DNAJC27 (DnaJ heat shock protein family (Hsp40) member C27)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 51277 |
| Gene name | DnaJ heat shock protein family (Hsp40) member C27 |
| Gene symbol | DNAJC27 |
| Synonyms (NCBI Gene) |
RBJRabJS
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| Chromosome | 2 |
| Chromosome location | 2p23.3 |
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miRNA
miRNA information provided by mirtarbase database.
480
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
10
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q9NZQ0 | |||||||||||||||
| Protein name | DnaJ homolog subfamily C member 27 (Rab and DnaJ domain-containing protein) | |||||||||||||||
| Protein function | GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. {ECO:0000 | |||||||||||||||
| PDB | 2YS8 | |||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Overexpressed in gastrointestinal cancers; expression correlates with later tumor-node-metastasis stages of colorectal cancers. {ECO:0000269|PubMed:24746703}. | |||||||||||||||
| Sequence |
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| Sequence length | 273 | |||||||||||||||
| Interactions | View interactions | |||||||||||||||
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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