Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	51194
Gene name	Importin 11
Gene symbol	IPO11
Synonyms (NCBI Gene)	RanBP11
Chromosome	5
Chromosome location	5q12.1
Summary	Importins, including IPO11, are a members of the karyopherin/importin-beta family of transport receptors (see KPNB1; 602738) that mediate nucleocytoplasmic transport of protein and RNA cargoes (Plafker and Macara, 2000 [PubMed 11032817]).[supplied by OMIM

Show/Hide all (96)

miRTarBase ID	miRNA	Experiments	Reference
MIRT032019	hsa-miR-16-5p	Proteomics	18668040
MIRT052306	hsa-let-7b-5p	CLASH	23622248
MIRT662152	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT662151	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT662149	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT662150	hsa-miR-3119	HITS-CLIP	23824327
MIRT662148	hsa-miR-4279	HITS-CLIP	23824327
MIRT662147	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT662146	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT662152	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT662151	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT662149	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT662150	hsa-miR-3119	HITS-CLIP	23824327
MIRT662148	hsa-miR-4279	HITS-CLIP	23824327
MIRT662147	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT662146	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT1068704	hsa-miR-105	CLIP-seq
MIRT1068705	hsa-miR-10a	CLIP-seq
MIRT1068706	hsa-miR-10b	CLIP-seq
MIRT1068707	hsa-miR-1224-5p	CLIP-seq
MIRT1068708	hsa-miR-1287	CLIP-seq
MIRT1068709	hsa-miR-1304	CLIP-seq
MIRT1068710	hsa-miR-21	CLIP-seq
MIRT1068711	hsa-miR-296-5p	CLIP-seq
MIRT1068712	hsa-miR-3135b	CLIP-seq
MIRT1068713	hsa-miR-3179	CLIP-seq
MIRT1068714	hsa-miR-3591-5p	CLIP-seq
MIRT1068715	hsa-miR-3606	CLIP-seq
MIRT1068716	hsa-miR-3915	CLIP-seq
MIRT1068717	hsa-miR-3928	CLIP-seq
MIRT1068718	hsa-miR-4292	CLIP-seq
MIRT1068719	hsa-miR-4313	CLIP-seq
MIRT1068720	hsa-miR-4450	CLIP-seq
MIRT1068721	hsa-miR-4464	CLIP-seq
MIRT1068722	hsa-miR-4666-5p	CLIP-seq
MIRT1068723	hsa-miR-4667-5p	CLIP-seq
MIRT1068724	hsa-miR-4689	CLIP-seq
MIRT1068725	hsa-miR-4700-5p	CLIP-seq
MIRT1068726	hsa-miR-4703-3p	CLIP-seq
MIRT1068727	hsa-miR-4748	CLIP-seq
MIRT1068728	hsa-miR-590-5p	CLIP-seq
MIRT1068729	hsa-miR-758	CLIP-seq
MIRT1068730	hsa-miR-921	CLIP-seq
MIRT1068731	hsa-miR-3199	CLIP-seq
MIRT1068732	hsa-miR-4648	CLIP-seq
MIRT1068733	hsa-miR-552	CLIP-seq
MIRT2016710	hsa-miR-520d-5p	CLIP-seq
MIRT2016711	hsa-miR-524-5p	CLIP-seq
MIRT1068704	hsa-miR-105	CLIP-seq
MIRT1068731	hsa-miR-3199	CLIP-seq
MIRT2248800	hsa-miR-342-3p	CLIP-seq
MIRT1068732	hsa-miR-4648	CLIP-seq
MIRT2248801	hsa-miR-4659a-3p	CLIP-seq
MIRT2248802	hsa-miR-4659b-3p	CLIP-seq
MIRT2016710	hsa-miR-520d-5p	CLIP-seq
MIRT2016711	hsa-miR-524-5p	CLIP-seq
MIRT2248803	hsa-miR-616	CLIP-seq
MIRT2248804	hsa-miR-646	CLIP-seq
MIRT1068731	hsa-miR-3199	CLIP-seq
MIRT1068732	hsa-miR-4648	CLIP-seq
MIRT1068733	hsa-miR-552	CLIP-seq
MIRT2552540	hsa-miR-1178	CLIP-seq
MIRT2552541	hsa-miR-1250	CLIP-seq
MIRT2552542	hsa-miR-3192	CLIP-seq
MIRT1068731	hsa-miR-3199	CLIP-seq
MIRT2552543	hsa-miR-3907	CLIP-seq
MIRT2552544	hsa-miR-4277	CLIP-seq
MIRT2552545	hsa-miR-4433	CLIP-seq
MIRT2552546	hsa-miR-4515	CLIP-seq
MIRT1068732	hsa-miR-4648	CLIP-seq
MIRT2248801	hsa-miR-4659a-3p	CLIP-seq
MIRT2248802	hsa-miR-4659b-3p	CLIP-seq
MIRT2552547	hsa-miR-495	CLIP-seq
MIRT2552548	hsa-miR-513a-5p	CLIP-seq
MIRT1068733	hsa-miR-552	CLIP-seq
MIRT2552549	hsa-miR-802	CLIP-seq
MIRT2552550	hsa-miR-942	CLIP-seq
MIRT2552540	hsa-miR-1178	CLIP-seq
MIRT2552541	hsa-miR-1250	CLIP-seq
MIRT2682873	hsa-miR-3117-3p	CLIP-seq
MIRT2682874	hsa-miR-3169	CLIP-seq
MIRT2552542	hsa-miR-3192	CLIP-seq
MIRT1068731	hsa-miR-3199	CLIP-seq
MIRT2552543	hsa-miR-3907	CLIP-seq
MIRT2552544	hsa-miR-4277	CLIP-seq
MIRT2552545	hsa-miR-4433	CLIP-seq
MIRT2552546	hsa-miR-4515	CLIP-seq
MIRT1068732	hsa-miR-4648	CLIP-seq
MIRT2248801	hsa-miR-4659a-3p	CLIP-seq
MIRT2248802	hsa-miR-4659b-3p	CLIP-seq
MIRT2682875	hsa-miR-4759	CLIP-seq
MIRT2552547	hsa-miR-495	CLIP-seq
MIRT2552548	hsa-miR-513a-5p	CLIP-seq
MIRT1068733	hsa-miR-552	CLIP-seq
MIRT2552549	hsa-miR-802	CLIP-seq
MIRT2552550	hsa-miR-942	CLIP-seq

Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 32296183, 33961781, 34819669, 35271311
GO:0005634	Component	Nucleus	IEA
GO:0005635	Component	Nuclear envelope	IBA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0006606	Process	Protein import into nucleus	IBA
GO:0006610	Process	Ribosomal protein import into nucleus	IEA
GO:0006886	Process	Intracellular protein transport	IEA
GO:0015031	Process	Protein transport	IEA
GO:0031267	Function	Small GTPase binding	IEA
GO:0061608	Function	Nuclear import signal receptor activity	IEA

MIM	HGNC	e!Ensembl
610889	20628	ENSG00000086200

Q9UI26

Protein name

Importin-11 (Imp11) (Ran-binding protein 11) (RanBP11)

Protein function

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) t

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03810	IBN_N	28 → 100	Importin-beta N-terminal domain	Family

Sequence

MDLNSASTVVLQVLTQATSQDTAVLKPAEEQLKQWETQPGFYSVLLNIFTNHTLDINVRW
LAVLYFKHGIDRYWRRVAPHALSEEEKTTLRAGLITNFNEPINQIATQIAVLIAKVARLD
CPRQWPELIPTLIESVKVQDDLRQHRALLTFYHVTKTLASKRLAADRKLFYDLASGIYNF
ACSLWNHHTDTFLQEVSSGNEAAILSSLERTLLSLKVLRKLTVNGFVEPHKNMEVMGFLH
GIFERLKQFLECSRSIGTDNVCRDRLEKTIILFTKVLLDFLDQHPFSFTPLIQRSLEFSV
SYVFTEVGEGVTFERFIVQCMNLIKMIVKNYAYKPSKNFEDSSPETLEAHKIKMAFFTYP
TLTEICRRLVSHYFLLTEEELTMWEEDPEGFTVEETGGDSWKYSLRPCTEVLFIDIFHEY
NQTLTPVLLEMMQTLQGPTNVEDMNALLIKDAVYNAVGLAAYELFDSVDFDQWFKNQLLP
ELQVIHNRYKPLRRRVIWLIGQWISVKFKSDLRPMLYEAICNLLQDQDLVVRIETATTLK
LTVDDFEFRTDQFLPYLETMFTLLFQLLQQVTECDTKMHVLHVLSCVIERVNMQIRPYVG
CLVQYLPLLWKQSEEHNMLRCAILTTLIHLVQGLGADSKNLYPFLLPVIQLSTDVSQPPH
VYLLEDGLELWLVTLENSPCITPELLRIFQNMSPLLELSSENLRTCFKIINGYIFLSSTE
FLQTYAVGLCQSFCELLKEITTEGQVQVLKVVENALKVNPILGPQMFQPILPYVFKGIIE
GERYPVVMSTYLGVMGRVLLQNTSFFSSLLNEMAHKFNQEMDQLLGNMIEMWVDRMDNIT
QPERRKLSALALLSLLPSDNSVIQDKFCGIINISVEGLHDVMTEDPETGTYKDCMLMSHL
EEPKVTEDEEPPTEQDKRKKMLALKDPVHTVSLQQFIYEKLKAQQEMLGEQGFQSLMETV
DTEIVTQLQEFLQGF

Sequence length

975

Interactions

View interactions

	KEGG
	Nucleocytoplasmic transport

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (11)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Clear cell carcinoma of kidney	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CONGENITAL HYDROCEPHALUS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VENOUS THROMBOEMBOLISM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (14)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Attention Deficit Disorder with Hyperactivity	Attention deficit hyperactivity disorder	Pubtator	26079129	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Attention deficit hyperactivity disorder	Attention Deficit Hyperactivity Disorder	BEFREE	26079129		★★★★★ ★☆☆☆☆ Found in Text Mining only
Bladder Neoplasm	Bladder Neoplasm	BEFREE	29602637		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of bladder	Bladder carcinoma	BEFREE	29602637		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	31881079	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	28736931		★★★★★ ★☆☆☆☆ Found in Text Mining only
Dyslipidemias	Dyslipidemias	BEFREE	28736931		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	GWASCAT_DG	27903959		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Diseases Interstitial	Lung disease	Pubtator	31339356	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung Neoplasms	BEFREE	28193700, 28258103		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	28258103		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of urinary bladder	Urinary bladder cancer	BEFREE	29602637		★★★★★ ★☆☆☆☆ Found in Text Mining only
Moyamoya Disease	Moyamoya disease	Pubtator	36883376	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	28193699, 28193700, 29602637		★★★★★ ★☆☆☆☆ Found in Text Mining only

IPO11 (importin 11)