Gene Gene information from NCBI Gene database.
Entrez ID 51277
Gene name DnaJ heat shock protein family (Hsp40) member C27
Gene symbol DNAJC27
Synonyms (NCBI Gene)
RBJRabJS
Chromosome 2
Chromosome location 2p23.3
miRNA miRNA information provided by mirtarbase database.
480
miRTarBase ID miRNA Experiments Reference
MIRT004525 hsa-miR-17-5p Luciferase reporter assay 19734348
MIRT016128 hsa-miR-421 Sequencing 20371350
MIRT021095 hsa-miR-186-5p Sequencing 20371350
MIRT021913 hsa-miR-128-3p Sequencing 20371350
MIRT025711 hsa-miR-7-5p Sequencing 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
10
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0003924 Function GTPase activity IBA
GO:0003924 Function GTPase activity IEA
GO:0005515 Function Protein binding IPI 25416956, 32296183
GO:0005525 Function GTP binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
613527 30290 ENSG00000115137
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9NZQ0
Protein name DnaJ homolog subfamily C member 27 (Rab and DnaJ domain-containing protein)
Protein function GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. {ECO:0000
PDB 2YS8
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras 18 184 Ras family Domain
PF00226 DnaJ 217 273 DnaJ domain Domain
Tissue specificity TISSUE SPECIFICITY: Overexpressed in gastrointestinal cancers; expression correlates with later tumor-node-metastasis stages of colorectal cancers. {ECO:0000269|PubMed:24746703}.
Sequence
Sequence length 273
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
METABOLIC SYNDROME GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
OBESITY GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Breast Carcinoma Breast Carcinoma BEFREE 28197363
★☆☆☆☆
Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent Diabetes Mellitus BEFREE 30131766
★☆☆☆☆
Found in Text Mining only
Glaucoma Open Angle Open angle glaucoma Pubtator 32178636 Associate
★☆☆☆☆
Found in Text Mining only
Inflammatory Bowel Diseases Inflammatory bowel disease Pubtator 37988718 Associate
★☆☆☆☆
Found in Text Mining only
Intervertebral Disc Degeneration Intervertebral disc disease Pubtator 38492610 Associate
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of breast Breast Cancer BEFREE 28197363
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of gastrointestinal tract Malignant gastrointestinal tract tumors BEFREE 24746703, 28197363
★☆☆☆☆
Found in Text Mining only
Neoplasms Neoplasms BEFREE 28197363
★☆☆☆☆
Found in Text Mining only
Obesity Obesity BEFREE 24788522, 30131766
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Obesity Obesity Pubtator 26800887, 32733386, 34207686, 34836030 Associate
★★☆☆☆
Found in Text Mining + Unknown/Other Associations