MS4A4A (membrane spanning 4-domains A4A)

Gene

• Entrez ID: 51338
• Gene name: Membrane spanning 4-domains A4A
• Gene symbol: MS4A4A
• Synonyms (NCBI Gene): 4SPAN1, CD20-L1, CD20L1, HDCME31P, MS4A4, MS4A7
• Chromosome: 11
• Chromosome location: 11q12.2
• Summary: This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features, similar intron/exon splice boundaries, and display unique expression patterns in hematopoietic cell

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT025653	hsa-miR-7-5p	Microarray	17612493
MIRT509336	hsa-miR-4700-3p	PAR-CLIP	23446348
MIRT509335	hsa-miR-4433b-3p	PAR-CLIP	23446348
MIRT509334	hsa-miR-6504-3p	PAR-CLIP	23446348
MIRT509333	hsa-miR-4433a-3p	PAR-CLIP	23446348
MIRT509332	hsa-miR-1292-3p	PAR-CLIP	23446348
MIRT509331	hsa-miR-5095	PAR-CLIP	23446348
MIRT509330	hsa-miR-7151-3p	PAR-CLIP	23446348
MIRT509329	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT509336	hsa-miR-4700-3p	PAR-CLIP	23446348
MIRT509335	hsa-miR-4433b-3p	PAR-CLIP	23446348
MIRT509334	hsa-miR-6504-3p	PAR-CLIP	23446348
MIRT509333	hsa-miR-4433a-3p	PAR-CLIP	23446348
MIRT509332	hsa-miR-1292-3p	PAR-CLIP	23446348
MIRT509331	hsa-miR-5095	PAR-CLIP	23446348
MIRT509330	hsa-miR-7151-3p	PAR-CLIP	23446348
MIRT509329	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT1161028	hsa-miR-1276	CLIP-seq
MIRT1161029	hsa-miR-203	CLIP-seq
MIRT1161030	hsa-miR-4311	CLIP-seq
MIRT1161031	hsa-miR-4676-5p	CLIP-seq
MIRT1161032	hsa-miR-575	CLIP-seq
MIRT1161033	hsa-miR-583	CLIP-seq
MIRT1161034	hsa-miR-1252	CLIP-seq
MIRT1161035	hsa-miR-1272	CLIP-seq
MIRT1161036	hsa-miR-1284	CLIP-seq
MIRT1161037	hsa-miR-1322	CLIP-seq
MIRT1161038	hsa-miR-142-5p	CLIP-seq
MIRT1161039	hsa-miR-2116	CLIP-seq
MIRT1161040	hsa-miR-3153	CLIP-seq
MIRT1161041	hsa-miR-329	CLIP-seq
MIRT1161042	hsa-miR-340	CLIP-seq
MIRT1161043	hsa-miR-362-3p	CLIP-seq
MIRT1161044	hsa-miR-3675-3p	CLIP-seq
MIRT1161045	hsa-miR-3941	CLIP-seq
MIRT1161046	hsa-miR-410	CLIP-seq
MIRT1161047	hsa-miR-4434	CLIP-seq
MIRT1161048	hsa-miR-4516	CLIP-seq
MIRT1161049	hsa-miR-4722-5p	CLIP-seq
MIRT1161050	hsa-miR-4768-3p	CLIP-seq
MIRT1161051	hsa-miR-4789-5p	CLIP-seq
MIRT1161052	hsa-miR-561	CLIP-seq
MIRT1161053	hsa-miR-603	CLIP-seq
MIRT1161034	hsa-miR-1252	CLIP-seq
MIRT2275327	hsa-miR-128	CLIP-seq
MIRT2275328	hsa-miR-27a	CLIP-seq
MIRT2275329	hsa-miR-27b	CLIP-seq
MIRT2275330	hsa-miR-4310	CLIP-seq
MIRT2275331	hsa-miR-581	CLIP-seq
MIRT2275332	hsa-miR-592	CLIP-seq
MIRT2275333	hsa-miR-597	CLIP-seq
MIRT2275334	hsa-miR-599	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	30833792, 32296183
GO:0005783	Component	Endoplasmic reticulum	IDA	31413141
GO:0005794	Component	Golgi apparatus	IBA
GO:0005794	Component	Golgi apparatus	IDA	31413141
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	23874341
GO:0016020	Component	Membrane	IEA
GO:0044853	Component	Plasma membrane raft	IDA	31413141

Other IDs

• MIM: 606547
• HGNC: 13371
• e!Ensembl: ENSG00000110079

Protein

• UniProt ID: Q96JQ5
• Protein name: Membrane-spanning 4-domains subfamily A member 4A (CD20 antigen-like 1) (Four-span transmembrane protein 1)
• Protein function: May be involved in signal transduction as a component of a multimeric receptor complex.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04103	CD20	65 → 207	CD20-like family	Family

• Tissue specificity: TISSUE SPECIFICITY: Variable expression in multiple hemopoietic cell lines.
• Sequence:

  MHQTYSRHCRPEESTFSAAMTTMQGMEQAMPGAGPGVPQLGNMAVIHSHLWKGLQEKFLK
  GEPKVLGVVQILTALMSLSMGITMMCMASNTYGSNPISVYIGYTIWGSVMFIISGSLSIA
  AGIRTTKGLVRGSLGMNITSSVLAASGILINTFSLAFYSFHHPYCNYYGNSNNCHGTMSI
  LMGLDGMVLLLSVLEFCIAVSLSAFGCKVLCCTPGGVVLILPSHSHMAETASPTPLNEV

• Sequence length: 239

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ALZHEIMERS DISEASE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ARTHRITIS, JUVENILE	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTROPHIC CARDIOMYOPATHY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
JUVENILE CHRONIC POLYARTHRITIS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LATE-ONSET ALZHEIMER'S DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MONOARTICULAR JUVENILE RHEUMATOID ARTHRITIS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PAUCIARTICULAR JUVENILE RHEUMATOID ARTHRITIS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Acute Confusional Senile Dementia	Senile Dementia	CTD_human_DG	21460841		★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	25778476, 28199971, 30859738, 31144443, 33712570, 38172904	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Alzheimer Disease, Early Onset	Alzheimer disease	CTD_human_DG	21460841		★☆☆☆☆ Found in Text Mining only
Alzheimer Disease, Late Onset	Alzheimer disease	CTD_human_DG	21460841		★☆☆☆☆ Found in Text Mining only
Alzheimer Disease, Late Onset	Alzheimer disease	BEFREE	22722634		★☆☆☆☆ Found in Text Mining only
Alzheimer`s Disease	Alzheimer disease	CTD_human_DG	21460841		★☆☆☆☆ Found in Text Mining only
Alzheimer`s Disease	Alzheimer disease	GWASDB_DG	21460841, 21627779		★☆☆☆☆ Found in Text Mining only
Alzheimer`s Disease	Alzheimer disease	GWASCAT_DG	21460841, 21627779, 25778476, 29777097, 30617256		★☆☆☆☆ Found in Text Mining only
Alzheimer`s Disease, Focal Onset	Alzheimer disease	CTD_human_DG	21460841		★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	32483203, 34346525	Associate	★☆☆☆☆ Found in Text Mining only
Cerebral Infarction	Ischemic stroke	Pubtator	30859738	Associate	★☆☆☆☆ Found in Text Mining only
Diabetic Nephropathies	Diabetic neuropathy	Pubtator	37622120	Associate	★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophageal neoplasm	Pubtator	36569220	Associate	★☆☆☆☆ Found in Text Mining only
Familial Alzheimer Disease (FAD)	Alzheimer disease	CTD_human_DG	21460841		★☆☆☆☆ Found in Text Mining only
Immune System Diseases	Immune system disease	Pubtator	25717186	Associate	★☆☆☆☆ Found in Text Mining only
Ischemic stroke	Ischemic Stroke	BEFREE	30859738		★☆☆☆☆ Found in Text Mining only
Juvenile arthritis	Arthritis	CTD_human_DG	19565504		★☆☆☆☆ Found in Text Mining only
Juvenile psoriatic arthritis	Juvenile arthritis	CTD_human_DG	19565504		★☆☆☆☆ Found in Text Mining only
Juvenile-Onset Still Disease	Still Disease	CTD_human_DG	19565504		★☆☆☆☆ Found in Text Mining only
Lymphoma Follicular	Lymphoma	Pubtator	37373066	Associate	★☆☆☆☆ Found in Text Mining only
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	Malignant lymphoma, lymphocytic, intermediate differentiation	BEFREE	28303902		★☆☆☆☆ Found in Text Mining only
Mantle cell lymphoma	Mantle Cell Lymphoma	BEFREE	28303902		★☆☆☆☆ Found in Text Mining only
Microscopic Polyangiitis	Microscopic polyangiitis	Pubtator	23690996, 28569178	Associate	★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	BEFREE	28303902		★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	32444534, 35186171	Associate	★☆☆☆☆ Found in Text Mining only
Polyarthritis, Juvenile, Rheumatoid Factor Negative	Seronegative polyarthritis	CTD_human_DG	19565504		★☆☆☆☆ Found in Text Mining only
Polyarthritis, Juvenile, Rheumatoid Factor Positive	Polyarthritis, Rheumatoid Factor Positive	CTD_human_DG	19565504		★☆☆☆☆ Found in Text Mining only
Presenile dementia	Senile Dementia	CTD_human_DG	21460841		★☆☆☆☆ Found in Text Mining only