Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	51316
Gene name	Placenta associated 8
Gene symbol	PLAC8
Synonyms (NCBI Gene)	C15DGICPNAS-144onzin
Chromosome	4
Chromosome location	4q21.22

205

Show/Hide all (205)

miRTarBase ID	miRNA	Experiments	Reference
MIRT694987	hsa-miR-1285-5p	HITS-CLIP	23313552
MIRT694986	hsa-miR-939-3p	HITS-CLIP	23313552
MIRT694985	hsa-miR-1285-3p	HITS-CLIP	23313552
MIRT694984	hsa-miR-3187-5p	HITS-CLIP	23313552
MIRT694983	hsa-miR-5189-5p	HITS-CLIP	23313552
MIRT694982	hsa-miR-612	HITS-CLIP	23313552
MIRT694981	hsa-miR-6860	HITS-CLIP	23313552
MIRT694980	hsa-miR-661	HITS-CLIP	23313552
MIRT694979	hsa-miR-196a-3p	HITS-CLIP	23313552
MIRT694978	hsa-miR-4797-5p	HITS-CLIP	23313552
MIRT694977	hsa-miR-6513-3p	HITS-CLIP	23313552
MIRT694976	hsa-miR-759	HITS-CLIP	23313552
MIRT694975	hsa-miR-598-5p	HITS-CLIP	23313552
MIRT694974	hsa-miR-3920	HITS-CLIP	23313552
MIRT694973	hsa-miR-29a-5p	HITS-CLIP	23313552
MIRT694972	hsa-miR-4481	HITS-CLIP	23313552
MIRT694971	hsa-miR-4745-5p	HITS-CLIP	23313552
MIRT694970	hsa-miR-509-3p	HITS-CLIP	23313552
MIRT694969	hsa-miR-6772-5p	HITS-CLIP	23313552
MIRT694968	hsa-miR-4455	HITS-CLIP	23313552
MIRT694967	hsa-miR-609	HITS-CLIP	23313552
MIRT694966	hsa-miR-542-3p	HITS-CLIP	23313552
MIRT694965	hsa-miR-6748-5p	HITS-CLIP	23313552
MIRT694964	hsa-miR-1297	HITS-CLIP	23313552
MIRT694963	hsa-miR-26a-5p	HITS-CLIP	23313552
MIRT694962	hsa-miR-26b-5p	HITS-CLIP	23313552
MIRT694961	hsa-miR-4465	HITS-CLIP	23313552
MIRT694960	hsa-miR-1261	HITS-CLIP	23313552
MIRT694959	hsa-miR-498	HITS-CLIP	23313552
MIRT694987	hsa-miR-1285-5p	HITS-CLIP	23313552
MIRT694986	hsa-miR-939-3p	HITS-CLIP	23313552
MIRT694985	hsa-miR-1285-3p	HITS-CLIP	23313552
MIRT694984	hsa-miR-3187-5p	HITS-CLIP	23313552
MIRT694983	hsa-miR-5189-5p	HITS-CLIP	23313552
MIRT694982	hsa-miR-612	HITS-CLIP	23313552
MIRT694981	hsa-miR-6860	HITS-CLIP	23313552
MIRT694980	hsa-miR-661	HITS-CLIP	23313552
MIRT694979	hsa-miR-196a-3p	HITS-CLIP	23313552
MIRT694978	hsa-miR-4797-5p	HITS-CLIP	23313552
MIRT694977	hsa-miR-6513-3p	HITS-CLIP	23313552
MIRT694976	hsa-miR-759	HITS-CLIP	23313552
MIRT694975	hsa-miR-598-5p	HITS-CLIP	23313552
MIRT694974	hsa-miR-3920	HITS-CLIP	23313552
MIRT694973	hsa-miR-29a-5p	HITS-CLIP	23313552
MIRT694972	hsa-miR-4481	HITS-CLIP	23313552
MIRT694971	hsa-miR-4745-5p	HITS-CLIP	23313552
MIRT694970	hsa-miR-509-3p	HITS-CLIP	23313552
MIRT694969	hsa-miR-6772-5p	HITS-CLIP	23313552
MIRT694968	hsa-miR-4455	HITS-CLIP	23313552
MIRT694967	hsa-miR-609	HITS-CLIP	23313552
MIRT694966	hsa-miR-542-3p	HITS-CLIP	23313552
MIRT694965	hsa-miR-6748-5p	HITS-CLIP	23313552
MIRT694964	hsa-miR-1297	HITS-CLIP	23313552
MIRT694963	hsa-miR-26a-5p	HITS-CLIP	23313552
MIRT694962	hsa-miR-26b-5p	HITS-CLIP	23313552
MIRT694961	hsa-miR-4465	HITS-CLIP	23313552
MIRT694960	hsa-miR-1261	HITS-CLIP	23313552
MIRT694959	hsa-miR-498	HITS-CLIP	23313552
MIRT1238970	hsa-miR-1273f	CLIP-seq
MIRT1238971	hsa-miR-1285	CLIP-seq
MIRT1238972	hsa-miR-143	CLIP-seq
MIRT1238973	hsa-miR-1908	CLIP-seq
MIRT1238974	hsa-miR-3160-3p	CLIP-seq
MIRT1238975	hsa-miR-3173-3p	CLIP-seq
MIRT1238976	hsa-miR-3188	CLIP-seq
MIRT1238977	hsa-miR-3189-3p	CLIP-seq
MIRT1238978	hsa-miR-3613-3p	CLIP-seq
MIRT1238979	hsa-miR-3617	CLIP-seq
MIRT1238980	hsa-miR-3622b-5p	CLIP-seq
MIRT1238981	hsa-miR-3689a-3p	CLIP-seq
MIRT1238982	hsa-miR-3689c	CLIP-seq
MIRT1238983	hsa-miR-3689d	CLIP-seq
MIRT1238984	hsa-miR-3713	CLIP-seq
MIRT1238985	hsa-miR-371-5p	CLIP-seq
MIRT1238986	hsa-miR-371b-5p	CLIP-seq
MIRT1238987	hsa-miR-3929	CLIP-seq
MIRT1238988	hsa-miR-3945	CLIP-seq
MIRT1238989	hsa-miR-4252	CLIP-seq
MIRT1238990	hsa-miR-4253	CLIP-seq
MIRT1238991	hsa-miR-4419b	CLIP-seq
MIRT1238992	hsa-miR-4428	CLIP-seq
MIRT1238993	hsa-miR-4459	CLIP-seq
MIRT1238994	hsa-miR-4477b	CLIP-seq
MIRT1238995	hsa-miR-4478	CLIP-seq
MIRT1238996	hsa-miR-4487	CLIP-seq
MIRT1238997	hsa-miR-4499	CLIP-seq
MIRT1238998	hsa-miR-4684-5p	CLIP-seq
MIRT1238999	hsa-miR-4708-5p	CLIP-seq
MIRT1239000	hsa-miR-4712-3p	CLIP-seq
MIRT1239001	hsa-miR-4728-5p	CLIP-seq
MIRT1239002	hsa-miR-4770	CLIP-seq
MIRT1239003	hsa-miR-4793-3p	CLIP-seq
MIRT1239004	hsa-miR-485-5p	CLIP-seq
MIRT1239005	hsa-miR-508-5p	CLIP-seq
MIRT1239006	hsa-miR-548c-3p	CLIP-seq
MIRT1239007	hsa-miR-558	CLIP-seq
MIRT1239008	hsa-miR-641	CLIP-seq
MIRT1239009	hsa-miR-643	CLIP-seq
MIRT1239010	hsa-miR-649	CLIP-seq
MIRT1239011	hsa-miR-663	CLIP-seq
MIRT1239012	hsa-miR-665	CLIP-seq
MIRT1239013	hsa-miR-766	CLIP-seq
MIRT1238971	hsa-miR-1285	CLIP-seq
MIRT1238973	hsa-miR-1908	CLIP-seq
MIRT1239014	hsa-miR-197	CLIP-seq
MIRT1238980	hsa-miR-3622b-5p	CLIP-seq
MIRT1238988	hsa-miR-3945	CLIP-seq
MIRT1238990	hsa-miR-4253	CLIP-seq
MIRT1239015	hsa-miR-4328	CLIP-seq
MIRT1238998	hsa-miR-4684-5p	CLIP-seq
MIRT1239016	hsa-miR-5096	CLIP-seq
MIRT1239006	hsa-miR-548c-3p	CLIP-seq
MIRT1239011	hsa-miR-663	CLIP-seq
MIRT2070305	hsa-miR-361-5p	CLIP-seq
MIRT2070306	hsa-miR-579	CLIP-seq
MIRT2297552	hsa-miR-607	CLIP-seq
MIRT2392594	hsa-miR-1228	CLIP-seq
MIRT2392595	hsa-miR-24	CLIP-seq
MIRT2392596	hsa-miR-3065-3p	CLIP-seq
MIRT1238975	hsa-miR-3173-3p	CLIP-seq
MIRT2392597	hsa-miR-338-3p	CLIP-seq
MIRT2392598	hsa-miR-342-3p	CLIP-seq
MIRT2392599	hsa-miR-3606	CLIP-seq
MIRT1238979	hsa-miR-3617	CLIP-seq
MIRT2392600	hsa-miR-4284	CLIP-seq
MIRT1238992	hsa-miR-4428	CLIP-seq
MIRT1238994	hsa-miR-4477b	CLIP-seq
MIRT2392601	hsa-miR-4530	CLIP-seq
MIRT2392602	hsa-miR-4637	CLIP-seq
MIRT2392603	hsa-miR-4725-5p	CLIP-seq
MIRT2392604	hsa-miR-504	CLIP-seq
MIRT1239008	hsa-miR-641	CLIP-seq
MIRT1238971	hsa-miR-1285	CLIP-seq
MIRT1238973	hsa-miR-1908	CLIP-seq
MIRT1238980	hsa-miR-3622b-5p	CLIP-seq
MIRT1238988	hsa-miR-3945	CLIP-seq
MIRT1238990	hsa-miR-4253	CLIP-seq
MIRT1238998	hsa-miR-4684-5p	CLIP-seq
MIRT1239006	hsa-miR-548c-3p	CLIP-seq
MIRT1239011	hsa-miR-663	CLIP-seq
MIRT2392594	hsa-miR-1228	CLIP-seq
MIRT1238971	hsa-miR-1285	CLIP-seq
MIRT2594925	hsa-miR-1827	CLIP-seq
MIRT1238973	hsa-miR-1908	CLIP-seq
MIRT2392596	hsa-miR-3065-3p	CLIP-seq
MIRT2594926	hsa-miR-3165	CLIP-seq
MIRT1238977	hsa-miR-3189-3p	CLIP-seq
MIRT2392597	hsa-miR-338-3p	CLIP-seq
MIRT1238978	hsa-miR-3613-3p	CLIP-seq
MIRT1238980	hsa-miR-3622b-5p	CLIP-seq
MIRT2594927	hsa-miR-3665	CLIP-seq
MIRT1238981	hsa-miR-3689a-3p	CLIP-seq
MIRT1238982	hsa-miR-3689c	CLIP-seq
MIRT1238985	hsa-miR-371-5p	CLIP-seq
MIRT1238986	hsa-miR-371b-5p	CLIP-seq
MIRT1238987	hsa-miR-3929	CLIP-seq
MIRT1238988	hsa-miR-3945	CLIP-seq
MIRT1238989	hsa-miR-4252	CLIP-seq
MIRT1238990	hsa-miR-4253	CLIP-seq
MIRT2594928	hsa-miR-4293	CLIP-seq
MIRT1238991	hsa-miR-4419b	CLIP-seq
MIRT2594929	hsa-miR-4433	CLIP-seq
MIRT1238993	hsa-miR-4459	CLIP-seq
MIRT1238995	hsa-miR-4478	CLIP-seq
MIRT2392601	hsa-miR-4530	CLIP-seq
MIRT1238998	hsa-miR-4684-5p	CLIP-seq
MIRT1239001	hsa-miR-4728-5p	CLIP-seq
MIRT2594930	hsa-miR-4736	CLIP-seq
MIRT2594931	hsa-miR-4768-3p	CLIP-seq
MIRT2594932	hsa-miR-4786-5p	CLIP-seq
MIRT1239003	hsa-miR-4793-3p	CLIP-seq
MIRT1239004	hsa-miR-485-5p	CLIP-seq
MIRT1239005	hsa-miR-508-5p	CLIP-seq
MIRT1239006	hsa-miR-548c-3p	CLIP-seq
MIRT1239011	hsa-miR-663	CLIP-seq
MIRT1239013	hsa-miR-766	CLIP-seq
MIRT2594933	hsa-miR-940	CLIP-seq
MIRT1238971	hsa-miR-1285	CLIP-seq
MIRT2594925	hsa-miR-1827	CLIP-seq
MIRT1238973	hsa-miR-1908	CLIP-seq
MIRT2594926	hsa-miR-3165	CLIP-seq
MIRT1238978	hsa-miR-3613-3p	CLIP-seq
MIRT1238980	hsa-miR-3622b-5p	CLIP-seq
MIRT2594927	hsa-miR-3665	CLIP-seq
MIRT1238985	hsa-miR-371-5p	CLIP-seq
MIRT1238986	hsa-miR-371b-5p	CLIP-seq
MIRT1238988	hsa-miR-3945	CLIP-seq
MIRT1238989	hsa-miR-4252	CLIP-seq
MIRT1238990	hsa-miR-4253	CLIP-seq
MIRT2594928	hsa-miR-4293	CLIP-seq
MIRT2687992	hsa-miR-4426	CLIP-seq
MIRT2594929	hsa-miR-4433	CLIP-seq
MIRT1238993	hsa-miR-4459	CLIP-seq
MIRT2687993	hsa-miR-4647	CLIP-seq
MIRT2687994	hsa-miR-4662b	CLIP-seq
MIRT1238998	hsa-miR-4684-5p	CLIP-seq
MIRT2594930	hsa-miR-4736	CLIP-seq
MIRT2594931	hsa-miR-4768-3p	CLIP-seq
MIRT2594932	hsa-miR-4786-5p	CLIP-seq
MIRT1239003	hsa-miR-4793-3p	CLIP-seq
MIRT1239005	hsa-miR-508-5p	CLIP-seq
MIRT1239006	hsa-miR-548c-3p	CLIP-seq
MIRT1239011	hsa-miR-663	CLIP-seq
MIRT1239013	hsa-miR-766	CLIP-seq
MIRT2594933	hsa-miR-940	CLIP-seq

Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003682	Function	Chromatin binding	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0006366	Process	Transcription by RNA polymerase II	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0009409	Process	Response to cold	IEA
GO:0035578	Component	Azurophil granule lumen	TAS
GO:0040015	Process	Negative regulation of multicellular organism growth	IEA
GO:0042742	Process	Defense response to bacterium	IEA
GO:0043066	Process	Negative regulation of apoptotic process	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0050873	Process	Brown fat cell differentiation	IEA
GO:0120162	Process	Positive regulation of cold-induced thermogenesis	IEA
GO:0120162	Process	Positive regulation of cold-induced thermogenesis	ISS	21982742

MIM	HGNC	e!Ensembl
607515	19254	ENSG00000145287

Q9NZF1

Protein name

Placenta-specific gene 8 protein (Protein C15)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04749	PLAC8	26 → 105	PLAC8 family	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed at high levels in plasmacytoid dendritic cells. High expression in spleen, lymph nodes, peripheral blood leukocytes, and bone marrow, with lower expression in thymus, appendix, and fetal liver.

Sequence

MQAQAPVVVVTQPGVGPGPAPQNSNWQTGMCDCFSDCGVCLCGTFCFPCLGCQVAADMNE
CCLCGTSVAMRTLYRTRYGIPGSICDDYMATLCCPHCTLCQIKRDINRRRAMRTF

Sequence length

115

Interactions

View interactions

	Reactome
			Neutrophil degranulation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CARCINOMA, HEPATOCELLULAR	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, EXPERIMENTAL	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SYSTEMIC LUPUS ERYTHEMATOSUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (44)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	31620204		★★★★★ ★☆☆☆☆ Found in Text Mining only
ANOPHTHALMIA AND PULMONARY HYPOPLASIA	Syndromic microphthalmia	BEFREE	26669866		★★★★★ ★☆☆☆☆ Found in Text Mining only
ATRIAL SEPTAL DEFECT 1	Atrial Septal Defect	BEFREE	30404814		★★★★★ ★☆☆☆☆ Found in Text Mining only
Atrial Septal Defects	Atrial Septal Defect	BEFREE	30404814		★★★★★ ★☆☆☆☆ Found in Text Mining only
Autism Spectrum Disorders	Autism Spectrum Disorder	BEFREE	30404814		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	31448883		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	36543379	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	36543379	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	15826317	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	37209778	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	29789534		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	24691442		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	31974611	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma	Renal Carcinoma	BEFREE	28349447		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Gestational	Gestational diabetes	Pubtator	25720387	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Gallbladder Carcinoma	Gallbladder cancer	BEFREE	31272718		★★★★★ ★☆☆☆☆ Found in Text Mining only
Gastrointestinal Neoplasms	Gastrointestinal neoplasm	Pubtator	31974611	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hepatitis B	Hepatitis b	Pubtator	37209778	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hyperglycemia	Hyperglycemia	Pubtator	25720387	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	37885015	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	15826317	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	CTD_human_DG	28284560		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	36124427	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	31448883		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of kidney	Kidney Cancer	BEFREE	31696435		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of liver	Liver Cancer	BEFREE	31620204		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	29789534		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	22920440, 24794439, 26669866		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	23708710		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	22920440, 24691442, 28349447, 31620204		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	24691442		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasopharyngeal carcinoma	Nasopharyngeal Carcinoma	BEFREE	29511439, 30496758		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	23708710, 24794439, 26669866, 28349447, 29789534, 30427722, 31018208, 31620204		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	31289574		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	30041188		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	24794439, 26669866		★★★★★ ★☆☆☆☆ Found in Text Mining only
Patent ductus arteriosus	Patent ductus arteriosus	BEFREE	24794439		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	23708710		★★★★★ ★☆☆☆☆ Found in Text Mining only
Renal carcinoma	Renal Carcinoma	BEFREE	31696435		★★★★★ ★☆☆☆☆ Found in Text Mining only
Sarcoidosis	Sarcoidosis	Pubtator	36472318	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Sepsis	Sepsis	Pubtator	36851633	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Septicemia	Septicemia	BEFREE	30408726		★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	36543379	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	32368784	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

PLAC8 (placenta associated 8)