SCCPDH (saccharopine dehydrogenase (putative))

Gene

• Entrez ID: 51097
• Gene name: Saccharopine dehydrogenase (putative)
• Gene symbol: SCCPDH
• Synonyms (NCBI Gene): CGI-49, CGI49, NET11
• Chromosome: 1
• Chromosome location: 1q44

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT046432	hsa-miR-15b-5p	CLASH	23622248
MIRT1328712	hsa-miR-144	CLIP-seq
MIRT1328713	hsa-miR-1470	CLIP-seq
MIRT1328714	hsa-miR-2053	CLIP-seq
MIRT1328715	hsa-miR-299-3p	CLIP-seq
MIRT1328716	hsa-miR-3121-3p	CLIP-seq
MIRT1328717	hsa-miR-3123	CLIP-seq
MIRT1328718	hsa-miR-3190	CLIP-seq
MIRT1328719	hsa-miR-3202	CLIP-seq
MIRT1328720	hsa-miR-3647-3p	CLIP-seq
MIRT1328721	hsa-miR-3671	CLIP-seq
MIRT1328722	hsa-miR-3925-5p	CLIP-seq
MIRT1328723	hsa-miR-3976	CLIP-seq
MIRT1328724	hsa-miR-4446-5p	CLIP-seq
MIRT1328725	hsa-miR-4491	CLIP-seq
MIRT1328726	hsa-miR-4533	CLIP-seq
MIRT1328727	hsa-miR-4645-3p	CLIP-seq
MIRT1328728	hsa-miR-4657	CLIP-seq
MIRT1328729	hsa-miR-4667-3p	CLIP-seq
MIRT1328730	hsa-miR-4755-5p	CLIP-seq
MIRT1328731	hsa-miR-4760-3p	CLIP-seq
MIRT1328732	hsa-miR-4766-3p	CLIP-seq
MIRT1328733	hsa-miR-548p	CLIP-seq
MIRT1328734	hsa-miR-569	CLIP-seq
MIRT1328735	hsa-miR-607	CLIP-seq
MIRT1328736	hsa-miR-617	CLIP-seq
MIRT1328737	hsa-miR-642a	CLIP-seq
MIRT1328738	hsa-miR-873	CLIP-seq
MIRT1328739	hsa-miR-935	CLIP-seq
MIRT2097581	hsa-miR-4463	CLIP-seq
MIRT2097582	hsa-miR-4494	CLIP-seq
MIRT2097583	hsa-miR-4772-3p	CLIP-seq
MIRT2321837	hsa-miR-1284	CLIP-seq
MIRT2321838	hsa-miR-300	CLIP-seq
MIRT2321839	hsa-miR-331-5p	CLIP-seq
MIRT1328721	hsa-miR-3671	CLIP-seq
MIRT2321840	hsa-miR-3685	CLIP-seq
MIRT2321841	hsa-miR-381	CLIP-seq
MIRT2321842	hsa-miR-384	CLIP-seq
MIRT2097581	hsa-miR-4463	CLIP-seq
MIRT2097582	hsa-miR-4494	CLIP-seq
MIRT2321843	hsa-miR-4666-3p	CLIP-seq
MIRT2097583	hsa-miR-4772-3p	CLIP-seq
MIRT1328733	hsa-miR-548p	CLIP-seq
MIRT1328735	hsa-miR-607	CLIP-seq
MIRT2618240	hsa-miR-1202	CLIP-seq
MIRT2618241	hsa-miR-1281	CLIP-seq
MIRT2618242	hsa-miR-1305	CLIP-seq
MIRT2618243	hsa-miR-132	CLIP-seq
MIRT2618244	hsa-miR-194	CLIP-seq
MIRT2618245	hsa-miR-212	CLIP-seq
MIRT2618246	hsa-miR-3194-5p	CLIP-seq
MIRT2321839	hsa-miR-331-5p	CLIP-seq
MIRT2618247	hsa-miR-361-3p	CLIP-seq
MIRT2618248	hsa-miR-3684	CLIP-seq
MIRT2618249	hsa-miR-3972	CLIP-seq
MIRT2618250	hsa-miR-4267	CLIP-seq
MIRT2618251	hsa-miR-455-3p	CLIP-seq
MIRT2618252	hsa-miR-4722-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005576	Component	Extracellular region	TAS
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005739	Component	Mitochondrion	HDA	20833797
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005811	Component	Lipid droplet	IBA
GO:0005811	Component	Lipid droplet	IDA	14741744
GO:0009247	Process	Glycolipid biosynthetic process	IBA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0030496	Component	Midbody	IDA	15166316
GO:0031093	Component	Platelet alpha granule lumen	TAS

Other IDs

• MIM: 620831
• HGNC: 24275
• e!Ensembl: ENSG00000143653

Protein

• UniProt ID: Q8NBX0
• Protein name: Saccharopine dehydrogenase-like oxidoreductase (EC 1.-.-.-)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03435	Sacchrp_dh_NADP	10 → 149	Saccharopine dehydrogenase NADP binding domain	Family
  PF16653	Sacchrp_dh_C	153 → 419	Saccharopine dehydrogenase C-terminal domain	Domain

• Sequence:

  MATEQRPFHLVVFGASGFTGQFVTEEVAREQVDPERSSRLPWAVAGRSREKLQRVLEKAA
  LKLGRPTLSSEVGIIICDIANPASLDEMAKQATVVLNCVGPYRFYGEPVIKACIENGASC
  IDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIPADLGVIYTRNKMNGTLTAVESF
  LTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRE
  LKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFV
  RFGIGRQLLIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKI
  CTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIE
  FSVISSSEV

• Sequence length: 429

Pathways

Reactome:

Platelet degranulation

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
VASCULAR DEMENTIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations