UBR5 (ubiquitin protein ligase E3 component n-recognin 5)

Gene

• Entrez ID: 51366
• Gene name: Ubiquitin protein ligase E3 component n-recognin 5
• Gene symbol: UBR5
• Synonyms (NCBI Gene): DD5, EDD, EDD1, HYD
• Chromosome: 8
• Chromosome location: 8q22.3
• Summary: This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016621	hsa-miR-484	Sequencing	20371350
MIRT024039	hsa-miR-1-3p	Proteomics	18668040
MIRT028107	hsa-miR-93-5p	Sequencing	20371350
MIRT031026	hsa-miR-21-5p	Microarray	18591254
MIRT043427	hsa-miR-331-3p	CLASH	23622248
MIRT439352	ebv-miR-BART10-3p	HITS-CLIP	22473208
MIRT439350	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT439349	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT439352	ebv-miR-BART10-3p	HITS-CLIP	22473208
MIRT439350	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT726187	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT726188	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT028107	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT726186	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT439349	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT726185	hsa-miR-27a-3p	HITS-CLIP	22473208
MIRT726184	hsa-miR-27b-3p	HITS-CLIP	22473208
MIRT1471499	hsa-miR-106a	CLIP-seq
MIRT1471500	hsa-miR-106b	CLIP-seq
MIRT1471501	hsa-miR-1178	CLIP-seq
MIRT1471502	hsa-miR-1244	CLIP-seq
MIRT1471503	hsa-miR-1245	CLIP-seq
MIRT1471504	hsa-miR-1284	CLIP-seq
MIRT1471505	hsa-miR-1301	CLIP-seq
MIRT1471506	hsa-miR-140-5p	CLIP-seq
MIRT1471507	hsa-miR-17	CLIP-seq
MIRT1471508	hsa-miR-203	CLIP-seq
MIRT1471509	hsa-miR-20a	CLIP-seq
MIRT1471510	hsa-miR-20b	CLIP-seq
MIRT1471511	hsa-miR-219-5p	CLIP-seq
MIRT1471512	hsa-miR-2277-3p	CLIP-seq
MIRT1471513	hsa-miR-300	CLIP-seq
MIRT1471514	hsa-miR-3121-5p	CLIP-seq
MIRT1471515	hsa-miR-3148	CLIP-seq
MIRT1471516	hsa-miR-3156-5p	CLIP-seq
MIRT1471517	hsa-miR-3163	CLIP-seq
MIRT1471518	hsa-miR-3182	CLIP-seq
MIRT1471519	hsa-miR-320e	CLIP-seq
MIRT1471520	hsa-miR-33a	CLIP-seq
MIRT1471521	hsa-miR-33b	CLIP-seq
MIRT1471522	hsa-miR-340	CLIP-seq
MIRT1471523	hsa-miR-3606	CLIP-seq
MIRT1471524	hsa-miR-3609	CLIP-seq
MIRT1471525	hsa-miR-361-5p	CLIP-seq
MIRT1471526	hsa-miR-3670	CLIP-seq
MIRT1471527	hsa-miR-3679-3p	CLIP-seq
MIRT1471528	hsa-miR-3688-3p	CLIP-seq
MIRT1471529	hsa-miR-3689a-5p	CLIP-seq
MIRT1471530	hsa-miR-3689b	CLIP-seq
MIRT1471531	hsa-miR-3689e	CLIP-seq
MIRT1471532	hsa-miR-3689f	CLIP-seq
MIRT1471533	hsa-miR-3692	CLIP-seq
MIRT1471534	hsa-miR-3714	CLIP-seq
MIRT1471535	hsa-miR-371b-3p	CLIP-seq
MIRT1471536	hsa-miR-381	CLIP-seq
MIRT1471537	hsa-miR-3929	CLIP-seq
MIRT1471538	hsa-miR-3934	CLIP-seq
MIRT1471539	hsa-miR-3938	CLIP-seq
MIRT1471540	hsa-miR-3942-3p	CLIP-seq
MIRT1471541	hsa-miR-410	CLIP-seq
MIRT1471542	hsa-miR-425	CLIP-seq
MIRT1471543	hsa-miR-4310	CLIP-seq
MIRT1471544	hsa-miR-433	CLIP-seq
MIRT1471545	hsa-miR-4419b	CLIP-seq
MIRT1471546	hsa-miR-4445	CLIP-seq
MIRT1471547	hsa-miR-4446-5p	CLIP-seq
MIRT1471548	hsa-miR-4477b	CLIP-seq
MIRT1471549	hsa-miR-4478	CLIP-seq
MIRT1471550	hsa-miR-4499	CLIP-seq
MIRT1471551	hsa-miR-4513	CLIP-seq
MIRT1471552	hsa-miR-4519	CLIP-seq
MIRT1471553	hsa-miR-4652-3p	CLIP-seq
MIRT1471554	hsa-miR-4659a-3p	CLIP-seq
MIRT1471555	hsa-miR-4659b-3p	CLIP-seq
MIRT1471556	hsa-miR-4666-3p	CLIP-seq
MIRT1471557	hsa-miR-4666-5p	CLIP-seq
MIRT1471558	hsa-miR-4672	CLIP-seq
MIRT1471559	hsa-miR-4682	CLIP-seq
MIRT1471560	hsa-miR-4694-3p	CLIP-seq
MIRT1471561	hsa-miR-4719	CLIP-seq
MIRT1471562	hsa-miR-4729	CLIP-seq
MIRT1471563	hsa-miR-4733-3p	CLIP-seq
MIRT1471564	hsa-miR-4753-3p	CLIP-seq
MIRT1471565	hsa-miR-4782-3p	CLIP-seq
MIRT1471566	hsa-miR-4795-3p	CLIP-seq
MIRT1471567	hsa-miR-4796-3p	CLIP-seq
MIRT1471568	hsa-miR-494	CLIP-seq
MIRT1471569	hsa-miR-5047	CLIP-seq
MIRT1471570	hsa-miR-508-3p	CLIP-seq
MIRT1471571	hsa-miR-519d	CLIP-seq
MIRT1471572	hsa-miR-520d-5p	CLIP-seq
MIRT1471573	hsa-miR-524-5p	CLIP-seq
MIRT1471574	hsa-miR-545	CLIP-seq
MIRT1471575	hsa-miR-548ac	CLIP-seq
MIRT1471576	hsa-miR-548ae	CLIP-seq
MIRT1471577	hsa-miR-548ag	CLIP-seq
MIRT1471578	hsa-miR-548ah	CLIP-seq
MIRT1471579	hsa-miR-548ai	CLIP-seq
MIRT1471580	hsa-miR-548aj	CLIP-seq
MIRT1471581	hsa-miR-548am	CLIP-seq
MIRT1471582	hsa-miR-548an	CLIP-seq
MIRT1471583	hsa-miR-548b-3p	CLIP-seq
MIRT1471584	hsa-miR-548c-3p	CLIP-seq
MIRT1471585	hsa-miR-548d-3p	CLIP-seq
MIRT1471586	hsa-miR-548l	CLIP-seq
MIRT1471587	hsa-miR-548n	CLIP-seq
MIRT1471588	hsa-miR-548p	CLIP-seq
MIRT1471589	hsa-miR-548t	CLIP-seq
MIRT1471590	hsa-miR-548x	CLIP-seq
MIRT1471591	hsa-miR-548z	CLIP-seq
MIRT1471592	hsa-miR-582-5p	CLIP-seq
MIRT1471593	hsa-miR-628-5p	CLIP-seq
MIRT1471594	hsa-miR-642a	CLIP-seq
MIRT1471595	hsa-miR-767-3p	CLIP-seq
MIRT1471596	hsa-miR-889	CLIP-seq
MIRT1471597	hsa-miR-921	CLIP-seq
MIRT1471598	hsa-miR-93	CLIP-seq
MIRT2141905	hsa-miR-128	CLIP-seq
MIRT2141906	hsa-miR-1825	CLIP-seq
MIRT2141907	hsa-miR-1912	CLIP-seq
MIRT2141908	hsa-miR-1972	CLIP-seq
MIRT1471512	hsa-miR-2277-3p	CLIP-seq
MIRT2141909	hsa-miR-27a	CLIP-seq
MIRT2141910	hsa-miR-27b	CLIP-seq
MIRT1471514	hsa-miR-3121-5p	CLIP-seq
MIRT2141911	hsa-miR-3159	CLIP-seq
MIRT2141912	hsa-miR-3170	CLIP-seq
MIRT2141913	hsa-miR-3646	CLIP-seq
MIRT2141914	hsa-miR-3652	CLIP-seq
MIRT2141915	hsa-miR-3662	CLIP-seq
MIRT1471527	hsa-miR-3679-3p	CLIP-seq
MIRT2141916	hsa-miR-3684	CLIP-seq
MIRT1471533	hsa-miR-3692	CLIP-seq
MIRT1471534	hsa-miR-3714	CLIP-seq
MIRT2141917	hsa-miR-3941	CLIP-seq
MIRT1471540	hsa-miR-3942-3p	CLIP-seq
MIRT1471543	hsa-miR-4310	CLIP-seq
MIRT2141918	hsa-miR-4320	CLIP-seq
MIRT2141919	hsa-miR-4430	CLIP-seq
MIRT2141920	hsa-miR-4435	CLIP-seq
MIRT1471547	hsa-miR-4446-5p	CLIP-seq
MIRT2141921	hsa-miR-4505	CLIP-seq
MIRT1471552	hsa-miR-4519	CLIP-seq
MIRT1471558	hsa-miR-4672	CLIP-seq
MIRT2141922	hsa-miR-4731-5p	CLIP-seq
MIRT2141923	hsa-miR-4755-3p	CLIP-seq
MIRT2141924	hsa-miR-4775	CLIP-seq
MIRT2141925	hsa-miR-4781-3p	CLIP-seq
MIRT1471568	hsa-miR-494	CLIP-seq
MIRT1471574	hsa-miR-545	CLIP-seq
MIRT1471582	hsa-miR-548an	CLIP-seq
MIRT1471588	hsa-miR-548p	CLIP-seq
MIRT2141926	hsa-miR-570	CLIP-seq
MIRT2141927	hsa-miR-577	CLIP-seq
MIRT1471592	hsa-miR-582-5p	CLIP-seq
MIRT2141928	hsa-miR-587	CLIP-seq
MIRT2141929	hsa-miR-590-3p	CLIP-seq
MIRT2141930	hsa-miR-626	CLIP-seq
MIRT1471593	hsa-miR-628-5p	CLIP-seq
MIRT2141931	hsa-miR-647	CLIP-seq
MIRT2141932	hsa-miR-651	CLIP-seq
MIRT2141933	hsa-miR-9	CLIP-seq
MIRT1471512	hsa-miR-2277-3p	CLIP-seq
MIRT1471524	hsa-miR-3609	CLIP-seq
MIRT1471527	hsa-miR-3679-3p	CLIP-seq
MIRT1471533	hsa-miR-3692	CLIP-seq
MIRT1471534	hsa-miR-3714	CLIP-seq
MIRT2141917	hsa-miR-3941	CLIP-seq
MIRT1471540	hsa-miR-3942-3p	CLIP-seq
MIRT1471542	hsa-miR-425	CLIP-seq
MIRT1471543	hsa-miR-4310	CLIP-seq
MIRT1471547	hsa-miR-4446-5p	CLIP-seq
MIRT1471548	hsa-miR-4477b	CLIP-seq
MIRT1471552	hsa-miR-4519	CLIP-seq
MIRT1471558	hsa-miR-4672	CLIP-seq
MIRT1471563	hsa-miR-4733-3p	CLIP-seq
MIRT1471577	hsa-miR-548ag	CLIP-seq
MIRT1471578	hsa-miR-548ah	CLIP-seq
MIRT1471579	hsa-miR-548ai	CLIP-seq
MIRT1471582	hsa-miR-548an	CLIP-seq
MIRT1471587	hsa-miR-548n	CLIP-seq
MIRT1471589	hsa-miR-548t	CLIP-seq
MIRT1471592	hsa-miR-582-5p	CLIP-seq
MIRT2141928	hsa-miR-587	CLIP-seq
MIRT1471595	hsa-miR-767-3p	CLIP-seq
MIRT1471558	hsa-miR-4672	CLIP-seq
MIRT1471533	hsa-miR-3692	CLIP-seq
MIRT1471534	hsa-miR-3714	CLIP-seq
MIRT1471540	hsa-miR-3942-3p	CLIP-seq
MIRT1471552	hsa-miR-4519	CLIP-seq
MIRT1471568	hsa-miR-494	CLIP-seq
MIRT1471582	hsa-miR-548an	CLIP-seq
MIRT1471515	hsa-miR-3148	CLIP-seq
MIRT2462825	hsa-miR-3591-3p	CLIP-seq
MIRT2141913	hsa-miR-3646	CLIP-seq
MIRT2141915	hsa-miR-3662	CLIP-seq
MIRT1471528	hsa-miR-3688-3p	CLIP-seq
MIRT1471560	hsa-miR-4694-3p	CLIP-seq
MIRT1471584	hsa-miR-548c-3p	CLIP-seq
MIRT2656489	hsa-miR-105	CLIP-seq
MIRT1471499	hsa-miR-106a	CLIP-seq
MIRT1471500	hsa-miR-106b	CLIP-seq
MIRT2656490	hsa-miR-1179	CLIP-seq
MIRT2141905	hsa-miR-128	CLIP-seq
MIRT1471507	hsa-miR-17	CLIP-seq
MIRT1471508	hsa-miR-203	CLIP-seq
MIRT1471509	hsa-miR-20a	CLIP-seq
MIRT1471510	hsa-miR-20b	CLIP-seq
MIRT1471511	hsa-miR-219-5p	CLIP-seq
MIRT1471512	hsa-miR-2277-3p	CLIP-seq
MIRT2141909	hsa-miR-27a	CLIP-seq
MIRT2141910	hsa-miR-27b	CLIP-seq
MIRT1471515	hsa-miR-3148	CLIP-seq
MIRT2141911	hsa-miR-3159	CLIP-seq
MIRT2656491	hsa-miR-3189-5p	CLIP-seq
MIRT2656492	hsa-miR-328	CLIP-seq
MIRT1471520	hsa-miR-33a	CLIP-seq
MIRT1471521	hsa-miR-33b	CLIP-seq
MIRT2656493	hsa-miR-3613-3p	CLIP-seq
MIRT1471527	hsa-miR-3679-3p	CLIP-seq
MIRT1471528	hsa-miR-3688-3p	CLIP-seq
MIRT1471529	hsa-miR-3689a-5p	CLIP-seq
MIRT1471530	hsa-miR-3689b	CLIP-seq
MIRT1471531	hsa-miR-3689e	CLIP-seq
MIRT1471532	hsa-miR-3689f	CLIP-seq
MIRT1471533	hsa-miR-3692	CLIP-seq
MIRT1471534	hsa-miR-3714	CLIP-seq
MIRT1471535	hsa-miR-371b-3p	CLIP-seq
MIRT1471540	hsa-miR-3942-3p	CLIP-seq
MIRT2656494	hsa-miR-4273	CLIP-seq
MIRT2656495	hsa-miR-4290	CLIP-seq
MIRT1471543	hsa-miR-4310	CLIP-seq
MIRT2141918	hsa-miR-4320	CLIP-seq
MIRT1471546	hsa-miR-4445	CLIP-seq
MIRT1471547	hsa-miR-4446-5p	CLIP-seq
MIRT1471552	hsa-miR-4519	CLIP-seq
MIRT1471557	hsa-miR-4666-5p	CLIP-seq
MIRT2656496	hsa-miR-4677-5p	CLIP-seq
MIRT1471560	hsa-miR-4694-3p	CLIP-seq
MIRT1471562	hsa-miR-4729	CLIP-seq
MIRT2141925	hsa-miR-4781-3p	CLIP-seq
MIRT1471565	hsa-miR-4782-3p	CLIP-seq
MIRT1471568	hsa-miR-494	CLIP-seq
MIRT1471570	hsa-miR-508-3p	CLIP-seq
MIRT1471571	hsa-miR-519d	CLIP-seq
MIRT1471572	hsa-miR-520d-5p	CLIP-seq
MIRT1471573	hsa-miR-524-5p	CLIP-seq
MIRT1471574	hsa-miR-545	CLIP-seq
MIRT1471582	hsa-miR-548an	CLIP-seq
MIRT1471584	hsa-miR-548c-3p	CLIP-seq
MIRT1471586	hsa-miR-548l	CLIP-seq
MIRT1471587	hsa-miR-548n	CLIP-seq
MIRT1471588	hsa-miR-548p	CLIP-seq
MIRT1471589	hsa-miR-548t	CLIP-seq
MIRT2141927	hsa-miR-577	CLIP-seq
MIRT2141928	hsa-miR-587	CLIP-seq
MIRT2141932	hsa-miR-651	CLIP-seq
MIRT1471595	hsa-miR-767-3p	CLIP-seq
MIRT2656497	hsa-miR-888	CLIP-seq
MIRT1471598	hsa-miR-93	CLIP-seq
MIRT2656490	hsa-miR-1179	CLIP-seq
MIRT2141905	hsa-miR-128	CLIP-seq
MIRT1471508	hsa-miR-203	CLIP-seq
MIRT1471511	hsa-miR-219-5p	CLIP-seq
MIRT1471512	hsa-miR-2277-3p	CLIP-seq
MIRT2141909	hsa-miR-27a	CLIP-seq
MIRT2141910	hsa-miR-27b	CLIP-seq
MIRT1471515	hsa-miR-3148	CLIP-seq
MIRT2141911	hsa-miR-3159	CLIP-seq
MIRT2656491	hsa-miR-3189-5p	CLIP-seq
MIRT2656492	hsa-miR-328	CLIP-seq
MIRT1471520	hsa-miR-33a	CLIP-seq
MIRT1471521	hsa-miR-33b	CLIP-seq
MIRT1471527	hsa-miR-3679-3p	CLIP-seq
MIRT1471528	hsa-miR-3688-3p	CLIP-seq
MIRT1471529	hsa-miR-3689a-5p	CLIP-seq
MIRT1471530	hsa-miR-3689b	CLIP-seq
MIRT1471531	hsa-miR-3689e	CLIP-seq
MIRT1471532	hsa-miR-3689f	CLIP-seq
MIRT1471533	hsa-miR-3692	CLIP-seq
MIRT1471534	hsa-miR-3714	CLIP-seq
MIRT1471540	hsa-miR-3942-3p	CLIP-seq
MIRT1471543	hsa-miR-4310	CLIP-seq
MIRT2141918	hsa-miR-4320	CLIP-seq
MIRT1471546	hsa-miR-4445	CLIP-seq
MIRT1471547	hsa-miR-4446-5p	CLIP-seq
MIRT1471552	hsa-miR-4519	CLIP-seq
MIRT1471560	hsa-miR-4694-3p	CLIP-seq
MIRT1471562	hsa-miR-4729	CLIP-seq
MIRT1471565	hsa-miR-4782-3p	CLIP-seq
MIRT1471568	hsa-miR-494	CLIP-seq
MIRT1471570	hsa-miR-508-3p	CLIP-seq
MIRT1471572	hsa-miR-520d-5p	CLIP-seq
MIRT1471573	hsa-miR-524-5p	CLIP-seq
MIRT1471574	hsa-miR-545	CLIP-seq
MIRT1471582	hsa-miR-548an	CLIP-seq
MIRT1471586	hsa-miR-548l	CLIP-seq
MIRT1471587	hsa-miR-548n	CLIP-seq
MIRT1471588	hsa-miR-548p	CLIP-seq
MIRT1471589	hsa-miR-548t	CLIP-seq
MIRT2141927	hsa-miR-577	CLIP-seq
MIRT2141928	hsa-miR-587	CLIP-seq
MIRT2141932	hsa-miR-651	CLIP-seq
MIRT1471595	hsa-miR-767-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000209	Process	Protein polyubiquitination	IBA
GO:0000209	Process	Protein polyubiquitination	IDA	21118991, 28689657
GO:0000785	Component	Chromatin	IDA	37478846
GO:0003723	Function	RNA binding	IEA
GO:0004842	Function	Ubiquitin-protein transferase activity	IEA
GO:0005515	Function	Protein binding	IPI	12011095, 16601676, 21118991, 24417819, 33122718
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	37478846
GO:0005634	Component	Nucleus	IDA	12011095, 21118991, 28689657
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	29033132
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0006281	Process	DNA repair	IEA
GO:0006974	Process	DNA damage response	IDA	12011095
GO:0006974	Process	DNA damage response	IEA
GO:0006979	Process	Response to oxidative stress	IDA	17603038
GO:0008270	Function	Zinc ion binding	IEA
GO:0010498	Process	Proteasomal protein catabolic process	IDA	34711951
GO:0010628	Process	Positive regulation of gene expression	IDA	18076571
GO:0016020	Component	Membrane	HDA	19946888
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030520	Process	Estrogen receptor signaling pathway	IDA	7481822, 9338790, 15831516
GO:0032991	Component	Protein-containing complex	IDA	18076571
GO:0033696	Process	Heterochromatin boundary formation	IMP	22884692
GO:0034450	Function	Ubiquitin-ubiquitin ligase activity	IBA
GO:0034450	Function	Ubiquitin-ubiquitin ligase activity	IDA	21118991, 29378950
GO:0035519	Process	Protein K29-linked ubiquitination	IDA	21118991
GO:0042307	Process	Positive regulation of protein import into nucleus	IMP	21118991
GO:0043130	Function	Ubiquitin binding	IDA	17897937, 37620400
GO:0043130	Function	Ubiquitin binding	IEA
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IDA	29378950
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IEA
GO:0045879	Process	Negative regulation of smoothened signaling pathway	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0048384	Process	Retinoic acid receptor signaling pathway	IDA	9267036, 19917671
GO:0048384	Process	Retinoic acid receptor signaling pathway	IMP	28698609
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	18076571
GO:0050847	Process	Progesterone receptor signaling pathway	IDA	9620806, 10757795
GO:0050847	Process	Progesterone receptor signaling pathway	IDA	12011095
GO:0050847	Process	Progesterone receptor signaling pathway	IMP	10757795
GO:0061630	Function	Ubiquitin protein ligase activity	IDA	28689657, 29033132, 29378950, 33208877, 35217622, 37040767, 37409633, 37478846, 37478862, 37620400
GO:0061630	Function	Ubiquitin protein ligase activity	IEA
GO:0070561	Process	Vitamin D receptor signaling pathway	IDA	9267036
GO:0070936	Process	Protein K48-linked ubiquitination	IDA	28689657, 29033132, 29378950, 37620400
GO:0070979	Process	Protein K11-linked ubiquitination	IDA	21118991
GO:0071629	Process	Cytoplasm protein quality control by the ubiquitin-proteasome system	IDA	29033132
GO:0071630	Process	Nuclear protein quality control by the ubiquitin-proteasome system	IDA	37478846, 37478862
GO:0090263	Process	Positive regulation of canonical Wnt signaling pathway	IBA
GO:0090263	Process	Positive regulation of canonical Wnt signaling pathway	IMP	21118991, 28689657
GO:0140455	Process	Cytoplasm protein quality control	IDA	29033132
GO:0140861	Process	DNA repair-dependent chromatin remodeling	IMP	22884692
GO:0141198	Process	Protein branched polyubiquitination	IDA	29033132, 29378950

Other IDs

• MIM: 608413
• HGNC: 16806
• e!Ensembl: ENSG00000104517

Protein

• UniProt ID: O95071
• Protein name: E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein)
• Protein function: E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubi
• PDB: 1I2T, 2QHO, 3PT3, 8BJA, 8C06, 8C07, 8D4X, 8E0Q, 8EWI, 8P82, 8P83
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF11547	E3_UbLigase_EDD	179 → 230	E3 ubiquitin ligase EDD	Domain
  PF00658	PABP	2385 → 2449	Poly-adenylate binding protein, unique domain	Family
  PF00632	HECT	2498 → 2799	HECT-domain (ubiquitin-transferase)	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. Most abundant in testis and expressed at high levels in brain, pituitary and kidney. {ECO:0000269|PubMed:10030672}.
• Sequence:

  MTSIHFVVHPLPGTEDQLNDRLREVSEKLNKYNLNSHPPLNVLEQATIKQCVVGPNHAAF
  LLEDGRVCRIGFSVQPDRLELGKPDNNDGSKLNSNSGAGRTSRPGRTSDSPWFLSGSETL
  GRLAGNTLGSRWSSGVGGSGGGSSGRSSAGARDSRRQTRVIRTGRDRGSGLLGSQPQPVI
  PASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASE
  SYLPGEDLMSLLDADIHSAHPSVIIDADAMFSEDISYFGYPSFRRSSLSRLGSSRVLLLP
  LERDSELLRERESVLRLRERRWLDGASFDNERGSTSKEGEPNLDKKNTPVQSPVSLGEDL
  QWWPDKDGTKFICIGALYSELLAVSSKGELYQWKWSESEPYRNAQNPSLHHPRATFLGLT
  NEKIVLLSANSIRATVATENNKVATWVDETLSSVASKLEHTAQTYSELQGERIVSLHCCA
  LYTCAQLENSLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNP
  LYHAGAVAFSISAGIPKVGVLMESVWNMNDSCRFQLRSPESLKNMEKASKTTEAKPESKQ
  EPVKTEMGPPPSPASTCSDASSIASSASMPYKRRRSTPAPKEEEKVNEEQWSLREVVFVE
  DVKNVPVGKVLKVDGAYVAVKFPGTSSNTNCQNSSGPDADPSSLLQDCRLLRIDELQVVK
  TGGTPKVPDCFQRTPKKLCIPEKTEILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQ
  ENNFPTSSIAFLGQNERNVAIFTAGQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPP
  ISSLGMGVHSLINLPANSTIKKKAAVIIMAVEKQTLMQHILRCDYEACRQYLMNLEQAVV
  LEQNLQMLQTFISHRCDGNRNILHACVSVCFPTSNKETKEEEEAERSERNTFAERLSAVE
  AIANAISVVSSNGPGNRAGSSSSRSLRLREMMRRSLRAAGLGRHEAGASSSDHQDPVSPP
  IAPPSWVPDPPAMDPDGDIDFILAPAVGSLTTAATGTGQGPSTSTIPGPSTEPSVVESKD
  RKANAHFILKLLCDSVVLQPYLRELLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIA
  KAEISSSEKEEDVFMGMVCPSGTNPDDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCG
  LLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLT
  ATNLVTLPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIREDRNRKTASPEDSDMPDHDLE
  PPRFAQLALERVLQDWNALKSMIMFGSQENKDPLSASSRIGHLLPEEQVYLNQQSGTIRL
  DCFTHCLIVKCTADILLLDTLLGTLVKELQNKYTPGRREEAIAVTMRFLRSVARVFVILS
  VEMASSKKKNNFIPQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLA
  STSIDAMQGSEELFSVEPLPPRPSSDQSSSSSQSQSSYIIRNPQQRRISQSQPVRGRDEE
  QDDIVSADVEEVEVVEGVAGEEDHHDEQEEHGEENAEAEGQHDEHDEDGSDMELDLLAAA
  ETESDSESNHSNQDNASGRRSVVTAATAGSEAGASSVPAFFSEDDSQSNDSSDSDSSSSQ
  SDDIEQETFMLDEPLERTTNSSHANGAAQAPRSMQWAVRNTQHQRAASTAPSSTSTPAAS
  SAGLIYIDPSNLRRSGTISTSAAAAAAALEASNASSYLTSASSLARAYSIVIRQISDLMG
  LIPKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEKLIPTWNWMVSIMDSTEAQLRYGSALA
  SAGDPGHPNHPLHASQNSARRERMTAREEASLRTLEGRRRATLLSARQGMMSARGDFLNY
  ALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDTPQLERKRTREL
  LELGIDNEDSEHENDDDTNQSATLNDKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPF
  EVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPT
  KMSYAANLKNVMNMQNRQKKEGEEQPVLPEETESSKPGPSAHDLAAQLKSSLLAEIGLTE
  SEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEV
  KESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCATTPMAVHRVKVT
  FKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLECIQNANKGTHTSLMQRLRNRGERDRER
  EREREMRRSSGLRAGSRRDRDRDFRRQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGER
  LYPRVQAMQPAFASKITGMLLELSPAQLLLLLASEDSLRARVDEAMELIIAHGRENGADS
  ILDLGLVDSSEKVQQENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGK
  NTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLR
  QLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAE
  HRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDES
  GENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQ
  HLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV

• Sequence length: 2799

Pathways

KEGG:

Ubiquitin mediated proteolysis

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Acute myeloid leukemia	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Adrenocortical carcinoma, hereditary	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATRIAL FIBRILLATION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cholangiocarcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Chronic lymphocytic leukemia/small lymphocytic lymphoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal cancer	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial pancreatic carcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GASTROESOPHAGEAL REFLUX DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Long QT syndrome	Uncertain significance	ClinVar Disgenet	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Lung cancer	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant lymphoma, large B-cell, diffuse	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Neurodevelopmental disorder	Uncertain significance	ClinVar GenCC	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
NEURODEVELOPMENTAL DISORDERS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian cancer	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UBR5-associated neurodevelopmental condition	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UBR5-related disorder	Uncertain significance; Likely benign; Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adenocarcinoma of large intestine	Colorectal Cancer	CGI_DG			★☆☆☆☆ Found in Text Mining only
Adenomatous Polyposis Coli	Multiple polyposis syndrome	BEFREE	18076571		★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	22833209	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Autism Spectrum Disorder	Autism	Pubtator	31413120	Associate	★☆☆☆☆ Found in Text Mining only
Benign neoplasm of stomach	Benign Neoplasm Of Stomach	CGI_DG			★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	21949371, 24441042, 31392083		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	21383020, 24441042, 32363114, 35551175, 40004017	Associate	★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	21949371	Stimulate	★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	22884692	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	12902990		★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	36388433	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma in situ of stomach	Stomach Carcinoma	CGI_DG			★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	21949371		★☆☆☆☆ Found in Text Mining only
Carcinoma Ovarian Epithelial	Epithelial ovarian carcinoma	Pubtator	18349819	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	33710368	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Small Cell	Small cell carcinoma	Pubtator	35662501	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	12902990, 24379240, 27721409		★☆☆☆☆ Found in Text Mining only
Cerebrovascular accident	Stroke	BEFREE	28583071		★☆☆☆☆ Found in Text Mining only
Cognitive Dysfunction	Cognition disorder	Pubtator	22833209	Associate	★☆☆☆☆ Found in Text Mining only
Colitis	Colitis	Pubtator	33122718	Associate	★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	29441938		★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	28856538, 29296225		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal Neoplasms	BEFREE	18076571		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	18076571	Inhibit	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	30804124	Associate	★☆☆☆☆ Found in Text Mining only
Congestive heart failure	Congestive Heart Failure	BEFREE	19945062, 31679641		★☆☆☆☆ Found in Text Mining only
Dementia	Dementia	BEFREE	21660677		★☆☆☆☆ Found in Text Mining only
Ductal Breast Carcinoma	Breast Carcinoma	BEFREE	14871824		★☆☆☆☆ Found in Text Mining only
Epithelial ovarian cancer	Ovarian cancer	BEFREE	24379240		★☆☆☆☆ Found in Text Mining only
Esophageal carcinoma	Esophageal Carcinoma	BEFREE	28856538		★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophagus Neoplasm	BEFREE	28856538		★☆☆☆☆ Found in Text Mining only
Gallbladder Carcinoma	Gallbladder cancer	BEFREE	30775814		★☆☆☆☆ Found in Text Mining only
Heart failure	Heart Failure	BEFREE	19945062, 31679641		★☆☆☆☆ Found in Text Mining only
Huntington Disease	Huntington Disease	BEFREE	30038412		★☆☆☆☆ Found in Text Mining only
Impaired cognition	Impaired Cognition	GWASCAT_DG	22833209		★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Disease 25 Autosomal Recessive	Inflammatory bowel disease	Pubtator	33122718	Associate	★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory bowel disease	Pubtator	33122718	Associate	★☆☆☆☆ Found in Text Mining only
Laryngeal Neoplasms	Laryngeal neoplasm	Pubtator	32468011	Associate	★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	29441057		★☆☆☆☆ Found in Text Mining only
Leukemia, T-Cell	T-cell leukemia	BEFREE	29441057		★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	36388433	Stimulate	★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	BEFREE	29441057		★☆☆☆☆ Found in Text Mining only
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	Malignant lymphoma, lymphocytic, intermediate differentiation	BEFREE	23407552		★☆☆☆☆ Found in Text Mining only
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	Malignant lymphoma, lymphocytic, intermediate differentiation	CGI_DG			★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	21949371, 24441042, 31392083		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of esophagus	Esophagus Neoplasm	BEFREE	28856538		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of gallbladder	Gallbladder cancer	BEFREE	30775814		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	21949371		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	12902990, 24379240, 27721409, 28330927		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	31472148		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	16721783, 27590582		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	CGI_DG			★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	23499005, 27590582, 28330927, 28856538, 29296225, 29441057, 29742019		★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	29441938		★☆☆☆☆ Found in Text Mining only
Mammary Ductal Carcinoma	Marfan Syndrome	BEFREE	14871824		★☆☆☆☆ Found in Text Mining only
Mantle cell lymphoma	Mantle Cell Lymphoma	BEFREE	23407552		★☆☆☆☆ Found in Text Mining only
Mild cognitive disorder	Cognitive disorder	BEFREE	22833209		★☆☆☆☆ Found in Text Mining only
Nasopharyngeal carcinoma	Nasopharyngeal Carcinoma	BEFREE	23878065		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	18076571, 23499005, 23878065, 24379240, 27590582, 28330927, 28856538, 29296225, 29935477, 29944885, 30775814		★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	29944885		★☆☆☆☆ Found in Text Mining only
Noninfiltrating Intraductal Carcinoma	Ductal carcinoma	BEFREE	31392083		★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	BEFREE	12902990, 27721409		★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	LHGDN	18349819		★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	18349819, 27721409, 36528667	Associate	★☆☆☆☆ Found in Text Mining only
Peritonitis	Peritonitis	Pubtator	30804124	Associate	★☆☆☆☆ Found in Text Mining only
Presenile dementia	Senile Dementia	BEFREE	21660677		★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	31472148		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	34897998	Associate	★☆☆☆☆ Found in Text Mining only
Pulmonary Arterial Hypertension	Pulmonary arterial hypertension	Pubtator	30699358	Associate	★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	38577917	Associate	★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	16721783, 27590582		★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	CGI_DG			★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach Neoplasms	CGI_DG			★☆☆☆☆ Found in Text Mining only
Tay-Sachs Disease	Tay-Sachs Disease	BEFREE	22833209		★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple Negative Breast Neoplasms	BEFREE	28330927		★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	35551175	Associate	★☆☆☆☆ Found in Text Mining only
Williams Syndrome	Williams syndrome	Pubtator	31413120	Associate	★☆☆☆☆ Found in Text Mining only