LACTB2 (lactamase beta 2)

Gene

• Entrez ID: 51110
• Gene name: Lactamase beta 2
• Gene symbol: LACTB2
• Synonyms (NCBI Gene): CGI-83
• Chromosome: 8
• Chromosome location: 8q13.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT029045	hsa-miR-26b-5p	Microarray	19088304
MIRT052096	hsa-let-7b-5p	CLASH	23622248
MIRT047857	hsa-miR-30c-5p	CLASH	23622248
MIRT1103042	hsa-miR-1224-5p	CLIP-seq
MIRT1103043	hsa-miR-296-3p	CLIP-seq
MIRT1103044	hsa-miR-3915	CLIP-seq
MIRT1103045	hsa-miR-3928	CLIP-seq
MIRT1103046	hsa-miR-4689	CLIP-seq
MIRT1103047	hsa-miR-548m	CLIP-seq
MIRT2452843	hsa-miR-330-3p	CLIP-seq
MIRT2452844	hsa-miR-494	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	IEA
GO:0003727	Function	Single-stranded RNA binding	IBA
GO:0003727	Function	Single-stranded RNA binding	IDA	26826708
GO:0004518	Function	Nuclease activity	IEA
GO:0004519	Function	Endonuclease activity	IEA
GO:0004521	Function	RNA endonuclease activity	IBA
GO:0004521	Function	RNA endonuclease activity	IDA	26826708
GO:0005515	Function	Protein binding	IPI	25416956
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IEA
GO:0005759	Component	Mitochondrial matrix	IBA
GO:0005759	Component	Mitochondrial matrix	IDA	26826708
GO:0005759	Component	Mitochondrial matrix	IEA
GO:0008270	Function	Zinc ion binding	IDA	26826708
GO:0016787	Function	Hydrolase activity	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 618921
• HGNC: 18512
• e!Ensembl: ENSG00000147592

Protein

• UniProt ID: Q53H82
• Protein name: Endoribonuclease LACTB2 (EC 3.1.27.-) (Beta-lactamase-like protein 2)
• Protein function: Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial fu
• PDB: 4AD9
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00753	Lactamase_B	26 → 199	Metallo-beta-lactamase superfamily	Domain
  PF17778	BLACT_WH	237 → 284	Beta-lactamase associated winged helix domain	Domain

• Sequence:

  MAAVLQRVERLSNRVVRVLGCNPGPMTLQGTNTYLVGTGPRRILIDTGEPAIPEYISCLK
  QALTEFNTAIQEIVVTHWHRDHSGGIGDICKSINNDTTYCIKKLPRNPQREEIIGNGEQQ
  YVYLKDGDVIKTEGATLRVLYTPGHTDDHMALLLEEENAIFSGDCILGEGTTVFEDLYDY
  MNSLKELLKIKADIIYPGHGPVIHNAEAKIQQYISHRNIREQQILTLFRENFEKSFTVME
  LVKIIYKNTPENLHEMAKHNLLLHLKKLEKEGKIFSNTDPDKKWKAHL

• Sequence length: 288

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
DIVERTICULAR DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Colorectal Carcinoma	Colorectal Cancer	BEFREE	25823027		★☆☆☆☆ Found in Text Mining only