTIQVSNATKPRKVFCDLQSSGGRWTLIQRRENGTVNFQRNWKDYKQGFGDPAGEH
WLGNEVVHQLTRRAAYSLRVELQDWEGHEAYAQYEHFHLGSENQLYRLSVVGYSGSAGRQ
SSLVLQNTSFSTLDSDNDHCLCKCAQVMSGGWWFDACGLSNLNGVYYHAPDNKYKMDGIR
WHYFKGPSYSLRASRMMIRPL
DI
Sequence length 503
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
HIF-1 signaling pathway
PI3K-Akt signaling pathway
  Tie2 Signaling
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
7
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BRAIN ANEURYSM GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PERIPHERAL NEUROPATHY GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
POSTERIOR CORTICAL ATROPHY GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Brain Neoplasms Brain neoplasms Pubtator 26277786 Associate
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 15342395
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 31642813, 34685578 Associate
★☆☆☆☆
Found in Text Mining only
Cardiovascular Diseases Cardiovascular Diseases BEFREE 31738968
★☆☆☆☆
Found in Text Mining only
Cerebrovascular accident Stroke BEFREE 30949864
★☆☆☆☆
Found in Text Mining only
Chronic Disease Chronic disease Pubtator 27773939 Associate
★☆☆☆☆
Found in Text Mining only
Corneal Neovascularization Corneal Neovascularization BEFREE 15284220
★☆☆☆☆
Found in Text Mining only
Corneal Neovascularization Corneal Neovascularization LHGDN 15284220
★☆☆☆☆
Found in Text Mining only
Degenerative polyarthritis Arthritis BEFREE 30957437
★☆☆☆☆
Found in Text Mining only
Dementia, Vascular Dementia BEFREE 20596041
★☆☆☆☆
Found in Text Mining only