Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	51076
Gene name	CutC copper transporter
Gene symbol	CUTC
Synonyms (NCBI Gene)	CGI-32
Chromosome	10
Chromosome location	10q24.2
Summary	Members of the CUT family of copper transporters are associated with copper homeostasis and are involved in the uptake, storage, delivery, and efflux of copper (Gupta et al., 1995 [PubMed 7635807]; Li et al., 2005 [PubMed 16182249]).[supplied by OMIM, Mar

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Show/Hide all (112)

miRTarBase ID	miRNA	Experiments
MIRT916775	hsa-miR-134	CLIP-seq
MIRT916776	hsa-miR-200b	CLIP-seq
MIRT916777	hsa-miR-200c	CLIP-seq
MIRT916778	hsa-miR-219-2-3p	CLIP-seq
MIRT916779	hsa-miR-2964a-3p	CLIP-seq
MIRT916780	hsa-miR-3118	CLIP-seq
MIRT916781	hsa-miR-3120-5p	CLIP-seq
MIRT916782	hsa-miR-3182	CLIP-seq
MIRT916783	hsa-miR-3185	CLIP-seq
MIRT916784	hsa-miR-3671	CLIP-seq
MIRT916785	hsa-miR-3675-3p	CLIP-seq
MIRT916786	hsa-miR-3688-3p	CLIP-seq
MIRT916787	hsa-miR-429	CLIP-seq
MIRT916788	hsa-miR-4452	CLIP-seq
MIRT916789	hsa-miR-4659a-3p	CLIP-seq
MIRT916790	hsa-miR-4659b-3p	CLIP-seq
MIRT916791	hsa-miR-4698	CLIP-seq
MIRT916792	hsa-miR-4778-3p	CLIP-seq
MIRT916793	hsa-miR-4796-5p	CLIP-seq
MIRT916794	hsa-miR-607	CLIP-seq
MIRT916795	hsa-miR-635	CLIP-seq
MIRT916796	hsa-miR-7	CLIP-seq
MIRT916797	hsa-miR-943	CLIP-seq
MIRT916785	hsa-miR-3675-3p	CLIP-seq
MIRT1971972	hsa-miR-4275	CLIP-seq
MIRT1971973	hsa-miR-4282	CLIP-seq
MIRT1971974	hsa-miR-4427	CLIP-seq
MIRT1971975	hsa-miR-4446-5p	CLIP-seq
MIRT916788	hsa-miR-4452	CLIP-seq
MIRT1971976	hsa-miR-4680-3p	CLIP-seq
MIRT1971977	hsa-miR-4714-5p	CLIP-seq
MIRT1971978	hsa-miR-4760-3p	CLIP-seq
MIRT1971979	hsa-miR-485-3p	CLIP-seq
MIRT916783	hsa-miR-3185	CLIP-seq
MIRT2207596	hsa-miR-320a	CLIP-seq
MIRT2207597	hsa-miR-320b	CLIP-seq
MIRT2207598	hsa-miR-320c	CLIP-seq
MIRT2207599	hsa-miR-320d	CLIP-seq
MIRT2207600	hsa-miR-34b	CLIP-seq
MIRT2207601	hsa-miR-376a	CLIP-seq
MIRT2207602	hsa-miR-376b	CLIP-seq
MIRT2207603	hsa-miR-3919	CLIP-seq
MIRT2207604	hsa-miR-3976	CLIP-seq
MIRT2207605	hsa-miR-4429	CLIP-seq
MIRT2207606	hsa-miR-4432	CLIP-seq
MIRT2207607	hsa-miR-4490	CLIP-seq
MIRT2207608	hsa-miR-4705	CLIP-seq
MIRT2207609	hsa-miR-499-5p	CLIP-seq
MIRT2207610	hsa-miR-592	CLIP-seq
MIRT2207611	hsa-miR-597	CLIP-seq
MIRT2510935	hsa-miR-1253	CLIP-seq
MIRT2510936	hsa-miR-136	CLIP-seq
MIRT916779	hsa-miR-2964a-3p	CLIP-seq
MIRT2510937	hsa-miR-3123	CLIP-seq
MIRT916783	hsa-miR-3185	CLIP-seq
MIRT2510938	hsa-miR-3187-3p	CLIP-seq
MIRT2207596	hsa-miR-320a	CLIP-seq
MIRT2207597	hsa-miR-320b	CLIP-seq
MIRT2207598	hsa-miR-320c	CLIP-seq
MIRT2207599	hsa-miR-320d	CLIP-seq
MIRT2510939	hsa-miR-3607-5p	CLIP-seq
MIRT916784	hsa-miR-3671	CLIP-seq
MIRT916785	hsa-miR-3675-3p	CLIP-seq
MIRT2510940	hsa-miR-3678-3p	CLIP-seq
MIRT2207601	hsa-miR-376a	CLIP-seq
MIRT2207602	hsa-miR-376b	CLIP-seq
MIRT2207603	hsa-miR-3919	CLIP-seq
MIRT2510941	hsa-miR-3925-5p	CLIP-seq
MIRT2207604	hsa-miR-3976	CLIP-seq
MIRT2207605	hsa-miR-4429	CLIP-seq
MIRT2510942	hsa-miR-4435	CLIP-seq
MIRT2510943	hsa-miR-4529-5p	CLIP-seq
MIRT916789	hsa-miR-4659a-3p	CLIP-seq
MIRT916790	hsa-miR-4659b-3p	CLIP-seq
MIRT2510944	hsa-miR-4738-3p	CLIP-seq
MIRT916792	hsa-miR-4778-3p	CLIP-seq
MIRT2510945	hsa-miR-515-5p	CLIP-seq
MIRT2207610	hsa-miR-592	CLIP-seq
MIRT2207611	hsa-miR-597	CLIP-seq
MIRT916794	hsa-miR-607	CLIP-seq
MIRT916795	hsa-miR-635	CLIP-seq
MIRT2510935	hsa-miR-1253	CLIP-seq
MIRT2510936	hsa-miR-136	CLIP-seq
MIRT916779	hsa-miR-2964a-3p	CLIP-seq
MIRT2510937	hsa-miR-3123	CLIP-seq
MIRT916783	hsa-miR-3185	CLIP-seq
MIRT2510938	hsa-miR-3187-3p	CLIP-seq
MIRT2207596	hsa-miR-320a	CLIP-seq
MIRT2207597	hsa-miR-320b	CLIP-seq
MIRT2207598	hsa-miR-320c	CLIP-seq
MIRT2207599	hsa-miR-320d	CLIP-seq
MIRT2510939	hsa-miR-3607-5p	CLIP-seq
MIRT916784	hsa-miR-3671	CLIP-seq
MIRT916785	hsa-miR-3675-3p	CLIP-seq
MIRT2510940	hsa-miR-3678-3p	CLIP-seq
MIRT2207601	hsa-miR-376a	CLIP-seq
MIRT2207602	hsa-miR-376b	CLIP-seq
MIRT2207603	hsa-miR-3919	CLIP-seq
MIRT2510941	hsa-miR-3925-5p	CLIP-seq
MIRT2207604	hsa-miR-3976	CLIP-seq
MIRT2207605	hsa-miR-4429	CLIP-seq
MIRT2510942	hsa-miR-4435	CLIP-seq
MIRT2510943	hsa-miR-4529-5p	CLIP-seq
MIRT916789	hsa-miR-4659a-3p	CLIP-seq
MIRT916790	hsa-miR-4659b-3p	CLIP-seq
MIRT2510944	hsa-miR-4738-3p	CLIP-seq
MIRT916792	hsa-miR-4778-3p	CLIP-seq
MIRT2510945	hsa-miR-515-5p	CLIP-seq
MIRT2207610	hsa-miR-592	CLIP-seq
MIRT2207611	hsa-miR-597	CLIP-seq
MIRT916794	hsa-miR-607	CLIP-seq
MIRT916795	hsa-miR-635	CLIP-seq

Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005507	Function	Copper ion binding	IBA
GO:0005507	Function	Copper ion binding	IDA	19878721
GO:0005507	Function	Copper ion binding	NAS	16182249
GO:0005515	Function	Protein binding	IPI	25416956, 29748336, 31515488, 32296183, 35271311
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IDA	16182249
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IDA	16182249
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0006825	Process	Copper ion transport	NAS	16182249
GO:0046872	Function	Metal ion binding	IEA
GO:0051262	Process	Protein tetramerization	IPI	19878721
GO:0055070	Process	Copper ion homeostasis	NAS	16182249

MIM	HGNC	e!Ensembl
610101	24271	ENSG00000119929

Q9NTM9

Protein name

Copper homeostasis protein cutC homolog

Protein function

May play a role in copper homeostasis. Can bind one Cu(1+) per subunit.

PDB

3IWP

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03932	CutC	26 → 227	CutC family	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:16182249}.

Sequence

MKRQGASSERKRARIPSGKAGAANGFLMEVCVDSVESAVNAERGGADRIELCSGLSEGGT
TPSMGVLQVVKQSVQIPVFVMIRPRGGDFLYSDREIEVMKADIRLAKLYGADGLVFGALT
EDGHIDKELCMSLMAICRPLPVTFHRAFDMVHDPMAALETLLTLGFERVLTSGCDSSALE
GLPLIKRLIEQAKGRIVVMPGGGITDRNLQRILEGSGATEFHCSARSTRDSGMKFRNSSV
AMGASLSCSEYSLKVTDVTKVRTLNAIAKNILV

Sequence length

273

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
INSOMNIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MITOCHONDRIAL COMPLEX IV DEFICIENCY, NUCLEAR TYPE 1	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (4)

Disease Name	Disease (Merged)	Source	PMID	Evidence Score
Associations from Text Mining Disease associations identified through text mining
CARDIOENCEPHALOMYOPATHY, FATAL INFANTILE, DUE TO CYTOCHROME c OXIDASE DEFICIENCY 2	Cardioencephalomyopathy	CLINVAR_DG		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leigh Disease	Leigh Syndrome	CLINVAR_DG	15863660, 21412973, 22310368, 26959537	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leigh Syndrome due to Mitochondrial Complex IV Deficiency	Leigh Syndrome	CLINVAR_DG		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	UNIPROT_DG		★★★★★ ★☆☆☆☆ Found in Text Mining only

CUTC (cutC copper transporter)