Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	51301
Gene name	Glucosaminyl (N-acetyl) transferase 4
Gene symbol	GCNT4
Synonyms (NCBI Gene)	C2GNT3LINC01336
Chromosome	5
Chromosome location	5q13.3

Show/Hide all (82)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018642	hsa-miR-335-5p	Microarray	18185580
MIRT668209	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT668208	hsa-miR-6894-5p	HITS-CLIP	23824327
MIRT668207	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT668206	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT668205	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT668204	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT668203	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT668202	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT668201	hsa-miR-7977	HITS-CLIP	23824327
MIRT668200	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT668199	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT668198	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT668197	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT668196	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT668195	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT668194	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT668193	hsa-miR-3689c	HITS-CLIP	23824327
MIRT668192	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT668191	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT668190	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT668189	hsa-miR-3122	HITS-CLIP	23824327
MIRT668188	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT668187	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT668186	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT668209	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT668208	hsa-miR-6894-5p	HITS-CLIP	23824327
MIRT668207	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT668206	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT668205	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT668204	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT668203	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT668202	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT668201	hsa-miR-7977	HITS-CLIP	23824327
MIRT668200	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT668199	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT668198	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT668197	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT668196	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT668195	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT668194	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT668193	hsa-miR-3689c	HITS-CLIP	23824327
MIRT668192	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT668191	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT668190	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT668189	hsa-miR-3122	HITS-CLIP	23824327
MIRT668188	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT668187	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT668186	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT1015031	hsa-miR-101	CLIP-seq
MIRT1015032	hsa-miR-106a	CLIP-seq
MIRT1015033	hsa-miR-106b	CLIP-seq
MIRT1015034	hsa-miR-122	CLIP-seq
MIRT1015035	hsa-miR-128	CLIP-seq
MIRT1015036	hsa-miR-17	CLIP-seq
MIRT1015037	hsa-miR-20a	CLIP-seq
MIRT1015038	hsa-miR-20b	CLIP-seq
MIRT1015039	hsa-miR-27a	CLIP-seq
MIRT1015040	hsa-miR-27b	CLIP-seq
MIRT1015041	hsa-miR-3659	CLIP-seq
MIRT1015042	hsa-miR-515-3p	CLIP-seq
MIRT1015043	hsa-miR-519d	CLIP-seq
MIRT1015044	hsa-miR-519e	CLIP-seq
MIRT1015045	hsa-miR-548t	CLIP-seq
MIRT1015046	hsa-miR-550a	CLIP-seq
MIRT1015047	hsa-miR-93	CLIP-seq
MIRT2000514	hsa-miR-2116	CLIP-seq
MIRT2000515	hsa-miR-223	CLIP-seq
MIRT2000516	hsa-miR-3117-5p	CLIP-seq
MIRT2000517	hsa-miR-3614-5p	CLIP-seq
MIRT2000518	hsa-miR-4277	CLIP-seq
MIRT2000519	hsa-miR-432	CLIP-seq
MIRT2000520	hsa-miR-4633-3p	CLIP-seq
MIRT2000521	hsa-miR-587	CLIP-seq
MIRT2000522	hsa-miR-890	CLIP-seq
MIRT2234078	hsa-miR-199a-3p	CLIP-seq
MIRT2234079	hsa-miR-199b-3p	CLIP-seq
MIRT2234080	hsa-miR-24	CLIP-seq
MIRT2234081	hsa-miR-3129-5p	CLIP-seq
MIRT2234082	hsa-miR-4276	CLIP-seq
MIRT2234083	hsa-miR-4778-3p	CLIP-seq
MIRT2234084	hsa-miR-936	CLIP-seq

Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0000139	Component	Golgi membrane	TAS
GO:0001780	Process	Neutrophil homeostasis	IEA
GO:0002121	Process	Inter-male aggressive behavior	IEA
GO:0003829	Function	Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity	IEA
GO:0003829	Function	Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity	TAS
GO:0005794	Component	Golgi apparatus	IEA
GO:0005975	Process	Carbohydrate metabolic process	TAS	10753916
GO:0006486	Process	Protein glycosylation	IEA
GO:0006493	Process	Protein O-linked glycosylation	TAS	10753916
GO:0008109	Function	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity	TAS	10753916
GO:0008194	Function	UDP-glycosyltransferase activity	IEA
GO:0008375	Function	Acetylglucosaminyltransferase activity	IBA
GO:0009101	Process	Glycoprotein biosynthetic process	IEA
GO:0016020	Component	Membrane	IEA
GO:0016266	Process	Protein O-linked glycosylation via N-acetyl-galactosamine	TAS
GO:0016740	Function	Transferase activity	IEA
GO:0016757	Function	Glycosyltransferase activity	IEA
GO:0042403	Process	Thyroid hormone metabolic process	IEA
GO:0048729	Process	Tissue morphogenesis	IEA
GO:0060993	Process	Kidney morphogenesis	IEA

MIM	HGNC	e!Ensembl
616782	17973	ENSG00000176928

Q9P109

Protein name

Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 (EC 2.4.1.102) (Core 2-branching enzyme 3) (Core2-GlcNAc-transferase 3) (C2GnT3)

Protein function

Glycosyltransferase that mediates core 2 O-glycan branching, an important step in mucin-type biosynthesis. Does not have core 4 O-glycan or I-branching enzyme activity.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02485	Branch	133 → 402	Core-2/I-Branching enzyme	Family

Tissue specificity

TISSUE SPECIFICITY: Predominantly expressed in thymus. Weakly expressed in pancreas, peripheral blood leukocytes, placenta, small intestine and stomach. Barely detectable in liver, spleen, lung and lymph node. {ECO:0000269|PubMed:10753916}.

Sequence

MKIFKCYFKHTLQQKVFILFLTLWLLSLLKLLNVRRLFPQKDIYLVEYSLSTSPFVRNRY
THVKDEVRYEVNCSGIYEQEPLEIGKSLEIRRRDIIDLEDDDVVAMTSDCDIYQTLRGYA
QKLVSKEEKSFPIAYSLVVHKDAIMVERLIHAIYNQHNIYCIHYDRKAPDTFKVAMNNLA
KCFSNIFIASKLEAVEYAHISRLQADLNCLSDLLKSSIQWKYVINLCGQDFPLKSNFELV
SELKKLNGANMLETVKPPNSKLERFTYHHELRRVPYEYVKLPIRTNISKEAPPHNIQIFV
GSAYFVLSQAFVKYIFNNSIVQDFFAWSKDTYSPDEHFWATLIRVPGIPGEISRSAQDVS
DLQSKTRLVKWNYYEGFFYPSCTGSHLRSVCIYGAAELRWLIKDGHWFANKFDSKVDPIL
IKCLAEKLEEQQRDWITLPSEKLFMDRNLTTTS

Sequence length

453

Interactions

View interactions

	KEGG
	Mucin type O-glycan biosynthesis Metabolic pathways

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (2)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Cerebral Infarction	Ischemic stroke	Pubtator	31436916	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stroke	Stroke	Pubtator	31436916	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

GCNT4 (glucosaminyl (N-acetyl) transferase 4)