Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	51247
Gene name	Poly(A) binding protein interacting protein 2
Gene symbol	PAIP2
Synonyms (NCBI Gene)	PAIP-2PAIP2A
Chromosome	5
Chromosome location	5q31.2

265

Show/Hide all (265)

miRTarBase ID	miRNA	Experiments	Reference
MIRT049925	hsa-miR-30a-3p	CLASH	23622248
MIRT046752	hsa-miR-222-3p	CLASH	23622248
MIRT046752	hsa-miR-222-3p	PAR-CLIP	20371350
MIRT256500	hsa-miR-221-3p	PAR-CLIP	20371350
MIRT571835	hsa-miR-218-5p	PAR-CLIP	20371350
MIRT312075	hsa-miR-128-3p	PAR-CLIP	20371350
MIRT312074	hsa-miR-216a-3p	PAR-CLIP	20371350
MIRT312076	hsa-miR-3681-3p	PAR-CLIP	20371350
MIRT357684	hsa-miR-27b-3p	PAR-CLIP	20371350
MIRT357683	hsa-miR-27a-3p	PAR-CLIP	20371350
MIRT357687	hsa-miR-4302	PAR-CLIP	20371350
MIRT571834	hsa-miR-4297	PAR-CLIP	20371350
MIRT571833	hsa-miR-5581-5p	PAR-CLIP	20371350
MIRT256499	hsa-miR-187-5p	PAR-CLIP	20371350
MIRT256501	hsa-miR-548v	PAR-CLIP	20371350
MIRT256503	hsa-miR-5093	PAR-CLIP	20371350
MIRT571832	hsa-miR-3190-3p	PAR-CLIP	20371350
MIRT357688	hsa-miR-3911	PAR-CLIP	20371350
MIRT357685	hsa-miR-513a-5p	PAR-CLIP	20371350
MIRT357689	hsa-miR-6833-5p	PAR-CLIP	20371350
MIRT046752	hsa-miR-222-3p	PAR-CLIP	20371350
MIRT256500	hsa-miR-221-3p	PAR-CLIP	20371350
MIRT571835	hsa-miR-218-5p	PAR-CLIP	20371350
MIRT312075	hsa-miR-128-3p	PAR-CLIP	20371350
MIRT312074	hsa-miR-216a-3p	PAR-CLIP	20371350
MIRT312076	hsa-miR-3681-3p	PAR-CLIP	20371350
MIRT357684	hsa-miR-27b-3p	PAR-CLIP	20371350
MIRT357683	hsa-miR-27a-3p	PAR-CLIP	20371350
MIRT357687	hsa-miR-4302	PAR-CLIP	20371350
MIRT571834	hsa-miR-4297	PAR-CLIP	20371350
MIRT571833	hsa-miR-5581-5p	PAR-CLIP	20371350
MIRT256499	hsa-miR-187-5p	PAR-CLIP	20371350
MIRT256501	hsa-miR-548v	PAR-CLIP	20371350
MIRT256503	hsa-miR-5093	PAR-CLIP	20371350
MIRT571832	hsa-miR-3190-3p	PAR-CLIP	20371350
MIRT357688	hsa-miR-3911	PAR-CLIP	20371350
MIRT357685	hsa-miR-513a-5p	PAR-CLIP	20371350
MIRT357689	hsa-miR-6833-5p	PAR-CLIP	20371350
MIRT1210997	hsa-miR-1264	CLIP-seq
MIRT1210998	hsa-miR-128	CLIP-seq
MIRT1210999	hsa-miR-200b	CLIP-seq
MIRT1211000	hsa-miR-200c	CLIP-seq
MIRT1211001	hsa-miR-218	CLIP-seq
MIRT1211002	hsa-miR-221	CLIP-seq
MIRT1211003	hsa-miR-222	CLIP-seq
MIRT1211004	hsa-miR-23a	CLIP-seq
MIRT1211005	hsa-miR-23b	CLIP-seq
MIRT1211006	hsa-miR-23c	CLIP-seq
MIRT1211007	hsa-miR-27a	CLIP-seq
MIRT1211008	hsa-miR-27b	CLIP-seq
MIRT1211009	hsa-miR-3124-3p	CLIP-seq
MIRT1211010	hsa-miR-3136-5p	CLIP-seq
MIRT1211011	hsa-miR-3190	CLIP-seq
MIRT1211012	hsa-miR-3613-3p	CLIP-seq
MIRT1211013	hsa-miR-371b-5p	CLIP-seq
MIRT1211014	hsa-miR-3907	CLIP-seq
MIRT1211015	hsa-miR-412	CLIP-seq
MIRT1211016	hsa-miR-429	CLIP-seq
MIRT1211017	hsa-miR-4439	CLIP-seq
MIRT1211018	hsa-miR-4775	CLIP-seq
MIRT1211019	hsa-miR-502-5p	CLIP-seq
MIRT1211020	hsa-miR-513b	CLIP-seq
MIRT1211021	hsa-miR-548q	CLIP-seq
MIRT1211022	hsa-miR-576-5p	CLIP-seq
MIRT1211023	hsa-miR-626	CLIP-seq
MIRT1211024	hsa-miR-636	CLIP-seq
MIRT1211025	hsa-miR-943	CLIP-seq
MIRT1211026	hsa-miR-1245b-3p	CLIP-seq
MIRT1211027	hsa-miR-1271	CLIP-seq
MIRT1211028	hsa-miR-1305	CLIP-seq
MIRT1211029	hsa-miR-151-3p	CLIP-seq
MIRT1211030	hsa-miR-182	CLIP-seq
MIRT1211031	hsa-miR-194	CLIP-seq
MIRT1211004	hsa-miR-23a	CLIP-seq
MIRT1211005	hsa-miR-23b	CLIP-seq
MIRT1211006	hsa-miR-23c	CLIP-seq
MIRT1211009	hsa-miR-3124-3p	CLIP-seq
MIRT1211010	hsa-miR-3136-5p	CLIP-seq
MIRT1211032	hsa-miR-3143	CLIP-seq
MIRT1211033	hsa-miR-377	CLIP-seq
MIRT1211014	hsa-miR-3907	CLIP-seq
MIRT1211034	hsa-miR-3940-5p	CLIP-seq
MIRT1211015	hsa-miR-412	CLIP-seq
MIRT1211035	hsa-miR-4330	CLIP-seq
MIRT1211036	hsa-miR-4438	CLIP-seq
MIRT1211017	hsa-miR-4439	CLIP-seq
MIRT1211037	hsa-miR-4507	CLIP-seq
MIRT1211038	hsa-miR-4696	CLIP-seq
MIRT1211039	hsa-miR-495	CLIP-seq
MIRT1211019	hsa-miR-502-5p	CLIP-seq
MIRT1211040	hsa-miR-5095	CLIP-seq
MIRT1211020	hsa-miR-513b	CLIP-seq
MIRT1211041	hsa-miR-543	CLIP-seq
MIRT1211042	hsa-miR-548ae	CLIP-seq
MIRT1211043	hsa-miR-548aj	CLIP-seq
MIRT1211044	hsa-miR-548am	CLIP-seq
MIRT1211021	hsa-miR-548q	CLIP-seq
MIRT1211045	hsa-miR-548x	CLIP-seq
MIRT1211046	hsa-miR-595	CLIP-seq
MIRT1211023	hsa-miR-626	CLIP-seq
MIRT1211024	hsa-miR-636	CLIP-seq
MIRT1211025	hsa-miR-943	CLIP-seq
MIRT1211047	hsa-miR-96	CLIP-seq
MIRT1211001	hsa-miR-218	CLIP-seq
MIRT1211002	hsa-miR-221	CLIP-seq
MIRT1211003	hsa-miR-222	CLIP-seq
MIRT1211011	hsa-miR-3190	CLIP-seq
MIRT1552010	hsa-miR-583	CLIP-seq
MIRT1210997	hsa-miR-1264	CLIP-seq
MIRT2060534	hsa-miR-132	CLIP-seq
MIRT1211031	hsa-miR-194	CLIP-seq
MIRT2060535	hsa-miR-212	CLIP-seq
MIRT2060536	hsa-miR-2277-3p	CLIP-seq
MIRT2060537	hsa-miR-3144-5p	CLIP-seq
MIRT2060538	hsa-miR-3191	CLIP-seq
MIRT2060539	hsa-miR-4652-5p	CLIP-seq
MIRT2060540	hsa-miR-514	CLIP-seq
MIRT2060541	hsa-miR-514b-3p	CLIP-seq
MIRT1211022	hsa-miR-576-5p	CLIP-seq
MIRT2289244	hsa-miR-101	CLIP-seq
MIRT2289245	hsa-miR-1207-3p	CLIP-seq
MIRT1210997	hsa-miR-1264	CLIP-seq
MIRT1211027	hsa-miR-1271	CLIP-seq
MIRT1210998	hsa-miR-128	CLIP-seq
MIRT2289246	hsa-miR-1287	CLIP-seq
MIRT2060534	hsa-miR-132	CLIP-seq
MIRT2289247	hsa-miR-144	CLIP-seq
MIRT1211030	hsa-miR-182	CLIP-seq
MIRT2289248	hsa-miR-183	CLIP-seq
MIRT1211031	hsa-miR-194	CLIP-seq
MIRT1210999	hsa-miR-200b	CLIP-seq
MIRT1211000	hsa-miR-200c	CLIP-seq
MIRT2060535	hsa-miR-212	CLIP-seq
MIRT1211001	hsa-miR-218	CLIP-seq
MIRT1211002	hsa-miR-221	CLIP-seq
MIRT1211003	hsa-miR-222	CLIP-seq
MIRT2060536	hsa-miR-2277-3p	CLIP-seq
MIRT1211007	hsa-miR-27a	CLIP-seq
MIRT1211008	hsa-miR-27b	CLIP-seq
MIRT2289249	hsa-miR-296-5p	CLIP-seq
MIRT2289250	hsa-miR-3065-3p	CLIP-seq
MIRT2289251	hsa-miR-3115	CLIP-seq
MIRT2289252	hsa-miR-3158-5p	CLIP-seq
MIRT2289253	hsa-miR-3166	CLIP-seq
MIRT1211011	hsa-miR-3190	CLIP-seq
MIRT2289254	hsa-miR-375	CLIP-seq
MIRT1211033	hsa-miR-377	CLIP-seq
MIRT2289255	hsa-miR-382	CLIP-seq
MIRT1211034	hsa-miR-3940-5p	CLIP-seq
MIRT1211016	hsa-miR-429	CLIP-seq
MIRT2289256	hsa-miR-4477a	CLIP-seq
MIRT2289257	hsa-miR-4503	CLIP-seq
MIRT2289258	hsa-miR-4504	CLIP-seq
MIRT1211037	hsa-miR-4507	CLIP-seq
MIRT2289259	hsa-miR-4517	CLIP-seq
MIRT2289260	hsa-miR-4637	CLIP-seq
MIRT2289261	hsa-miR-4686	CLIP-seq
MIRT1211038	hsa-miR-4696	CLIP-seq
MIRT2289262	hsa-miR-4720-3p	CLIP-seq
MIRT2289263	hsa-miR-4724-5p	CLIP-seq
MIRT2289264	hsa-miR-4771	CLIP-seq
MIRT2289265	hsa-miR-4804-3p	CLIP-seq
MIRT1211039	hsa-miR-495	CLIP-seq
MIRT2060540	hsa-miR-514	CLIP-seq
MIRT2060541	hsa-miR-514b-3p	CLIP-seq
MIRT2289266	hsa-miR-548n	CLIP-seq
MIRT2289267	hsa-miR-548t	CLIP-seq
MIRT1211022	hsa-miR-576-5p	CLIP-seq
MIRT2289268	hsa-miR-582-5p	CLIP-seq
MIRT1552010	hsa-miR-583	CLIP-seq
MIRT1211046	hsa-miR-595	CLIP-seq
MIRT2289269	hsa-miR-628-5p	CLIP-seq
MIRT2289270	hsa-miR-802	CLIP-seq
MIRT2289271	hsa-miR-885-3p	CLIP-seq
MIRT2289272	hsa-miR-888	CLIP-seq
MIRT1211047	hsa-miR-96	CLIP-seq
MIRT1210997	hsa-miR-1264	CLIP-seq
MIRT2586973	hsa-miR-1270	CLIP-seq
MIRT1211027	hsa-miR-1271	CLIP-seq
MIRT1210998	hsa-miR-128	CLIP-seq
MIRT1211030	hsa-miR-182	CLIP-seq
MIRT1211031	hsa-miR-194	CLIP-seq
MIRT1210999	hsa-miR-200b	CLIP-seq
MIRT1211000	hsa-miR-200c	CLIP-seq
MIRT1211001	hsa-miR-218	CLIP-seq
MIRT1211002	hsa-miR-221	CLIP-seq
MIRT1211003	hsa-miR-222	CLIP-seq
MIRT1211007	hsa-miR-27a	CLIP-seq
MIRT1211008	hsa-miR-27b	CLIP-seq
MIRT2289249	hsa-miR-296-5p	CLIP-seq
MIRT2586974	hsa-miR-3129-3p	CLIP-seq
MIRT2060537	hsa-miR-3144-5p	CLIP-seq
MIRT1211011	hsa-miR-3190	CLIP-seq
MIRT2060538	hsa-miR-3191	CLIP-seq
MIRT2586975	hsa-miR-371-5p	CLIP-seq
MIRT1211013	hsa-miR-371b-5p	CLIP-seq
MIRT2586976	hsa-miR-425	CLIP-seq
MIRT2586977	hsa-miR-4251	CLIP-seq
MIRT1211016	hsa-miR-429	CLIP-seq
MIRT2586978	hsa-miR-4329	CLIP-seq
MIRT2289258	hsa-miR-4504	CLIP-seq
MIRT2289259	hsa-miR-4517	CLIP-seq
MIRT2289260	hsa-miR-4637	CLIP-seq
MIRT2060539	hsa-miR-4652-5p	CLIP-seq
MIRT2586979	hsa-miR-4683	CLIP-seq
MIRT2289261	hsa-miR-4686	CLIP-seq
MIRT2586980	hsa-miR-4694-3p	CLIP-seq
MIRT2289262	hsa-miR-4720-3p	CLIP-seq
MIRT2586981	hsa-miR-4797-3p	CLIP-seq
MIRT2289265	hsa-miR-4804-3p	CLIP-seq
MIRT1211039	hsa-miR-495	CLIP-seq
MIRT2586982	hsa-miR-539	CLIP-seq
MIRT1211042	hsa-miR-548ae	CLIP-seq
MIRT1211043	hsa-miR-548aj	CLIP-seq
MIRT1211044	hsa-miR-548am	CLIP-seq
MIRT1211045	hsa-miR-548x	CLIP-seq
MIRT1211022	hsa-miR-576-5p	CLIP-seq
MIRT1552010	hsa-miR-583	CLIP-seq
MIRT1211046	hsa-miR-595	CLIP-seq
MIRT2586983	hsa-miR-620	CLIP-seq
MIRT2289269	hsa-miR-628-5p	CLIP-seq
MIRT1211047	hsa-miR-96	CLIP-seq
MIRT1210997	hsa-miR-1264	CLIP-seq
MIRT1211039	hsa-miR-495	CLIP-seq
MIRT1210997	hsa-miR-1264	CLIP-seq
MIRT2586973	hsa-miR-1270	CLIP-seq
MIRT1211027	hsa-miR-1271	CLIP-seq
MIRT1210998	hsa-miR-128	CLIP-seq
MIRT1211030	hsa-miR-182	CLIP-seq
MIRT1211031	hsa-miR-194	CLIP-seq
MIRT1210999	hsa-miR-200b	CLIP-seq
MIRT1211000	hsa-miR-200c	CLIP-seq
MIRT1211001	hsa-miR-218	CLIP-seq
MIRT1211002	hsa-miR-221	CLIP-seq
MIRT1211003	hsa-miR-222	CLIP-seq
MIRT1211007	hsa-miR-27a	CLIP-seq
MIRT1211008	hsa-miR-27b	CLIP-seq
MIRT2289249	hsa-miR-296-5p	CLIP-seq
MIRT2586974	hsa-miR-3129-3p	CLIP-seq
MIRT2060537	hsa-miR-3144-5p	CLIP-seq
MIRT1211011	hsa-miR-3190	CLIP-seq
MIRT2060538	hsa-miR-3191	CLIP-seq
MIRT2586975	hsa-miR-371-5p	CLIP-seq
MIRT1211013	hsa-miR-371b-5p	CLIP-seq
MIRT2586976	hsa-miR-425	CLIP-seq
MIRT1211016	hsa-miR-429	CLIP-seq
MIRT2289258	hsa-miR-4504	CLIP-seq
MIRT2289259	hsa-miR-4517	CLIP-seq
MIRT2289260	hsa-miR-4637	CLIP-seq
MIRT2060539	hsa-miR-4652-5p	CLIP-seq
MIRT2586979	hsa-miR-4683	CLIP-seq
MIRT2289261	hsa-miR-4686	CLIP-seq
MIRT2586980	hsa-miR-4694-3p	CLIP-seq
MIRT2586981	hsa-miR-4797-3p	CLIP-seq
MIRT1211039	hsa-miR-495	CLIP-seq
MIRT1211042	hsa-miR-548ae	CLIP-seq
MIRT1211043	hsa-miR-548aj	CLIP-seq
MIRT1211044	hsa-miR-548am	CLIP-seq
MIRT1211045	hsa-miR-548x	CLIP-seq
MIRT1211022	hsa-miR-576-5p	CLIP-seq
MIRT1552010	hsa-miR-583	CLIP-seq
MIRT1211046	hsa-miR-595	CLIP-seq
MIRT2586983	hsa-miR-620	CLIP-seq
MIRT2289269	hsa-miR-628-5p	CLIP-seq
MIRT1211047	hsa-miR-96	CLIP-seq

Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000900	Function	MRNA regulatory element binding translation repressor activity	IEA
GO:0003729	Function	MRNA binding	IEA
GO:0005515	Function	Protein binding	IPI	11172725, 14685257, 16601676, 32296183, 32529326, 32814053, 33961781, 35511136, 37100772
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	11172725
GO:0005737	Component	Cytoplasm	IEA
GO:0006412	Process	Translation	IEA
GO:0006417	Process	Regulation of translation	IEA
GO:0006417	Process	Regulation of translation	IEA
GO:0007283	Process	Spermatogenesis	IEA
GO:0007613	Process	Memory	IEA
GO:0017148	Process	Negative regulation of translation	IBA
GO:0017148	Process	Negative regulation of translation	IEA
GO:0030371	Function	Translation repressor activity	IBA
GO:0030371	Function	Translation repressor activity	IDA	11172725
GO:0045947	Process	Negative regulation of translational initiation	IDA	11172725
GO:0045947	Process	Negative regulation of translational initiation	IEA
GO:1900271	Process	Regulation of long-term synaptic potentiation	IEA

MIM	HGNC	e!Ensembl
605604	17970	ENSG00000120727

Q9BPZ3

Protein name

Polyadenylate-binding protein-interacting protein 2 (PABP-interacting protein 2) (PAIP-2) (Poly(A)-binding protein-interacting protein 2)

Protein function

Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP

PDB

1JGN , 3KUS , 3KUT

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07145	PAM2	106 → 123	Ataxin-2 C-terminal region	Motif

Tissue specificity

TISSUE SPECIFICITY: Expressed at highest level in testis, but also abundant in brain, cervix, lung, ovary, placenta, adipose tissue, thymus and thyroid. {ECO:0000269|PubMed:16804161}.

Sequence

MKDPSRSSTSPSIINEDVIINGHSHEDDNPFAEYMWMENEEEFNRQIEEELWEEEFIERC
FQEMLEEEEEHEWFIPARDLPQTMDQIQDQFNDLVISDGSSLEDLVVKSNLNPNAKEFVP
GVKYGNI

Sequence length

127

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
COLORECTAL NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (8)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Carcinoma	Carcinoma	BEFREE	16641910		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	CTD_human_DG	25944804		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal Neoplasms	CTD_human_DG	25944804		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Head and Neck Carcinoma	Head And Neck Carcinoma	BEFREE	16641910		★★★★★ ★☆☆☆☆ Found in Text Mining only
Head and Neck Neoplasms	Head and neck neoplasm	Pubtator	16641910	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Head and Neck Neoplasm	Head and neck cancer	BEFREE	16641910		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	16641910		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	16641910, 24403051	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

PAIP2 (poly(A) binding protein interacting protein 2)