FAM135B (family with sequence similarity 135 member B)

Gene

• Entrez ID: 51059
• Gene name: Family with sequence similarity 135 member B
• Gene symbol: FAM135B
• Synonyms (NCBI Gene): C8ORFK32
• Chromosome: 8
• Chromosome location: 8q24.23

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT572561	hsa-miR-361-3p	PAR-CLIP	20371350
MIRT572559	hsa-miR-615-3p	PAR-CLIP	20371350
MIRT572558	hsa-miR-2114-3p	PAR-CLIP	20371350
MIRT572557	hsa-miR-6823-3p	PAR-CLIP	20371350
MIRT572561	hsa-miR-361-3p	PAR-CLIP	20371350
MIRT572559	hsa-miR-615-3p	PAR-CLIP	20371350
MIRT572558	hsa-miR-2114-3p	PAR-CLIP	20371350
MIRT572557	hsa-miR-6823-3p	PAR-CLIP	20371350
MIRT980542	hsa-miR-127-5p	CLIP-seq
MIRT980543	hsa-miR-1298	CLIP-seq
MIRT980544	hsa-miR-186	CLIP-seq
MIRT980545	hsa-miR-203	CLIP-seq
MIRT980546	hsa-miR-21	CLIP-seq
MIRT980547	hsa-miR-3183	CLIP-seq
MIRT980548	hsa-miR-338-5p	CLIP-seq
MIRT980549	hsa-miR-3670	CLIP-seq
MIRT980550	hsa-miR-3677-5p	CLIP-seq
MIRT980551	hsa-miR-3976	CLIP-seq
MIRT980552	hsa-miR-4300	CLIP-seq
MIRT980553	hsa-miR-4436b-5p	CLIP-seq
MIRT980554	hsa-miR-451b	CLIP-seq
MIRT980555	hsa-miR-4659a-3p	CLIP-seq
MIRT980556	hsa-miR-4659b-3p	CLIP-seq
MIRT980557	hsa-miR-4699-3p	CLIP-seq
MIRT980558	hsa-miR-4723-3p	CLIP-seq
MIRT980559	hsa-miR-4753-3p	CLIP-seq
MIRT980560	hsa-miR-4766-5p	CLIP-seq
MIRT980561	hsa-miR-522	CLIP-seq
MIRT980562	hsa-miR-590-5p	CLIP-seq
MIRT980563	hsa-miR-621	CLIP-seq
MIRT980564	hsa-miR-627	CLIP-seq
MIRT980565	hsa-miR-653	CLIP-seq
MIRT980566	hsa-miR-920	CLIP-seq
MIRT980567	hsa-miR-939	CLIP-seq
MIRT1990494	hsa-miR-3686	CLIP-seq
MIRT1990495	hsa-miR-4264	CLIP-seq
MIRT2224681	hsa-miR-3150b-3p	CLIP-seq
MIRT2224682	hsa-miR-4434	CLIP-seq
MIRT2224683	hsa-miR-4516	CLIP-seq
MIRT2224684	hsa-miR-4691-5p	CLIP-seq
MIRT2224685	hsa-miR-4784	CLIP-seq
MIRT2224686	hsa-miR-520d-5p	CLIP-seq
MIRT2224687	hsa-miR-524-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	24705354, 32814053, 33961781
GO:0006629	Process	Lipid metabolic process	IBA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q49AJ0
• Protein name: Protein FAM135B
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF12394	DUF3657	111 → 172	Protein FAM135	Family
  PF05057	DUF676	1135 → 1331	Putative serine esterase (DUF676)	Family

• Sequence:

  MSEIQGTVEFSVELHKFYNVDLFQRGYYQIRVTLKVSSRIPHRLSASIAGQTESSSLHSA
  CVHDSTVHSRVFQILYRNEEVPINDAVVFRVHLLLGGERMEDALSEVDFQLKVDLHFTDS
  EQQLRDVAGAPMVSSRTLGLHFHPRNGLHHQVPVMFDYFHLSVISVTVHAALVALQQPLI
  SFTRPGRGSWLGKGGPDTGQEQSIISLENLVFGAGYCKPTSSEGSFYITSENCMQHAHKW
  HRDLCLLLLHAYRGLRLHFLVIMRDIPELPHTELEALAVEETLSQLCSELQMLNNPEKIA
  EQISKDLAWLTSHMMTLWTQFLDTVTLHSQVTTYLTQEHHTLRVRRFSEAFFYMEHQKLA
  VLTFQENLIQTHSQLSLDIRNSEYLTSMPPLPAECLDIDGDWNTLPVIFEDRYVDCPATG
  HNLSVYPNFDVPVTSPTIMNLKDKEDNCMVNSNLSFREDLVLSTIKPSQMDSDEEVIRCP
  EPGENVATQNHMDMCSESQVYISIGEFQNKAGVPEDECWTGQTSDAGTYPVADVDTSRRS
  PGPEDGQAPVLTYIDVKSSNKNPSRAEPLVAFNAQHESRSSRDKYGLDRTGLSKVVVGGS
  HQNAISSDKTTLHELSTLGKGIDQEGKMVLLSLKLTPSEPCDPLSSTLREPLDIRSSLKD
  SHTEEQEELSVLSGVIKRSSSIISDSGIESEPSSVAWSEARSRALELPSDREVLHPFVRR
  HALHRNSLEGGHTESNTSLPSGIQASLTSISSLPFEEDEREVALTKLTKSVSAPHISSPE
  EAAEDADTKQQDGGFAEPSDMHSKSQGSPGSCSQLCGDSGTDAGADHPLVEIVLDADNQQ
  GPGYIDIPKGKGKQFDAQGHCLPDGRTENTPGVETKGLNLKIPRVIALENPRTRSLHRAL
  EETPKGMPKDLNVGQQALSNSGISEVEGLSQHQVPELSCTSAADAINRNSTGQQSQSGSP
  CIMDDTAFNRGVNAFPEAKHKAGTVCPTVTHSVHSQVLKNQELKAGTSIMGSHLTSAETF
  TLDSLKAVEVVNLSVSCTATCLPFSSVPKETPARAGFSSKQTLFPITHQPLGSFGVVSTH
  SSTLDEEVSERMFSFYQAKEKFKKELKIEGFLYSDLTVLASDIPYFPPEEEEENLEDGIH
  LVVCVHGLDGNSADLRLVKTFIELGLPGGKLDFLMSEKNQMDTFADFDTMTDRLLDEIIQ
  HIQLYNLSISRISFIGHSLGNIIIRSVLTRPRFRYYLNKLHTFLSLSGPHLGTLYNNSTL
  VSTGLWLMQKLKKSGSLLQLTFRDNADLRKCFLYQLSQKTGLQYFKNVVLVASPQDRYVP
  FHSARIEMCKTALKDRHTGPVYAEMINNLLGPLVEAKDCTLIRHNVFHALPNTANTLIGR
  AAHIAVLDSELFLEKFFLVAGLNYFK

• Sequence length: 1406

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CENTRAL NERVOUS SYSTEM CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EWING SARCOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GASTROESOPHAGEAL REFLUX DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUROTIC DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OLIGODENDROGLIOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PERIODONTITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSYCHIATRIC DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SUBSTANCE ABUSE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Autistic Disorder	Autism	GWASDB_DG	22935194		★☆☆☆☆ Found in Text Mining only
Autistic Disorder	Autism	Pubtator	24204716	Associate	★☆☆☆☆ Found in Text Mining only
Bulbo-Spinal Atrophy, X-Linked	Bulbospinal Atrophy, X-Linked	BEFREE	30391288		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	24670651		★☆☆☆☆ Found in Text Mining only
Melanoma Cutaneous Malignant	Melanoma	Pubtator	32639949	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	24670651		★☆☆☆☆ Found in Text Mining only
Pulmonary Disease Chronic Obstructive	Chronic obstructive pulmonary disease	Pubtator	35610288	Associate	★☆☆☆☆ Found in Text Mining only
Small Cell Lung Carcinoma	Small cell lung carcinoma	Pubtator	31199602	Associate	★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	24670651		★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	29927694	Associate	★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of the head and neck	Carcinoma Of The Head And Neck	BEFREE	29927694		★☆☆☆☆ Found in Text Mining only