Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	51149
Gene name	MRN complex interacting protein
Gene symbol	MRNIP
Synonyms (NCBI Gene)	C5orf45
Chromosome	5
Chromosome location	5q35.3

Show/Hide all (97)

miRTarBase ID	miRNA	Experiments	Reference
MIRT690227	hsa-miR-34b-3p	HITS-CLIP	23313552
MIRT636899	hsa-miR-216a-5p	HITS-CLIP	23313552
MIRT690226	hsa-miR-216b-5p	HITS-CLIP	23313552
MIRT690225	hsa-miR-3929	HITS-CLIP	23313552
MIRT690224	hsa-miR-4419b	HITS-CLIP	23313552
MIRT690223	hsa-miR-4478	HITS-CLIP	23313552
MIRT690222	hsa-miR-3614-5p	HITS-CLIP	23313552
MIRT690221	hsa-miR-6500-3p	HITS-CLIP	23313552
MIRT690220	hsa-miR-5690	HITS-CLIP	23313552
MIRT690219	hsa-miR-6746-5p	HITS-CLIP	23313552
MIRT636892	hsa-miR-6787-3p	HITS-CLIP	23313552
MIRT690218	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT690217	hsa-miR-1827	HITS-CLIP	23313552
MIRT690216	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT690215	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT690214	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT690213	hsa-miR-6771-5p	HITS-CLIP	23313552
MIRT690212	hsa-miR-665	HITS-CLIP	23313552
MIRT690211	hsa-miR-3714	HITS-CLIP	23313552
MIRT690210	hsa-miR-383-5p	HITS-CLIP	23313552
MIRT690209	hsa-miR-5694	HITS-CLIP	23313552
MIRT690208	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT690207	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT690206	hsa-miR-940	HITS-CLIP	23313552
MIRT690205	hsa-miR-3927-3p	HITS-CLIP	23313552
MIRT690204	hsa-miR-6831-5p	HITS-CLIP	23313552
MIRT690203	hsa-miR-3622a-3p	HITS-CLIP	23313552
MIRT690202	hsa-miR-3622b-3p	HITS-CLIP	23313552
MIRT690201	hsa-miR-6765-3p	HITS-CLIP	23313552
MIRT690200	hsa-miR-4736	HITS-CLIP	23313552
MIRT690199	hsa-miR-7106-5p	HITS-CLIP	23313552
MIRT690198	hsa-miR-149-3p	HITS-CLIP	23313552
MIRT690197	hsa-miR-4728-5p	HITS-CLIP	23313552
MIRT690196	hsa-miR-6785-5p	HITS-CLIP	23313552
MIRT690195	hsa-miR-6883-5p	HITS-CLIP	23313552
MIRT690194	hsa-miR-6799-5p	HITS-CLIP	23313552
MIRT690193	hsa-miR-30c-1-3p	HITS-CLIP	23313552
MIRT690192	hsa-miR-30c-2-3p	HITS-CLIP	23313552
MIRT690191	hsa-miR-6788-5p	HITS-CLIP	23313552
MIRT690190	hsa-miR-1273h-5p	HITS-CLIP	23313552
MIRT690189	hsa-miR-30b-3p	HITS-CLIP	23313552
MIRT690188	hsa-miR-3689a-3p	HITS-CLIP	23313552
MIRT690187	hsa-miR-3689b-3p	HITS-CLIP	23313552
MIRT690186	hsa-miR-3689c	HITS-CLIP	23313552
MIRT690185	hsa-miR-6779-5p	HITS-CLIP	23313552
MIRT690184	hsa-miR-6780a-5p	HITS-CLIP	23313552
MIRT690183	hsa-miR-450a-1-3p	HITS-CLIP	23313552
MIRT690182	hsa-miR-3122	HITS-CLIP	23313552
MIRT690181	hsa-miR-3913-5p	HITS-CLIP	23313552
MIRT690180	hsa-miR-887-5p	HITS-CLIP	23313552
MIRT690179	hsa-miR-6513-5p	HITS-CLIP	23313552
MIRT617514	hsa-miR-4282	HITS-CLIP	23824327
MIRT617513	hsa-miR-520f-5p	HITS-CLIP	23824327
MIRT617512	hsa-miR-1267	HITS-CLIP	23824327
MIRT617511	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT617510	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT617509	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT617508	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT617507	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT617506	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT636899	hsa-miR-216a-5p	HITS-CLIP	23824327
MIRT636898	hsa-miR-532-5p	HITS-CLIP	23824327
MIRT636897	hsa-miR-4714-3p	HITS-CLIP	23824327
MIRT636896	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT636895	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT636894	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT636892	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT636893	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT636891	hsa-miR-4633-5p	HITS-CLIP	23824327
MIRT617514	hsa-miR-4282	HITS-CLIP	23824327
MIRT617513	hsa-miR-520f-5p	HITS-CLIP	23824327
MIRT617512	hsa-miR-1267	HITS-CLIP	23824327
MIRT617511	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT617510	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT617509	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT617508	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT617507	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT617506	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT617514	hsa-miR-4282	HITS-CLIP	23824327
MIRT617513	hsa-miR-520f-5p	HITS-CLIP	23824327
MIRT617512	hsa-miR-1267	HITS-CLIP	23824327
MIRT617511	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT617510	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT617509	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT617508	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT617507	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT617506	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT514831	hsa-miR-552-3p	PAR-CLIP	23446348
MIRT514830	hsa-miR-6504-3p	PAR-CLIP	23446348
MIRT514829	hsa-miR-3934-5p	PAR-CLIP	23446348
MIRT514828	hsa-miR-1273g-3p	PAR-CLIP	23446348
MIRT514827	hsa-miR-4252	PAR-CLIP	23446348
MIRT514826	hsa-miR-668-5p	PAR-CLIP	23446348
MIRT514825	hsa-miR-6720-3p	PAR-CLIP	23446348
MIRT514824	hsa-miR-5095	PAR-CLIP	23446348
MIRT514823	hsa-miR-7151-3p	PAR-CLIP	23446348
MIRT514822	hsa-miR-6807-5p	PAR-CLIP	23446348

Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003682	Function	Chromatin binding	IBA
GO:0003682	Function	Chromatin binding	IDA	27568553
GO:0005515	Function	Protein binding	IPI	27568553, 32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	27568553
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA	27568553
GO:0005654	Component	Nucleoplasm	IEA
GO:0006281	Process	DNA repair	IEA
GO:0006974	Process	DNA damage response	IEA
GO:0006974	Process	DNA damage response	IMP	27568553
GO:0007095	Process	Mitotic G2 DNA damage checkpoint signaling	IBA
GO:0007095	Process	Mitotic G2 DNA damage checkpoint signaling	IMP	27568553
GO:0010212	Process	Response to ionizing radiation	IMP	27568553
GO:0030870	Component	Mre11 complex	IDA	27568553
GO:0045860	Process	Positive regulation of protein kinase activity	IMP	27568553
GO:0071168	Process	Protein localization to chromatin	IDA	27568553
GO:1905168	Process	Positive regulation of double-strand break repair via homologous recombination	IMP	27568553
GO:2001032	Process	Regulation of double-strand break repair via nonhomologous end joining	IMP	27568553

MIM	HGNC	e!Ensembl
617154	30817	ENSG00000161010

Q6NTE8

Protein name

MRN complex-interacting protein (MRN-interacting protein)

Protein function

Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex (PubMed:27568553). Promotes chromatin loading and activity of the MRN complex to facilitate s

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15749	MRNIP	9 → 110	MRN-interacting protein	Family

Sequence

MASLQRSRVLRCCSCRLFQAHQVKKSVKWTCKACGEKQSFLQAYGEGSGADCRRHVQKLN
LLQGQVSELPLRSLEETVSASEEENVGHQQAGNVKQQEKSQPSESRWLKYLEKDSQELEL
EGTGVCFSKQPSSKMEEPGPRFSQDLPRKRKWSRSTVQPPCSRGVQDSGGSEVAWGPQKG
QAGLTWKVKQGSSPCLQENSADCSAGELRGPGKELWSPIQQVTATSSKWAQFVLPPRKSS
HVDSEQPRSLQRDPRPAGPAQAKQGTPRAQASREGLSRPTAAVQLPRATHPVTSGSERPC
GKTSWDARTPWAEGGPLVLEAQNPRPTRLCDLFITGEDFDDDV

Sequence length

343

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PAGET DISEASE OF BONE 3	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (2)

Disease Name	Disease (Merged)	Source	PMID	Evidence Score
Associations from Text Mining Disease associations identified through text mining
FRONTOTEMPORAL DEMENTIA AND/OR AMYOTROPHIC LATERAL SCLEROSIS 3	Frontotemporal Dementia With Or Without Amyotrophic Lateral Sclerosis	CLINVAR_DG	11992264, 15493999, 18765443, 19589897, 21195346, 21515589, 23417734, 23942205, 24042580, 24899140, 25241215	★★★★★ ★☆☆☆☆ Found in Text Mining only
PAGET DISEASE OF BONE 3	Paget disease	CLINVAR_DG	11992264, 15176995, 15493999, 15647816, 15765181, 16813535, 17229007, 18543015, 18765443, 19257822, 19589897, 20499339, 21195346, 21515589, 21878516 View all (6 more)	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

MRNIP (MRN complex interacting protein)