Gene Gene information from NCBI Gene database.
Entrez ID 51092
Gene name SID1 transmembrane family member 2
Gene symbol SIDT2
Synonyms (NCBI Gene)
CGI-40
Chromosome 11
Chromosome location 11q23.3
miRNA miRNA information provided by mirtarbase database.
341
miRTarBase ID miRNA Experiments Reference
MIRT443813 hsa-miR-6838-5p PAR-CLIP 22100165
MIRT443814 hsa-miR-195-5p PAR-CLIP 22100165
MIRT443812 hsa-miR-15b-5p PAR-CLIP 22100165
MIRT443811 hsa-miR-424-5p PAR-CLIP 22100165
MIRT443810 hsa-miR-497-5p PAR-CLIP 22100165
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
31
GO ID Ontology Definition Evidence Reference
GO:0000902 Process Cell morphogenesis IEA
GO:0003323 Process Type B pancreatic cell development IEA
GO:0003677 Function DNA binding IEA
GO:0003723 Function RNA binding IEA
GO:0003725 Function Double-stranded RNA binding IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
617551 24272 ENSG00000149577
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8NBJ9
Protein name SID1 transmembrane family member 2
Protein function Mediates the translocation of RNA and DNA across the lysosomal membrane during RNA and DNA autophagy (RDA), a process in which RNA or DNA is directly imported into lysosomes in an ATP-dependent manner, and degraded (PubMed:27046251, PubMed:27846
PDB 7Y63 , 7Y68 , 7Y69 , 8J6O , 8K10 , 8K11 , 8K12
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13965 SID-1_RNA_chan 169 832 dsRNA-gated channel SID-1 Family
Sequence
MFALGLPFLVLLVASVESHLGVLGPKNVSQKDAEFERTYVDEVNSELVNIYTFNHTVTRN
RTEGVRVSVNVLNKQKGAPLLFVVRQKEAVVSFQVPLILRGMFQRKYLYQKVERTLCQPP
TKNESEIQFFYVDVSTLSPVNTTYQLRVSRMDDFVLRTGEQFSFNTTAAQPQYFKYEFPE
GVDSVIVKVTSNKAFPCSVISIQDVLCPVYDLDNNVAFIGMYQTMTKKAAITVQRKDFPS
NSFYVVVVVKTEDQACGGSLPFYPFAEDEPVDQGHRQKTLSVLVSQAVTSEAYVSGMLFC
LGIFLSFYLLTVLLACWENWRQKKKTLLVAIDRACPESGHPRVLADSFPGSSPYEGYNYG
SFENVSGSTDGLVDSAGTGDLSYGYQGRSFEPVGTRPRVDSMSSVEEDDYDTLTDIDSDK
NVIRTKQYLYVADLARKDKRVLRKKYQIYFWNIATIAVFYALPVVQLVITYQTVVNVTGN
QDICYYNFLCAHPLGNLSAFNNILSNLGYILLGLLFLLIILQREINHNRALLRNDLCALE
CGIPKHFGLFYAMGTALMMEGLLSACYHVCPNYTNFQFDTSFMYMIAGLCMLKLYQKRHP
DINASAYSAYACLAIVIFFSVLGVVFGKGNTAFWIVFSIIHIIATLLLSTQLYYMGRWKL
DSGIFRRILHVLYTDCIRQCSGPLYVDRMVLLVMGNVINWSLAAYGLIMRPNDFASYLLA
IGICNLLLYFAFYIIMKLRSGERIKLIPLLCIVCTSVVWGFALFFFFQGLSTWQKTPAES
REHNRDCILLDFFDDHDIWHFLSSIAMFGSFLVLLTLDDDLDTVQRDKIYVF
Sequence length 832
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
LUNG NEOPLASMS CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Critical Illness Critical illness Pubtator 38275610 Associate
★☆☆☆☆
Found in Text Mining only
Diabetes Mellitus Type 2 Diabetes mellitus, type 2 Pubtator 33066450 Associate
★☆☆☆☆
Found in Text Mining only
Lung Neoplasms Lung Neoplasms CTD_human_DG 27935865
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Malignant neoplasm of lung Lung Cancer CTD_human_DG 27935865
★☆☆☆☆
Found in Text Mining only
Metabolic Syndrome Metabolic syndrome Pubtator 30382898, 33066450, 38201907 Associate
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Metabolic Syndrome X Metabolic Syndrome BEFREE 30382898
★☆☆☆☆
Found in Text Mining only
Muscular Dystrophy Muscular dystrophy BEFREE 29752955
★☆☆☆☆
Found in Text Mining only
Thyroid Cancer Papillary Papillary thyroid cancer Pubtator 34781815 Associate
★☆☆☆☆
Found in Text Mining only