Gene Gene information from NCBI Gene database.
Entrez ID 51228
Gene name Glycolipid transfer protein
Gene symbol GLTP
Synonyms (NCBI Gene)
-
Chromosome 12
Chromosome location 12q24.11
Summary The protein encoded by this gene is similar to bovine and porcine proteins which accelerate transfer of certain glycosphingolipids and glyceroglycolipids between membranes. It is thought to be a cytoplasmic protein. [provided by RefSeq, Jul 2008]
miRNA miRNA information provided by mirtarbase database.
564
miRTarBase ID miRNA Experiments Reference
MIRT002530 hsa-miR-373-3p Microarray 15685193
MIRT002530 hsa-miR-373-3p Microarray 15685193
MIRT048270 hsa-miR-196a-5p CLASH 23622248
MIRT042188 hsa-miR-484 CLASH 23622248
MIRT670576 hsa-miR-125a-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
22
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 25416956, 31515488
GO:0005737 Component Cytoplasm IEA
GO:0005829 Component Cytosol IBA
GO:0005829 Component Cytosol IDA 15901739
GO:0005829 Component Cytosol TAS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
608949 24867 ENSG00000139433
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9NZD2
Protein name Glycolipid transfer protein (GLTP)
Protein function Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of gluc
PDB 1SWX , 1SX6 , 2EUK , 2EUM , 2EVD , 2EVL , 2EVS , 2EVT , 3RIC , 3RWV , 3RZN , 3S0I , 3S0K , 4GH0 , 4GHP , 4GHS , 4GIX , 4GJQ , 4GVT , 4GXD , 4GXG , 4H2Z
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF08718 GLTP 18 167 Glycolipid transfer protein (GLTP) Domain
Tissue specificity TISSUE SPECIFICITY: Detected in fibroblasts (at protein level). Detected in fibroblasts and in various cancer cell lines. {ECO:0000269|PubMed:17980653, ECO:0000269|PubMed:18261224}.
Sequence
Sequence length 209
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Glycosphingolipid metabolism
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
AUTISM SPECTRUM DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Carcinogenesis Carcinogenesis Pubtator 29532406 Associate
★☆☆☆☆
Found in Text Mining only
Colon Carcinoma Colon Carcinoma BEFREE 30472325
★☆☆☆☆
Found in Text Mining only
Colonic Neoplasms Colonic neoplasm Pubtator 30472325 Inhibit
★☆☆☆☆
Found in Text Mining only
Colorectal Carcinoma Colorectal Cancer BEFREE 29532406
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Colorectal neoplasm Pubtator 29532406, 39898245 Associate
★☆☆☆☆
Found in Text Mining only
Prostatic Neoplasms Prostatic neoplasm Pubtator 25026280 Associate
★☆☆☆☆
Found in Text Mining only
Uterine Cervical Neoplasms Uterine neoplasm Pubtator 34498424 Associate
★☆☆☆☆
Found in Text Mining only
Uterine Cervical Neoplasms Uterine neoplasm Pubtator 35845139 Stimulate
★☆☆☆☆
Found in Text Mining only