Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	51090
Gene name	Plasmolipin
Gene symbol	PLLP
Synonyms (NCBI Gene)	PMLPTM4SF11
Chromosome	16
Chromosome location	16q13

141

Show/Hide all (141)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017174	hsa-miR-335-5p	Microarray	18185580
MIRT696824	hsa-miR-124-3p	HITS-CLIP	23313552
MIRT696834	hsa-miR-3714	HITS-CLIP	23313552
MIRT696833	hsa-miR-3910	HITS-CLIP	23313552
MIRT462542	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT462541	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT462540	hsa-miR-940	HITS-CLIP	23313552
MIRT696832	hsa-miR-3937	HITS-CLIP	23313552
MIRT696831	hsa-miR-3975	HITS-CLIP	23313552
MIRT696830	hsa-miR-7106-5p	HITS-CLIP	23313552
MIRT696829	hsa-miR-149-3p	HITS-CLIP	23313552
MIRT696828	hsa-miR-4728-5p	HITS-CLIP	23313552
MIRT696827	hsa-miR-6785-5p	HITS-CLIP	23313552
MIRT696826	hsa-miR-6883-5p	HITS-CLIP	23313552
MIRT696825	hsa-miR-6799-5p	HITS-CLIP	23313552
MIRT696824	hsa-miR-124-3p	HITS-CLIP	23313552
MIRT696823	hsa-miR-506-3p	HITS-CLIP	23313552
MIRT696822	hsa-miR-30c-1-3p	HITS-CLIP	23313552
MIRT696821	hsa-miR-30c-2-3p	HITS-CLIP	23313552
MIRT696820	hsa-miR-6788-5p	HITS-CLIP	23313552
MIRT696819	hsa-miR-1273h-5p	HITS-CLIP	23313552
MIRT696818	hsa-miR-30b-3p	HITS-CLIP	23313552
MIRT696817	hsa-miR-3689a-3p	HITS-CLIP	23313552
MIRT696816	hsa-miR-3689b-3p	HITS-CLIP	23313552
MIRT696815	hsa-miR-3689c	HITS-CLIP	23313552
MIRT696814	hsa-miR-6779-5p	HITS-CLIP	23313552
MIRT696813	hsa-miR-6780a-5p	HITS-CLIP	23313552
MIRT696812	hsa-miR-450a-1-3p	HITS-CLIP	23313552
MIRT696811	hsa-miR-3122	HITS-CLIP	23313552
MIRT696810	hsa-miR-3913-5p	HITS-CLIP	23313552
MIRT696809	hsa-miR-887-5p	HITS-CLIP	23313552
MIRT696808	hsa-miR-6513-5p	HITS-CLIP	23313552
MIRT462545	hsa-miR-302f	PAR-CLIP	20371350
MIRT462544	hsa-miR-1295b-5p	PAR-CLIP	20371350
MIRT462543	hsa-miR-1912	PAR-CLIP	20371350
MIRT462539	hsa-miR-4768-3p	PAR-CLIP	20371350
MIRT462537	hsa-miR-219b-3p	PAR-CLIP	20371350
MIRT462535	hsa-miR-4722-5p	PAR-CLIP	20371350
MIRT462534	hsa-miR-25-5p	PAR-CLIP	20371350
MIRT462533	hsa-miR-1273e	PAR-CLIP	20371350
MIRT462545	hsa-miR-302f	PAR-CLIP	21572407
MIRT462544	hsa-miR-1295b-5p	PAR-CLIP	21572407
MIRT462543	hsa-miR-1912	PAR-CLIP	21572407
MIRT462539	hsa-miR-4768-3p	PAR-CLIP	21572407
MIRT462537	hsa-miR-219b-3p	PAR-CLIP	21572407
MIRT462535	hsa-miR-4722-5p	PAR-CLIP	21572407
MIRT462534	hsa-miR-25-5p	PAR-CLIP	21572407
MIRT462533	hsa-miR-1273e	PAR-CLIP	21572407
MIRT462545	hsa-miR-302f	PAR-CLIP	23592263
MIRT462544	hsa-miR-1295b-5p	PAR-CLIP	23592263
MIRT462543	hsa-miR-1912	PAR-CLIP	23592263
MIRT462542	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT462541	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT462540	hsa-miR-940	PAR-CLIP	23592263
MIRT462539	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT462538	hsa-miR-4649-3p	PAR-CLIP	23592263
MIRT462537	hsa-miR-219b-3p	PAR-CLIP	23592263
MIRT462536	hsa-miR-1827	PAR-CLIP	23592263
MIRT462535	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT462534	hsa-miR-25-5p	PAR-CLIP	23592263
MIRT462533	hsa-miR-1273e	PAR-CLIP	23592263
MIRT696824	hsa-miR-124-3p	HITS-CLIP	23313552
MIRT696834	hsa-miR-3714	HITS-CLIP	23313552
MIRT696833	hsa-miR-3910	HITS-CLIP	23313552
MIRT462542	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT462541	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT462540	hsa-miR-940	HITS-CLIP	23313552
MIRT696832	hsa-miR-3937	HITS-CLIP	23313552
MIRT696831	hsa-miR-3975	HITS-CLIP	23313552
MIRT696830	hsa-miR-7106-5p	HITS-CLIP	23313552
MIRT696829	hsa-miR-149-3p	HITS-CLIP	23313552
MIRT696828	hsa-miR-4728-5p	HITS-CLIP	23313552
MIRT696827	hsa-miR-6785-5p	HITS-CLIP	23313552
MIRT696826	hsa-miR-6883-5p	HITS-CLIP	23313552
MIRT696825	hsa-miR-6799-5p	HITS-CLIP	23313552
MIRT696824	hsa-miR-124-3p	HITS-CLIP	23313552
MIRT696823	hsa-miR-506-3p	HITS-CLIP	23313552
MIRT696822	hsa-miR-30c-1-3p	HITS-CLIP	23313552
MIRT696821	hsa-miR-30c-2-3p	HITS-CLIP	23313552
MIRT696820	hsa-miR-6788-5p	HITS-CLIP	23313552
MIRT696819	hsa-miR-1273h-5p	HITS-CLIP	23313552
MIRT696818	hsa-miR-30b-3p	HITS-CLIP	23313552
MIRT696817	hsa-miR-3689a-3p	HITS-CLIP	23313552
MIRT696816	hsa-miR-3689b-3p	HITS-CLIP	23313552
MIRT696815	hsa-miR-3689c	HITS-CLIP	23313552
MIRT696814	hsa-miR-6779-5p	HITS-CLIP	23313552
MIRT696813	hsa-miR-6780a-5p	HITS-CLIP	23313552
MIRT696812	hsa-miR-450a-1-3p	HITS-CLIP	23313552
MIRT696811	hsa-miR-3122	HITS-CLIP	23313552
MIRT696810	hsa-miR-3913-5p	HITS-CLIP	23313552
MIRT696809	hsa-miR-887-5p	HITS-CLIP	23313552
MIRT696808	hsa-miR-6513-5p	HITS-CLIP	23313552
MIRT462545	hsa-miR-302f	PAR-CLIP	20371350
MIRT462544	hsa-miR-1295b-5p	PAR-CLIP	20371350
MIRT462543	hsa-miR-1912	PAR-CLIP	20371350
MIRT462539	hsa-miR-4768-3p	PAR-CLIP	20371350
MIRT462537	hsa-miR-219b-3p	PAR-CLIP	20371350
MIRT462535	hsa-miR-4722-5p	PAR-CLIP	20371350
MIRT462534	hsa-miR-25-5p	PAR-CLIP	20371350
MIRT462533	hsa-miR-1273e	PAR-CLIP	20371350
MIRT462545	hsa-miR-302f	PAR-CLIP	21572407
MIRT462544	hsa-miR-1295b-5p	PAR-CLIP	21572407
MIRT462543	hsa-miR-1912	PAR-CLIP	21572407
MIRT462539	hsa-miR-4768-3p	PAR-CLIP	21572407
MIRT462537	hsa-miR-219b-3p	PAR-CLIP	21572407
MIRT462535	hsa-miR-4722-5p	PAR-CLIP	21572407
MIRT462534	hsa-miR-25-5p	PAR-CLIP	21572407
MIRT462533	hsa-miR-1273e	PAR-CLIP	21572407
MIRT462545	hsa-miR-302f	PAR-CLIP	23592263
MIRT462544	hsa-miR-1295b-5p	PAR-CLIP	23592263
MIRT462543	hsa-miR-1912	PAR-CLIP	23592263
MIRT462542	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT462541	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT462540	hsa-miR-940	PAR-CLIP	23592263
MIRT462539	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT462538	hsa-miR-4649-3p	PAR-CLIP	23592263
MIRT462537	hsa-miR-219b-3p	PAR-CLIP	23592263
MIRT462536	hsa-miR-1827	PAR-CLIP	23592263
MIRT462535	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT462534	hsa-miR-25-5p	PAR-CLIP	23592263
MIRT462533	hsa-miR-1273e	PAR-CLIP	23592263
MIRT1242984	hsa-miR-2355-5p	CLIP-seq
MIRT1242985	hsa-miR-3155	CLIP-seq
MIRT1242986	hsa-miR-3155b	CLIP-seq
MIRT1242987	hsa-miR-4270	CLIP-seq
MIRT1242988	hsa-miR-4441	CLIP-seq
MIRT1242989	hsa-miR-4685-5p	CLIP-seq
MIRT1242990	hsa-miR-484	CLIP-seq
MIRT1242991	hsa-miR-5095	CLIP-seq
MIRT1242992	hsa-miR-545	CLIP-seq
MIRT1242993	hsa-miR-552	CLIP-seq
MIRT1242994	hsa-miR-553	CLIP-seq
MIRT1242995	hsa-miR-563	CLIP-seq
MIRT1242984	hsa-miR-2355-5p	CLIP-seq
MIRT1242985	hsa-miR-3155	CLIP-seq
MIRT1242986	hsa-miR-3155b	CLIP-seq
MIRT1242990	hsa-miR-484	CLIP-seq
MIRT2298951	hsa-miR-1178	CLIP-seq
MIRT1242987	hsa-miR-4270	CLIP-seq
MIRT1242988	hsa-miR-4441	CLIP-seq
MIRT2298952	hsa-miR-4804-5p	CLIP-seq

Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005794	Component	Golgi apparatus	IEA
GO:0005886	Component	Plasma membrane	IDA	26002055
GO:0005886	Component	Plasma membrane	IEA
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0016324	Component	Apical plasma membrane	IEA
GO:0019911	Function	Structural constituent of myelin sheath	IBA
GO:0030100	Process	Regulation of endocytosis	ISS
GO:0032288	Process	Myelin assembly	IDA	26002055
GO:0042552	Process	Myelination	IBA
GO:0042552	Process	Myelination	IEA
GO:0042802	Function	Identical protein binding	IDA	26002055
GO:0043209	Component	Myelin sheath	IDA	26002055
GO:0043209	Component	Myelin sheath	IEA
GO:0043218	Component	Compact myelin	IEA
GO:0045121	Component	Membrane raft	IEA
GO:1904298	Process	Regulation of transcytosis	IDA	34999972

MIM	HGNC	e!Ensembl
600340	18553	ENSG00000102934

Q9Y342

Protein name

Plasmolipin (Plasma membrane proteolipid)

Protein function

Main component of the myelin sheath that plays an important role in myelin membrane biogenesis and myelination (PubMed:26002055). Plays an essential function in apical endocytosis. Regulates epithelial development through the regulation of apica

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01284	MARVEL	32 → 160	Membrane-associating domain	Domain

Sequence

MAEFPSKVSTRTSSPAQGAEASVSALRPDLGFVRSRLGALMLLQLVLGLLVWALIADTPY
HLYPAYGWVMFVAVFLWLVTIVLFNLYLFQLHMKLYMVPWPLVLMIFNISATVLYITAFI
ACSAAVDLTSLRGTRPYNQRAAASFFACLVMIAYGVSAFFSYQAWRGVGSNAATSQMAGG
YA

Sequence length

182

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Cervical cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MESOTHELIOMA, MALIGNANT	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (13)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Bardet-Biedl Syndrome	Bardet-Biedl Syndrome	BEFREE	11707781		★★★★★ ★☆☆☆☆ Found in Text Mining only
Bardet-Biedl syndrome 2 (disorder)	Bardet-Biedl Syndrome	BEFREE	11707781		★★★★★ ★☆☆☆☆ Found in Text Mining only
Bipolar Disorder	Bipolar disorder	Pubtator	38082312	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Focal cortical dysplasia of Taylor	Focal cortical dysplasia	Pubtator	34301297	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hematuria	Hematuria	Pubtator	35474271	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Keratoconus	Keratoconus	BEFREE	29321650		★★★★★ ★☆☆☆☆ Found in Text Mining only
Keratoconus	Keratoconus	Pubtator	29321650	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant mesothelioma	Malignant Mesothelioma	CTD_human_DG	25756049		★★★★★ ★☆☆☆☆ Found in Text Mining only
Peripheral demyelinating neuropathy	Demyelinating neuropathy	BEFREE	11707781		★★★★★ ★☆☆☆☆ Found in Text Mining only
Retinal Dystrophies	Retinal Dystrophy	CLINVAR_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
RETINITIS PIGMENTOSA 82 WITH OR WITHOUT SITUS INVERSUS	Retinitis Pigmentosa With Or Without Situs Inversus	CLINVAR_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	PSYGENET_DG	15334603		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	Pubtator	38082312	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

PLLP (plasmolipin)