Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	51292
Gene name	Guanosine monophosphate reductase 2
Gene symbol	GMPR2
Synonyms (NCBI Gene)	GMPR 2hGMPR-II
Chromosome	14
Chromosome location	14q12
Summary	This gene encodes an enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of guanosine monophosphate (GMP) to inosine monophosphate (IMP). The protein also functions in the re-utilization of free intracellular bases and purine

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miRTarBase ID	miRNA	Experiments	Reference
MIRT022133	hsa-miR-124-3p	Microarray	18668037
MIRT027420	hsa-miR-98-5p	Microarray	19088304
MIRT041522	hsa-miR-193b-3p	CLASH	23622248
MIRT1022761	hsa-let-7a	CLIP-seq
MIRT1022762	hsa-let-7b	CLIP-seq
MIRT1022763	hsa-let-7c	CLIP-seq
MIRT1022764	hsa-let-7d	CLIP-seq
MIRT1022765	hsa-let-7e	CLIP-seq
MIRT1022766	hsa-let-7f	CLIP-seq
MIRT1022767	hsa-let-7g	CLIP-seq
MIRT1022768	hsa-let-7i	CLIP-seq
MIRT1022769	hsa-miR-147	CLIP-seq
MIRT1022770	hsa-miR-202	CLIP-seq
MIRT1022771	hsa-miR-2113	CLIP-seq
MIRT1022772	hsa-miR-2115	CLIP-seq
MIRT1022773	hsa-miR-2355-5p	CLIP-seq
MIRT1022774	hsa-miR-300	CLIP-seq
MIRT1022775	hsa-miR-3174	CLIP-seq
MIRT1022776	hsa-miR-3189-3p	CLIP-seq
MIRT1022777	hsa-miR-3670	CLIP-seq
MIRT1022778	hsa-miR-3671	CLIP-seq
MIRT1022779	hsa-miR-381	CLIP-seq
MIRT1022780	hsa-miR-3944-5p	CLIP-seq
MIRT1022781	hsa-miR-3945	CLIP-seq
MIRT1022782	hsa-miR-3977	CLIP-seq
MIRT1022783	hsa-miR-4253	CLIP-seq
MIRT1022784	hsa-miR-4312	CLIP-seq
MIRT1022785	hsa-miR-4458	CLIP-seq
MIRT1022786	hsa-miR-4461	CLIP-seq
MIRT1022787	hsa-miR-4494	CLIP-seq
MIRT1022788	hsa-miR-4500	CLIP-seq
MIRT1022789	hsa-miR-452	CLIP-seq
MIRT1022790	hsa-miR-4666-3p	CLIP-seq
MIRT1022791	hsa-miR-4676-3p	CLIP-seq
MIRT1022792	hsa-miR-4678	CLIP-seq
MIRT1022793	hsa-miR-4691-5p	CLIP-seq
MIRT1022794	hsa-miR-4753-3p	CLIP-seq
MIRT1022795	hsa-miR-499a-5p	CLIP-seq
MIRT1022796	hsa-miR-502-5p	CLIP-seq
MIRT1022797	hsa-miR-515-3p	CLIP-seq
MIRT1022798	hsa-miR-516a-3p	CLIP-seq
MIRT1022799	hsa-miR-519e	CLIP-seq
MIRT1022800	hsa-miR-556-5p	CLIP-seq
MIRT1022801	hsa-miR-582-5p	CLIP-seq
MIRT1022802	hsa-miR-599	CLIP-seq
MIRT1022803	hsa-miR-607	CLIP-seq
MIRT1022804	hsa-miR-635	CLIP-seq
MIRT1022805	hsa-miR-98	CLIP-seq
MIRT2539954	hsa-miR-1224-5p	CLIP-seq
MIRT2539955	hsa-miR-1262	CLIP-seq
MIRT2539956	hsa-miR-1278	CLIP-seq
MIRT2539957	hsa-miR-3132	CLIP-seq
MIRT1022776	hsa-miR-3189-3p	CLIP-seq
MIRT2539958	hsa-miR-3189-5p	CLIP-seq
MIRT2539959	hsa-miR-3529	CLIP-seq
MIRT2539960	hsa-miR-3614-5p	CLIP-seq
MIRT2539961	hsa-miR-3689a-3p	CLIP-seq
MIRT2539962	hsa-miR-3689c	CLIP-seq
MIRT2539963	hsa-miR-374c	CLIP-seq
MIRT2539964	hsa-miR-379	CLIP-seq
MIRT2539965	hsa-miR-3973	CLIP-seq
MIRT2539966	hsa-miR-4286	CLIP-seq
MIRT1022784	hsa-miR-4312	CLIP-seq
MIRT2539967	hsa-miR-4451	CLIP-seq
MIRT2539968	hsa-miR-450b-3p	CLIP-seq
MIRT2539969	hsa-miR-4650-3p	CLIP-seq
MIRT2539970	hsa-miR-4701-3p	CLIP-seq
MIRT2539971	hsa-miR-4710	CLIP-seq
MIRT2539972	hsa-miR-4728-5p	CLIP-seq
MIRT2539973	hsa-miR-4751	CLIP-seq
MIRT2539974	hsa-miR-4758-3p	CLIP-seq
MIRT2539975	hsa-miR-4797-5p	CLIP-seq
MIRT2539976	hsa-miR-548a-5p	CLIP-seq
MIRT2539977	hsa-miR-548ab	CLIP-seq
MIRT2539978	hsa-miR-548ak	CLIP-seq
MIRT2539979	hsa-miR-548b-5p	CLIP-seq
MIRT2539980	hsa-miR-548c-5p	CLIP-seq
MIRT2539981	hsa-miR-548d-5p	CLIP-seq
MIRT2539982	hsa-miR-548h	CLIP-seq
MIRT2539983	hsa-miR-548i	CLIP-seq
MIRT2539984	hsa-miR-548j	CLIP-seq
MIRT2539985	hsa-miR-548q	CLIP-seq
MIRT2539986	hsa-miR-548w	CLIP-seq
MIRT2539987	hsa-miR-548y	CLIP-seq
MIRT2539988	hsa-miR-558	CLIP-seq
MIRT2539989	hsa-miR-559	CLIP-seq
MIRT2539990	hsa-miR-655	CLIP-seq
MIRT2539991	hsa-miR-767-3p	CLIP-seq
MIRT2539992	hsa-miR-769-3p	CLIP-seq
MIRT2539954	hsa-miR-1224-5p	CLIP-seq
MIRT2539955	hsa-miR-1262	CLIP-seq
MIRT2539956	hsa-miR-1278	CLIP-seq
MIRT1022776	hsa-miR-3189-3p	CLIP-seq
MIRT2539958	hsa-miR-3189-5p	CLIP-seq
MIRT2539959	hsa-miR-3529	CLIP-seq
MIRT2539960	hsa-miR-3614-5p	CLIP-seq
MIRT2539961	hsa-miR-3689a-3p	CLIP-seq
MIRT2539962	hsa-miR-3689c	CLIP-seq
MIRT2539963	hsa-miR-374c	CLIP-seq
MIRT2539964	hsa-miR-379	CLIP-seq
MIRT2539965	hsa-miR-3973	CLIP-seq
MIRT2539966	hsa-miR-4286	CLIP-seq
MIRT1022784	hsa-miR-4312	CLIP-seq
MIRT2539967	hsa-miR-4451	CLIP-seq
MIRT2539968	hsa-miR-450b-3p	CLIP-seq
MIRT2539969	hsa-miR-4650-3p	CLIP-seq
MIRT2539970	hsa-miR-4701-3p	CLIP-seq
MIRT2539971	hsa-miR-4710	CLIP-seq
MIRT2539972	hsa-miR-4728-5p	CLIP-seq
MIRT2539973	hsa-miR-4751	CLIP-seq
MIRT2539974	hsa-miR-4758-3p	CLIP-seq
MIRT2539975	hsa-miR-4797-5p	CLIP-seq
MIRT2539976	hsa-miR-548a-5p	CLIP-seq
MIRT2539977	hsa-miR-548ab	CLIP-seq
MIRT2539978	hsa-miR-548ak	CLIP-seq
MIRT2539979	hsa-miR-548b-5p	CLIP-seq
MIRT2539980	hsa-miR-548c-5p	CLIP-seq
MIRT2539981	hsa-miR-548d-5p	CLIP-seq
MIRT2539982	hsa-miR-548h	CLIP-seq
MIRT2539983	hsa-miR-548i	CLIP-seq
MIRT2539984	hsa-miR-548j	CLIP-seq
MIRT2539985	hsa-miR-548q	CLIP-seq
MIRT2539986	hsa-miR-548w	CLIP-seq
MIRT2539987	hsa-miR-548y	CLIP-seq
MIRT2539988	hsa-miR-558	CLIP-seq
MIRT2539989	hsa-miR-559	CLIP-seq
MIRT2539990	hsa-miR-655	CLIP-seq
MIRT2539992	hsa-miR-769-3p	CLIP-seq

Show/Hide all (12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003824	Function	Catalytic activity	IEA
GO:0003920	Function	GMP reductase activity	IDA	12669231, 22037469
GO:0003920	Function	GMP reductase activity	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 33961781
GO:0005829	Component	Cytosol	TAS
GO:0006144	Process	Purine nucleobase metabolic process	IEA
GO:0006163	Process	Purine nucleotide metabolic process	IEA
GO:0009117	Process	Nucleotide metabolic process	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0046037	Process	GMP metabolic process	IDA	22037469
GO:0046872	Function	Metal ion binding	IEA
GO:1902560	Component	GMP reductase complex	IEA

MIM	HGNC	e!Ensembl
610781	4377	ENSG00000100938

Q9P2T1

Protein name

GMP reductase 2 (GMPR 2) (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase 2) (Guanosine monophosphate reductase 2)

Protein function

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides

PDB

2A7R , 2BZN , 2C6Q

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00478	IMPDH	9 → 341	IMP dehydrogenase / GMP reductase domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in heart, skeletal muscle, kidney, brain, liver, prostate, spleen, placenta, testis and ovary. Low expression in colon, thymus and peripheral blood leukocytes. {ECO:0000269|PubMed:12009299, ECO:0000269|PubMed:12669231}

Sequence

MPHIDNDVKLDFKDVLLRPKRSTLKSRSEVDLTRSFSFRNSKQTYSGVPIIAANMDTVGT
FEMAKVLCKFSLFTAVHKHYSLVQWQEFAGQNPDCLEHLAASSGTGSSDFEQLEQILEAI
PQVKYICLDVANGYSEHFVEFVKDVRKRFPQHTIMAGNVVTGEMVEELILSGADIIKVGI
GPGSVCTTRKKTGVGYPQLSAVMECADAAHGLKGHIISDGGCSCPGDVAKAFGAGADFVM
LGGMLAGHSESGGELIERDGKKYKLFYGMSSEMAMKKYAGGVAEYRASEGKTVEVPFKGD
VEHTIRDILGGIRSTCTYVGAAKLKELSRRTTFIRVTQQVNPIFSEAC

Sequence length

348

Interactions

View interactions

	KEGG		Reactome
	Purine metabolism Metabolic pathways Nucleotide metabolism		Purine salvage

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
STOMACH NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UTERINE FIBROID	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (13)

Disease Name	Disease (Merged)	Source	PMID	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma	Adenocarcinoma	CTD_human_DG	15378696	★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma, Basal Cell	Adenocarcinoma	CTD_human_DG	15378696	★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma, Oxyphilic	Adenocarcinoma	CTD_human_DG	15378696	★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma, Tubular	Adenocarcinoma	CTD_human_DG	15378696	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	23208589	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Cribriform	Carcinoma	CTD_human_DG	15378696	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Granular Cell	Carcinoma	CTD_human_DG	15378696	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hereditary Diffuse Gastric Cancer	Gastric Cancer	CTD_human_DG	15378696	★★★★★ ★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	LHGDN	12669231	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	23208589	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	CTD_human_DG	15378696	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	23208589	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach Neoplasms	CTD_human_DG	15378696	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

GMPR2 (guanosine monophosphate reductase 2)