Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	51361
Gene name	Hook microtubule tethering protein 1
Gene symbol	HOOK1
Synonyms (NCBI Gene)	HK1
Chromosome	1
Chromosome location	1p32.1
Summary	This gene encodes a member of the hook family of coiled-coil proteins, which bind to microtubules and organelles through their N- and C-terminal domains, respectively. The encoded protein localizes to discrete punctuate subcellular structures, and interac

283

Show/Hide all (283)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017608	hsa-miR-335-5p	Microarray	18185580
MIRT023735	hsa-miR-1-3p	Microarray	18668037
MIRT028032	hsa-miR-93-5p	Sequencing	20371350
MIRT557194	hsa-miR-4453	HITS-CLIP	21572407
MIRT557193	hsa-miR-4538	HITS-CLIP	21572407
MIRT557192	hsa-miR-7705	HITS-CLIP	21572407
MIRT557196	hsa-miR-548n	HITS-CLIP	21572407
MIRT557195	hsa-miR-548l	HITS-CLIP	21572407
MIRT194395	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT557191	hsa-miR-4719	HITS-CLIP	21572407
MIRT194394	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT557190	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT557194	hsa-miR-4453	HITS-CLIP	21572407
MIRT557193	hsa-miR-4538	HITS-CLIP	21572407
MIRT557192	hsa-miR-7705	HITS-CLIP	21572407
MIRT194395	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT194394	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT557190	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT557194	hsa-miR-4453	HITS-CLIP	23313552
MIRT557193	hsa-miR-4538	HITS-CLIP	23313552
MIRT557192	hsa-miR-7705	HITS-CLIP	23313552
MIRT194395	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT194394	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT557190	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT557194	hsa-miR-4453	HITS-CLIP	23824327
MIRT557193	hsa-miR-4538	HITS-CLIP	23824327
MIRT557192	hsa-miR-7705	HITS-CLIP	23824327
MIRT194395	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT194394	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT557190	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT557194	hsa-miR-4453	HITS-CLIP	23824327
MIRT557193	hsa-miR-4538	HITS-CLIP	23824327
MIRT557192	hsa-miR-7705	HITS-CLIP	23824327
MIRT194395	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT670312	hsa-miR-3160-5p	HITS-CLIP	23824327
MIRT194394	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT557190	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT282721	hsa-miR-218-2-3p	HITS-CLIP	23824327
MIRT282703	hsa-miR-758-5p	HITS-CLIP	23824327
MIRT657323	hsa-miR-4764-3p	HITS-CLIP	23824327
MIRT282702	hsa-miR-584-5p	HITS-CLIP	23824327
MIRT557196	hsa-miR-548n	PAR-CLIP	21572407
MIRT557195	hsa-miR-548l	PAR-CLIP	21572407
MIRT557194	hsa-miR-4453	PAR-CLIP	21572407
MIRT557193	hsa-miR-4538	PAR-CLIP	21572407
MIRT557192	hsa-miR-7705	PAR-CLIP	21572407
MIRT557191	hsa-miR-4719	PAR-CLIP	21572407
MIRT194394	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT557190	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT282704	hsa-miR-3120-3p	PAR-CLIP	22100165
MIRT441809	hsa-miR-4762-5p	PAR-CLIP	22100165
MIRT441808	hsa-miR-139-5p	PAR-CLIP	22100165
MIRT557194	hsa-miR-4453	HITS-CLIP	21572407
MIRT557193	hsa-miR-4538	HITS-CLIP	21572407
MIRT557192	hsa-miR-7705	HITS-CLIP	21572407
MIRT557196	hsa-miR-548n	HITS-CLIP	21572407
MIRT557195	hsa-miR-548l	HITS-CLIP	21572407
MIRT194395	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT557191	hsa-miR-4719	HITS-CLIP	21572407
MIRT194394	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT557190	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT557194	hsa-miR-4453	HITS-CLIP	21572407
MIRT557193	hsa-miR-4538	HITS-CLIP	21572407
MIRT557192	hsa-miR-7705	HITS-CLIP	21572407
MIRT194395	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT194394	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT557190	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT557194	hsa-miR-4453	HITS-CLIP	23313552
MIRT557193	hsa-miR-4538	HITS-CLIP	23313552
MIRT557192	hsa-miR-7705	HITS-CLIP	23313552
MIRT194395	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT194394	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT557190	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT557194	hsa-miR-4453	HITS-CLIP	23824327
MIRT557193	hsa-miR-4538	HITS-CLIP	23824327
MIRT557192	hsa-miR-7705	HITS-CLIP	23824327
MIRT194395	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT194394	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT557190	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT557194	hsa-miR-4453	HITS-CLIP	23824327
MIRT557193	hsa-miR-4538	HITS-CLIP	23824327
MIRT557192	hsa-miR-7705	HITS-CLIP	23824327
MIRT194395	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT670312	hsa-miR-3160-5p	HITS-CLIP	23824327
MIRT194394	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT557190	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT282721	hsa-miR-218-2-3p	HITS-CLIP	23824327
MIRT282703	hsa-miR-758-5p	HITS-CLIP	23824327
MIRT657323	hsa-miR-4764-3p	HITS-CLIP	23824327
MIRT282702	hsa-miR-584-5p	HITS-CLIP	23824327
MIRT557196	hsa-miR-548n	PAR-CLIP	21572407
MIRT557195	hsa-miR-548l	PAR-CLIP	21572407
MIRT557194	hsa-miR-4453	PAR-CLIP	21572407
MIRT557193	hsa-miR-4538	PAR-CLIP	21572407
MIRT557192	hsa-miR-7705	PAR-CLIP	21572407
MIRT557191	hsa-miR-4719	PAR-CLIP	21572407
MIRT194394	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT557190	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT282704	hsa-miR-3120-3p	PAR-CLIP	22100165
MIRT441809	hsa-miR-4762-5p	PAR-CLIP	22100165
MIRT441808	hsa-miR-139-5p	PAR-CLIP	22100165
MIRT1052661	hsa-miR-1197	CLIP-seq
MIRT1052662	hsa-miR-1238	CLIP-seq
MIRT1052663	hsa-miR-1305	CLIP-seq
MIRT1052664	hsa-miR-135a	CLIP-seq
MIRT1052665	hsa-miR-135b	CLIP-seq
MIRT1052666	hsa-miR-138	CLIP-seq
MIRT1052667	hsa-miR-181a	CLIP-seq
MIRT1052668	hsa-miR-181b	CLIP-seq
MIRT1052669	hsa-miR-181c	CLIP-seq
MIRT1052670	hsa-miR-181d	CLIP-seq
MIRT1052671	hsa-miR-203	CLIP-seq
MIRT1052672	hsa-miR-2113	CLIP-seq
MIRT1052673	hsa-miR-218	CLIP-seq
MIRT1052674	hsa-miR-224	CLIP-seq
MIRT1052675	hsa-miR-24	CLIP-seq
MIRT1052676	hsa-miR-302a	CLIP-seq
MIRT1052677	hsa-miR-302b	CLIP-seq
MIRT1052678	hsa-miR-302c	CLIP-seq
MIRT1052679	hsa-miR-302d	CLIP-seq
MIRT1052680	hsa-miR-302e	CLIP-seq
MIRT1052681	hsa-miR-3065-5p	CLIP-seq
MIRT1052682	hsa-miR-3117-5p	CLIP-seq
MIRT1052683	hsa-miR-3143	CLIP-seq
MIRT1052684	hsa-miR-3158-3p	CLIP-seq
MIRT1052685	hsa-miR-3166	CLIP-seq
MIRT1052686	hsa-miR-3179	CLIP-seq
MIRT1052687	hsa-miR-3190	CLIP-seq
MIRT1052688	hsa-miR-338-5p	CLIP-seq
MIRT1052689	hsa-miR-3613-5p	CLIP-seq
MIRT1052690	hsa-miR-3647-3p	CLIP-seq
MIRT1052691	hsa-miR-3652	CLIP-seq
MIRT1052692	hsa-miR-3671	CLIP-seq
MIRT1052693	hsa-miR-372	CLIP-seq
MIRT1052694	hsa-miR-373	CLIP-seq
MIRT1052695	hsa-miR-374a	CLIP-seq
MIRT1052696	hsa-miR-374b	CLIP-seq
MIRT1052697	hsa-miR-409-3p	CLIP-seq
MIRT1052698	hsa-miR-410	CLIP-seq
MIRT1052699	hsa-miR-4261	CLIP-seq
MIRT1052700	hsa-miR-4262	CLIP-seq
MIRT1052701	hsa-miR-4284	CLIP-seq
MIRT1052702	hsa-miR-4430	CLIP-seq
MIRT1052703	hsa-miR-4474-3p	CLIP-seq
MIRT1052704	hsa-miR-4477b	CLIP-seq
MIRT1052705	hsa-miR-4490	CLIP-seq
MIRT1052706	hsa-miR-4499	CLIP-seq
MIRT1052707	hsa-miR-4505	CLIP-seq
MIRT1052708	hsa-miR-4682	CLIP-seq
MIRT1052709	hsa-miR-4699-5p	CLIP-seq
MIRT1052710	hsa-miR-4709-3p	CLIP-seq
MIRT1052711	hsa-miR-4720-3p	CLIP-seq
MIRT1052712	hsa-miR-4742-5p	CLIP-seq
MIRT1052713	hsa-miR-4766-5p	CLIP-seq
MIRT1052714	hsa-miR-4774-5p	CLIP-seq
MIRT1052715	hsa-miR-4804-3p	CLIP-seq
MIRT1052716	hsa-miR-488	CLIP-seq
MIRT1052717	hsa-miR-494	CLIP-seq
MIRT1052718	hsa-miR-513a-3p	CLIP-seq
MIRT1052719	hsa-miR-513a-5p	CLIP-seq
MIRT1052720	hsa-miR-520a-3p	CLIP-seq
MIRT1052721	hsa-miR-520b	CLIP-seq
MIRT1052722	hsa-miR-520c-3p	CLIP-seq
MIRT1052723	hsa-miR-520d-3p	CLIP-seq
MIRT1052724	hsa-miR-520d-5p	CLIP-seq
MIRT1052725	hsa-miR-520e	CLIP-seq
MIRT1052726	hsa-miR-520f	CLIP-seq
MIRT1052727	hsa-miR-524-5p	CLIP-seq
MIRT1052728	hsa-miR-543	CLIP-seq
MIRT1052729	hsa-miR-548ad	CLIP-seq
MIRT1052730	hsa-miR-548m	CLIP-seq
MIRT1052731	hsa-miR-548q	CLIP-seq
MIRT1052732	hsa-miR-607	CLIP-seq
MIRT1052733	hsa-miR-636	CLIP-seq
MIRT2011949	hsa-let-7a	CLIP-seq
MIRT2011950	hsa-let-7b	CLIP-seq
MIRT2011951	hsa-let-7c	CLIP-seq
MIRT2011952	hsa-let-7d	CLIP-seq
MIRT2011953	hsa-let-7e	CLIP-seq
MIRT2011954	hsa-let-7f	CLIP-seq
MIRT2011955	hsa-let-7g	CLIP-seq
MIRT2011956	hsa-let-7i	CLIP-seq
MIRT1052664	hsa-miR-135a	CLIP-seq
MIRT1052665	hsa-miR-135b	CLIP-seq
MIRT2011957	hsa-miR-142-5p	CLIP-seq
MIRT2011958	hsa-miR-196a	CLIP-seq
MIRT2011959	hsa-miR-196b	CLIP-seq
MIRT2011960	hsa-miR-216a	CLIP-seq
MIRT2011961	hsa-miR-3121-3p	CLIP-seq
MIRT1052683	hsa-miR-3143	CLIP-seq
MIRT2011962	hsa-miR-323b-3p	CLIP-seq
MIRT1052692	hsa-miR-3671	CLIP-seq
MIRT2011963	hsa-miR-3682-5p	CLIP-seq
MIRT2011964	hsa-miR-383	CLIP-seq
MIRT2011965	hsa-miR-412	CLIP-seq
MIRT2011966	hsa-miR-4277	CLIP-seq
MIRT2011967	hsa-miR-4421	CLIP-seq
MIRT2011968	hsa-miR-4458	CLIP-seq
MIRT2011969	hsa-miR-4491	CLIP-seq
MIRT2011970	hsa-miR-4500	CLIP-seq
MIRT2011971	hsa-miR-4657	CLIP-seq
MIRT2011972	hsa-miR-4698	CLIP-seq
MIRT1052711	hsa-miR-4720-3p	CLIP-seq
MIRT2011973	hsa-miR-4762-3p	CLIP-seq
MIRT2011974	hsa-miR-4772-5p	CLIP-seq
MIRT2011975	hsa-miR-4778-3p	CLIP-seq
MIRT1052715	hsa-miR-4804-3p	CLIP-seq
MIRT2011976	hsa-miR-505	CLIP-seq
MIRT2011977	hsa-miR-511	CLIP-seq
MIRT1052718	hsa-miR-513a-3p	CLIP-seq
MIRT2011978	hsa-miR-513b	CLIP-seq
MIRT1052728	hsa-miR-543	CLIP-seq
MIRT2011979	hsa-miR-544	CLIP-seq
MIRT2011980	hsa-miR-552	CLIP-seq
MIRT2011981	hsa-miR-561	CLIP-seq
MIRT2011982	hsa-miR-590-3p	CLIP-seq
MIRT2011983	hsa-miR-603	CLIP-seq
MIRT2011984	hsa-miR-764	CLIP-seq
MIRT2011985	hsa-miR-98	CLIP-seq
MIRT1052661	hsa-miR-1197	CLIP-seq
MIRT2244234	hsa-miR-1225-3p	CLIP-seq
MIRT2244235	hsa-miR-1233	CLIP-seq
MIRT2244236	hsa-miR-1263	CLIP-seq
MIRT2244237	hsa-miR-1273g	CLIP-seq
MIRT1052663	hsa-miR-1305	CLIP-seq
MIRT2244238	hsa-miR-140-3p	CLIP-seq
MIRT2244239	hsa-miR-146b-3p	CLIP-seq
MIRT2244240	hsa-miR-155	CLIP-seq
MIRT2011960	hsa-miR-216a	CLIP-seq
MIRT2244241	hsa-miR-216b	CLIP-seq
MIRT1052674	hsa-miR-224	CLIP-seq
MIRT2244242	hsa-miR-299-3p	CLIP-seq
MIRT1052681	hsa-miR-3065-5p	CLIP-seq
MIRT1052682	hsa-miR-3117-5p	CLIP-seq
MIRT1052685	hsa-miR-3166	CLIP-seq
MIRT2244243	hsa-miR-3173-5p	CLIP-seq
MIRT2244244	hsa-miR-323-3p	CLIP-seq
MIRT2011962	hsa-miR-323b-3p	CLIP-seq
MIRT2244245	hsa-miR-323b-5p	CLIP-seq
MIRT2244246	hsa-miR-339-5p	CLIP-seq
MIRT2244247	hsa-miR-3660	CLIP-seq
MIRT2244248	hsa-miR-3680	CLIP-seq
MIRT2011963	hsa-miR-3682-5p	CLIP-seq
MIRT2244249	hsa-miR-3688-3p	CLIP-seq
MIRT1052695	hsa-miR-374a	CLIP-seq
MIRT1052696	hsa-miR-374b	CLIP-seq
MIRT2244250	hsa-miR-3907	CLIP-seq
MIRT2011965	hsa-miR-412	CLIP-seq
MIRT1052704	hsa-miR-4477b	CLIP-seq
MIRT2011969	hsa-miR-4491	CLIP-seq
MIRT2244251	hsa-miR-4526	CLIP-seq
MIRT2011971	hsa-miR-4657	CLIP-seq
MIRT2244252	hsa-miR-4729	CLIP-seq
MIRT1052712	hsa-miR-4742-5p	CLIP-seq
MIRT2011975	hsa-miR-4778-3p	CLIP-seq
MIRT2244253	hsa-miR-499-3p	CLIP-seq
MIRT2244254	hsa-miR-499a-3p	CLIP-seq
MIRT2011976	hsa-miR-505	CLIP-seq
MIRT1052719	hsa-miR-513a-5p	CLIP-seq
MIRT2011978	hsa-miR-513b	CLIP-seq
MIRT1052724	hsa-miR-520d-5p	CLIP-seq
MIRT1052727	hsa-miR-524-5p	CLIP-seq
MIRT2011980	hsa-miR-552	CLIP-seq
MIRT2244255	hsa-miR-577	CLIP-seq
MIRT2244256	hsa-miR-584	CLIP-seq
MIRT2011984	hsa-miR-764	CLIP-seq
MIRT2244257	hsa-miR-874	CLIP-seq
MIRT2389116	hsa-miR-4301	CLIP-seq
MIRT2389117	hsa-miR-4461	CLIP-seq
MIRT1052703	hsa-miR-4474-3p	CLIP-seq
MIRT1052718	hsa-miR-513a-3p	CLIP-seq
MIRT2244237	hsa-miR-1273g	CLIP-seq
MIRT2547177	hsa-miR-129-5p	CLIP-seq
MIRT2547178	hsa-miR-2052	CLIP-seq
MIRT2244242	hsa-miR-299-3p	CLIP-seq
MIRT2011969	hsa-miR-4491	CLIP-seq
MIRT2011971	hsa-miR-4657	CLIP-seq
MIRT2244237	hsa-miR-1273g	CLIP-seq
MIRT2547177	hsa-miR-129-5p	CLIP-seq
MIRT2547178	hsa-miR-2052	CLIP-seq
MIRT2244242	hsa-miR-299-3p	CLIP-seq
MIRT2011969	hsa-miR-4491	CLIP-seq
MIRT2011971	hsa-miR-4657	CLIP-seq

Show/Hide all (38)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003779	Function	Actin binding	IEA
GO:0005515	Function	Protein binding	IPI	15471887, 17043677, 18799622, 25416956, 25910212, 28514442, 29423001, 31413325, 31515488, 32073997, 32296183, 32814053, 33961781
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	15471887
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IBA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IEA
GO:0007030	Process	Golgi organization	IEA
GO:0007032	Process	Endosome organization	IEA
GO:0007032	Process	Endosome organization	IMP	18799622
GO:0007040	Process	Lysosome organization	IEA
GO:0007040	Process	Lysosome organization	IMP	18799622
GO:0007283	Process	Spermatogenesis	IEA
GO:0007286	Process	Spermatid development	IEA
GO:0008017	Function	Microtubule binding	IBA
GO:0008017	Function	Microtubule binding	IEA
GO:0008333	Process	Endosome to lysosome transport	IEA
GO:0008333	Process	Endosome to lysosome transport	IMP	18799622
GO:0015031	Process	Protein transport	IEA
GO:0015630	Component	Microtubule cytoskeleton	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0030705	Process	Cytoskeleton-dependent intracellular transport	IBA
GO:0030705	Process	Cytoskeleton-dependent intracellular transport	IEA
GO:0030897	Component	HOPS complex	IDA	18799622
GO:0031122	Process	Cytoplasmic microtubule organization	IBA
GO:0031122	Process	Cytoplasmic microtubule organization	IEA
GO:0031122	Process	Cytoplasmic microtubule organization	IEA
GO:0042802	Function	Identical protein binding	IPI	18799622, 25416956, 32073997, 32296183
GO:0042803	Function	Protein homodimerization activity	IDA	32073997
GO:0045022	Process	Early endosome to late endosome transport	IEA
GO:0045022	Process	Early endosome to late endosome transport	IMP	18799622
GO:0051959	Function	Dynein light intermediate chain binding	IBA
GO:0070695	Component	FHF complex	IDA	18799622, 32073997
GO:0070695	Component	FHF complex	IEA
GO:1905198	Process	Manchette assembly	IEA
GO:1905719	Process	Protein localization to perinuclear region of cytoplasm	IEA
GO:1905719	Process	Protein localization to perinuclear region of cytoplasm	IMP	32073997

MIM	HGNC	e!Ensembl
607820	19884	ENSG00000134709

Q9UJC3

Protein name

Protein Hook homolog 1 (h-hook1) (hHK1)

Protein function

Component of the FTS/Hook/FHIP complex (FHF complex) (PubMed:18799622, PubMed:32073997). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (PubMed:187

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF19047	HOOK_N	13 → 163	HOOK domain	Domain
PF05622	HOOK	186 → 719	HOOK protein coiled-coil region	Coiled-coil

Sequence

MEETQPPPQPKLPLCDSLMIWLQTFNTASPCQDVKQLTSGVAMAQVLHQIDAAWFNESWL
SRIKEDVGDNWRIKASNVKKVLQGIMSYYHEFLGQQISEALIPDLNQITECSDPVELGRL
LQLILGCAINCEKKQEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQL
KRALEELQEALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPN
TVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETR
ALKDEIDVLRATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEE
LKKANAARTQLETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQR
DTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQ
QEGSENERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEG
ESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMK
AMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKERRIEILESECKVAKFRDY
EEKLIVSAWYNKSLAFQKLGMESRLVSGGGACSDTGACTPARSFLAQQRHITNTRRNLSV
KVPATTSD

Sequence length

728

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CENTRAL NERVOUS SYSTEM CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SUBSTANCE ABUSE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (20)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	28718370	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	31413587		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cognition Disorders	Cognitive disorder	BEFREE	29074463		★★★★★ ★☆☆☆☆ Found in Text Mining only
Degenerative polyarthritis	Arthritis	BEFREE	30944034		★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometriosis	Endometriosis	Pubtator	37817158	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophageal neoplasm	Pubtator	38101299	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Impaired cognition	Impaired Cognition	BEFREE	29074463, 29431277		★★★★★ ★☆☆☆☆ Found in Text Mining only
Juvenile Neuronal Ceroid Lipofuscinosis	Neuronal Ceroid Lipofuscinosis	BEFREE	15823567, 17101785		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	28718370		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	UNIPROT_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	31413587		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	28718370		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	29953894		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	31413587		★★★★★ ★☆☆☆☆ Found in Text Mining only
Rett Syndrome	Rett Syndrome	BEFREE	28399682		★★★★★ ★☆☆☆☆ Found in Text Mining only
Rett Syndrome, Atypical	Rett Syndrome	BEFREE	29431277		★★★★★ ★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	30944034		★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	29431277		★★★★★ ★☆☆☆☆ Found in Text Mining only
Senile Plaques	Senile Plaques	BEFREE	25799409		★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid carcinoma	Thyroid Carcinoma	BEFREE	29953894		★★★★★ ★☆☆☆☆ Found in Text Mining only

HOOK1 (hook microtubule tethering protein 1)