Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	51184
Gene name	GPN-loop GTPase 3
Gene symbol	GPN3
Synonyms (NCBI Gene)	ATPBD1C
Chromosome	12
Chromosome location	12q24.11

102

Show/Hide all (102)

miRTarBase ID	miRNA	Experiments	Reference
MIRT028058	hsa-miR-93-5p	Sequencing	20371350
MIRT1029621	hsa-miR-106a	CLIP-seq
MIRT1029622	hsa-miR-106b	CLIP-seq
MIRT1029623	hsa-miR-17	CLIP-seq
MIRT1029624	hsa-miR-200b	CLIP-seq
MIRT1029625	hsa-miR-200c	CLIP-seq
MIRT1029626	hsa-miR-20a	CLIP-seq
MIRT1029627	hsa-miR-20b	CLIP-seq
MIRT1029628	hsa-miR-3609	CLIP-seq
MIRT1029629	hsa-miR-369-3p	CLIP-seq
MIRT1029630	hsa-miR-374a	CLIP-seq
MIRT1029631	hsa-miR-374b	CLIP-seq
MIRT1029632	hsa-miR-429	CLIP-seq
MIRT1029633	hsa-miR-4509	CLIP-seq
MIRT1029634	hsa-miR-4744	CLIP-seq
MIRT1029635	hsa-miR-4796-3p	CLIP-seq
MIRT1029636	hsa-miR-519d	CLIP-seq
MIRT1029637	hsa-miR-520d-5p	CLIP-seq
MIRT1029638	hsa-miR-524-5p	CLIP-seq
MIRT1029639	hsa-miR-548ah	CLIP-seq
MIRT1029640	hsa-miR-93	CLIP-seq
MIRT1029621	hsa-miR-106a	CLIP-seq
MIRT1029622	hsa-miR-106b	CLIP-seq
MIRT2542123	hsa-miR-15a	CLIP-seq
MIRT2542124	hsa-miR-15b	CLIP-seq
MIRT2542125	hsa-miR-16	CLIP-seq
MIRT1029623	hsa-miR-17	CLIP-seq
MIRT2542126	hsa-miR-186	CLIP-seq
MIRT2542127	hsa-miR-195	CLIP-seq
MIRT1029624	hsa-miR-200b	CLIP-seq
MIRT1029625	hsa-miR-200c	CLIP-seq
MIRT1029626	hsa-miR-20a	CLIP-seq
MIRT1029627	hsa-miR-20b	CLIP-seq
MIRT2542128	hsa-miR-2467-5p	CLIP-seq
MIRT2542129	hsa-miR-3133	CLIP-seq
MIRT2542130	hsa-miR-3188	CLIP-seq
MIRT1029628	hsa-miR-3609	CLIP-seq
MIRT1029629	hsa-miR-369-3p	CLIP-seq
MIRT1029630	hsa-miR-374a	CLIP-seq
MIRT1029631	hsa-miR-374b	CLIP-seq
MIRT2542131	hsa-miR-3929	CLIP-seq
MIRT2542132	hsa-miR-3942-3p	CLIP-seq
MIRT2542133	hsa-miR-3975	CLIP-seq
MIRT2542134	hsa-miR-424	CLIP-seq
MIRT2542135	hsa-miR-4269	CLIP-seq
MIRT2542136	hsa-miR-4282	CLIP-seq
MIRT1029632	hsa-miR-429	CLIP-seq
MIRT2542137	hsa-miR-4419b	CLIP-seq
MIRT2542138	hsa-miR-4436b-5p	CLIP-seq
MIRT2542139	hsa-miR-4478	CLIP-seq
MIRT1029633	hsa-miR-4509	CLIP-seq
MIRT2542140	hsa-miR-4514	CLIP-seq
MIRT2542141	hsa-miR-4692	CLIP-seq
MIRT2542142	hsa-miR-4742-5p	CLIP-seq
MIRT1029634	hsa-miR-4744	CLIP-seq
MIRT1029635	hsa-miR-4796-3p	CLIP-seq
MIRT2542143	hsa-miR-485-5p	CLIP-seq
MIRT2542144	hsa-miR-497	CLIP-seq
MIRT1029636	hsa-miR-519d	CLIP-seq
MIRT1029637	hsa-miR-520d-5p	CLIP-seq
MIRT1029638	hsa-miR-524-5p	CLIP-seq
MIRT1029639	hsa-miR-548ah	CLIP-seq
MIRT2542145	hsa-miR-548c-3p	CLIP-seq
MIRT1029640	hsa-miR-93	CLIP-seq
MIRT1029621	hsa-miR-106a	CLIP-seq
MIRT1029622	hsa-miR-106b	CLIP-seq
MIRT2542123	hsa-miR-15a	CLIP-seq
MIRT2542124	hsa-miR-15b	CLIP-seq
MIRT2542125	hsa-miR-16	CLIP-seq
MIRT1029623	hsa-miR-17	CLIP-seq
MIRT2542127	hsa-miR-195	CLIP-seq
MIRT1029624	hsa-miR-200b	CLIP-seq
MIRT1029625	hsa-miR-200c	CLIP-seq
MIRT1029626	hsa-miR-20a	CLIP-seq
MIRT1029627	hsa-miR-20b	CLIP-seq
MIRT2542128	hsa-miR-2467-5p	CLIP-seq
MIRT2542130	hsa-miR-3188	CLIP-seq
MIRT1029628	hsa-miR-3609	CLIP-seq
MIRT1029629	hsa-miR-369-3p	CLIP-seq
MIRT1029630	hsa-miR-374a	CLIP-seq
MIRT1029631	hsa-miR-374b	CLIP-seq
MIRT2542132	hsa-miR-3942-3p	CLIP-seq
MIRT2542133	hsa-miR-3975	CLIP-seq
MIRT2542134	hsa-miR-424	CLIP-seq
MIRT2542135	hsa-miR-4269	CLIP-seq
MIRT2542136	hsa-miR-4282	CLIP-seq
MIRT1029632	hsa-miR-429	CLIP-seq
MIRT2542138	hsa-miR-4436b-5p	CLIP-seq
MIRT1029633	hsa-miR-4509	CLIP-seq
MIRT2542140	hsa-miR-4514	CLIP-seq
MIRT2542141	hsa-miR-4692	CLIP-seq
MIRT2542142	hsa-miR-4742-5p	CLIP-seq
MIRT1029634	hsa-miR-4744	CLIP-seq
MIRT1029635	hsa-miR-4796-3p	CLIP-seq
MIRT2542143	hsa-miR-485-5p	CLIP-seq
MIRT2542144	hsa-miR-497	CLIP-seq
MIRT1029636	hsa-miR-519d	CLIP-seq
MIRT1029637	hsa-miR-520d-5p	CLIP-seq
MIRT1029638	hsa-miR-524-5p	CLIP-seq
MIRT1029639	hsa-miR-548ah	CLIP-seq
MIRT2542145	hsa-miR-548c-3p	CLIP-seq
MIRT1029640	hsa-miR-93	CLIP-seq

Show/Hide all (6)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003924	Function	GTPase activity	IBA
GO:0005515	Function	Protein binding	IPI	25241168, 32296183, 33961781
GO:0005525	Function	GTP binding	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0032991	Component	Protein-containing complex	IDA

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Q9UHW5

Protein name

GPN-loop GTPase 3 (ATP-binding domain 1 family member C)

Protein function

Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03029	ATP_bind_1	8 → 254	Conserved hypothetical ATP binding protein	Domain

Sequence

MPRYAQLVMGPAGSGKSTYCATMVQHCEALNRSVQVVNLDPAAEHFNYSVMADIRELIEV
DDVMEDDSLRFGPNGGLVFCMEYFANNFDWLENCLGHVEDDYILFDCPGQIELYTHLPVM
KQLVQQLEQWEFRVCGVFLVDSQFMVESFKFISGILAALSAMISLEIPQVNIMTKMDLLS
KKAKKEIEKFLDPDMYSLLEDSTSDLRSKKFKKLTKAICGLIDDYSMVRFLPYDQSDEES
MNIVLQHIDFAIQYGEDLEFKEPKEREDESSSMFDEYFQECQDE

Sequence length

284

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
OBESITY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (6)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Carcinoma	Breast Carcinoma	BEFREE	31431135		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	31431135	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	37951201	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	31431135		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	28940195, 31431135		★★★★★ ★☆☆☆☆ Found in Text Mining only
Trigeminal Neuralgia	Trigeminal neuralgia	BEFREE	30095334		★★★★★ ★☆☆☆☆ Found in Text Mining only

GPN3 (GPN-loop GTPase 3)