PCSK2 (proprotein convertase subtilisin/kexin type 2)

Gene

• Entrez ID: 5126
• Gene name: Proprotein convertase subtilisin/kexin type 2
• Gene symbol: PCSK2
• Synonyms (NCBI Gene): NEC 2, NEC-2, NEC2, PC2, SPC2
• Chromosome: 20
• Chromosome location: 20p12.1
• Summary: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The protein undergoes an

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT483164	hsa-miR-4694-3p	HITS-CLIP	21572407
MIRT483163	hsa-miR-224-3p	HITS-CLIP	21572407
MIRT483162	hsa-miR-522-3p	HITS-CLIP	21572407
MIRT483161	hsa-miR-211-3p	HITS-CLIP	21572407
MIRT483160	hsa-miR-4270	HITS-CLIP	21572407
MIRT483159	hsa-miR-4441	HITS-CLIP	21572407
MIRT483158	hsa-miR-6754-5p	HITS-CLIP	21572407
MIRT483157	hsa-miR-3664-3p	HITS-CLIP	21572407
MIRT483156	hsa-miR-1266-5p	HITS-CLIP	21572407
MIRT483155	hsa-miR-4518	HITS-CLIP	21572407
MIRT483154	hsa-miR-1288-3p	HITS-CLIP	21572407
MIRT483153	hsa-miR-3199	HITS-CLIP	21572407
MIRT483152	hsa-miR-8052	HITS-CLIP	21572407
MIRT483151	hsa-miR-5011-3p	HITS-CLIP	21572407
MIRT483150	hsa-miR-4666b	HITS-CLIP	21572407
MIRT483149	hsa-miR-6843-3p	HITS-CLIP	21572407
MIRT483148	hsa-miR-6848-3p	HITS-CLIP	21572407
MIRT610273	hsa-miR-144-5p	HITS-CLIP	23824327
MIRT610272	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT610271	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT610270	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT610269	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT614875	hsa-miR-4328	HITS-CLIP	23824327
MIRT610273	hsa-miR-144-5p	HITS-CLIP	23824327
MIRT610272	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT610271	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT610270	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT610269	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT614875	hsa-miR-4328	HITS-CLIP	23824327
MIRT610273	hsa-miR-144-5p	HITS-CLIP	23824327
MIRT610272	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT610271	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT610270	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT610269	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT614875	hsa-miR-4328	HITS-CLIP	23824327
MIRT610273	hsa-miR-144-5p	HITS-CLIP	23824327
MIRT610272	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT610271	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT610270	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT610269	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT618721	hsa-miR-660-5p	HITS-CLIP	23824327
MIRT618720	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT610273	hsa-miR-144-5p	HITS-CLIP	23824327
MIRT610272	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT610271	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT610270	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT610269	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT614875	hsa-miR-4328	HITS-CLIP	23824327
MIRT610273	hsa-miR-144-5p	HITS-CLIP	23824327
MIRT610272	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT610271	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT610270	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT610269	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT614875	hsa-miR-4328	HITS-CLIP	23824327
MIRT610273	hsa-miR-144-5p	HITS-CLIP	23824327
MIRT610272	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT610271	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT610270	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT610269	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT614875	hsa-miR-4328	HITS-CLIP	23824327
MIRT610273	hsa-miR-144-5p	HITS-CLIP	23824327
MIRT610272	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT610271	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT610270	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT610269	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT610273	hsa-miR-144-5p	HITS-CLIP	23824327
MIRT610272	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT610271	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT610270	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT610269	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT483164	hsa-miR-4694-3p	PAR-CLIP	21572407
MIRT483163	hsa-miR-224-3p	PAR-CLIP	21572407
MIRT483162	hsa-miR-522-3p	PAR-CLIP	21572407
MIRT483161	hsa-miR-211-3p	PAR-CLIP	21572407
MIRT483160	hsa-miR-4270	PAR-CLIP	21572407
MIRT483159	hsa-miR-4441	PAR-CLIP	21572407
MIRT483158	hsa-miR-6754-5p	PAR-CLIP	21572407
MIRT483157	hsa-miR-3664-3p	PAR-CLIP	21572407
MIRT483156	hsa-miR-1266-5p	PAR-CLIP	21572407
MIRT483155	hsa-miR-4518	PAR-CLIP	21572407
MIRT483154	hsa-miR-1288-3p	PAR-CLIP	21572407
MIRT483153	hsa-miR-3199	PAR-CLIP	21572407
MIRT483152	hsa-miR-8052	PAR-CLIP	21572407
MIRT483151	hsa-miR-5011-3p	PAR-CLIP	21572407
MIRT483150	hsa-miR-4666b	PAR-CLIP	21572407
MIRT483149	hsa-miR-6843-3p	PAR-CLIP	21572407
MIRT483148	hsa-miR-6848-3p	PAR-CLIP	21572407
MIRT483164	hsa-miR-4694-3p	PAR-CLIP	24398324
MIRT483163	hsa-miR-224-3p	PAR-CLIP	24398324
MIRT483162	hsa-miR-522-3p	PAR-CLIP	24398324
MIRT483161	hsa-miR-211-3p	PAR-CLIP	24398324
MIRT483160	hsa-miR-4270	PAR-CLIP	24398324
MIRT483159	hsa-miR-4441	PAR-CLIP	24398324
MIRT483158	hsa-miR-6754-5p	PAR-CLIP	24398324
MIRT483157	hsa-miR-3664-3p	PAR-CLIP	24398324
MIRT483156	hsa-miR-1266-5p	PAR-CLIP	24398324
MIRT483155	hsa-miR-4518	PAR-CLIP	24398324
MIRT483154	hsa-miR-1288-3p	PAR-CLIP	24398324
MIRT483153	hsa-miR-3199	PAR-CLIP	24398324
MIRT483152	hsa-miR-8052	PAR-CLIP	24398324
MIRT483151	hsa-miR-5011-3p	PAR-CLIP	24398324
MIRT483150	hsa-miR-4666b	PAR-CLIP	24398324
MIRT483149	hsa-miR-6843-3p	PAR-CLIP	24398324
MIRT483148	hsa-miR-6848-3p	PAR-CLIP	24398324
MIRT483164	hsa-miR-4694-3p	PAR-CLIP	23592263
MIRT483163	hsa-miR-224-3p	PAR-CLIP	23592263
MIRT483162	hsa-miR-522-3p	PAR-CLIP	23592263
MIRT483161	hsa-miR-211-3p	PAR-CLIP	23592263
MIRT483160	hsa-miR-4270	PAR-CLIP	23592263
MIRT483159	hsa-miR-4441	PAR-CLIP	23592263
MIRT483158	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT483157	hsa-miR-3664-3p	PAR-CLIP	23592263
MIRT483156	hsa-miR-1266-5p	PAR-CLIP	23592263
MIRT483155	hsa-miR-4518	PAR-CLIP	23592263
MIRT483154	hsa-miR-1288-3p	PAR-CLIP	23592263
MIRT483153	hsa-miR-3199	PAR-CLIP	23592263
MIRT483152	hsa-miR-8052	PAR-CLIP	23592263
MIRT483151	hsa-miR-5011-3p	PAR-CLIP	23592263
MIRT483150	hsa-miR-4666b	PAR-CLIP	23592263
MIRT483149	hsa-miR-6843-3p	PAR-CLIP	23592263
MIRT483148	hsa-miR-6848-3p	PAR-CLIP	23592263
MIRT483156	hsa-miR-1266-5p	PAR-CLIP	26701625
MIRT483156	hsa-miR-1266-5p	PAR-CLIP	26701625
MIRT483154	hsa-miR-1288-3p	PAR-CLIP	26701625
MIRT483154	hsa-miR-1288-3p	PAR-CLIP	26701625
MIRT483161	hsa-miR-211-3p	PAR-CLIP	26701625
MIRT483161	hsa-miR-211-3p	PAR-CLIP	26701625
MIRT483163	hsa-miR-224-3p	PAR-CLIP	26701625
MIRT483163	hsa-miR-224-3p	PAR-CLIP	26701625
MIRT483153	hsa-miR-3199	PAR-CLIP	26701625
MIRT483153	hsa-miR-3199	PAR-CLIP	26701625
MIRT483157	hsa-miR-3664-3p	PAR-CLIP	26701625
MIRT483157	hsa-miR-3664-3p	PAR-CLIP	26701625
MIRT483160	hsa-miR-4270	PAR-CLIP	26701625
MIRT483160	hsa-miR-4270	PAR-CLIP	26701625
MIRT483159	hsa-miR-4441	PAR-CLIP	26701625
MIRT483159	hsa-miR-4441	PAR-CLIP	26701625
MIRT483155	hsa-miR-4518	PAR-CLIP	26701625
MIRT483155	hsa-miR-4518	PAR-CLIP	26701625
MIRT483150	hsa-miR-4666b	PAR-CLIP	26701625
MIRT483150	hsa-miR-4666b	PAR-CLIP	26701625
MIRT483164	hsa-miR-4694-3p	PAR-CLIP	26701625
MIRT483164	hsa-miR-4694-3p	PAR-CLIP	26701625
MIRT483151	hsa-miR-5011-3p	PAR-CLIP	26701625
MIRT483151	hsa-miR-5011-3p	PAR-CLIP	26701625
MIRT483162	hsa-miR-522-3p	PAR-CLIP	26701625
MIRT483162	hsa-miR-522-3p	PAR-CLIP	26701625
MIRT483158	hsa-miR-6754-5p	PAR-CLIP	26701625
MIRT483158	hsa-miR-6754-5p	PAR-CLIP	26701625
MIRT483149	hsa-miR-6843-3p	PAR-CLIP	26701625
MIRT483149	hsa-miR-6843-3p	PAR-CLIP	26701625
MIRT483148	hsa-miR-6848-3p	PAR-CLIP	26701625
MIRT483148	hsa-miR-6848-3p	PAR-CLIP	26701625
MIRT483152	hsa-miR-8052	PAR-CLIP	26701625
MIRT483152	hsa-miR-8052	PAR-CLIP	26701625
MIRT610273	hsa-miR-144-5p	HITS-CLIP	27418678
MIRT610273	hsa-miR-144-5p	HITS-CLIP	27418678
MIRT610273	hsa-miR-144-5p	HITS-CLIP	27418678
MIRT610273	hsa-miR-144-5p	HITS-CLIP	27418678
MIRT610273	hsa-miR-144-5p	HITS-CLIP	27418678
MIRT610272	hsa-miR-30a-3p	HITS-CLIP	27418678
MIRT610272	hsa-miR-30a-3p	HITS-CLIP	27418678
MIRT610272	hsa-miR-30a-3p	HITS-CLIP	27418678
MIRT610272	hsa-miR-30a-3p	HITS-CLIP	27418678
MIRT610272	hsa-miR-30a-3p	HITS-CLIP	27418678
MIRT610271	hsa-miR-30d-3p	HITS-CLIP	27418678
MIRT610271	hsa-miR-30d-3p	HITS-CLIP	27418678
MIRT610271	hsa-miR-30d-3p	HITS-CLIP	27418678
MIRT610271	hsa-miR-30d-3p	HITS-CLIP	27418678
MIRT610271	hsa-miR-30d-3p	HITS-CLIP	27418678
MIRT610270	hsa-miR-30e-3p	HITS-CLIP	27418678
MIRT610270	hsa-miR-30e-3p	HITS-CLIP	27418678
MIRT610270	hsa-miR-30e-3p	HITS-CLIP	27418678
MIRT610270	hsa-miR-30e-3p	HITS-CLIP	27418678
MIRT610270	hsa-miR-30e-3p	HITS-CLIP	27418678
MIRT610269	hsa-miR-335-3p	HITS-CLIP	27418678
MIRT610269	hsa-miR-335-3p	HITS-CLIP	27418678
MIRT610269	hsa-miR-335-3p	HITS-CLIP	27418678
MIRT610269	hsa-miR-335-3p	HITS-CLIP	27418678
MIRT610269	hsa-miR-335-3p	HITS-CLIP	27418678
MIRT614875	hsa-miR-4328	HITS-CLIP	27418678
MIRT614875	hsa-miR-4328	HITS-CLIP	27418678
MIRT614875	hsa-miR-4328	HITS-CLIP	27418678
MIRT614875	hsa-miR-4328	HITS-CLIP	27418678
MIRT614875	hsa-miR-4328	HITS-CLIP	27418678
MIRT738878	hsa-miR-1288	HITS-CLIP	33718276
MIRT483160	hsa-miR-4270	HITS-CLIP	33718276
MIRT483155	hsa-miR-4518	HITS-CLIP	33718276
MIRT483164	hsa-miR-4694-3p	HITS-CLIP	33718276
MIRT483164	hsa-miR-4694-3p	HITS-CLIP	21572407
MIRT483163	hsa-miR-224-3p	HITS-CLIP	21572407
MIRT483162	hsa-miR-522-3p	HITS-CLIP	21572407
MIRT483161	hsa-miR-211-3p	HITS-CLIP	21572407
MIRT483160	hsa-miR-4270	HITS-CLIP	21572407
MIRT483159	hsa-miR-4441	HITS-CLIP	21572407
MIRT483158	hsa-miR-6754-5p	HITS-CLIP	21572407
MIRT483157	hsa-miR-3664-3p	HITS-CLIP	21572407
MIRT483156	hsa-miR-1266-5p	HITS-CLIP	21572407
MIRT483155	hsa-miR-4518	HITS-CLIP	21572407
MIRT483154	hsa-miR-1288-3p	HITS-CLIP	21572407
MIRT483153	hsa-miR-3199	HITS-CLIP	21572407
MIRT483152	hsa-miR-8052	HITS-CLIP	21572407
MIRT483151	hsa-miR-5011-3p	HITS-CLIP	21572407
MIRT483150	hsa-miR-4666b	HITS-CLIP	21572407
MIRT483149	hsa-miR-6843-3p	HITS-CLIP	21572407
MIRT483148	hsa-miR-6848-3p	HITS-CLIP	21572407
MIRT610273	hsa-miR-144-5p	HITS-CLIP	23824327
MIRT610272	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT610271	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT610270	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT610269	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT614875	hsa-miR-4328	HITS-CLIP	23824327
MIRT610273	hsa-miR-144-5p	HITS-CLIP	23824327
MIRT610272	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT610271	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT610270	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT610269	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT614875	hsa-miR-4328	HITS-CLIP	23824327
MIRT610273	hsa-miR-144-5p	HITS-CLIP	23824327
MIRT610272	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT610271	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT610270	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT610269	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT614875	hsa-miR-4328	HITS-CLIP	23824327
MIRT610273	hsa-miR-144-5p	HITS-CLIP	23824327
MIRT610272	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT610271	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT610270	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT610269	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT618721	hsa-miR-660-5p	HITS-CLIP	23824327
MIRT618720	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT610273	hsa-miR-144-5p	HITS-CLIP	23824327
MIRT610272	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT610271	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT610270	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT610269	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT614875	hsa-miR-4328	HITS-CLIP	23824327
MIRT610273	hsa-miR-144-5p	HITS-CLIP	23824327
MIRT610272	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT610271	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT610270	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT610269	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT614875	hsa-miR-4328	HITS-CLIP	23824327
MIRT610273	hsa-miR-144-5p	HITS-CLIP	23824327
MIRT610272	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT610271	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT610270	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT610269	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT614875	hsa-miR-4328	HITS-CLIP	23824327
MIRT610273	hsa-miR-144-5p	HITS-CLIP	23824327
MIRT610272	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT610271	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT610270	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT610269	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT610273	hsa-miR-144-5p	HITS-CLIP	23824327
MIRT610272	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT610271	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT610270	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT610269	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT483164	hsa-miR-4694-3p	PAR-CLIP	21572407
MIRT483163	hsa-miR-224-3p	PAR-CLIP	21572407
MIRT483162	hsa-miR-522-3p	PAR-CLIP	21572407
MIRT483161	hsa-miR-211-3p	PAR-CLIP	21572407
MIRT483160	hsa-miR-4270	PAR-CLIP	21572407
MIRT483159	hsa-miR-4441	PAR-CLIP	21572407
MIRT483158	hsa-miR-6754-5p	PAR-CLIP	21572407
MIRT483157	hsa-miR-3664-3p	PAR-CLIP	21572407
MIRT483156	hsa-miR-1266-5p	PAR-CLIP	21572407
MIRT483155	hsa-miR-4518	PAR-CLIP	21572407
MIRT483154	hsa-miR-1288-3p	PAR-CLIP	21572407
MIRT483153	hsa-miR-3199	PAR-CLIP	21572407
MIRT483152	hsa-miR-8052	PAR-CLIP	21572407
MIRT483151	hsa-miR-5011-3p	PAR-CLIP	21572407
MIRT483150	hsa-miR-4666b	PAR-CLIP	21572407
MIRT483149	hsa-miR-6843-3p	PAR-CLIP	21572407
MIRT483148	hsa-miR-6848-3p	PAR-CLIP	21572407
MIRT483164	hsa-miR-4694-3p	PAR-CLIP	24398324
MIRT483163	hsa-miR-224-3p	PAR-CLIP	24398324
MIRT483162	hsa-miR-522-3p	PAR-CLIP	24398324
MIRT483161	hsa-miR-211-3p	PAR-CLIP	24398324
MIRT483160	hsa-miR-4270	PAR-CLIP	24398324
MIRT483159	hsa-miR-4441	PAR-CLIP	24398324
MIRT483158	hsa-miR-6754-5p	PAR-CLIP	24398324
MIRT483157	hsa-miR-3664-3p	PAR-CLIP	24398324
MIRT483156	hsa-miR-1266-5p	PAR-CLIP	24398324
MIRT483155	hsa-miR-4518	PAR-CLIP	24398324
MIRT483154	hsa-miR-1288-3p	PAR-CLIP	24398324
MIRT483153	hsa-miR-3199	PAR-CLIP	24398324
MIRT483152	hsa-miR-8052	PAR-CLIP	24398324
MIRT483151	hsa-miR-5011-3p	PAR-CLIP	24398324
MIRT483150	hsa-miR-4666b	PAR-CLIP	24398324
MIRT483149	hsa-miR-6843-3p	PAR-CLIP	24398324
MIRT483148	hsa-miR-6848-3p	PAR-CLIP	24398324
MIRT483164	hsa-miR-4694-3p	PAR-CLIP	23592263
MIRT483163	hsa-miR-224-3p	PAR-CLIP	23592263
MIRT483162	hsa-miR-522-3p	PAR-CLIP	23592263
MIRT483161	hsa-miR-211-3p	PAR-CLIP	23592263
MIRT483160	hsa-miR-4270	PAR-CLIP	23592263
MIRT483159	hsa-miR-4441	PAR-CLIP	23592263
MIRT483158	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT483157	hsa-miR-3664-3p	PAR-CLIP	23592263
MIRT483156	hsa-miR-1266-5p	PAR-CLIP	23592263
MIRT483155	hsa-miR-4518	PAR-CLIP	23592263
MIRT483154	hsa-miR-1288-3p	PAR-CLIP	23592263
MIRT483153	hsa-miR-3199	PAR-CLIP	23592263
MIRT483152	hsa-miR-8052	PAR-CLIP	23592263
MIRT483151	hsa-miR-5011-3p	PAR-CLIP	23592263
MIRT483150	hsa-miR-4666b	PAR-CLIP	23592263
MIRT483149	hsa-miR-6843-3p	PAR-CLIP	23592263
MIRT483148	hsa-miR-6848-3p	PAR-CLIP	23592263
MIRT738879	hsa-miR-1266	CLIP-seq
MIRT738880	hsa-miR-522	CLIP-seq
MIRT738879	hsa-miR-1266	CLIP-seq
MIRT1218467	hsa-miR-200b	CLIP-seq
MIRT1218468	hsa-miR-200c	CLIP-seq
MIRT1218469	hsa-miR-2355-5p	CLIP-seq
MIRT1218470	hsa-miR-3124-3p	CLIP-seq
MIRT1218471	hsa-miR-3613-3p	CLIP-seq
MIRT1218472	hsa-miR-3646	CLIP-seq
MIRT1218473	hsa-miR-3662	CLIP-seq
MIRT1218474	hsa-miR-3679-3p	CLIP-seq
MIRT1218475	hsa-miR-3690	CLIP-seq
MIRT1218476	hsa-miR-374c	CLIP-seq
MIRT1218477	hsa-miR-4254	CLIP-seq
MIRT1218478	hsa-miR-429	CLIP-seq
MIRT1218479	hsa-miR-4753-3p	CLIP-seq
MIRT738880	hsa-miR-522	CLIP-seq
MIRT1218480	hsa-miR-655	CLIP-seq
MIRT738879	hsa-miR-1266	CLIP-seq
MIRT738880	hsa-miR-522	CLIP-seq
MIRT738879	hsa-miR-1266	CLIP-seq
MIRT738880	hsa-miR-522	CLIP-seq
MIRT738879	hsa-miR-1266	CLIP-seq
MIRT738880	hsa-miR-522	CLIP-seq
MIRT738879	hsa-miR-1266	CLIP-seq
MIRT738880	hsa-miR-522	CLIP-seq
MIRT2589366	hsa-miR-1253	CLIP-seq
MIRT2589367	hsa-miR-1303	CLIP-seq
MIRT2589368	hsa-miR-3123	CLIP-seq
MIRT2589369	hsa-miR-3925-5p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
EGR1	Activation	9359835

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004175	Function	Endopeptidase activity	IEA
GO:0004252	Function	Serine-type endopeptidase activity	IBA
GO:0004252	Function	Serine-type endopeptidase activity	IDA	7626024
GO:0004252	Function	Serine-type endopeptidase activity	IEA
GO:0005515	Function	Protein binding	IPI	7913882, 32814053
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IDA	9020868, 28719828
GO:0005615	Component	Extracellular space	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0006508	Process	Proteolysis	IDA	7626024
GO:0006508	Process	Proteolysis	IEA
GO:0006508	Process	Proteolysis	IEA
GO:0007399	Process	Nervous system development	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008236	Function	Serine-type peptidase activity	IEA
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IDA	8034613
GO:0016485	Process	Protein processing	IEA
GO:0016486	Process	Peptide hormone processing	IBA
GO:0016486	Process	Peptide hormone processing	IDA	28719828
GO:0016486	Process	Peptide hormone processing	IEA
GO:0016540	Process	Protein autoprocessing	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0030070	Process	Insulin processing	IDA	7626024
GO:0030070	Process	Insulin processing	IEA
GO:0030133	Component	Transport vesicle	IEA
GO:0030141	Component	Secretory granule	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0034230	Process	Enkephalin processing	IEA
GO:0034230	Process	Enkephalin processing	ISS
GO:0034231	Process	Islet amyloid polypeptide processing	ISS
GO:0043005	Component	Neuron projection	IBA
GO:0070013	Component	Intracellular organelle lumen	IEA

Other IDs

• MIM: 162151
• HGNC: 8744
• e!Ensembl: ENSG00000125851

Protein

• UniProt ID: P16519
• Protein name: Neuroendocrine convertase 2 (NEC 2) (EC 3.4.21.94) (KEX2-like endoprotease 2) (Prohormone convertase 2) (Proprotein convertase 2) (PC2)
• Protein function: Serine endopeptidase which is involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells. {ECO:00002
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF16470	S8_pro-domain	33 → 109	Peptidase S8 pro-domain	Domain
  PF00082	Peptidase_S8	158 → 445	Subtilase family	Domain
  PF01483	P_proprotein	504 → 591	Proprotein convertase P-domain	Family

• Sequence:

  MKGGCVSQWKAAAGFLFCVMVFASAERPVFTNHFLVELHKGGEDKARQVAAEHGFGVRKL
  PFAEGLYHFYHNGLAKAKRRRSLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDIN
  MNDPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASN
  YNAEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRM
  LDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGK
  GSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRK
  RNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRN
  QLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIP
  STGKLVLTLTTDACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRP
  RDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGVLKEWTLMLHGTQSAPYI
  DQVVRDYQSKLAMSKKEELEEELDEAVERSLKSILNKN

• Sequence length: 638

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
BRAIN ANEURYSM	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC KIDNEY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS, EXPERIMENTAL	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS, NON-INSULIN-DEPENDENT	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS, TYPE 2	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EOSINOPHILIC ESOPHAGITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL INFARCTION	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RESTLESS LEGS SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
ACTH-Secreting Pituitary Adenoma	Pituitary adenoma	BEFREE	20501680		★☆☆☆☆ Found in Text Mining only
Adrenal Gland Pheochromocytoma	Adrenal Gland Pheochromocytoma	BEFREE	22217803		★☆☆☆☆ Found in Text Mining only
Amish lethal microcephaly	Amish lethal microcephaly	Pubtator	28719828	Associate	★☆☆☆☆ Found in Text Mining only
Amyotrophic Lateral Sclerosis	Amyotrophic Lateral Sclerosis	BEFREE	22470424		★☆☆☆☆ Found in Text Mining only
Amyotrophic Lateral Sclerosis	Amyotrophic lateral sclerosis	Pubtator	22470424	Associate	★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	Pubtator	17903303	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoid Tumor	Carcinoid tumor	Pubtator	32794589	Stimulate	★☆☆☆☆ Found in Text Mining only
Carcinoma, Neuroendocrine	Carcinoma	BEFREE	29557695		★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	25123959		★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	UNIPROT_DG			★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn disease	Pubtator	21383526	Associate	★☆☆☆☆ Found in Text Mining only
Dermatitis	Dermatitis	BEFREE	31220451		★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	BEFREE	26607656, 28719828		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	26607656, 28719828		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes mellitus	Pubtator	26607656, 28719828, 29739359	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 1	Diabetes mellitus, type 1	Pubtator	36201618	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	17618154, 24705588, 26607656, 26634513, 28719828, 40141237	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	CTD_human_DG	16123366		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	17618154, 21437630, 23011353, 26607656, 28719828, 7698505		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Diabetic Retinopathy	Diabetic Retinopathy	BEFREE	29739359		★☆☆☆☆ Found in Text Mining only
Diabetic Retinopathy	Diabetic retinopathy	Pubtator	29739359	Associate	★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophageal neoplasm	Pubtator	36588538	Associate	★☆☆☆☆ Found in Text Mining only
Follicular adenoma	Adenoma	BEFREE	15713710		★☆☆☆☆ Found in Text Mining only
Follicular thyroid carcinoma	Follicular Thyroid Carcinoma	BEFREE	15713710		★☆☆☆☆ Found in Text Mining only
Hyperglycemia	Hyperglycemia	Pubtator	23985558	Inhibit	★☆☆☆☆ Found in Text Mining only
Kidney Failure Chronic	Kidney failure	Pubtator	17618154	Associate	★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	23409034	Inhibit	★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	LHGDN	11720250		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	31819499		★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial Infarction	BEFREE	20036365		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Necrotizing enterocolitis in fetus OR newborn	Necrotizing Enterocolitis	BEFREE	29557695		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	20501680, 31819499		★☆☆☆☆ Found in Text Mining only
nervous system disorder	Nervous System Disorder	BEFREE	28367114		★☆☆☆☆ Found in Text Mining only
Neuroectodermal Tumor, Primitive	Neuroectodermal Tumors	BEFREE	9881669		★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	24932808, 30926952	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Paraganglioma	Paraganglioma	Pubtator	32794589	Stimulate	★☆☆☆☆ Found in Text Mining only
Pheochromocytoma	Pheochromocytoma	BEFREE	22217803		★☆☆☆☆ Found in Text Mining only
Pheochromocytoma	Pheochromocytoma	Pubtator	32794589	Associate	★☆☆☆☆ Found in Text Mining only
PIGMENTARY DISORDER, RETICULATE, WITH SYSTEMIC MANIFESTATIONS	Pigmentary Disorder, Reticulate, With Systemic Manifestations	BEFREE	29739359		★☆☆☆☆ Found in Text Mining only
Pituitary Neoplasms	Pituitary neoplasm	Pubtator	7747813	Associate	★☆☆☆☆ Found in Text Mining only
Polycystic Kidney, Autosomal Dominant	Polycystic kidney disease	BEFREE	21392577		★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	31819499		★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasm	Thyroid Neoplasm	BEFREE	18661512		★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasms	Thyroid cancer	Pubtator	18661512	Associate	★☆☆☆☆ Found in Text Mining only
Thyroiditis	Thyroiditis	Pubtator	18661512	Associate	★☆☆☆☆ Found in Text Mining only