Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	51116
Gene name	Mitochondrial ribosomal protein S2
Gene symbol	MRPS2
Synonyms (NCBI Gene)	CGI-91COXPD36MRP-S2S2mtuS2m
Chromosome	9
Chromosome location	9q34.3
Summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% prot

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Show/Hide all (326)

miRTarBase ID	miRNA	Experiments	Reference
MIRT027648	hsa-miR-98-5p	Microarray	19088304
MIRT029413	hsa-miR-26b-5p	Microarray	19088304
MIRT031702	hsa-miR-16-5p	Proteomics	18668040
MIRT052610	hsa-let-7a-5p	CLASH	23622248
MIRT051703	hsa-let-7e-5p	CLASH	23622248
MIRT037669	hsa-miR-744-5p	CLASH	23622248
MIRT440212	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440212	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT1159976	hsa-miR-103a	CLIP-seq
MIRT1159977	hsa-miR-107	CLIP-seq
MIRT1159978	hsa-miR-1185	CLIP-seq
MIRT1159979	hsa-miR-1207-3p	CLIP-seq
MIRT1159980	hsa-miR-1273g	CLIP-seq
MIRT1159981	hsa-miR-1324	CLIP-seq
MIRT1159982	hsa-miR-15a	CLIP-seq
MIRT1159983	hsa-miR-15b	CLIP-seq
MIRT1159984	hsa-miR-16	CLIP-seq
MIRT1159985	hsa-miR-1915	CLIP-seq
MIRT1159986	hsa-miR-195	CLIP-seq
MIRT1159987	hsa-miR-2110	CLIP-seq
MIRT1159988	hsa-miR-3122	CLIP-seq
MIRT1159989	hsa-miR-3130-3p	CLIP-seq
MIRT1159990	hsa-miR-3179	CLIP-seq
MIRT1159991	hsa-miR-3202	CLIP-seq
MIRT1159992	hsa-miR-346	CLIP-seq
MIRT1159993	hsa-miR-3605-5p	CLIP-seq
MIRT1159994	hsa-miR-3679-5p	CLIP-seq
MIRT1159995	hsa-miR-3689a-3p	CLIP-seq
MIRT1159996	hsa-miR-3689c	CLIP-seq
MIRT1159997	hsa-miR-3913-3p	CLIP-seq
MIRT1159998	hsa-miR-3913-5p	CLIP-seq
MIRT1159999	hsa-miR-424	CLIP-seq
MIRT1160000	hsa-miR-4267	CLIP-seq
MIRT1160001	hsa-miR-4271	CLIP-seq
MIRT1160002	hsa-miR-4288	CLIP-seq
MIRT1160003	hsa-miR-4438	CLIP-seq
MIRT1160004	hsa-miR-4446-3p	CLIP-seq
MIRT1160005	hsa-miR-4492	CLIP-seq
MIRT1160006	hsa-miR-4498	CLIP-seq
MIRT1160007	hsa-miR-4504	CLIP-seq
MIRT1160008	hsa-miR-4505	CLIP-seq
MIRT1160009	hsa-miR-4652-5p	CLIP-seq
MIRT1160010	hsa-miR-4667-5p	CLIP-seq
MIRT1160011	hsa-miR-4685-5p	CLIP-seq
MIRT1160012	hsa-miR-4687-3p	CLIP-seq
MIRT1160013	hsa-miR-4700-5p	CLIP-seq
MIRT1160014	hsa-miR-4725-3p	CLIP-seq
MIRT1160015	hsa-miR-4731-5p	CLIP-seq
MIRT1160016	hsa-miR-4747-5p	CLIP-seq
MIRT1160017	hsa-miR-4793-3p	CLIP-seq
MIRT1160018	hsa-miR-489	CLIP-seq
MIRT1160019	hsa-miR-497	CLIP-seq
MIRT1160020	hsa-miR-513a-5p	CLIP-seq
MIRT1160021	hsa-miR-542-3p	CLIP-seq
MIRT1160022	hsa-miR-632	CLIP-seq
MIRT1160023	hsa-miR-647	CLIP-seq
MIRT1160024	hsa-miR-654-3p	CLIP-seq
MIRT1160025	hsa-miR-762	CLIP-seq
MIRT1159976	hsa-miR-103a	CLIP-seq
MIRT1159977	hsa-miR-107	CLIP-seq
MIRT1159978	hsa-miR-1185	CLIP-seq
MIRT2045937	hsa-miR-1202	CLIP-seq
MIRT1159979	hsa-miR-1207-3p	CLIP-seq
MIRT2045938	hsa-miR-1224-3p	CLIP-seq
MIRT2045939	hsa-miR-1260	CLIP-seq
MIRT2045940	hsa-miR-1260b	CLIP-seq
MIRT2045941	hsa-miR-1280	CLIP-seq
MIRT2045942	hsa-miR-1287	CLIP-seq
MIRT1159981	hsa-miR-1324	CLIP-seq
MIRT1159982	hsa-miR-15a	CLIP-seq
MIRT1159983	hsa-miR-15b	CLIP-seq
MIRT1159984	hsa-miR-16	CLIP-seq
MIRT1159986	hsa-miR-195	CLIP-seq
MIRT1159987	hsa-miR-2110	CLIP-seq
MIRT2045943	hsa-miR-3064-5p	CLIP-seq
MIRT2045944	hsa-miR-3126-3p	CLIP-seq
MIRT1159989	hsa-miR-3130-3p	CLIP-seq
MIRT2045945	hsa-miR-3135b	CLIP-seq
MIRT2045946	hsa-miR-3165	CLIP-seq
MIRT2045947	hsa-miR-3176	CLIP-seq
MIRT1159990	hsa-miR-3179	CLIP-seq
MIRT2045948	hsa-miR-3192	CLIP-seq
MIRT2045949	hsa-miR-3194-5p	CLIP-seq
MIRT2045950	hsa-miR-3200-5p	CLIP-seq
MIRT1159991	hsa-miR-3202	CLIP-seq
MIRT2045951	hsa-miR-331-3p	CLIP-seq
MIRT1159992	hsa-miR-346	CLIP-seq
MIRT1159993	hsa-miR-3605-5p	CLIP-seq
MIRT2045952	hsa-miR-3677-5p	CLIP-seq
MIRT1159994	hsa-miR-3679-5p	CLIP-seq
MIRT2045953	hsa-miR-3691-5p	CLIP-seq
MIRT1159997	hsa-miR-3913-3p	CLIP-seq
MIRT2045954	hsa-miR-3921	CLIP-seq
MIRT2045955	hsa-miR-3922-3p	CLIP-seq
MIRT2045956	hsa-miR-3943	CLIP-seq
MIRT2045957	hsa-miR-3972	CLIP-seq
MIRT1159999	hsa-miR-424	CLIP-seq
MIRT1160000	hsa-miR-4267	CLIP-seq
MIRT1160001	hsa-miR-4271	CLIP-seq
MIRT1160002	hsa-miR-4288	CLIP-seq
MIRT2045958	hsa-miR-4300	CLIP-seq
MIRT2045959	hsa-miR-4308	CLIP-seq
MIRT2045960	hsa-miR-4313	CLIP-seq
MIRT1160003	hsa-miR-4438	CLIP-seq
MIRT1160007	hsa-miR-4504	CLIP-seq
MIRT2045961	hsa-miR-4530	CLIP-seq
MIRT1160009	hsa-miR-4652-5p	CLIP-seq
MIRT2045962	hsa-miR-4653-5p	CLIP-seq
MIRT2045963	hsa-miR-4662a-5p	CLIP-seq
MIRT2045964	hsa-miR-4682	CLIP-seq
MIRT1160012	hsa-miR-4687-3p	CLIP-seq
MIRT2045965	hsa-miR-4722-3p	CLIP-seq
MIRT1160014	hsa-miR-4725-3p	CLIP-seq
MIRT1160016	hsa-miR-4747-5p	CLIP-seq
MIRT2045966	hsa-miR-4763-5p	CLIP-seq
MIRT2045967	hsa-miR-4764-5p	CLIP-seq
MIRT1160017	hsa-miR-4793-3p	CLIP-seq
MIRT1160018	hsa-miR-489	CLIP-seq
MIRT1160019	hsa-miR-497	CLIP-seq
MIRT2045968	hsa-miR-520d-5p	CLIP-seq
MIRT2045969	hsa-miR-524-5p	CLIP-seq
MIRT1160021	hsa-miR-542-3p	CLIP-seq
MIRT1160022	hsa-miR-632	CLIP-seq
MIRT1160024	hsa-miR-654-3p	CLIP-seq
MIRT2045970	hsa-miR-802	CLIP-seq
MIRT2045971	hsa-miR-920	CLIP-seq
MIRT1159976	hsa-miR-103a	CLIP-seq
MIRT1159977	hsa-miR-107	CLIP-seq
MIRT2275021	hsa-miR-1184	CLIP-seq
MIRT1159979	hsa-miR-1207-3p	CLIP-seq
MIRT2045938	hsa-miR-1224-3p	CLIP-seq
MIRT2045939	hsa-miR-1260	CLIP-seq
MIRT2045940	hsa-miR-1260b	CLIP-seq
MIRT1159980	hsa-miR-1273g	CLIP-seq
MIRT2045941	hsa-miR-1280	CLIP-seq
MIRT2045942	hsa-miR-1287	CLIP-seq
MIRT2275022	hsa-miR-129-5p	CLIP-seq
MIRT1159981	hsa-miR-1324	CLIP-seq
MIRT2275023	hsa-miR-133a	CLIP-seq
MIRT2275024	hsa-miR-133b	CLIP-seq
MIRT1159982	hsa-miR-15a	CLIP-seq
MIRT1159983	hsa-miR-15b	CLIP-seq
MIRT1159984	hsa-miR-16	CLIP-seq
MIRT1159986	hsa-miR-195	CLIP-seq
MIRT2045943	hsa-miR-3064-5p	CLIP-seq
MIRT1159988	hsa-miR-3122	CLIP-seq
MIRT2045944	hsa-miR-3126-3p	CLIP-seq
MIRT1159989	hsa-miR-3130-3p	CLIP-seq
MIRT2045945	hsa-miR-3135b	CLIP-seq
MIRT2275025	hsa-miR-3150b-3p	CLIP-seq
MIRT2275026	hsa-miR-3157-5p	CLIP-seq
MIRT2045947	hsa-miR-3176	CLIP-seq
MIRT2275027	hsa-miR-3187-3p	CLIP-seq
MIRT2045951	hsa-miR-331-3p	CLIP-seq
MIRT1159995	hsa-miR-3689a-3p	CLIP-seq
MIRT1159996	hsa-miR-3689c	CLIP-seq
MIRT1159997	hsa-miR-3913-3p	CLIP-seq
MIRT1159998	hsa-miR-3913-5p	CLIP-seq
MIRT2045955	hsa-miR-3922-3p	CLIP-seq
MIRT1159999	hsa-miR-424	CLIP-seq
MIRT2275028	hsa-miR-4252	CLIP-seq
MIRT2045959	hsa-miR-4308	CLIP-seq
MIRT2045960	hsa-miR-4313	CLIP-seq
MIRT2275029	hsa-miR-4418	CLIP-seq
MIRT2275030	hsa-miR-4435	CLIP-seq
MIRT1160003	hsa-miR-4438	CLIP-seq
MIRT2275031	hsa-miR-4453	CLIP-seq
MIRT2275032	hsa-miR-4524	CLIP-seq
MIRT2275033	hsa-miR-4529-5p	CLIP-seq
MIRT2275034	hsa-miR-4538	CLIP-seq
MIRT2045963	hsa-miR-4662a-5p	CLIP-seq
MIRT2045964	hsa-miR-4682	CLIP-seq
MIRT1160012	hsa-miR-4687-3p	CLIP-seq
MIRT2275035	hsa-miR-4691-3p	CLIP-seq
MIRT2275036	hsa-miR-4693-3p	CLIP-seq
MIRT2275037	hsa-miR-4701-5p	CLIP-seq
MIRT2275038	hsa-miR-4728-5p	CLIP-seq
MIRT2275039	hsa-miR-4784	CLIP-seq
MIRT1160017	hsa-miR-4793-3p	CLIP-seq
MIRT1160018	hsa-miR-489	CLIP-seq
MIRT1160019	hsa-miR-497	CLIP-seq
MIRT2275040	hsa-miR-503	CLIP-seq
MIRT2275041	hsa-miR-509-3-5p	CLIP-seq
MIRT2275042	hsa-miR-509-5p	CLIP-seq
MIRT2275043	hsa-miR-548s	CLIP-seq
MIRT2275044	hsa-miR-572	CLIP-seq
MIRT2275045	hsa-miR-588	CLIP-seq
MIRT2275046	hsa-miR-634	CLIP-seq
MIRT2275047	hsa-miR-646	CLIP-seq
MIRT1160023	hsa-miR-647	CLIP-seq
MIRT2275048	hsa-miR-765	CLIP-seq
MIRT2045970	hsa-miR-802	CLIP-seq
MIRT1159976	hsa-miR-103a	CLIP-seq
MIRT1159977	hsa-miR-107	CLIP-seq
MIRT1159982	hsa-miR-15a	CLIP-seq
MIRT1159983	hsa-miR-15b	CLIP-seq
MIRT1159984	hsa-miR-16	CLIP-seq
MIRT1159986	hsa-miR-195	CLIP-seq
MIRT1159999	hsa-miR-424	CLIP-seq
MIRT2275032	hsa-miR-4524	CLIP-seq
MIRT1160012	hsa-miR-4687-3p	CLIP-seq
MIRT1160019	hsa-miR-497	CLIP-seq
MIRT2275040	hsa-miR-503	CLIP-seq
MIRT2275047	hsa-miR-646	CLIP-seq
MIRT1160023	hsa-miR-647	CLIP-seq
MIRT1159976	hsa-miR-103a	CLIP-seq
MIRT1159977	hsa-miR-107	CLIP-seq
MIRT2275021	hsa-miR-1184	CLIP-seq
MIRT1159980	hsa-miR-1273g	CLIP-seq
MIRT2573992	hsa-miR-1321	CLIP-seq
MIRT1159981	hsa-miR-1324	CLIP-seq
MIRT1159982	hsa-miR-15a	CLIP-seq
MIRT1159983	hsa-miR-15b	CLIP-seq
MIRT1159984	hsa-miR-16	CLIP-seq
MIRT1159985	hsa-miR-1915	CLIP-seq
MIRT1159986	hsa-miR-195	CLIP-seq
MIRT1159987	hsa-miR-2110	CLIP-seq
MIRT1159988	hsa-miR-3122	CLIP-seq
MIRT1159990	hsa-miR-3179	CLIP-seq
MIRT2275027	hsa-miR-3187-3p	CLIP-seq
MIRT1159991	hsa-miR-3202	CLIP-seq
MIRT1159998	hsa-miR-3913-5p	CLIP-seq
MIRT2573993	hsa-miR-3974	CLIP-seq
MIRT1159999	hsa-miR-424	CLIP-seq
MIRT2275028	hsa-miR-4252	CLIP-seq
MIRT1160000	hsa-miR-4267	CLIP-seq
MIRT1160001	hsa-miR-4271	CLIP-seq
MIRT2275029	hsa-miR-4418	CLIP-seq
MIRT2275030	hsa-miR-4435	CLIP-seq
MIRT1160003	hsa-miR-4438	CLIP-seq
MIRT1160004	hsa-miR-4446-3p	CLIP-seq
MIRT2275031	hsa-miR-4453	CLIP-seq
MIRT1160005	hsa-miR-4492	CLIP-seq
MIRT1160006	hsa-miR-4498	CLIP-seq
MIRT1160008	hsa-miR-4505	CLIP-seq
MIRT2573994	hsa-miR-450b-3p	CLIP-seq
MIRT2275032	hsa-miR-4524	CLIP-seq
MIRT2275033	hsa-miR-4529-5p	CLIP-seq
MIRT2275034	hsa-miR-4538	CLIP-seq
MIRT1160009	hsa-miR-4652-5p	CLIP-seq
MIRT1160010	hsa-miR-4667-5p	CLIP-seq
MIRT1160011	hsa-miR-4685-5p	CLIP-seq
MIRT1160012	hsa-miR-4687-3p	CLIP-seq
MIRT2275035	hsa-miR-4691-3p	CLIP-seq
MIRT1160013	hsa-miR-4700-5p	CLIP-seq
MIRT2275037	hsa-miR-4701-5p	CLIP-seq
MIRT2573995	hsa-miR-4713-3p	CLIP-seq
MIRT2573996	hsa-miR-4721	CLIP-seq
MIRT1160014	hsa-miR-4725-3p	CLIP-seq
MIRT2275038	hsa-miR-4728-5p	CLIP-seq
MIRT1160015	hsa-miR-4731-5p	CLIP-seq
MIRT2573997	hsa-miR-4739	CLIP-seq
MIRT1160016	hsa-miR-4747-5p	CLIP-seq
MIRT2573998	hsa-miR-4756-5p	CLIP-seq
MIRT1160019	hsa-miR-497	CLIP-seq
MIRT2275040	hsa-miR-503	CLIP-seq
MIRT2275041	hsa-miR-509-3-5p	CLIP-seq
MIRT2275042	hsa-miR-509-5p	CLIP-seq
MIRT1160020	hsa-miR-513a-5p	CLIP-seq
MIRT2275043	hsa-miR-548s	CLIP-seq
MIRT2275045	hsa-miR-588	CLIP-seq
MIRT2275046	hsa-miR-634	CLIP-seq
MIRT2573999	hsa-miR-638	CLIP-seq
MIRT2275047	hsa-miR-646	CLIP-seq
MIRT1160023	hsa-miR-647	CLIP-seq
MIRT1160025	hsa-miR-762	CLIP-seq
MIRT2574000	hsa-miR-769-3p	CLIP-seq
MIRT1159976	hsa-miR-103a	CLIP-seq
MIRT1159977	hsa-miR-107	CLIP-seq
MIRT2275021	hsa-miR-1184	CLIP-seq
MIRT2573992	hsa-miR-1321	CLIP-seq
MIRT1159981	hsa-miR-1324	CLIP-seq
MIRT1159982	hsa-miR-15a	CLIP-seq
MIRT1159983	hsa-miR-15b	CLIP-seq
MIRT1159984	hsa-miR-16	CLIP-seq
MIRT1159985	hsa-miR-1915	CLIP-seq
MIRT1159986	hsa-miR-195	CLIP-seq
MIRT1159987	hsa-miR-2110	CLIP-seq
MIRT1159990	hsa-miR-3179	CLIP-seq
MIRT2275027	hsa-miR-3187-3p	CLIP-seq
MIRT1159991	hsa-miR-3202	CLIP-seq
MIRT2573993	hsa-miR-3974	CLIP-seq
MIRT1159999	hsa-miR-424	CLIP-seq
MIRT2275028	hsa-miR-4252	CLIP-seq
MIRT1160000	hsa-miR-4267	CLIP-seq
MIRT1160001	hsa-miR-4271	CLIP-seq
MIRT2275029	hsa-miR-4418	CLIP-seq
MIRT2275030	hsa-miR-4435	CLIP-seq
MIRT1160003	hsa-miR-4438	CLIP-seq
MIRT1160004	hsa-miR-4446-3p	CLIP-seq
MIRT2275031	hsa-miR-4453	CLIP-seq
MIRT1160005	hsa-miR-4492	CLIP-seq
MIRT1160006	hsa-miR-4498	CLIP-seq
MIRT1160008	hsa-miR-4505	CLIP-seq
MIRT2573994	hsa-miR-450b-3p	CLIP-seq
MIRT2275032	hsa-miR-4524	CLIP-seq
MIRT2275033	hsa-miR-4529-5p	CLIP-seq
MIRT2275034	hsa-miR-4538	CLIP-seq
MIRT1160009	hsa-miR-4652-5p	CLIP-seq
MIRT1160010	hsa-miR-4667-5p	CLIP-seq
MIRT1160011	hsa-miR-4685-5p	CLIP-seq
MIRT1160012	hsa-miR-4687-3p	CLIP-seq
MIRT2275035	hsa-miR-4691-3p	CLIP-seq
MIRT1160013	hsa-miR-4700-5p	CLIP-seq
MIRT2275037	hsa-miR-4701-5p	CLIP-seq
MIRT2573995	hsa-miR-4713-3p	CLIP-seq
MIRT2573996	hsa-miR-4721	CLIP-seq
MIRT1160014	hsa-miR-4725-3p	CLIP-seq
MIRT2275038	hsa-miR-4728-5p	CLIP-seq
MIRT1160015	hsa-miR-4731-5p	CLIP-seq
MIRT2573997	hsa-miR-4739	CLIP-seq
MIRT1160016	hsa-miR-4747-5p	CLIP-seq
MIRT2573998	hsa-miR-4756-5p	CLIP-seq
MIRT1160019	hsa-miR-497	CLIP-seq
MIRT2275040	hsa-miR-503	CLIP-seq
MIRT2275041	hsa-miR-509-3-5p	CLIP-seq
MIRT2275042	hsa-miR-509-5p	CLIP-seq
MIRT1160020	hsa-miR-513a-5p	CLIP-seq
MIRT2275043	hsa-miR-548s	CLIP-seq
MIRT2275045	hsa-miR-588	CLIP-seq
MIRT2275046	hsa-miR-634	CLIP-seq
MIRT2573999	hsa-miR-638	CLIP-seq
MIRT2275047	hsa-miR-646	CLIP-seq
MIRT1160023	hsa-miR-647	CLIP-seq
MIRT1160025	hsa-miR-762	CLIP-seq
MIRT2574000	hsa-miR-769-3p	CLIP-seq

Show/Hide all (22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003735	Function	Structural constituent of ribosome	IBA
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0003735	Function	Structural constituent of ribosome	ISS	11402041
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	NAS	27023846
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0005763	Component	Mitochondrial small ribosomal subunit	IBA
GO:0005763	Component	Mitochondrial small ribosomal subunit	IDA	25838379
GO:0005763	Component	Mitochondrial small ribosomal subunit	IEA
GO:0005763	Component	Mitochondrial small ribosomal subunit	ISS	11402041
GO:0005763	Component	Mitochondrial small ribosomal subunit	NAS	25838379
GO:0005840	Component	Ribosome	IEA
GO:0006412	Process	Translation	IEA
GO:0015935	Component	Small ribosomal subunit	IEA
GO:0032543	Process	Mitochondrial translation	ISS	11402041
GO:0032543	Process	Mitochondrial translation	NAS	27023846
GO:0061668	Process	Mitochondrial ribosome assembly	IMP	29576219
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
611971	14495	ENSG00000122140

Q9Y399

Protein name

Small ribosomal subunit protein uS2m (28S ribosomal protein S2, mitochondrial) (MRP-S2) (S2mt)

Protein function

Required for mitoribosome formation and stability, and mitochondrial translation.

PDB

3J9M , 6NU2 , 6NU3 , 6RW4 , 6RW5 , 6VLZ , 6VMI , 6ZM5 , 6ZM6 , 6ZS9 , 6ZSA , 6ZSB , 6ZSC , 6ZSD , 6ZSE , 6ZSG , 7A5F , 7A5G , 7A5I , 7A5K , 7L08 , 7OG4 , 7P2E , 7PNX , 7PNY , 7PNZ , 7PO0 , 7PO1 , 7PO2 , 7PO3 , 7QI4 , 7QI5 , 7QI6 , 8ANY , 8CSP , 8CSQ , 8CSR , 8CSS , 8CST , 8CSU , 8K2A , 8OIR , 8OIS , 8QRK , 8QRL , 8QRM , 8QRN , 8RRI , 8XT0 , 8XT2

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00318	Ribosomal_S2	84 → 186	Ribosomal protein S2	Family
PF00318	Ribosomal_S2	183 → 260	Ribosomal protein S2	Family

Sequence

MATSSAALPRILGAGARAPSRWLGFLGKATPRPARPSRRTLGSATALMIRESEDSTDFND
KILNEPLKHSDFFNVKELFSVRSLFDARVHLGHKAGCRHRFMEPYIFGSRLDHDIIDLEQ
TATHLQLALNFTAHMAYRKGIILFISRNRQFSYLIENMARDCGEYAHTRYFRGGMLTNAR
LLFGPTVRLPDLIIFLHTLNNIFEPHVAVRDAAKMNIPTVGIVDTNCNPCLITYPVPGND
DSPLAVHLYCRLFQTAITRAKEKRQQVEALYRLQGQKEPGDQGPAHPPGADMSHSL

Sequence length

296

Interactions

View interactions

	KEGG		Reactome
	Ribosome		Mitochondrial translation elongation Mitochondrial translation termination

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Combined oxidative phosphorylation deficiency 36	Likely pathogenic; Pathogenic	rs1028488967, rs754750531, rs761334309	RCV003123499 RCV003232055 RCV000626471	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
MRPS2-related disorder	Conflicting classifications of pathogenicity; Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (19)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Acidosis Lactic	Lactic acidosis	Pubtator	34991560	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Autistic Disorder	Autism	Pubtator	38029925	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	23569218	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Combined Oxidative Phosphorylation Deficiency 1	Combined oxidative phosphorylation deficiency	Pubtator	38029925	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 36	Combined Oxidative Phosphorylation Deficiency	GENOMICS_ENGLAND_DG	29576219		★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 36	Combined Oxidative Phosphorylation Deficiency	UNIPROT_DG	29576219		★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 36	Combined Oxidative Phosphorylation Deficiency	CLINVAR_DG	29576219		★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Developmental Disabilities	Developmental disability	Pubtator	38029925	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Gallbladder Neoplasms	Gallbladder neoplasm	Pubtator	34991560	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Global developmental delay	Developmental Delay	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Hearing Loss Sensorineural	Hearing loss	Pubtator	29576219, 34991560, 38029925	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoglycemia	Hypoglycemia	Pubtator	29576219, 34991560, 38029925	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoglycemia	Hypoglycemia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Microcephaly	Microcephaly	Pubtator	38029925	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Mitochondrial Diseases	Mitochondrial Diseases	BEFREE	29576219		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mitochondrial Diseases	Mitochondrial disease	Pubtator	29576219, 34991560	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Sensorineural Hearing Loss (disorder)	Hearing Loss	BEFREE	29576219		★★★★★ ★☆☆☆☆ Found in Text Mining only
Sensorineural Hearing Loss (disorder)	Hearing Loss	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only

MRPS2 (mitochondrial ribosomal protein S2)