Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	51335
Gene name	Neugrin, neurite outgrowth associated
Gene symbol	NGRN
Synonyms (NCBI Gene)	DSC92
Chromosome	15
Chromosome location	15q26.1

184

Show/Hide all (184)

miRTarBase ID	miRNA	Experiments	Reference
MIRT046683	hsa-miR-222-3p	CLASH	23622248
MIRT045692	hsa-miR-149-5p	CLASH	23622248
MIRT043687	hsa-miR-342-3p	CLASH	23622248
MIRT721944	hsa-miR-100-3p	HITS-CLIP	19536157
MIRT721943	hsa-miR-200b-3p	HITS-CLIP	19536157
MIRT721942	hsa-miR-200c-3p	HITS-CLIP	19536157
MIRT721941	hsa-miR-429	HITS-CLIP	19536157
MIRT721940	hsa-miR-3161	HITS-CLIP	19536157
MIRT645012	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT645011	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT645010	hsa-miR-5189-3p	HITS-CLIP	23824327
MIRT645009	hsa-miR-544a	HITS-CLIP	23824327
MIRT721944	hsa-miR-100-3p	HITS-CLIP	19536157
MIRT721943	hsa-miR-200b-3p	HITS-CLIP	19536157
MIRT721942	hsa-miR-200c-3p	HITS-CLIP	19536157
MIRT721941	hsa-miR-429	HITS-CLIP	19536157
MIRT721940	hsa-miR-3161	HITS-CLIP	19536157
MIRT645012	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT645011	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT645010	hsa-miR-5189-3p	HITS-CLIP	23824327
MIRT645009	hsa-miR-544a	HITS-CLIP	23824327
MIRT1184211	hsa-miR-1252	CLIP-seq
MIRT1184212	hsa-miR-135a	CLIP-seq
MIRT1184213	hsa-miR-135b	CLIP-seq
MIRT1184214	hsa-miR-140-3p	CLIP-seq
MIRT1184215	hsa-miR-194	CLIP-seq
MIRT1184216	hsa-miR-3119	CLIP-seq
MIRT1184217	hsa-miR-3192	CLIP-seq
MIRT1184218	hsa-miR-3647-3p	CLIP-seq
MIRT1184219	hsa-miR-4300	CLIP-seq
MIRT1184220	hsa-miR-4463	CLIP-seq
MIRT1184221	hsa-miR-4470	CLIP-seq
MIRT1184222	hsa-miR-4494	CLIP-seq
MIRT1184223	hsa-miR-4643	CLIP-seq
MIRT1184224	hsa-miR-602	CLIP-seq
MIRT1184225	hsa-miR-920	CLIP-seq
MIRT1184211	hsa-miR-1252	CLIP-seq
MIRT2053411	hsa-miR-1278	CLIP-seq
MIRT2053412	hsa-miR-139-5p	CLIP-seq
MIRT1184214	hsa-miR-140-3p	CLIP-seq
MIRT2053413	hsa-miR-1911	CLIP-seq
MIRT2053414	hsa-miR-200b	CLIP-seq
MIRT2053415	hsa-miR-200c	CLIP-seq
MIRT2053416	hsa-miR-3174	CLIP-seq
MIRT1184217	hsa-miR-3192	CLIP-seq
MIRT2053417	hsa-miR-323-3p	CLIP-seq
MIRT2053418	hsa-miR-3618	CLIP-seq
MIRT2053419	hsa-miR-371-5p	CLIP-seq
MIRT2053420	hsa-miR-371b-5p	CLIP-seq
MIRT2053421	hsa-miR-374c	CLIP-seq
MIRT2053422	hsa-miR-4257	CLIP-seq
MIRT1184219	hsa-miR-4300	CLIP-seq
MIRT1184220	hsa-miR-4463	CLIP-seq
MIRT1184222	hsa-miR-4494	CLIP-seq
MIRT2053423	hsa-miR-451b	CLIP-seq
MIRT2053424	hsa-miR-4659a-3p	CLIP-seq
MIRT2053425	hsa-miR-4659b-3p	CLIP-seq
MIRT2053426	hsa-miR-4660	CLIP-seq
MIRT2053427	hsa-miR-4724-5p	CLIP-seq
MIRT2053428	hsa-miR-4778-3p	CLIP-seq
MIRT2053429	hsa-miR-4797-5p	CLIP-seq
MIRT2053430	hsa-miR-4803	CLIP-seq
MIRT2053431	hsa-miR-493	CLIP-seq
MIRT2053432	hsa-miR-499a-5p	CLIP-seq
MIRT2053433	hsa-miR-5096	CLIP-seq
MIRT2053434	hsa-miR-513c	CLIP-seq
MIRT2053435	hsa-miR-514b-5p	CLIP-seq
MIRT2053436	hsa-miR-587	CLIP-seq
MIRT2053437	hsa-miR-655	CLIP-seq
MIRT1184225	hsa-miR-920	CLIP-seq
MIRT2053438	hsa-miR-942	CLIP-seq
MIRT2282635	hsa-miR-1236	CLIP-seq
MIRT2053411	hsa-miR-1278	CLIP-seq
MIRT2282636	hsa-miR-1305	CLIP-seq
MIRT1184212	hsa-miR-135a	CLIP-seq
MIRT1184213	hsa-miR-135b	CLIP-seq
MIRT2282637	hsa-miR-136	CLIP-seq
MIRT1184214	hsa-miR-140-3p	CLIP-seq
MIRT2053413	hsa-miR-1911	CLIP-seq
MIRT2053414	hsa-miR-200b	CLIP-seq
MIRT2053415	hsa-miR-200c	CLIP-seq
MIRT1184216	hsa-miR-3119	CLIP-seq
MIRT2053417	hsa-miR-323-3p	CLIP-seq
MIRT2282638	hsa-miR-337-3p	CLIP-seq
MIRT2053419	hsa-miR-371-5p	CLIP-seq
MIRT2053420	hsa-miR-371b-5p	CLIP-seq
MIRT2053421	hsa-miR-374c	CLIP-seq
MIRT2282639	hsa-miR-421	CLIP-seq
MIRT2053423	hsa-miR-451b	CLIP-seq
MIRT2282640	hsa-miR-4645-5p	CLIP-seq
MIRT2053424	hsa-miR-4659a-3p	CLIP-seq
MIRT2053425	hsa-miR-4659b-3p	CLIP-seq
MIRT2282641	hsa-miR-4673	CLIP-seq
MIRT2282642	hsa-miR-4687-3p	CLIP-seq
MIRT2053427	hsa-miR-4724-5p	CLIP-seq
MIRT2282643	hsa-miR-4761-5p	CLIP-seq
MIRT2053428	hsa-miR-4778-3p	CLIP-seq
MIRT2053430	hsa-miR-4803	CLIP-seq
MIRT2053433	hsa-miR-5096	CLIP-seq
MIRT2053434	hsa-miR-513c	CLIP-seq
MIRT2053435	hsa-miR-514b-5p	CLIP-seq
MIRT2053436	hsa-miR-587	CLIP-seq
MIRT1184224	hsa-miR-602	CLIP-seq
MIRT2053437	hsa-miR-655	CLIP-seq
MIRT2053438	hsa-miR-942	CLIP-seq
MIRT1184215	hsa-miR-194	CLIP-seq
MIRT1184223	hsa-miR-4643	CLIP-seq
MIRT1184224	hsa-miR-602	CLIP-seq
MIRT2580608	hsa-miR-1238	CLIP-seq
MIRT1184211	hsa-miR-1252	CLIP-seq
MIRT1184214	hsa-miR-140-3p	CLIP-seq
MIRT2580609	hsa-miR-188-3p	CLIP-seq
MIRT2580610	hsa-miR-221	CLIP-seq
MIRT2580611	hsa-miR-222	CLIP-seq
MIRT2580612	hsa-miR-3124-3p	CLIP-seq
MIRT2580613	hsa-miR-3155	CLIP-seq
MIRT2580614	hsa-miR-3155b	CLIP-seq
MIRT2580615	hsa-miR-3591-5p	CLIP-seq
MIRT2580616	hsa-miR-3613-5p	CLIP-seq
MIRT2580617	hsa-miR-382	CLIP-seq
MIRT2580618	hsa-miR-4255	CLIP-seq
MIRT2580619	hsa-miR-4420	CLIP-seq
MIRT2580620	hsa-miR-455-3p	CLIP-seq
MIRT2282640	hsa-miR-4645-5p	CLIP-seq
MIRT2580621	hsa-miR-4646-3p	CLIP-seq
MIRT2053426	hsa-miR-4660	CLIP-seq
MIRT2282641	hsa-miR-4673	CLIP-seq
MIRT2580622	hsa-miR-4691-5p	CLIP-seq
MIRT2580623	hsa-miR-4698	CLIP-seq
MIRT2580624	hsa-miR-484	CLIP-seq
MIRT2580625	hsa-miR-532-3p	CLIP-seq
MIRT2580626	hsa-miR-548aa	CLIP-seq
MIRT2580627	hsa-miR-548v	CLIP-seq
MIRT2580608	hsa-miR-1238	CLIP-seq
MIRT1184211	hsa-miR-1252	CLIP-seq
MIRT2053411	hsa-miR-1278	CLIP-seq
MIRT2053412	hsa-miR-139-5p	CLIP-seq
MIRT1184214	hsa-miR-140-3p	CLIP-seq
MIRT2580609	hsa-miR-188-3p	CLIP-seq
MIRT2053413	hsa-miR-1911	CLIP-seq
MIRT2580610	hsa-miR-221	CLIP-seq
MIRT2580611	hsa-miR-222	CLIP-seq
MIRT2580612	hsa-miR-3124-3p	CLIP-seq
MIRT2580613	hsa-miR-3155	CLIP-seq
MIRT2580614	hsa-miR-3155b	CLIP-seq
MIRT2053416	hsa-miR-3174	CLIP-seq
MIRT1184217	hsa-miR-3192	CLIP-seq
MIRT2580615	hsa-miR-3591-5p	CLIP-seq
MIRT2580616	hsa-miR-3613-5p	CLIP-seq
MIRT2053418	hsa-miR-3618	CLIP-seq
MIRT2053419	hsa-miR-371-5p	CLIP-seq
MIRT2053420	hsa-miR-371b-5p	CLIP-seq
MIRT2580617	hsa-miR-382	CLIP-seq
MIRT2580618	hsa-miR-4255	CLIP-seq
MIRT2053422	hsa-miR-4257	CLIP-seq
MIRT1184219	hsa-miR-4300	CLIP-seq
MIRT2580619	hsa-miR-4420	CLIP-seq
MIRT1184220	hsa-miR-4463	CLIP-seq
MIRT1184221	hsa-miR-4470	CLIP-seq
MIRT1184222	hsa-miR-4494	CLIP-seq
MIRT2053423	hsa-miR-451b	CLIP-seq
MIRT2580620	hsa-miR-455-3p	CLIP-seq
MIRT2282640	hsa-miR-4645-5p	CLIP-seq
MIRT2580621	hsa-miR-4646-3p	CLIP-seq
MIRT2053424	hsa-miR-4659a-3p	CLIP-seq
MIRT2053425	hsa-miR-4659b-3p	CLIP-seq
MIRT2053426	hsa-miR-4660	CLIP-seq
MIRT2282641	hsa-miR-4673	CLIP-seq
MIRT2580622	hsa-miR-4691-5p	CLIP-seq
MIRT2580623	hsa-miR-4698	CLIP-seq
MIRT2053427	hsa-miR-4724-5p	CLIP-seq
MIRT2053428	hsa-miR-4778-3p	CLIP-seq
MIRT2053429	hsa-miR-4797-5p	CLIP-seq
MIRT2580624	hsa-miR-484	CLIP-seq
MIRT2053431	hsa-miR-493	CLIP-seq
MIRT2053432	hsa-miR-499a-5p	CLIP-seq
MIRT2053433	hsa-miR-5096	CLIP-seq
MIRT2053434	hsa-miR-513c	CLIP-seq
MIRT2053435	hsa-miR-514b-5p	CLIP-seq
MIRT2580625	hsa-miR-532-3p	CLIP-seq
MIRT2580626	hsa-miR-548aa	CLIP-seq
MIRT2580627	hsa-miR-548v	CLIP-seq
MIRT1184225	hsa-miR-920	CLIP-seq
MIRT2053438	hsa-miR-942	CLIP-seq

Show/Hide all (22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	11118320
GO:0005654	Component	Nucleoplasm	IDA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA
GO:0005739	Component	Mitochondrion	IEA
GO:0005759	Component	Mitochondrial matrix	IDA	27974379
GO:0016020	Component	Membrane	IEA
GO:0016604	Component	Nuclear body	IDA
GO:0019843	Function	RRNA binding	IDA	27667664
GO:0030154	Process	Cell differentiation	IEA
GO:0030182	Process	Neuron differentiation	NAS	11118320
GO:0031966	Component	Mitochondrial membrane	IDA	27667664
GO:0031966	Component	Mitochondrial membrane	IEA
GO:0045171	Component	Intercellular bridge	IDA
GO:0061668	Process	Mitochondrial ribosome assembly	IMP	27667664
GO:0070131	Process	Positive regulation of mitochondrial translation	IMP	27667664
GO:0072686	Component	Mitotic spindle	IDA

MIM	HGNC	e!Ensembl
616718	18077	ENSG00000182768

Q9NPE2

Protein name

Neugrin (Mesenchymal stem cell protein DSC92) (Neurite outgrowth-associated protein) (Spinal cord-derived protein FI58G)

Protein function

Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA ab

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF06413	Neugrin	73 → 291	Neugrin	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed at high levels in heart, brain and skeletal muscle. In brain, mainly expressed in neurons rather than glial cells. {ECO:0000269|PubMed:11118320}.

Sequence

MAVTLSLLLGGRVCAAVTRCGFATRGVAGPGPIGREPDPDSDWEPEERELQEVESTLKRQ
KQAIRFQKIRRQMEAPGAPPRTLTWEAMEQIRYLHEEFPESWSVPRLAEGFDVSTDVIRR
VLKSKFLPTLEQKLKQDQKVLKKAGLAHSLQHLRGSGNTSKLLPAGHSVSGSLLMPGHEA
SSKDPNHSTALKVIESDTHRTNTPRRRKGRNKEIQDLEESFVPVAAPLGHPRELQKYSSD
SESPRGTGSGALPSGQKLEELKAEEPDNFSSKVVQRGREFFDSNGNFLYRI

Sequence length

291

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
COLOR VISION DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (5)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Alzheimer Disease	Alzheimer disease	Pubtator	37438770	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Amyotrophic lateral sclerosis 1	Amyotrophic lateral sclerosis	Pubtator	12417341	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasopharyngeal Carcinoma	Nasopharyngeal carcinoma	Pubtator	16308470	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	11118320		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	15477757	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

NGRN (neugrin, neurite outgrowth associated)