Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	51329
Gene name	ARF like GTPase 6 interacting protein 4
Gene symbol	ARL6IP4
Synonyms (NCBI Gene)	SFRS20SR-25SRp25SRrp37
Chromosome	12
Chromosome location	12q24.31

Show/Hide all (60)

miRTarBase ID	miRNA	Experiments	Reference
MIRT045254	hsa-miR-186-5p	CLASH	23622248
MIRT045254	hsa-miR-186-5p	CLASH	23622248
MIRT042323	hsa-miR-484	CLASH	23622248
MIRT040563	hsa-miR-92b-3p	CLASH	23622248
MIRT721785	hsa-miR-942-3p	HITS-CLIP	19536157
MIRT721784	hsa-miR-6783-5p	HITS-CLIP	19536157
MIRT721783	hsa-miR-4431	HITS-CLIP	19536157
MIRT721782	hsa-miR-7110-3p	HITS-CLIP	19536157
MIRT721781	hsa-miR-1909-3p	HITS-CLIP	19536157
MIRT721780	hsa-miR-6722-3p	HITS-CLIP	19536157
MIRT721779	hsa-miR-671-5p	HITS-CLIP	19536157
MIRT721778	hsa-miR-1207-5p	HITS-CLIP	19536157
MIRT721777	hsa-miR-4763-3p	HITS-CLIP	19536157
MIRT721776	hsa-miR-4736	HITS-CLIP	19536157
MIRT721775	hsa-miR-4271	HITS-CLIP	19536157
MIRT721774	hsa-miR-4725-3p	HITS-CLIP	19536157
MIRT721773	hsa-miR-6780b-5p	HITS-CLIP	19536157
MIRT721772	hsa-miR-7150	HITS-CLIP	19536157
MIRT717001	hsa-miR-6768-3p	HITS-CLIP	19536157
MIRT717000	hsa-miR-4753-5p	HITS-CLIP	19536157
MIRT716999	hsa-miR-634	HITS-CLIP	19536157
MIRT716998	hsa-miR-6871-3p	HITS-CLIP	19536157
MIRT716997	hsa-miR-4717-5p	HITS-CLIP	19536157
MIRT716996	hsa-miR-1226-3p	HITS-CLIP	19536157
MIRT716995	hsa-miR-3065-3p	HITS-CLIP	19536157
MIRT716994	hsa-miR-3155a	HITS-CLIP	19536157
MIRT716993	hsa-miR-3155b	HITS-CLIP	19536157
MIRT042323	hsa-miR-484	HITS-CLIP	19536157
MIRT716992	hsa-miR-3153	HITS-CLIP	19536157
MIRT716991	hsa-miR-6733-5p	HITS-CLIP	19536157
MIRT716990	hsa-miR-6739-5p	HITS-CLIP	19536157
MIRT721785	hsa-miR-942-3p	HITS-CLIP	19536157
MIRT721784	hsa-miR-6783-5p	HITS-CLIP	19536157
MIRT721783	hsa-miR-4431	HITS-CLIP	19536157
MIRT721782	hsa-miR-7110-3p	HITS-CLIP	19536157
MIRT721781	hsa-miR-1909-3p	HITS-CLIP	19536157
MIRT721780	hsa-miR-6722-3p	HITS-CLIP	19536157
MIRT721779	hsa-miR-671-5p	HITS-CLIP	19536157
MIRT721778	hsa-miR-1207-5p	HITS-CLIP	19536157
MIRT721777	hsa-miR-4763-3p	HITS-CLIP	19536157
MIRT721776	hsa-miR-4736	HITS-CLIP	19536157
MIRT721775	hsa-miR-4271	HITS-CLIP	19536157
MIRT721774	hsa-miR-4725-3p	HITS-CLIP	19536157
MIRT721773	hsa-miR-6780b-5p	HITS-CLIP	19536157
MIRT721772	hsa-miR-7150	HITS-CLIP	19536157
MIRT717001	hsa-miR-6768-3p	HITS-CLIP	19536157
MIRT717000	hsa-miR-4753-5p	HITS-CLIP	19536157
MIRT716999	hsa-miR-634	HITS-CLIP	19536157
MIRT716998	hsa-miR-6871-3p	HITS-CLIP	19536157
MIRT716997	hsa-miR-4717-5p	HITS-CLIP	19536157
MIRT716996	hsa-miR-1226-3p	HITS-CLIP	19536157
MIRT716995	hsa-miR-3065-3p	HITS-CLIP	19536157
MIRT716994	hsa-miR-3155a	HITS-CLIP	19536157
MIRT716993	hsa-miR-3155b	HITS-CLIP	19536157
MIRT042323	hsa-miR-484	HITS-CLIP	19536157
MIRT716992	hsa-miR-3153	HITS-CLIP	19536157
MIRT716991	hsa-miR-6733-5p	HITS-CLIP	19536157
MIRT716990	hsa-miR-6739-5p	HITS-CLIP	19536157
MIRT2479181	hsa-miR-3620	CLIP-seq
MIRT2479182	hsa-miR-4505	CLIP-seq

Show/Hide all (9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0005515	Function	Protein binding	IPI	20098747, 23602568, 25416956, 25814554, 32707033, 32814053, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	10708573
GO:0005730	Component	Nucleolus	IEA
GO:0006397	Process	MRNA processing	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0008380	Process	RNA splicing	TAS	10708573
GO:0016607	Component	Nuclear speck	IEA

MIM	HGNC	e!Ensembl
607668	18076	ENSG00000182196

Q66PJ3

Protein name

ADP-ribosylation factor-like protein 6-interacting protein 4 (ARL-6-interacting protein 4) (Aip-4) (HSP-975) (HSVI-binding protein) (SR-15) (SRp25) (SR-25) (Splicing factor SRrp37)

Protein function

Involved in modulating alternative pre-mRNA splicing with either 5' distal site activation or preferential use of 3' proximal site. In case of infection by Herpes simplex virus (HSVI), may act as a splicing inhibitor of HSVI pre-mRNA. {ECO:00002

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10500	SR-25	191 → 419	Nuclear RNA-splicing-associated protein	Disordered

Tissue specificity

TISSUE SPECIFICITY: Isoforms 3 and 7 were identified in brain, pancreas, prostate, and testis, but little or no message could be detected in other tissues. {ECO:0000269|PubMed:19582790}.

Sequence

MPRCTYQLEQNPGFLPDGPGVHARAHCQDLSGPYGHEFATSESLGGRVGKTRAPQSGARS
RMERAGPAGEEGGAREGRLLPRAPGAWVLRACAERAALEVGAASADTGVRGCGARGPAPL
LASAGGGRARDGTWGVRTKGSGAALPSRPASRAAPRPEASSPPLPLEKARGGLSGPQGGR
ARGAMAHVGSRKRSRSRSRSRGRGSEKRKKKSRKDTSRNCSASTSQGRKASTAPGAEASP
SPCITERSKQKARRRTRSSSSSSSSSSSSSSSSSSSSSSSSSDGRKKRGKYKDKRRKKKK
KRKKLKKKGKEKAEAQQVEALPGPSLDQWHRSAGEEEDGPVLTDEQKSRIQAMKPMTKEE
WDARQSIIRKVVDPETGRTRLIKGDGEVLEEIVTKERHREINKQATRGDCLAFQMRAGLL
P

Sequence length

421

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (1)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Nasopharyngeal Carcinoma	Nasopharyngeal carcinoma	Pubtator	28827787	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

ARL6IP4 (ARF like GTPase 6 interacting protein 4)